• Advances in Traditional Medicine
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• v.7 no.2
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• pp.182-190
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• 2007

Alzheimer's disease is a neurodegenerative disorder associated with a decline in cognitive abilities. Dementia is one of the aged related mental problems and a characteristic symptom of Alzheimer's disease. Nootropic agents like piracetam and cholinesterase inhibitors like $Donepezil^{\circledR}$ are used in situations where there is organic disorder in learning abilities, but the resulting side-effects associated with these agents have limited their utility. Foeniculum (F.) vulgare Linn. is widely used in Indian traditional systems of medicines and also as a house remedy for nervous debility. The present work was undertaken to assess the potential of F. vulgare as a nootropic and anti-cholinesterase agent in mice. Exteroceptive behavioral models such as Elevated plus maze and Passive avoidance paradigm were employed to assess short term and long term memory in mice. To delineate the possible mechanism through which F. vulgare elicits the anti-amnesic effects, its influence on central cholinergic activity was studied by estimating the whole brain acetylcholinesterase activity. Pretreatment of methanolic extract of fruits of F. vulgare Linn. for 8 successive days, ameliorated the amnesic effect of scopolamine (0.4 mg/kg) and aging induced memory deficits in mice. F. vulgare extract significantly decreased transfer latencies of young mice and aged mice, increased step down latency and exhibited significant anti-acetyl cholinesterase effects, when compared to piracetam, scopolamine and control groups of mice. F. vulgare might prove to be a useful memory restorative agent in the treatment of dementia seen in the elderly.

• Journal of the Korean Institute of Telematics and Electronics
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• v.9 no.1
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• pp.17-24
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• 1972

A method utilizing vector representation is investigated for determining a faulty elenlent in passive and active networks by simple external measurements. A large system may be considered as an interconnection of a number of subnetlvorks. By utilizing the relationships between the magintudes of a transfer function at various frequencies and the deviations of a circuit element, the fault simulation curves can be drawn. The fault identification regions are defined from the fault simulation curves. A fault identlfication matrix is constructed corresponding the defined fault identification regions. The fault identification matrix, when premultiplied by a vector whose components are measured from a network, yieldg another vector whose components identify a network element which is faulty. A test procedure for the fault identification method is presented and verified by experiments.

• Molecules and Cells
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• v.28 no.6
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• pp.515-520
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• 2009

Applications of bone marrow-derived mesenchymal stem cells in gene therapy have been hampered by the low efficiency of gene transfer to these cells. In current transduction protocols, retrovirus particles with foreign genes make only limited contact with their target cells by passive diffusion and have short life spans, thereby limiting the chances of viral infection. We theorized that mechanically agitating the virus-containing cell suspensions would increase the movement of viruses and target cells, resulting in increase of contact between them. Application of our mechanical agitation for transduction process has increased the absorption of retrovirus particles more than five times compared to the previous static method without changing cell growth rate and viability. The addition of a mechanical agitation step increased transduction efficiency to 42%, higher than that of any other previously-known static transduction protocol.

• Journal of Ocean Engineering and Technology
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• v.34 no.2
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• pp.110-119
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• 2020

Explosions and fires on offshore drilling units and process plants, which cause loss of life and environmental damage, have been studied extensively. However, research on drilling units increased only after the 2010 Deepwater Horizon accident in the Gulf of Mexico. A major reason for explosions and fires on a drilling unit is blowout, which is caused by a failure to control the high temperatures and pressures upstream of the offshore underwater well. The area susceptible to explosion and fire due to blowout is the drill floor, which supports the main drilling system. Structural instability and collapse of the drill floor can threaten the structural integrity of the entire unit. This study simulates the behavior of fire subsequent to blowout and assesses the thermal load. A heat transfer structure analysis of the drill floor was carried out using the assessed thermal load, and the risk was noted. In order to maintain the structural integrity of the drill floor, passive fire protection of certain areas was recommended.

• Advances in aircraft and spacecraft science
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• v.6 no.6
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• pp.479-495
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• 2019

Periodic cellular core structures included in sandwich panels possess good stiffness while saving weight and only lately their potential to act as passive vibration filters is increasingly being studied. Classical homogeneous honeycombs show poor vibracoustic performance and only by varying certain geometrical features, a shift and/or variation in bandgap frequency range occurs. This work aims to investigate the vibration filtering properties of the AUXHEX "hybrid" core, which is a cellular structure containing cells of different shapes. Numerical simulations are carried out using two different approaches. The first technique used is the harmonic analysis with commercially available software, and the second one, which has been proved to be computationally more efficient, consists in the Wave Finite Element Method (WFEM), which still makes use of finite elements (FEM) packages, but instead of working with large models, it exploits the periodicity of the structure by analysing only the unit cell, thanks to the Floquet-Bloch theorem. Both techniques allow to produce graphs such as frequency response plots (FRF's) and dispersion curves, which are powerful tools used to identify the spectral bandgap signature of the considered structure. The hybrid cellular core pattern AUXHEX is analysed and results are discussed, focusing the investigation on the possible spectral bandgap signature heritage that a hybrid core experiences from their "parents" homogeneous cell cores.

• Proceedings of the KSME Conference
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• 2004.04a
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• pp.2053-2058
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• 2004

The pressurized light water cooled, medium power (330 MWt) SMART (System-integrated Modular Advanced ReacTor) has been under development at KAERI for a dual purpose : seawater desalination and electricity generation. The SMART design verification phase was followed to conduct various separate effects tests and comprehensive integral effect tests. The high temperature / high pressure thermal-hydraulic test facility, VISTA(Experimental Verification by Integral Simulation of Transient and Accidents) has been constructed to simulate the SMART-P (the one fifth scaled pilot plant) by KAERI. Experimental tests have been performed to investigate the thermal-hydraulic dynamic characteristics of the primary and the secondary systems. Heat transfer characteristics and natural circulation performance of the PRHRS (Passive Residual Heat Removal System) of SMART-P were also investigated using the VISTA facility. The coolant flows steadily in the natural circulation loop which is composed of the steam generator (SG) primary side, the secondary system, and the PRHRS. The heat transfers through the PRHRS heat exchanger and ECT are sufficient enough to enable the natural circulation of the coolant.

• The Transactions of The Korean Institute of Electrical Engineers
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• v.56 no.8
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• pp.1424-1429
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• 2007

This paper presents a simple and reliable one-touch type multi-immunosensing lab-on-a-chip (LOC) detecting antibodies as multi-disease markers using electrochemical method suitable for a portable point-of-care system (POCS). The multi-stacked LOC consists of a PDMS space layer for liquids loading, a PDMS valve layer with 50 im in height for the membrane, a PDMS channel layer for the fluid paths, and a glass layer for multi electrodes. For the disposable immunoassay which needs sequential flow control of sample and buffer liquids according to the designed strategies, reliable and easy-controlled on-chip operation mechanisms without any electric power are necessary. The driving forces of sequential liquids transfer are the capillary attraction force and the pneumatic pressure generated by air bladder push. These passive fluid transport mechanisms are suitable for single-use LOC module. Prior to the application of detection of the antibody as a disease marker, the model experiments were performed with anti-DNP antibody and anti-biotin antibody as target analytes. The flow test results demonstrate that we can control the fluid flow easily by using the capillary stop valve and the PDMS check valves. By the model tests, we confirmed that the proposed LOC is easily applicable to the bioanalytic immunosensors using bioelectrocatalysis.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.10a
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• pp.918-921
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• 2005

According to the mechanical-electrical coupling characteristics and the electrical Impedance property of resistor-inductor-capacitor(RLC) series resonant circuit, the mechanical impedance analysis of a bimorph piezoceramic patch shunted with a series RLC resonant circuit is conducted. The displacement transfer function of a cantilever beam bonded with a piezoelectric shunt damping module is deduced in the case of single mode vibration of the beam. By the use of vibration damping theory of tuned mass damper system, the parameter optimization of piezoelectric shunt damping system is performed. The optimal resonant state of the shunting circuit can be obtained when the resister and conductor are optimally adjusted. Test results show that the vibration control effect as well improved with optimized piezoelectric shunt system.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.39.1-39.1
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• 2020

We examine how the mass assembly of central galaxies depends on their location in the cosmic web. The HORIZON-AGN simulation is analysed at z~2 using the DISPERSE code to extract multi-scale cosmic filaments. We find that the dependency of galaxy properties on large-scale environment is mostly inherited from the (large-scale) environmental dependency of their host halo mass. When adopting a residual analysis that removes the host halo mass effect, we detect a direct and non-negligible influence of cosmic filaments. Proximity to filaments enhances the build-up of stellar mass, a result in agreement with previous studies. However, our multi-scale analysis also reveals that, at the edge of filaments, star formation is suppressed. In addition, we find clues for compaction of the stellar distribution at close proximity to filaments. We suggest that gas transfer from the outside to the inside of the haloes (where galaxies reside) becomes less efficient closer to filaments, due to high angular momentum supply at the vorticity-rich edge of filaments. This quenching mechanism may partly explain the larger fraction of passive galaxies in filaments, as inferred from observations at lower redshifts.

• Journal of Navigation and Port Research
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• v.40 no.6
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• pp.385-390
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• 2016

ELoran Systems can provide Position, Navigation, and Time services with comparable performance to Global Positioning Systems (GPS) as a back up or alternative system. High timing and navigation performance can be achieved by eLoran signals because eLoran receivers use "all-in-view" reception. This incorporates Time of Arrival (TOA) signals from all stations in the service range because each eLoran station is synchronized to Coordinated Universal Time (UTC). Transmission station information and the differential Loran correction data are transmitted via an additional Loran Data Channel (LDC) on the transmitted eLoran signal such that eLoran provides improved Position Navigation and Timing (PNT) over legacy Loran. In this paper, we propose a technique for adapting the delay time compensation values in eLoran timing receivers to provide precise time comparison. For this purpose, we have designed a system that measures time delay from the crossing point of the third cycle extracted from the current transformer at the end point of the transmitter. The receiver delay was measured by connecting an active H-field, an E-field and a passive loop antenna to a commercial eLoran timing receiver. The common-view time transfer technique using the calibrated eLoran timing receiver improved the eLoran transfer time. A eLoran timing receiver calibrated by this method can be utilized in the field for precise time comparison as a GNSS backup.