• 제목/요약/키워드: part of joint

검색결과 956건 처리시간 0.027초

몽수 이헌길(李獻吉)의 마진서(麻疹書) 판본 비교 고찰 (Comparison of Mongsoo Lee Heon-gil's Woodblock-printed Books on Measles)

  • 최진우;안상우
    • 한국의사학회지
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    • 제19권2호
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    • pp.67-85
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    • 2006
  • As Lee Heon-gil's books have been handed down in oral tradition and written form, there are several different versions including the one edited by the author. Books known to be his writings include Eulmisinbang, Majinbang contained in Susangsingam, and Majinbang, Majingibang and Majinbibang mentioned in Joseoneukhaksageupjilbyeongsa. Among Lee Heon-gil's books, Eulmisinbang was mentioned first in literature. Its original version is missing, but a large part of it is quoted in Magwahoitong, through which we can see the contents of Eulmisinbang. The meanings of Eulmisinbang are as follows. First, it is the most reliable woodblock-printed version as it was the base of Magwahoitong. Second, quotations in Magwahoitong are so accurate that they demonstrate the original texts of Eulmisinbang and can be used in comparison with other versions. Third, Eulmisinbang has the largest volume of contents among Lee Heon-gil's books. Susangsingam was printed again in the early 1900s by combing Majinbang and Sanbangsurok. Majinbang included in the book had been known to come from China but, through comparison with the original, it was found to be the same as Eulmisinbang. Majinbang is considered to be Eulmisinbang handed down in different name, and shows the original structure of Eulmisinbang. Considering its table of contents and the contents, Majinbang mentioned in Joseoneukhaksageupjilbyeongsa looks the same as Majinbang included in Susangsingam. Majingibang was edited by extracting the quotations of Eulmisinbang in Magwahoitong, and was reprinted in the name of Majinbibang. Through analyzing Lee Heon-gil's books, we found two courses through which his books have been handed down. First, Eulmisinbang was quoted separately according to the new structure of Magwahoitong, and the structure of Magwahoitong had been maintained and reprinted under the titles of Majingibang and Majinbibang. Second, Eulmisinbang had maintained its original structure, handed down in the name of Majinbang, and reprinted under the title of Susangsingam. Based on the findings, we selected the quotations of Eulmisinbang in Magwahoitong and Majinbang included in Susangsingam as texts for studying Lee Heon-gil's medicine for measles. Accordingly, it looks likely to rebuild a new research text based on the two woodblock-printed versions, and it will be a crucial material for studying Lee Heon-gil's medicine for measles.

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Railway Governance and Power Structure in China

  • Lee, Jinjing
    • International Journal of Railway
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    • 제1권4호
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    • pp.129-133
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    • 2008
  • Over the last $15{\sim}20$years, many countries have adopted policies of railway privatization to keep up with increasing competition from road and air transport. Although each country and case has its own history, market characteristics, political context as well as administrative process, railway privatizations (including railway restructure, concession etc.) in the west usually are accompanied with the establishment of new regulatory regimes. Therefore, railway governance has been innovating towards an interaction of government, regulator, industry bodies, user groups, trade unions and other interested groups within the regulatory framework. However, it is not the case in China. Although China had seen a partial privatization in some branch lines and is experiencing a much larger-scale privatization by establishing joint-ventures to build and operate high-speed passenger lines and implementing an asset-based securitization program, administrative control still occupies absolutely dominant position in the railway governance in China. Ministry of Railway (MOR) acts as the administrator, operator as well as regulator. There is no national policy that clearly positions railway in the transportation network and clarifies the role of government in railway development. There is also little participation from interested groups in the railway policy making, pricing, service standard or safety matter. Railway in China is solely governed by the mere executive agency. Efficiency-focused economic perspective explanation is far from satisfaction. A wider research perspective from political and social regime is of great potential to better explain and solve the problem. In the west, separation and constrains of power had long been established as a fundamental rule. In addition to internal separation of political power(legislation, execution and jurisdiction), rise of corporation in the 19th century and association revolution in the 20th century greatly fostered the growth of economic and social power. Therefore, political, social and economic organizations cooperate and compete with each other, which leads to a balanced and resonable power structure. While in China, political power, mainly party-controlled administrative power has been keeping a dominated position since the time of plan economy. Although the economic reform promoted the growth of economic power of enterprises, it is still not strong enough to compete with political power. Furthermore, under rigid political control, social organizations usually are affiliated to government, independent social power is still too weak to function. So, duo to the limited and slow reform in political and social regime in China, there is an unbalanced power structure within which political power is dominant, economic power expanding while social power still absent. Totally different power structure in China determines the fundamental institutional environment of her railway privatization and governance. It is expected that the exploration of who act behind railway governance and their acting strength (a power theory) will present us a better picture of railway governance as a relevant transportation mode. The paper first examines the railway governance in China and preliminarily establishes a linkage between railway governance and its fundamental institutional environment, i.e. power structure in a specific country. Secondly, the reason why there is no national policy in China is explored in the view of political power. In China, legislative power is more symbolic while party-controlled administrative power dominates political process and plays a fundamental role in Chinese railway governance. And then, in the part three railway finance reform is analyzed in the view of economic power, esp. the relationship of political power and economic power.

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동작침법의 국내 임상 연구 동향: 주제범위 문헌고찰 (Domestic Clinical Research Trends of Motion-Style Acupuncture Treatment: A Scoping Review)

  • 전종혁;우현준;하원배;금지혜;한윤희;박신혁;이정한
    • 한방재활의학과학회지
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    • 제32권4호
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    • pp.19-32
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    • 2022
  • Objectives This scoping review aimed to investigate the domestic clinical research trends of motion-style acupuncture treatment (MSAT), identify diseases and symptoms for which MSAT is used, summarize specific methods of MSAT, and suggest the direction of future studies. Methods The study was conducted in accordance with a previously specified methodology, using the preferred reporting items for systematic reviews and meta-analyses extension for scoping reviews (PRISMA-ScR) checklist. We searched nine electronic databases for studies on MSAT reported till March 21, 2022. The search terms were 'kinematic acupuncture,' 'MSAT,' 'motion style acupuncture,' and 'motion style treatment.' Results A total of 29 studies were included in our analyses; of them, 23 (79.3%) were before-after studies. Lumbosacral disease was the most common for which MSAT was applied (n=16). The frequency and duration of treatments differed depending on the researchers, and local acupoints (including ashi points) were used in 22 (75.9%) studies. In most cases, the method of mobilizing the joint or stretching the muscle in the disease area was used after inserting the acupuncture; however, in 7 studies, gait exercise was used. Most studies used MSAT in combination with other treatments. Conclusions This study supports the direction of future research by presenting the methodological applications of MSAT. To increase its clinical applicability, studies with a high level of evidence investigating the application to various body part, standardization and safety of MSAT are necessary.

한국인의 대표식품 및 축산식품에 대한 중금속 위해도 평가 (Risk Assessment for Heavy Metals in Korean Foods and Livestock Foodstuffs)

  • 권영민;이경희;이행신;박선오;박정민;김진만;강경모;노기미;김동술;이종옥;홍무기;최달웅
    • 한국축산식품학회지
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    • 제28권3호
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    • pp.373-389
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    • 2008
  • This study was conducted to evaluate exposure level and risk of heavy metals in livestock foodstuffs and Korean foods. Based on the "Food Intake Data," a part of the 2005 National Health & Nutrition Survey and the "2005 Seasonal Nutrition Survey", 113 Korean foods items were selected. 3 samples from different manufacturers of each 113 items of Korean foods were purchased on summer and fall, so total 678 samples were used. The food groups were classified into 15 categories. For the livestock foodstuffs category, meats and poultry (chicken, pork, pork belly, beef, beef feet soup), milks and dairy products (milk, ice cream, liquid yoghourt, sherbet), eggs (egg) were selected. It was found that the daily amount of heavy metals intake (mg/person/day) from livestock foodstuffs is 0.00020 arsenic, 0.00000 cadmium, 0.00020 lead, and 0.00006 mercury, and the daily amount of heavy metals intake (mg/person/day) from Korean foods is 0.0265 arsenic, 0.0083 cadmium, 0.0067 lead, and 0.0028 mercury. Daily amount of heavy metals intake from livestock foodstuffs was low among the food groups. For risk assessment, PDI (Probable Daily Intake) was calculated and compared with PTWI (Provisional Tolerable Weekly Intake) of JECFA (Joint FAO/WHO Expert Committee on Food Additive). Relative hazard of these livestock foodstuffs was 0.006% in arsenic, 0.000% in cadmium, 0.085% in lead, and 0.149% in mercury. Relative hazard of Korean foods was 0.941% in arsenic, 14.676% in cadmium, 3.319% in lead, and 6.860% in mercury. Thus, livestock foodstuffs and Korean foods were as safe as satisfied with the recommended standards of JECFA.

복합소재 사출인서트 알루미늄 바 카울크로스멤버 표면처리 특성에 따른 접합강도 분석 연구 (A Study on the Bonding Strength Analysis according to the Surface Treatment Characteristics of Aluminum Bar-Cowl Cross Member of Composite Material Injection Insert)

  • 손동일;소상우;황현태;최동혁;최완규;김선경;김대일
    • Composites Research
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    • 제33권6호
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    • pp.360-364
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    • 2020
  • 차량의 경량화를 위해 기존의 스틸로 제작된 카울크로스멤버를 마그네슘, 플라스틱으로 연구개발이 진행되었으나, 차량 장착상태의 성능적인 문제로 적용이 어려운 실정이다. 최근 부품양산에 가장 적합한 경량화 부품으로 복합소재 인서트 사출 카울크로스멤버에 대한 연구를 진행하고 있다. 이는 알루미늄 바에 복합소재 브라켓 부품을 인서트 사출하는 제조 공정으로 차량의 장착 상태를 고려할 때, 두 부품의 체결상태가 중요한 요소 중에 하나이다. 본 연구에서는, PA6-GF60 복합소재에 알루미늄 바를 인서트 사출하기 위한 연구로 알루미늄 바의 접합강도가 중요한 요소 중에 하나이다. 이를 위한 연구방법으로 알루미늄 바에 접착제를 분사하는 방식과 널링처리를 한 경우에 대해, 카울크로스멤버의 알루미늄 바와 복합재료 사출부품 형상간의 부분 파트별로 횡방향과 회전방향에 대한 접합강도를 분석 연구하였다.

딥러닝 자세 추정 모델을 이용한 지하공동구 다중 작업자 낙상 검출 모델 비교 (Comparison of Deep Learning Based Pose Detection Models to Detect Fall of Workers in Underground Utility Tunnels)

  • 김정수
    • 한국재난정보학회 논문집
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    • 제20권2호
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    • pp.302-314
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    • 2024
  • 연구목적: 본 연구는 지하공동구 내 다수 작업자의 낙상을 자동으로 판별하기 위한 Top-down 방식의 딥러닝 자세 추정 모델 기반 낙상 검출 모델을 제안하고, 제안 모델의 성능을 평가한다. 연구방법: Top-down 방식의 자세 추정모델 중 하나인 YOLOv8-pose로부터 추론된 결과와 낙상 판별 규칙을 결합한 모델을 제시하고, 지하공동구 내 2인 이하 작업자가 출현한 기립 및 낙상 이미지에 대해 모델 성능지표를 평가하였다. 또한 동일한 방법으로 Bottom-up 방식 자세추정모델(OpenPose)을 적용한 결과를 함께 분석하였다. 두 모델의 낙상 검출 결과는 각 딥러닝 모델의 작업자 인식 성능에 의존적이므로, 작업자 쓰러짐과 함께 작업자 존재 여부에 대한 성능지표도 함께 조사하였다. 연구결과: YOLOv8-pose와 OpenPose의 모델의 작업자 인식 성능은 F1-score 기준으로 각각 0.88, 0.71로 두 모델이 유사한 수준이었으나, 낙상 규칙을 적용함에 따라 0.71, 0.23로 저하되었다. 작업자의 신체 일부만 검출되거나 작업자간 구분을 실패하여, OpenPose 기반 낙상 추론 모델의 성능 저하를 야기한 것으로 분석된다. 결론: Top-down 방식의 딥러닝 자세 추정 모델을 사용하는 것이 신체 관절점 인식 및 개별 작업자 구분 측면에서 지하공동구 내 작업자 낙상 검출에 효과적이라 판단된다.

NUWARD SMR safety approach and licensing objectives for international deployment

  • D. Francis;S. Beils
    • Nuclear Engineering and Technology
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    • 제56권3호
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    • pp.1029-1036
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    • 2024
  • Drawing on the deep experience and understanding of the principles of nuclear safety, as well as many years of nuclear power plant design and operation, the EDF led NUWARD SMR Project is developing a design for a Small Modular Reactor (SMR) of 340 MWe composed of two 170 MWe independent units, that will supplement the offering of high-output nuclear reactors, especially in response to specific needs such as replacement of fossil-fuelled power plants. NUWARD SMR is a mix of proven and innovative design features that will make it more commercially competitive, while integrating safety features that comply with the highest international standards. Following the principles of redundancy and diversity and rigorous application of Defence in Depth (DID), with an international view on nuclear safety licensing, the Project also incorporates new safety approaches into its design development. The NUWARD SMR Project has been in development for a number of years, it entered conceptual design formally in mid-2019 and entered Basic Design in 2023. The objective of the concept design phase was to confirm the project technological choices and to define the first design configuration of the NUWARD SMR product, to document it, in order to launch pre-licensing with the French Safety Authority (ASN) and to define its estimated cost and its subsequent development and construction schedules. As a delivery milestone the Safety Options file (called the Dossier d'Options de Sûreté (DOS)) has been submitted to ASN in July 2023 for their opinion. An integral part of the NUWARD SMR Project, is not only to deliver a design suitable for France and to satisfy French regulation, but to develop a product suitable and indeed desirable, for the international market, with a first focus in Europe. In order to achieve its objectives and realise its market potential, the NUWARD SMR Project needs to define and realise its safety approach within an international environment and that is the key subject of this paper. The following paper: • Summarises the foundation principles and technological background which underpin the design; • Contextualises the key design features with regard to the international safety regulatory framework with particular emphasis on innovative passive safety aspects; • Illustrates the Project activities in preparation for first licensing in France, and also a wider international view via the ASN led Joint Early Review of the NUWARD SMR design, including Finnish and Czech Republic regulators, recently joined by the Swedish, Polish and Dutch regulators; • Articulates the collaborative approach to design development from involvement with the Project partners (the Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Naval Group, TechnicAtome, Framatome and Tractebel) to the establishment of the International NUWARD Advisory Board (INAB), to gain greater international insight and advice; • Concludes with the focus on next steps into detailed design development, standardisation of the design and its simplification to enhance its commercial competitiveness in a context of further harmonisation of the nuclear safety and licensing requirements and aspirations.

골육종의 c-fos 발현에 관한 면역조직화학적 검색 (Immunohistochemical c-fos Expression in Osteosarcoma)

  • 박용구;박혜림
    • 대한골관절종양학회지
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    • 제5권3호
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    • pp.162-168
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    • 1999
  • c-fos와 c-jun은 암 유전자의 하나이며, 이 유전자의 단백질 산물은 여러 가지의 다른 활성화 단백 (activator protein 1, AP-1)으로 골 종양에서 골세포의 증식과 분화를 조절하는 중요한 역할을 하는 인자 중 하나로 알려져 있다. 본 연구에서는 단클론 항체를 이용하여 포르말린에 고정된 파라핀 포매조직을 이용하여 35례의 사람 골육종에서 c-fos 단백의 발현을 연구하였다. c-fos의 발현은 골 형성 병변에서 주로 발현되며, 저등급의 연골형성 병변에서는 발현이 관찰되지 않았다. 높은 빈도의 c-fos 단백의 발현이 골아성 골육종에서 발현되었으나 (17례 중 13례에서 1등급 내지 2등급으로 발현), 2례의 연골형성 골육종, 1례의 섬유아세포성 골육종, 2례의 방골성 골육종에서는 음성으로 나타났다. 2례의 혈관확장성 골육종에서는 양성으로 c-fos 단백의 발현되었다. 비록 조직학적으로 고등급의 골육종에서 면역조직화학적 염색상 고 빈도의 c-fos 단백의 발현이 관찰되나, 조직학적 등급과, 면역염색상 발현사이에 통계적인 유의성은 관찰되지 않았다. 이상의 결과로 c-fos 단백이 골육종의 발생에 관여할 것으로 추론되며, 저등급의 연골형성 육종에 이 단백의 역할에는 추후 연구가 필요할 것으로 사료된다.

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모단(牡丹)(Paeonia moutan Sim) 접목(接木)이 작약(芍藥)(Paeonia albiflora Palls) 근(根)의 유효성분(有效成分)에 미치는 영향(影響) (Effect of Graft of Paeonia moutan into Paeonia albiflora on Pharmaceutical Components)

  • 장기운;김필주;정하일;문창식;안병창
    • 한국토양비료학회지
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    • 제24권3호
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    • pp.206-209
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    • 1991
  • 농가에서 3년간 재배중인 작약(芍藥), 목단(牧丹), 모단(牡丹)을 접붙인 작약(芍藥)(목단(牧丹)/작약(芍藥))근(根)을 수집해서 외형적(外形的) 생육특성(生育特性)과 유효성분(有效成分)을 분석한 결과 다음과 같은 결론(結論)을 얻었다. 1. 목단(牧丹)/작약(芍藥)을 접목(接木)한 지하부(地下部)의 외형적 생육상태(生育狀態)는 작약(芍藥)의 특성과 같았으나, 달관(達觀) 조사(調査)에 의하면 목단(牧丹)/작약접목근(芍藥接木根)이 작약(芍藥)에 비해 2~3배의 증수량(增收量)을 나타냈다. 2. 목단속(牧丹屬)(Paeonia linne) 식물의 주요(主要) 유효성분(有效成分)인 Paeoniflorin은 목단(牧丹)/작약근(芍藥根)이 0.98%로 작약(芍藥) 0.78%, 목단(牧丹) 0.46%보다 0.2%에서 0.5%까지 각각 높게 나타났으며, 목단(牧丹)에 다량 함유된 Paeonol은 목단접목(牧丹接木)으로 인해 목단(牧丹)/작약(芍藥) 접목근(接木根)에서 함량(含量)이 증가되지는 않았다. 3. 결과적(結果的)으로 수량(收量)과 유효성분(有效成分) 측면을 종합비교(綜合比較)해 볼 때, 작약(芍藥)의 뿌리를 대목(臺木)으로 하여 모단경(牡丹莖)을 접수(接穗)로 접목(接木)함으로서 근생육(根生育)이 괄목할만하게 증대되었고, 약효성분(藥效成分)은 작약(芍藥) 고유의 함량비(含量比)를 유지하는 것으로 추정되어 향후 체계적인 연구의 필요성을 제시해 주었다.

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인간의 대장암 HT-29 세포주에서 라이코펜이 Insulin-like Growth Factor-I Receptor Signaling Pathway에 미치는 영향 (Effect of Lycopene on the Insulin-like Growth Factor-I Receptor Signaling Pathway in Human Colon Cancer HT-29 Cells)

  • 이현숙;정재인;강영희;;윤정한
    • 한국식품영양과학회지
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    • 제32권3호
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    • pp.437-443
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    • 2003
  • 선행연구에서 라이코펜이 HT-29세포의 증식을 억제하는 것을 관찰하였기 때문에 본 연구는 그 기전을 연구하기 위하여 수행되 었다. 라이코펜이 HT-29 세포의 사멸을 유도하는지 조사하기 위해서 여러 농도의 라이코펜이 포함된 배지에서 세포를 4일 동안 배양하였다. 라이코펜 농도의 증가에 따라 사멸되는 세포에서 나타나는 특징의 하나인 DNA fragmentation이 증가하는 것을 관찰하였다. Western blot을 수행하여 얻은 결과에 의하면 라이코펜이 IGF-IR, IRS-1, PI3K, Akt와 같은 IGF-IR pathway에 속하는 단백질의 수준을 감소시켰다. IGF-IR의 인산화를 유도하기 위해서 라이코펜이 포함된 배지에서 세포를 배양하고 IGF-I을 첨가하여 0, 5, 10, 60분간 배양한 다음 IGF-IR antibody를 이용하여 immunoprecipitation을 수행하였다. 라이코펜은 IGF-I에 의한 IGF-IR, IRS-1의 인산화와 IGF-IR와 PI3K의 결합을 감소하고 인산화된 Akt를 감소시켰다. 이와 같은 IGF-IR signaling의 억제는 이 대장암세포에 존재하는 IGF-II의 autocrine loop을 억제하는 원인이 될 수 있어, 라이코펜의 암세포증식을 억제하는 기전 중의 하나가 될 수 있다. 라이코펜은 토마토와 그 가공품에 많이 존재하는 물질로 자연적인 식사를 통해 많이 섭취할 수 있는 물질이다. 라이코펜의 항암 기전을 밝혀냄으로써 미래 암예방과 치료를 위한 중요한 기능성 영양소를 생산할 수 있는 기초를 마련해줄 수 있을 것으로 기대된다.