• 한방안이비인후피부과학회지
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• 제11권1호
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• pp.197-218
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• 1998

In this study, I invastigate about oriental medical drug, dosage form and directions in external therapy of contact dermatitis. and after study on relationship oriental medical drug, dosage form and directions with cause, symptom and differentiation of symptom and sign. The results are as follows; 1. Most frequently used oriental medical drug is until qing(淸) dynasty Eriocheir sinensis H. Milne-Edwards(蟹), Salix babylonica L.(柳葉), Natrii sulfas(芒硝), Allium macrostemon Bge.(해), Nelumbo nucifera Gaertn.(荷葉), nowadays in Korea and China Phellodendron amurense Rupr.(黃柏), Gypsum(石膏), Rheum palmatum L.(大黃), Baphicacanthus cusia Bremek(靑黛), Talcum(滑石). 2. In the frequency of dosage form, until qing(淸) dynasty powder 1case, liquor 49cases, liquer and solid mixture 58cases, nowadays Korea and China powder 16cases, liquor 96cases, liquer and solid mixture 59cases. 3. Most frequently used directions of dosage is thinly attaching method(薄貼法), attaching method(敷貼法), furnigating and cleansing method(熏洗法), cleansing method(洗傷法), wet dressing method(濕敷法), spreading powder method(撲粉法), plaster method(途차法), rubbing skin method(摩擦法) 4. In the external therapy of contact dermatitis, oriental medical drug's usage is based on stage of contact dermatitis In acute stage, most frequently used drug is heat and damp remove drug(淸熱燥濕藥), nature of drug(藥性) is bitter taste and cold charactor(苦寒), In chronic stage, most frequently used drug is nourishing the blood drug(養血藥), promoting blood circulation drug(活血藥). 5. The dosage form of drug is based on symptom. In acute stage, when papules and vesicles, or erosion and exudation is the main symptom of skin, liquor or powder is used, when erosion and crust is the main symptom of skin, plaster is used. In chronic stage, plaster is used. 6. In the directions of dosage is based on dosage form of drug and symptom. In acute stage, when papules and vesicles is the main symptom of skin, fumigating and cleansing method, cleansing method, plaster method is used, when erosion, vesicles and exudation the main symptom of skill, cleansing method, wet dressing method, spreading powder method, attaching method, spreading powder method is used, when crust is the main symptom of skin, plaster method is used. In chronic stage, plaster method, rubbing skin method is used.

• 한국토양비료학회지
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• 제19권3호
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• pp.205-210
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• 1986

영남지역(嶺南地域)에 분포(分布)된 단구지토양(段丘地土壤)의 미세형태각적(微細形態覺的) 특징(特徵)을 토양생성(土壤生成)과 모재층구분(母材層區分)을 중심(中心)으로 실시(實施)한 결과(結果) ; 1. 단구토양(段丘土壤)의 원질배열(原質配列)은 Porphyroskelic 상(狀)이고 토양조직(土壤組織)(Soil fabric)은 Vosepic, Mosepic, Insepic, Masepic 등(等)이 대부분(大部分)이었으나 영일지역(迎日地域)의 극락통(極樂統)과 우평통(牛坪統)에서는 Asepic fabric도 있었다. 2. 단구토양(段丘土壤)의 B층(層)에는 ferriargillans, manganiferrous concretions과 papules 등(等)의 토양생성학적(土壤生成學的) 특징(特徵)이 현저(顯著)하게 발달(發達)된 Argillic B층(層)이 있었다. 3. 모재(母材)의 불연속성(不連續性)이 예상(豫想)되는 영천(永川)의 반천통(盤泉統)과 영일(迎日)의 우평통(牛坪統) 기층(基層)은 Plasmic fabric이 단구퇴적물(段丘堆積物)과 판이(判異)하였으므로 bisequum profile로 되어 있음을 알 수 있었으며 이들 토층(土層)에도 유리입자상(遊離粒子狀) 점토피막(粘土皮膜)(Free grain cutans)이 생성(生成)되어 있는 것으로 보아 단구퇴적물(段丘堆積物)의 퇴적전(堆積前)에 일정기간(一定期間) 동안 토양생성작용(土壤生成作用)을 받을 기회가 있었던 것으로 추측(推測)되었다.

• 대한약침학회지
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• 제17권2호
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• pp.80-83
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• 2014

Objectives: This case report is to present a complete recovery from Kaposi's varicelliform eruption (KVE) that occurred in a patient with atopic dermatitis by applying Korean Medicine therapies. Methods: Hwangyeonhaedoktang pharmacopuncture (HP), 0.3 mL, and 25% bee venom pharmacopuncture (BVP), 0.1 mL, were injected, 0.2 mL each, at both BL13 acupoints once a day in the morning. Acupuncture was applied at Sama Upper, Middle and Lower of the Master Tung acupuncture points and at ST44 on the left lateral for 30 minutes twice a day. The affected face was gauze dressed with mixture of 2.0 mL HP and 1.0 mL 25% BVP with 20 mL of normal saline twice a day. Herbal Medicine, Seungmagalgeuntang, was administered three times a day after each meal. Results: Rashes and papules on the face were completely cleared after 10 days of treatments. Conclusion: KVE, an acute and urgent dermatitis, can be effectively treated with Korean medicine.

• 한국임상수의학회지
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• 제21권2호
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• pp.209-213
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• 2004

A 8 kg, 3-year-old male West Highland white terrier dog with a 1.5-year history of chronic, severely pruritic, seborrheic skin disorder was referred to the Veterinary Medical Teaching Hospital of the Tokyo University of Agriculture and Technology. On physical examination, lesions were observed on entire cutaneous surface, except for face, dorsum of body, and footpads. Skin lesions were characterized by diffuse erythema, erythematous papules, severe alopecia, hyperpigmentation, and lichenification. Tape strip tests of skin lesions revealed cocci and Malassezia infections. The intradermal allergy tests revealed positive reactions to Japanese cedar pollen, but the non-seasonal clinical signs were not compatible with atopic dermatitis caused by this pollen. Results of hematological examination, serum chemistry and thyroid gland profile were normal. Examination of skin biopsy exhibited hyperplastic superficial perivascular dermatosis with severe acanthosis, excessive keratinocyte mitoses, patchy or diffuse mild spongiosis, and lymphocytic exocytosis in epidermis. Perivascular to interstitial mononuclear cells infiltration was seen in the superficial dermis. Based on the results of examination described above, epidermal dysplasia was diagnosed. Treatments with administration of antibiotics, etretinate, and prednisolone orally combined with topical ketoconazole cream and antiseborreic shampoos had no good results. Following treatment with long-term oral itraconazole at 10 mg/kg daily and chlorhexidine shampoos was successful. However, when itraconazole therapy was stopped, the condition worsened twice within 2 or 3 months. Readministration of itraconazole produced improvement within 4 weeks. This dog has now been controlled periodical itraconazole therapy.

• 생물정신의학
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• 제16권4호
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• pp.266-270
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• 2009

Adverse drug reactions are very common in clinical practice, and skin is one of the most frequent organs for adverse drug reactions. We report a case of a 71-year-old male patient who developed skin eruptions after switching formulation of quetiapine immediate release(IR) to quetiapine extended release(XR). He had been taking quetiapine IR(400mg/day) for treatment of manic episode which was developed one year ago. The patient showed great improvement of symptoms after taking quetiapine IR for about one year, thus dosage of medication was reduced to 50mg/day on the average. Unfortunately dose reduction has tended to worsen symptoms, so dose of quetiapine was increased again to 200mg/day with formulation changes to XR. Two days after he took new formulation, erythematous papules were occurred over his anterior neck and ventral side of left wrist. As he stopped quetiapine XR, the skin lesions gradually subsided. And he was successfully treated with readministration of quetiapine IR without any skin lesions.

• Archives of Plastic Surgery
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• 제33권5호
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• pp.666-668
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• 2006

Purpose: Livedo vasculitis is recurrent painful ulceration of the feet, ankles and legs characterized by purpuric papules and plaques that undergo superficial necrosis and healing with residual white atrophic scars (atrophie blanche). The typical histopathologic findings of livedo vasculitis are characterized by endothelial proliferation and hyaline degeneration along with thrombosis of dermal vessels. Standard therapeutic strategies for treatment of livedo vasculitis are usually on the basis of rheologic, anti-inflammatory or immnosuppressive treatments, a aspirin, dipyridamole, glucocorticosteroids, pentoxyfylline, or high-dose intravenous immunoglobulin are often ineffective or partially effective. Methods: We report a case of 24-year-old male patient with livedo vasculitis on the ankles and dorsal surfaces of both feet. Results: The lesion that had been unresponsive to medical treatment were successfully healed with complete debridement and skin grafting without recurrences. Conclusion: Surgical treatment can be one of the therapeutic choice in Livedo vasculitis.

• Journal of Yeungnam Medical Science
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• 제15권2호
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• pp.381-390
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• 1998

저자들은 출생시부터 군집상의 홍반성 수포와 부분적으로 사마귀양 병변이 섞여 있는 피부병변을 보인 남아에서 생후 10주부터 갈색 및 검은 색의 색소 침착이 나타나 Bloch-Sulzberger 형의 색소실조증(incontinentia pigmenti)이 의심되어 시행한 피부 생검소견으로 호산성질을 함유한 다수의 수포성 병변이 과각화증과 함께 관찰되는 수포기(bullous stage)와 우상기(verrucous stage)에 속하는 색소실소증으로 확진되고 동반된 증상으로는 경련과 좌안 망막의 삼출성 병변이 관찰된 증례를 경험하였다. 이에 저자들은 지금까지 우리 나라에서는 2례 밖에 소개된 바 없는 남아에서 발생한 색소실조증을 문헌고찰과 함께 보고하였다.

• 한방안이비인후피부과학회지
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• 제28권2호
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• pp.13-22
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• 2015

Objective : To investigate how general characteristics and life habits of patients affect severity of acne which was determined by Korean Acne Grading system(KAGS). To adress correlation between the severity of acne and subjective stresses from which patients suffer. Methods : 86 patients answered to questionaire sheet on their general characteristics and life habits and rated their level of stresses as a number in the range between 0 and 10. Then an oriental medical doctor evaluated subject's acne grades, based of KAGS, through observations on papules, nodules, and scars before (medical) treatments. All data (collected) were analyzed using SPSS 22 (software for windows). To clearly demonstrate association of subjects general characteristics, life habits with KAGS grades, Chi-square tests were performed. The correlation between the KAGS grades and the level of stresses was determined using one-way ANOVA followed by Scheffe's post-hoc analysis. Results & Conclusion : Majority of subjects were women, students between 15 and 25 years old, and patients with normal range of Body Mass Index(BMI). Dysmenorrhea presence and premenstrual exacerbation of acne had statistically significant relationship, suggesting their potential influences on KAGS grades as major factors.

• Archives of Plastic Surgery
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• 제33권2호
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• pp.241-244
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• 2006

Idiopathic scrotal calcinosis is rare entity, characterized by the presence of multiple, firm nodules within the dermis of scrotal skin. The lesions are evident as asymptomatic, round, firm, yellowish papules, from several millimeters up to 1 cm in diameter, with a tendency to occur symmetrically. Because polypoid formation of the calcified cysts is unusual in scrotal calcinosis, we report our experience of a case of scrotal calcinosis with cysts having polypoid appearence. A 34-year-old man was admitted to our department with painless, firm, widespread nodules within the scrotum. Patient started to have these lesions at puberty and progressed to a polypoid form over time. There was neither surgical nor medical treatment had been attempted before our treatment. Physical examination revealed localized polypoid cysts in addition to multiple small, firm nodules within the scrotal skin. No underlying anomalies were detected in the physical examination and laboratory analysis. We experienced the treatment of polypoid idiopathic scrotal calcinosis and a case is presented with the review of literatures.

• 한국수산과학회지
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• 제49권5호
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• pp.589-593
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• 2016

Propionibacterium acnes infection in skin tissue often causes acne vulgaris, commonly characterized by inflammatory papules, pustules, and nodules. Chitosan and its derivatives possess strong anti-inflammatory effects. In this study, the anti-inflammatory activity of chitosan-phytochemical conjugates on P. acnes-infected human skin keratinocytes (HaCaT) was evaluated. We designed a model of P. acnes-induced inflammation in viable HaCaT cells. Nitric oxide (NO), an inflammatory marker, was successfully elevated by P. acnes infection in HaCaT cells in a dose-dependent manner. Furthermore, the levels of NO were reduced by treatment with chitosan-phytochemical conjugates (chitosan-caffeic acid, -ferulic acid and -sinapic acid) in a dose-dependent manner. Among these conjugates, chitosan-caffeic acid exhibited the strongest NO suppression in HaCaT cells infected with P. acnes. The results obtained in this study suggest that chitosan-phytochemical conjugates could be used as a potential therapeutic agent against acne vulgaris.