• 제목/요약/키워드: pal

검색결과 1,094건 처리시간 0.037초

메탈 필름 저항의 펄스 대전력 시험 (Pulse energy high Power test of metal film resistor)

  • 손윤규;장성덕;권세진;오종석;조무현;이경태
    • 대한전기학회:학술대회논문집
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    • 대한전기학회 2005년도 제36회 하계학술대회 논문집 C
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    • pp.2103-2105
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    • 2005
  • Metal film type of resistor have been tested to invest maximum usable power at the pulsed high voltage and pulsed high current. Experiments were carried out using capacitor charging power supply and dump switch. Pulsed amplitude were varied from 1kV to 25kV. The peak current reached was 1kA. Datasheet are given for the limited pulsed power and energy for metal film type of resistor in nanosecond and microsecond time range. The experimental investigation of the threshold loading of the resistor in the high current and voltage pulsed mode has shown that the process of destruction of resistor has specific features for each mode. The mechanisms of failure and destruction of resistors under action of high-voltage and high-current pulses are discussed.

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논벼 장.단간품종의 증발산제계수와 건물량과의 관계에 대한 연구(I) (Studies on Relations between Various Coeffcients of Evapo-Transpiration and Quantities of Dry Matters for Tall-and Short Statured Varieties of Paddy Rice)

  • 류한열;김철기
    • 한국농공학회지
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    • 제16권2호
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    • pp.3361-3394
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    • 1974
  • The purpose of this thesis is to disclose some characteristics of water consumption in relation to the quantities of dry matters through the growing period for two statured varieties of paddy rice which are a tall statured variety and a short one, including the water consumption during seedling period, and to find out the various coefficients of evapotranspiration that are applicable for the water use of an expected yield of the two varieties. PAL-TAL, a tall statured variety, and TONG-lL, a short statured variety were chosen for this investigation. Experiments were performed in two consecutive periods, a seedling period and a paddy field period, In the investigation of seedling period, rectangular galvanized iron evapotranspirometers (91cm${\times}$85cm${\times}$65cm) were set up in a way of two levels (PAL-TAL and TONG-lL varieties) with two replications. A standard fertilization method was applied to all plots. In the experiment of paddy field period, evapotanspiration and evaporation were measured separately. For PAL-TAL variety, the evapotranspiration measurements of 43 plots of rectangular galvanized iron evapotranspirometer (91cm${\times}$85cm${\times}$65cm) and the evaporation measurements of 25 plots of rectangular galvanized iron evaporimeter (91cm${\times}$85cm${\times}$15cm) have been taken for seven years (1966 through 1972), and for TONG-IL variety, the evapotranspiration measurements of 19 plots and the evaporation measurements of 12 plots have been collected for two years (1971 through 1972) with five different fertilization levels. The results obtained from this investigation are summarized as follows: 1. Seedling period 1) The pan evaporation and evapotranspiration during seedling period were proved to have a highly significant correlation to solar radiation, sun shine hours and relative humidity. But they had no significant correlation to average temperature, wind velocity and atmospheric pressure, and were appeared to be negatively correlative to average temperature and wind velocity, and positively correlative to the atmospheric pressure, in a certain period. There was the highest significant correlation between the evapotranspiration and the pan evaporation, beyond all other meteorological factors considered. 2) The evapotranpiration and its coefficient for PAL-TAL variety were 194.5mm and 0.94∼1.21(1.05 in average) respectively, while those for TONG-lL variety were 182.8mm and 0.90∼1.10(0.99 in average) respectively. This indicates that the evapotranspiration for TONG-IL variety was 6.2% less than that for PAL-TAL variety during a seedling period. 3) The evapotranspiration ratio (the ratio of the evapotranspiration to the weight of dry matters) during the seedling period was 599 in average for PAL-TAL variety and 643 for TONG-IL variety. Therefore the ratio for TONG-IL was larger by 44 than that for PAL-TAL variety. 4) The K-values of Blaney and Criddle formula for PAL-TAL variety were 0.78∼1.06 (0.92 in average) and for TONG-lL variety 0.75∼0.97 (0.86 in average). 5) The evapotranspiration coefficient and the K-value of B1aney and Criddle formular for both PAL-TAL and TONG-lL varieties showed a tendency to be increasing, but the evapotranspiration ratio decreasing, with the increase in the weight of dry matters. 2. Paddy field period 1) Correlation between the pan evaporation and the meteorological factors and that between the evapotranspiration and the meteorological factors during paddy field period were almost same as that in case of the seedling period (Ref. to table IV-4 and table IV-5). 2) The plant height, in the same level of the weight of dry matters, for PAL-TAL variety was much larger than that for TONG-IL variety, and also the number of tillers per hill for PAL-TAL variety showed a trend to be larger than that for TONG-IL variety from about 40 days after transplanting. 3) Although there was a tendency that peak of leaf-area-index for TONG-IL variety was a little retarded than that for PAL-TAL variety, it appeared about 60∼80 days after transplanting. The peaks of the evapotranspiration coefficient and the weight of dry matters at each growth stage were overlapped at about the same time and especially in the later stage of growth, the leaf-area-index, the evapotranspiration coefficient and the weight of dry matters for TONG-IL variety showed a tendency to be larger then those for PAL-TAL variety. 4) The evaporation coefficient at each growth stage for TONG-IL and PAL-TALvarieties was decreased and increased with the increase and decrease in the leaf-area-index, and the evaporation coefficient of TONG-IL variety had a little larger value than that of PAL-TAL variety. 5) Meteorological factors (especially pan evaporation) had a considerable influence to the evapotranspiration, the evaporation and the transpiration. Under the same meteorological conditions, the evapotranspiration (ET) showed a increasing logarithmic function of the weight of dry matters (x), while the evaporation (EV) a decreasing logarithmic function of the weight of dry matters; 800kg/10a x 2000kg/10a, ET=al+bl logl0x (bl>0) EV=a2+b2 log10x (a2>0 b2<0) At the base of the weight of total dry matters, the evapotranspiration and the evaporation for TONG-IL variety were larger as much as 0.3∼2.5% and 7.5∼8.3% respectively than those of PAL-TAL variety, while the transpiration for PAL-TAL variety was larger as much as 1.9∼2.4% than that for TONG-IL variety on the contrary. At the base of the weight of rough rices the evapotranspiration and the transpiration for TONG-IL variety were less as much as 3.5% and 8.l∼16.9% respectively than those for PAL-TAL variety and the evaporation for TONG-IL was much larger by 11.6∼14.8% than that for PAL-TAL variety. 6) The evapotranspiration coefficient, the evaporation coefficient and the transpiration coefficient and the transpiration coefficient were affected by the weight of dry matters much more than by the meteorological conditions. The evapotranspiratioa coefficient (ETC) and the evaporation coefficient (EVC) can be related to the weight of dry matters (x) by the following equations: 800kg/10a x 2000kg/10a, ETC=a3+b3 logl0x (b3>0) EVC=a4+b4 log10x (a4>0, b4>0) At the base of the weights of dry matters, 800kg/10a∼2000kg/10a, the evapotranspiration coefficients for TONG-IL variety were 0.968∼1.474 and those for PAL-TAL variety, 0.939∼1.470, the evaporation coefficients for TONG-IL variety were 0.504∼0.331 and those for PAL-TAL variety, 0.469∼0.308, and the transpiration coefficients for TONG-IL variety were 0.464∼1.143 and those for PAL-TAL variety, 0.470∼1.162. 7) The evapotranspiration ratio, the evaporation ratio (the ratio of the evaporation to the weight of dry matters) and the transpiration ratio were highly affected by the meteorological conditions. And under the same meteorological condition, both the evapotranspiration ratio (ETR) and the evaporation ratio (EVR) showed to be a decreasing logarithmic function of the weight of dry matters (x) as follows: 800kg/10a x 2000kg/10a, ETR=a5+b5 logl0x (a5>0, b5<0) EVR=a6+b6 log10x (a6>0 b6<0) In comparison between TONG-IL and PAL-TAL varieties, at the base of the pan evaporation of 343mm and the weight of dry matters of 800∼2000kg/10a, the evapotranspiration ratios for TONG-IL variety were 413∼247, while those for PAL-TAL variety, 404∼250, the evaporation ratios for TONG-IL variety were 197∼38 while those for PAL-TAL variety, 182∼34, and the transpiration ratios for TONG-IL variety were 216∼209 while those for PAL-TAL variety, 222∼216 (Ref. to table IV-23, table IV-25 and table IV-26) 8) The accumulative values of evapotranspiration intensity and transpiration intensity for both PAL-TAL and TONG-IL varieties were almost constant in every climatic year without the affection of the weight of dry matters. Furthermore the evapotranspiration intensity appeared to have more stable at each growth stage. The peaks of the evapotranspiration intensity and transpiration intensity, for both TONG-IL and PAL-TAL varieties, appeared about 60∼70 days after transplanting, and the peak value of the former was 128.8${\pm}$0.7, for TONG-IL variety while that for PAL-TAL variety, 122.8${\pm}$0.3, and the peak value of the latter was 152.2${\pm}$1.0 for TONG-IL variety while that for PAL-TAL variety, 152.7${\pm}$1.9 (Ref.to table IV-27 and table IV-28) 9) The K-value in Blaney & Criddle formula was changed considerably by the meteorological condition (pan evaporation) and related to be a increasing logarithmic function of the weight of dry matters (x) for both PAL-TAL and TONG-L varieties as follows; 800kg/10a x 2000kg/10a, K=a7+b7 logl0x (b7>0) The K-value for TONG-IL variety was a little larger than that for PAL-TAL variety. 10) The peak values of the evapotranspiration coefficient and k-value at each growth stage for both TONG-IL and PAL-TAL varieties showed up about 60∼70 days after transplanting. The peak values of the former at the base of the weights of total dry matters, 800∼2000kg/10a, were 1.14∼1.82 for TONG-IL variety and 1.12∼1.80, for PAL-TAL variety, and at the base of the weights of rough rices, 400∼1000 kg/10a, were 1.11∼1.79 for TONG-IL variety and 1.17∼1.85 for PAL-TAL variety. The peak values of the latter, at the base of the weights of total dry matters, 800∼2000kg/10a, were 0.83∼1.39 for TONG-IL variety and 0.86∼1.36 for PAL-TAL variety and at the base of the weights of rough rices, 400∼1000kg/10a, 0.85∼1.38 for TONG-IL variety and 0.87∼1.40 for PAL-TAL variety (Ref. to table IV-18 and table IV-32) 11) The reasonable and practicable methods that are applicable for calculating the evapotranspiration of paddy rice in our country are to be followed the following priority a) Using the evapotranspiration coefficients based on an expected yield (Ref. to table IV-13 and table IV-18 or Fig. IV-13). b) Making use of the combination method of seasonal evapotranspiration coefficient and evapotranspiration intensity (Ref. to table IV-13 and table IV-27) c) Adopting the combination method of evapotranspiration ratio and evapotranspiration intensity, under the conditions of paddy field having a higher level of expected yield (Ref. to table IV-23 and table IV-27). d) Applying the k-values calculated by Blaney-Criddle formula. only within the limits of the drought year having the pan evaporation of about 450mm during paddy field period as the design year (Ref. to table IV-32 or Fig. IV-22).

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소상팔경(瀟湘八景), 전통경관 텍스트로서의 의미와 결속구조 (A Study on the Meaning and Coherence of Sosangpalkyung as a Text of Traditional Scenery)

  • 노재현
    • 한국조경학회지
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    • 제37권1호
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    • pp.110-119
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    • 2009
  • 소상팔경은 중국에서 태동하여 오랫동안 동아시아의 시와 그림에 지대한 영향을 미쳤으며, 한국과 일본에서 전통 경관의 원형을 이끄는 문화현상으로 자리하였다. 지금까지 팔경 등 '경(景)'에 대한 연구는 지속적으로 이루어져 왔지만 정작 국내 팔경문화의 원류가 되는 소상팔경의 형식과 의미를 집중적으로 조명한 조경학적 연구 성과는 찾을 수 없다. 본 연구는 '문화경관 텍스트'로서의 소상팔경가와 소상팔경도에 담겨진 정형적 모습은 무엇이며 소상팔경이라는 문화현상 속에는 과연 어떠한 인식체계와 사유방식(思惟方式)의 결속구조가 엮여져 있는가를 밝히기 위해 시도되었다. '팔(八)'의 상징성을 정리하고 경관 어휘소의 분절 및 해체를 통해 '소상팔경' 각 경의 표층구조와 상관관계를 기호학적 관점에서 아이콘과 코드로 풀이하는 한편 텍스트 '소상팔경가'와 '소상팔경도'의 결속구조와 그 의미를 파악하였다. 소상팔경은 음양관과 팔괘(八卦)를 기본으로, 인생과 자연의 순환 및 변환 원리를 문자와 그림 텍스트로 정리한 언어기호이며, 문장의 문법적 구조와 형식은 단어의 상징성을 강조한 함축언어를 유사성과 대비성의 원리로서 전개 대응시킴으로서 자연의 섭리를 인간의 의식 안으로 옮겨오려고 시도한 결속구조와 결속성이 강하게 작용하고 있다. 또한, '소상팔경'은 다양한 경관 요소를 일정한 형식과 구조의 틀 속에서 배열함으로써 인생과 자연의 생멸 과정과 교감 그리고 소통을 변증법적으로 묘사하고 있다. 소상팔경의 이미지 기호는 결국 인생과 자연의 순환론을 강조하기 위한 것으로 보이며, 시간 및 계절 순환체계에서 인간이 관조하여 바라본 서사적 풍경이다. 고려에서 조선으로 이입된 "소상팔경"의 문화현상은 성리학적 풍경으로 덧칠되면서 조선의 문예미학을 이끄는 원동력이 되었고, 그 결속구조는 조선의 색채 풍경으로 변형되었지만 결속력은 꾸준히 전승되어 전래 문화경관의 기본 텍스트이자 한국적 풍경의 원형이 되었다.

스트레인 게이지를 이용한 적층방법에 따른 복합레진의 중합수축에 관한 연구 (A STUDY OF POLYMERIZATION SHRINKAGE OF COMPOSITE RESIN ACCORDING TO FILLING METHODS USING STRAIN GAUGE)

  • 김응학;김종수;유승훈
    • 대한소아치과학회지
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    • 제35권1호
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    • pp.18-29
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    • 2008
  • 본 연구는 복합레진 적층방법에 따른 복합레진의 수축양상을 스트레인 게이지를 이용하여 비교 평가하고자 하였다. 사용된 광중합기의 광원은 light-emitting diode(LED)와 plasma arc lamp(PAL)이었으며, 복합레진은 Filtek $Z350^{TM}$를 사용하였다. 교정 치료를 목적으로 발거된 60개의 소구치를 대상으로 하여, 교합면에 와동을 형성하고 일회충전법, 수평적층법, 사면적층법으로 나누어 복합레진을 충전하여 치면에 발생된 strain과 응력을 측정하였고, 법랑질 표면에 시편을 부착하여 동일한 적층방법으로 충전한 후 전단결합강도를 측정한 결과 다음과 같은 결론을 얻었다. 1. Strain의 변화를 살펴보면, LED와 PAL 조사군 모두 와동의 협설면에서는 주로 팽창이 일어났다가 시간이 지남에 따라 서서히 수축하는 양상을 보여주었다. 2. 와동의 근원심면에서는 팽창과 수축이 반복적으로 나타나면서 서서히 수축량이 증가하였다. 3. LED와 PAL 조사군 모두 적층방법 간의 응력 차이는 없었다(p>0.05). 4. LED 및 PAL 조사군 간의 응력 차이는 협면에서만 존재하였다(p<0.05). 5. 전단결합강도 측정 결과 LED 군에서는 사면적층법이 일회충전법, 수평적층법 보다 유의하게 낮게 나타났으나(p<0.05), PAL 광조사군에서는 유의차가 없었다(p>0.05). 6. 각 치면에 발생된 응력은 전단결합강도보다 낮았다(p<0.05).

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모바일 기기를 위한 NTSC, PAL, SECAM 비디오 인코더의 설계 (Design of NTSC/PAL/SECAM Video Encoder for Mobile Device)

  • 김주현;양훈기;강봉순
    • 한국통신학회논문지
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    • 제30권11C호
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    • pp.1083-1090
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    • 2005
  • 본 논문은 TV 출력 기능이 필요한 기기를 위한 비디오 인코더의 설계에 관한 것이다. 설계된 비디오 인코더는 International Telecommunication Union-Radiocommunication (ITU-R) BT.470 표준을 모두 지원한다. ITU-R BT.470에는 NTSC, PAL, SECAM의 3가지로 구분되는데, NTSC와 PAL은 색차 신호를 전송하기 위해서 진폭변조(AM)를 사용하고, SECAM은 주파수변조(FM)를 사용한다. SECAM에서는 anti-cloche 필터가 필요한데, 표준(ITU-R BT.470)에서 권장하는 필터의 특성이 아주 예리해서 이전까지는 아날로그 필터를 사용하여 설계하였다. 본 논문에서는 anti-cloche 필터를 디지털 필터로 설계하고 필터의 특성을 설계하기 쉽도록 바꾸었다. 그리고 표준에서 요구하는 결과와 동일하도록 수정된 변조 방법을 제안한다. 또한 핸드폰 등의 모바일 기기에 적용 할 수 있도록 동작 모드에 따른 소비전력을 가변 하였다. 제안된 비디오 인코더는 Altera사의 FPGA APEX20K1000-EBC652-3과 삼성 LCD-TV를 이용하여 실시간 검증을 수행하였다.

Preparation and Characterization of Self-assembled Glycol Chitosan Hydrogels Containing Palmityl-acylated Exendin-4 for Extended Hypoglycemic Action

  • Lee, Ju-Ho;Lee, Chang-Kyu;Bae, Sung-Ho;Yoon, Jeong-Hyun;Choi, Eun-Joo;Oh, Kyung-Taek;Lee, Eun-Seong;Lee, Kang-Choon;Youn, Yu-Seok
    • Journal of Pharmaceutical Investigation
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    • 제41권3호
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    • pp.173-178
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    • 2011
  • Injectable chitosan hydrogels have attracted great potential due to sustained-release property and safety. Here, palmityl-acylated glycol chitosan (Pal-GC) was used to generate physically cross-linked hydrogels by virtue of hydrophobic attraction of linear fatty carbons. Glycol chitosan was chemically modified with N-hydroxysuccinimide-activated palmitic acid in dimethylsulfoxide (DMSO) containing dimethylaminopyridine. Through a series of preparation steps of (i) dialysis with DMSO, (ii) addition of palmityl-acylated exendin-4 (Ex4-C16), and (iii) dialysis with water, Pal-GC was self-assembled to form physically cross-linked hydrogels entrapped with Ex4-C16. The Pal-GC derivative was analyzed by using 1H NMR, and the surface morphology of Pal-GC hydrogels formed was examined by scanning electron microscopy. Also, the hypoglycemic effect induced by Pal-GC hydrogels containing Ex4-C16 (250 nmol/kg) was evaluated in non-fasted type 2 diabetic db/db mice and compared with GC hydrogels containing native Ex4 at the same dose. Results showed that palmityl group was successfully conjugated with the amines of glycol chitosan, and that Pal-GC efficiently generated the hydrogels formation. Moreover, Pal-GC hydrogels containing Ex4-C16 was found to greatly prolong the hypoglycemia duration (~ 4 days). This was due to the dual-functions of the palmityl groups present in both GC and exendin-4 such as hydrophobic attraction and plasma albumin-binding. We consider this new type of self-assembled GC hydrogels loaded with Ex4-C16 would be a promising long-acting sustained-release system with anti-diabetic property.

III. 벼 교잡종의 Allelopathy 효과 구명 (III. Investigation on Allelopathic Effect from Various Crosses of Rice Cultivars)

  • 이재현;신동현;이인중;김길웅
    • Current Research on Agriculture and Life Sciences
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    • 제20권
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    • pp.65-70
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    • 2002
  • 본 연구는 allelopathic potential을 지닌 벼의 교잡종을 포장에서 재배하여 그 식물체의 잎을 생물검정에 이용하여 allelopathy 효과 유무를 검정하고, 생물검정으로 선발된 교잡종을 대상으로 phenolic compounds를 조사하여 allelochemical로써의 가능성을 확인하고 나아가 phenolic compounds 생합성에 관여하는 효소의 활성 측정과 이 효소의 작용에 의해 유도되는 phenolic compounds를 구명한 결과는 다음과 같다. 1. 포장상태에서 피를 대상으로 생물검정을 실시한 결과 양친으로는 Kouketsumochi, Woo co chin yu에서 공통적으로 90% 이상의 높은 피뿌리 생장 억제율을 보였고, 교잡종에서는 Kouketsumochi/Woo co chin yu, Dongjinbyeo/Kouketsumochi, Dongjinbyeo/Woo co chin yu 조합에서 80% 이상의 높은 억제율을 나타냈다. 2. Kouketsumochi의 PAL 활성은 protein 1kg당 $63.46{\mu}kats$로 타 공시품종보다 높았다. 또한 Kouketsumochi와의 교잡종도 타교잡종보다 높은 것으로 나타났다. 3. Kouketsumochi의 cinnamate 함량은 생체중 1g당 $2.64{\mu}g$으로서 다른품종이나 교잡종보다 2~5배 높았고, Kouketsumochi와의 교잡종도 타교잡종보다 높았다.

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Screening of Volatile Organic Compound-Producing Yeasts and Yeast-Like Fungi against Aflatoxigenic Aspergillus flavus

  • Nasanit, Rujikan;Jaibangyang, Sopin;Onwibunsiri, Tikamporn;Khunnamwong, Pannida
    • 한국미생물·생명공학회지
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    • 제50권2호
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    • pp.202-210
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    • 2022
  • Aflatoxin contamination in rice has been documented in a number of studies, and has a high incidence in Asian countries, and as such, there has been a growing interest in alternative biocontrol strategies to address this issue. In this study, 147 strains of yeasts and yeast-like fungi were screened for their potential to produce volatile organic compounds (VOCs) active against Aspergillus flavus strains that produce aflatoxin B1 (AFB1). Five strains within four different genera showed greater than 50% growth inhibition of some strains of A. flavus. These were Anthracocystis sp. DMKU-PAL124, Aureobasidium sp. DMKU-PAL120, Aureobasidium sp. DMKU-PAL144, Rhodotorula sp. DMKU-PAL99, and Solicococcus keelungensis DMKU-PAL84. VOCs produced by these microorganisms ranged from 4 to 14 compounds and included alcohols, alkenes, aromatics, esters and furans. The major VOCs produced by the closely related Aureobasidium strains were found to bedistinct. Moreover, 2-phenylethanol was the most abundant compound generated by Aureobasidium sp. DMKU-PAL120, while methyl benzeneacetate was the major compound emitted from Aureobasidium sp. DMKU-PAL144. On the other hand, 2-methyl-1-butanol and 3-methyl-1-butanol were significant compounds produced by the other three genera. These antagonists apparently inhibited A. flavus sporulation and mycelial development. Additionally, the reduction of the AFB1 in the fungal-contaminated rice grains was observed after co-incubation with these VOC-producing strains and ranged from 37.7 ± 8.3% to 60.3 ± 3.4%. Our findings suggest that these same microorganisms are promising biological control agents for use against aflatoxin-producing fungi in rice and other agricultural products.

Three-dimensional analysis of dermal backflow in cancer-related lymphedema using photoacoustic lymphangiography

  • Oh, Anna;Kajita, Hiroki;Imanishi, Nobuaki;Sakuma, Hisashi;Takatsume, Yoshifumi;Okabe, Keisuke;Aiso, Sadakazu;Kishi, Kazuo
    • Archives of Plastic Surgery
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    • 제49권1호
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    • pp.99-107
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    • 2022
  • Background Dermal backflow (DBF), which refers to lymphatic reflux due to lymphatic valve insufficiency, is a diagnostic finding in lymphedema. However, the three-dimensional structure of DBF remains unknown. Photoacoustic lymphangiography (PAL) is a new technique that enables the visualization of the distribution of light-absorbing molecules, such as hemoglobin or indocyanine green (ICG), and can provide three-dimensional images of superficial lymphatic vessels and the venous system. This study reports the use of PAL to visualize DBF structures in the extremities of patients with lymphedema after cancer surgery. Methods Patients with a clinical or lymphographic diagnosis of lymphedema who previously underwent surgery for cancer at one of two participating hospitals were included in this study. PAL was performed using the PAI-05 system. ICG was administered subcutaneously in the affected hand or foot, and ICG fluorescence lymphography was performed using a near-infrared camera system prior to PAL. Results Between April 2018 and January 2019, 21 patients were enrolled and examined using PAL. The DBF was composed of dense, interconnecting, three-dimensional lymphatic vessels. It was classified into three patterns according to the composition of the lymphatic vessels: a linear structure of lymphatic collectors (pattern 1), a network of lymphatic capillaries and lymphatic collectors in an underlying layer (pattern 2), and lymphatic capillaries and precollectors with no lymphatic collectors (pattern 3). Conclusions PAL showed the structure of DBF more precisely than ICG fluorescence lymphography. The use of PAL to visualize DBF assists in understanding the pathophysiology and assessing the severity of cancer-related lymphedema.

세포투과 펩티드를 이용한 주름개선 펩티드 GHKs의 피부흡수 증진 (Enhancement of Skin Permeation of Anti-wrinkle Peptide GHKs Using Cell Penetrating Peptides)

  • 박수인;안규민;김민기;허수현;신문삼
    • Korean Chemical Engineering Research
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    • 제58권1호
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    • pp.29-35
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    • 2020
  • 본 연구에서는 경피흡수가 잘 안되는 주름개선 펩티드인 GHK, GHK-Cu, Pal-GHK에 대하여 세포투과 펩티드인 알르기닌 올리고머(tetra-D-arginine, R4)와 hexa-D-arginine, R6)를 첨가한 후 경피 투과도를 측정하여 그 결과를 다음 6가지 경우로 분석하였다. 첫번째로 주름개선 펩티드만 함유한 경우는 구리이온(Cu2+)과 팔미트산이 경피 투과율을 증진시키는 것을 알 수 있다. 두번째로, GHK에 알르기닌 올리고머(R4, R6)를 첨가한 경우는 알르기닌 올리고머(R4, R6)가 경피 투과율을 증가시켰으며, R4에서 더 좋은 경피 투과율 증가를 나타났다. 세번째로, GHK-Cu에 R4, R6를 첨가한 경우는 경피 투과율 증가가 나타났으며, R6 < R4 경피 투과율 순서로 나타났다. 네번째로 Pal-GHK에 R4, R6를 첨가한 경우에도 경피 투과율 증가가 나타났으며, R6 < R4 경피 투과율 순서로 나타났다. 다섯번 째로, R4를 GHK, GHK-Cu, Pal-GHK에 첨가한 경우에는 GHK+R4 < GHK-Cu+R4 < Pal-GHK+R4 순서로 경피 투과율 증가가 나타났다. 마지막으로 R6를 GHK, GHK-Cu, Pal-GHK에 첨가한 경우에는 GHK+R4 < GHK-Cu+R4 < Pal-GHK+R4 순서로 경피 투과율 증가가 나타났다. 이를 통하여 주름 개선 펩티드인 GHK, GHK-Cu, Pal-GHK의 피부 투과를 증가를 위한 최적의 조건을 제시하여 그 효능을 극대화할 수 있는 방안을 제시함으로써 주름 개선 기능성 화장품에서의 폭넓은 활용과 응용을 제안하고자 한다.