• Title/Summary/Keyword: pKa

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Design of Ka-Band 3 Stage MMIC Low Noise Amplifiers (KaBand 3단 MMIC 저잡음 증폭기 설계)

  • 염인복;정진철;이성팔
    • Proceedings of the Korea Electromagnetic Engineering Society Conference
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    • 2000.11a
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    • pp.216-219
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    • 2000
  • A Ka Band 3-stage MMIC (Monolithic Microwave Integrated Circuits) LNA(Low Noise Amplifiers) has been designed. The MMIC LNA consists of two single-ended type amplication stapes and one balanced type amplication stage to satisfy noise figure characteristics and high gain and amplitude linearity. The 0.15um pHEMT has been used to provide a ultra low noise figure and high gain amplification. Series and Shunt feedback circuits were inserted to ensure high stability over frequency range of DC to 80 GHz. The size of designed MMIC LNA is 3100mm ${\times}$ 2400um(7.44$\textrm{mm}^2$). The on wafer measured noise figure of the MMIC LNA is less than 2.0 dB over frequency range of 22 GHz to 30 GHz.

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0.2W Ka-band MMIC CPW Power Amplifier Design and Fabrication (0.2W급 Ka-band MMIC CPW 전력증폭기 설계 및 제작)

  • 정상화;이상효;김대현;홍성철;권영우;서광석
    • The Journal of Korean Institute of Communications and Information Sciences
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    • v.26 no.8B
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    • pp.1035-1040
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    • 2001
  • SNU-ISRC 0.25$\mu\textrm{m}$ pHEMT 표준 공정을 사용하여 Ka-band에서 동작하는 0.2W급 MMIC CPW 전력증폭기를 설계, 제작하였다. 기존의 MMIC 공정에서 사용되는 마이크로스트립 전송선 대신 CPW 전송선을 사용함으로써 보다 간단하고 저가의 공정이 가능하였다. 전력증폭기의 설계에서는 보다 넓은 주파수 대역에서 원하는 출력전력을 얻기 위해서 출력단을 Wilkinson coupler를 사용하였는데, 일반적으로 Wilkinson coupler에 사용되는 50Ω 특성임피던스 전송선 대신에 25Ω 특성임피던스 전송선을 사용하여 좋은 출력단 전력 정합과 출력 반사손실을 동시에 얻을 수 있었다. 제작된 전력증폭기의 측정결과, 주파수 27GHz에서 출력전력 23.4dBm과 Power-added Efficiency 21.7%의 결과를 보였다.

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Development or 170KV 50KA GCB with Common three-pole operating mechanism (3상일괄조작형 170KV 50KA GCB의 개발)

  • Song, W.P.;kim, H.J.;Sung, B.J.;Lee, C.H.;Noh, C.W.;Kwon, W.H.
    • Proceedings of the KIEE Conference
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    • 1992.07b
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    • pp.626-628
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    • 1992
  • GCB(Gas Circuit Breaker) and GIS(Gas Insulated Switchgear) using $SF_6$ are worldwidely applied over 72.5KV classes. It Is known that $SF_6$ gas has the most superior characteristics among the extingushing and insulating media. Our Company has produced GCB and GIS from early 1980's and at present, we are producing 362KV 40KA class which is the highest voltage in our country. According to change KEPCO's standards (ESB standards), our company has redeveloped and tested for all productions type from 1989. During redeveloping, we largely contribute raise reliability of power system, through all the more improvement for performance and quality of manufactures. One of them, we developed 170KV 50KA GCB with common three-pole operating mechanism and sucessfully completed test of KERI under KEPCO presence, at first in our country. Thus, we announce the outline of it.

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A Study on the development of high gain and high power Ka-band hybrid power amplifier module (고출력, 고이득 Ka-band 하이브리드 전력증폭기 모듈 개발에 관한 연구)

  • Lee, Sang-Hyo;Kim, Hong-Teuk;Jeong, Jin-Ho;Kwon, Young-Woo
    • Journal of the Institute of Electronics Engineers of Korea TC
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    • v.38 no.11
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    • pp.49-54
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    • 2001
  • In this work, we developed a Ka-band hybrid 4-stage power amplifier module using GaAs pHEMTs and waveguide to microstrip transitions. It has high gain and high output power characteristics. We used a 10 mil- thickness duroid substrate to fabricate this power amplifier and waveguide to microstrip transitions. The fabricated waveguide to microstrip transition showed about 1 dB insertion loss(back to back) at 32 40 GHz. The measured results of power amplifier module showed over 1W output power at 36.1 - 37.1 GHz. And it showed 31 dBm output power, 24 dB power gain and 15 % power-added efficiency(PAE) at 36.5 GHz.

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Neuroprotective Effect of Visnagin on Kainic Acid-induced Neuronal Cell Death in the Mice Hippocampus

  • Kwon, Min-Soo;Lee, Jin-Koo;Park, Soo-Hyun;Sim, Yun-Beom;Jung, Jun-Sub;Won, Moo-Ho;Kim, Seon-Mi;Suh, Hong-Won
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.5
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    • pp.257-263
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    • 2010
  • Visnagin (4-methoxy-7-methyl-5H-furo[3,2-g][1]-benzopyran-5-one), which is an active principle extracted from the fruits of Ammi visnaga, has been used as a treatment for low blood-pressure and blocked blood vessel contraction by inhibition of calcium influx into blood cells. However, the neuroprotective effect of visnagin was not clearly known until now. Thus, we investigated whether visnagin has a neuroprotective effect against kainic acid (KA)-induced neuronal cell death. In the cresyl violet staining, pre-treatment or post-treatment visnagin (100 mg/kg, p.o. or i.p.) showed a neuroprotective effect on KA ($0.1{\mu}g$) toxicity. KA-induced gliosis and proinflammatory marker (IL-$1{\beta}$, TNF-${\alpha}$, IL-6, and COX-2) inductions were also suppressed by visnagin administration. These results suggest that visnagin has a neuroprotective effect in terms of suppressing KA-induced pathogenesis in the brain, and that these neuroprotective effects are associated with its anti-inflammatory effects.

Seasonal Effects on the Performance of Newly Evolved Bivoltine Hybrids of the Silkworm (Bombyx mori L.) Under Tropics

  • Rao, P.Sudhakara;Datta, R.K.;Palit, A.K.;Haque Rufaie, S.Z.
    • International Journal of Industrial Entomology and Biomaterials
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    • v.9 no.2
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    • pp.193-198
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    • 2004
  • Seasonal effects of the newly evolved bivoltine hybrid namely CSR$_2$${\times}$SR$_{5}$, SR$_1$ ${\times}$SR$_4$ and control hybrid KA${\times}$NB$_4$D$_2$ along with their parents SR$_1$, SR$_4$, SR$_{5}$, CSR$_2$ KA and NB$_4$D$_2$ were evaluated during different seasons of the year to understand genotype and environment interactions. Data were collected on five economic importance namely, pupation rate, cocoon yield, cocoon weight, cocoon shell ratio and filament length of the lines, hybrids and the control breeds/hybrid in three different seasons i.e., Pre-Monsoon, Monsoon and post-monsoon and subjected to relevant statistical methods. Seasonal performance of CSR$_2$, SR$_1$, SR$_4$ and SR$_{5}$ revealed superiority over control breeds KA and NB$_4$D$_2$. Both the hybrids i.e., CSR$_2$${\times}$SR$_{5}$ and SR$_1$${\times}$SR$_4$ performed well under diversified environmental conditions of tropical climate in a year indicating overall stability. These hybrids revealed highly significant (P < 0.01) variations for majority of the traits studied over the control hybrid KA${\times}$NB$_4$D$_2$.$.

An Essential Histidine Residue in the Catalytic Mechanism of the Rat Kidney γ-Glutamyl Transpeptidase

  • Kim, Soo-Ja;Ko, Moon-Kyu;Chai, Kyu-Yun;Cho, Seong-Wan;Lee, Woo-Yiel
    • Bulletin of the Korean Chemical Society
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    • v.28 no.2
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    • pp.271-275
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    • 2007
  • γ -Glutamyl transpeptidase (EC 2.3.2.2) plays a key role in glutathione metabolism by catalyzing the transfer of the γ -glutamyl residue and hydrolysis of glutathione. The functional residues at the active site of the rat kidney γ -glutamyl transpeptidase were investigated by kinetic studies at various pH, the treatment of diethylpyrocarbonate (DEPC), and photooxidation in presence of methylene blue. An ionizable group affecting the enzymatic activity with an apparent pKa value of 7.1, which is in the range of pKa values for a histidine residue in protein, was obtained by examining the pH-dependence of kinetic parameters. The pH effect on the photoinduced inactivation rate of the enzyme corresponds to that expected for the photooxidation of the free histidine. The involvement of a histidine in the catalytic site of the enzyme was further supported by DEPC modification accompanied by an increase in absorbance at 240 nm, indicating the formation of Ncarbethoxyhistidine. The histidine located at the position of 382 in the precursor of the enzyme is primarily suspected based on the amino acid sequence alignment of the transpeptidases from various organisms.

Ionization and Divalent Cation Complexation of Quinolone Antibiotics in Aqueous Solution

  • Park, Hyeong Ryun;Jeong, Gwang Yeong;Lee, Hyeong Cheol;Lee, Jin Gi;Baek, Gi Min
    • Bulletin of the Korean Chemical Society
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    • v.21 no.9
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    • pp.849-854
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    • 2000
  • The protonation and divalent cation complexation equilibria of several quinolone antibiotics such as nalidixic acid (NAL),flumequine (FLU), oxolinic acid (OXO), ofloxacin (OFL), norfloxacin (NOR) and enoxacin (ENO) have been examined by potentiome tric titration and spectrophotometric method. The antibacterial activity of these drugs depends upon the pH and the concentration of metal cations such as Mg2+ , Ca2+ in solu-tion. The apparent ionization constants of NAL, FLU, OXO, OFL, NOR and ENO in aqueous solution were found to be 6.33, 6.51, 6.72, 7.18, 7.26, and 7.53, respectively. In aqueous solution, NAL, FLU and OXO were found to be present mainly as two chemical species : molecularand anionic; but OFL, NOR and ENO were present mainly as three chemical species : anionic, neutral zwitterionic and cationic form, in equilibrium. The pKa1 and pKa2are found to be 6.10 and 8.28 for OFL; 6.23 and 8.55 for NOR; 6.32 and8.62 for ENO, respec-tively. The complex formation constants between OFL, NOR or FLU and some divalent cations are measured at pH 7.5. The 1 : 1 complexes are formed mainly by ion-dipole interaction. FLU has somewhat larger Kf values than OFL and NOR because its molecular size is small and the FLU is present asanionic form at pH 7.5.

Post LGM Fluvial Environment and Palynological Changes of South Korea

  • Kim, Ju-Yong;Yang, Dong-Yoon;Bong, Pil-Yoon;Nahm, Wook-Hyun;Lee, Heon-Jong;Lee, Yung-Jo;Hong, Sei-Sun;Lee, Jin-Young;Kim, Jin-Wkan;Oh, Keun-Chang
    • The Korean Journal of Quaternary Research
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    • v.17 no.2
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    • pp.17-23
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    • 2003
  • In Korea terrestrial fluvial sequences can be used as pedological and sedimentological markers indicating a millenium-scale environmental and climatic changes imprinted in fluvial sub-environments, which in turn are represented by the cyclicity of fluvial sands, backswamp organic muds, and flooding muds intercalations of frostcracked or dessicated brown paleosols. Post LGM and Holocene fluvial and alluvial sedimentary sequences of Korea are formed in such landscapes of coastal, floodplain, backswamp and hillslope areas. Among them, the most outstanding depositional sequences are fluvial gravels, sands and organic mud deposits in coastal, fluvial, or alluvial wetlands. The aim of this study is to explain the sedimentary sequences and palynofloral zones since the last 15,000years, on the basis of organic muds layers intercalated in fluvial sand deposits. Jangheung-ri site of Nam river, Soro-ri site of Miho river, Youngsan rivermouth site in Muan, Oksan-ri site of Hampyeong and Sanggap-ri site of Gochang are illustrated to interpret their sedimentary facies, radiocarbon datings, and palynofloral zonation. Up to the Middle to Late Last Glacial(up to 30-35Ka), old river-bed, flooding, and backswamp sequences contain such arboreal pollens as Pinus, Abies, and Picea, and rich in non-arboreal pollens like Cyperaceae, Gramineae, Ranunculaceae, and Compositae. During the LGM and post-LGM periods until Younger Dryas, vegetation has changes from the sub-alpine conifer forest(up to about 17-11Ka), through the conifer and broad-leaved deciduous forest, or mixed forest (formed during 16,680-13,010yrB.P), to the deciduous and broad-leaved forest (older than 9,500yrB.P). In the Earliest Holocene flooding deposits, fragments of plant roots are abundant and subjected to intensive pedogenic processes. During Holocene, three arboreal pollen zones are identified in the ascending order of strata; Pinus-Colyus zone(mixed conifer and deciduous broad-leaved forest, about up to 10Ka), Alnus-Quercus forest (the cool temperate deciduous broad-leaved forest, about 10Ka-2Ka), and Pinus forest (the conifer forest, about after 2Ka), as examplified in Soro-ri site of Cheonwon county. The palynological zonations of Soro-ri, Oksan-ri, Sanggap-ri, Youngsan estuary, and Gimhae fluvial plain have been recognized as a provisional correlation tool, and zonations based on fluvial backswamp and flooding deposits shows a similar result with those of previous researchers.

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Crystal Structure of $\Delta$-3-Ketosteroid Isomerase From Pseudomonas testosteroni in Complex with Equilenin Settles the Correct Hydrogen Bonding Scheme for Transition-State Stabilization

  • Cho, Hyun-Soo;Ha, Nam-Chul;Park, Gildon
    • Proceedings of the Korean Biophysical Society Conference
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    • 1999.06a
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    • pp.36-36
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    • 1999
  • Bacterial Δ-3-ketosteroid isomerase (KSI) catalyzes the conversion of Δ-to Δ-3-ketosteroids via enolate formation, which is also found in the synthesis of all steroid hormones in mammals. In Pseudomonas testosteroni, KSI Asp38 (pKa ~ 4.7) was identified as the general base which abstracts the steroid C4b-H (pKa ~ 12.7) to form the dienolate intermediate.(omitted)

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