• 한국정보과학회논문지:정보통신
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• 제30권5호
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• pp.668-675
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• 2003

본 논문은 WDM(Wavelength Division Multiplexing) 망에서 서비스 품질에 따른 제약조건을 고려하였을 때 장애 복구에 적용될 수 있도록 개선된 p-cycle(preconfigured protection cycle) 기법을 제안한다. 기존의 p-cycle에서는 양방향으로 동일한 대역폭을 가지는 연결만을 고려하기 때문에 단방향 멀티캐스팅이나 양방향으로 서로 다른 대역폭을 사용하는 경우에는 적용하기 어려운 문제점이 있다. 또한 대체 경로의 서비스 품질은 고려하지 않으므로 장애 발생 시 대체 경로에서 서비스 품질을 만족시킬 수 없을 수 있다는 문제점이 있다. 본 논문에서는 단방향 멀티캐스팅이나 양방향 비대칭 대역폭을 사용하는 광대역 멀티미디어 통신에서 사용되는 단방향 연결의 장애복구를 효율적으로 구현할 수 있도록 P-cycle 기법을 개선하였다. 또한 장애복구를 위한 대체 경로의 P-Cycle에서 서비스 품질을 보장할 수 있도록 하기 위해서 P-cycle 선정을 위한 새로운 절차를 제안한다. 단방향 연결 개념을 사용한 P-cycle을 적용함으로서 비대칭적인 대역폭을 사용하는 통신환경에서 장애 복구를 위해 요구되는 대역폭을 줄일 수 있었으며, 제안된 p-cycle 선정 절차에 의해 구성된 대체 경로가 서비스 품질을 보장할 수 있는지의 여부를 시험하기 위해서 미국 시험망에 적용하고 그 결과를 분석하였다.

• Molecules and Cells
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• 제44권11호
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• pp.795-804
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• 2021

Memory T (T_M) cells play an important role in the long-term defense against pathogen reinvasion. However, it is still unclear how these cells receive the crucial signals necessary for their longevity and homeostatic turnover. To understand how T_M cells receive these signals, we infected mice with lymphocytic choriomeningitis virus (LCMV) and examined the expression sites of neural cadherin (N-cadherin) by immunofluorescence microscopy. We found that N-cadherin was expressed in the surroundings of the white pulps of the spleen and medulla of lymph nodes (LNs). Moreover, T_M cells expressing high levels of killer cell lectin-like receptor G1 (KLRG1), a ligand of N-cadherin, were co-localized with N-cadherin⁺ cells in the spleen but not in LNs. We then blocked N-cadherin in vivo to investigate whether it regulates the formation or function of T_M cells. The numbers of CD127^hiCD62L^hi T_M cells in the spleen of memory P14 chimeric mice declined when N-cadherin was blocked during the contraction phase, without functional impairment of these cells. In addition, when CD127^loKLRG1^hi T_M cells were adoptively transferred into anti-N-cadherin-treated mice compared with control mice, the number of these cells was reduced in the bone marrow and LNs, without functional loss. Taken together, our results suggest that N-cadherin participates in the development of CD127^hiCD62L^hi T_M cells and homing of CD127^loKLRG1^hi T_M cells to lymphoid organs.

• 대한치과기공학회지
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• 제10권1호
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• pp.47-54
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• 1988

The purpose of this study is to evaluate the castability of Ni-Cr alloys for crown and bridge. New young, Hi-Crown and CB-80 which are widely used in dental laboratory were chosen, casting and increased the temperature of furnace 100$^{\circ}C$ of each 7 grades from 600$^{\circ}C$ to 1200$^{\circ}C$. The results are as follows : 1. CB-80 is the most prominent castability among the three Ni-Cr alloys which are Hi-Crown, New-young and Hi-Cr. 2. The good burning temperatures of casting for CB-8p are 900$^{\circ}C$, 100$^{\circ}C$ and 1100$^{\circ}C$ which are obtained four complate casting body of five former patterns. 3. The most proper burning temperature for three Ni-Cr alloys is 900$^{\circ}C$.

• Tuberculosis and Respiratory Diseases
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• 제44권5호
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• pp.1040-1050
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• 1997

연구배경 : 만성폐쇄성폐질환 환자의 치료에 널리 적용되고 호흡재활치료는 폐기능을 호전시키지는 못하지만 호흡곤란 등의 증상과 운동능력을 호전시키는 것으로 알려져 있다. 그러나 이런 운동능력 개선의 기전은 여러 각도에서 해석되고 있다. 저자들은 $^{31}P$ MRS를 이용하여 만성 폐질환 환자들을 호흡재활치료 전후 전박근의 대사 변화를 관찰함으로써, 호흡재활치료 후 운동능력호전에 골격근 대사개선을 기여할 가능성을 조사하였다. 방 법 : 총 9명의 만성 폐질환을 갖고 있는 남자 환지들을 대상으로 하였고 이들의 평균 연령은 $58{\pm}11$세였으며, 이들의 기저 질환은 만성폐쇄성폐질환 8예 및 폐유육종증 1예였다. 호흡재활치료는 근육강화운동, 답차운동(treadmill walking), 자전거 운동(stationary bicycle riding) 및 상지 운동력측정계(arm ergometer)를 이용한 상지운동으로 구성했으며, 호흡재활치료 전후로 폐기능 검사, 운동부하 검사, 상하지의 지구력 측정 및 6분 보행거리 검사를 실시하였다. $^{31}P$ MRS검사를 치료 전후 전박근을 대상으로 안정시, 운동시 및 20분간의 회복시에 시행하여 세포내 산소성 인산화 능력을 반영하는 Pi/PCr의 비와 pHi(intracellular pH)를 구하여 비교하였다. 결 과 : 호흡재활치료 후 환자의 폐기능과 가스 교환의 호전은 없었으나, 운동지구력 및 보행능력은 현저한 호전을 보였으며 최대산소섭취량은 증가하는 경향을 보였고, 동 운동량에서의 분당환기량은 감소하는 경향을 나타내었다. $^{31}P$ MRS를 이용하여 재활치료 전후의 골격근 대사를 비교해 본 결과, 치료 후 운동시 및 극심한 피로상태에서의 pHi는 유의하게 높았고 산소성 인산화 과정을 반영하는 지표인 Pi/PCr는 감소하는 경향을 보였으나 안정시 및 회복기의 골격근 대사과정은 변화가 없었다. 결 론 : 이상으로 만성 폐질환 환자에서 6주간의 호흡재활치료는 운동지구력 및 보행 호전시켰으며 이러한 운동능력 호전에는 골격근 대사의 개선으로 초래된 골격근 세포내의 산성화 지연으로 인한 환기량의 감소가 기여할 사료되었다.

• Journal of Nutrition and Health
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• 제35권5호
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• pp.544-557
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• 2002

This study was performed to evaluate the quality of nutrient intakes of the hemodialysis patients (26 men and 23 women) according to the socioeconomic status by 3-day dietary recall in Daejeon city and Chungnam area, Korea. Mean age of the subjects was 50.7 yrs and BMI was 22.0 $\pm$ 0.4 kg/$m^2$. Education level was divided into two groups ($\leq$ 9 years： LE group, 9 years： HE group), and monthly family income level was divided into three groups (< 500,000 won: LI group, 500,000-1,499,999 won: MI group, $\geq$ 1,500,000 won : HI group). The data were analyzed by Student t-test and Oneway ANOVA using SPSS 9.0 version at p < 0.05 level. Intakes of energy, carbohydrates, cholesterol, potassium, thiamin and riboflavin were significantly higher in HE group than in LE group (p < 0.05). Intakes of all the nutrients except protein and phosphorus were less than Korean RDA, and INQs (Index of Nutritional Quality) of most nutrients were lower than 1.0 but cholesterol, phosphorus. thiamin and niacin being over 1.0 in HE group. MAR (Mean adequacy ratio) of all the nutrients (e.g., energy, protein, calcium, phosphorus, iron, vitamin A, vitamin C, thiamin, riboflavin and niacin) was significantly higher in HE group (0.61 $\pm$ 0.04) than in LE group (0.48 $\pm$ 0.03) at p = 0.036. Intakes of energy, protein (total, animal and plant), fat, cholesterol, potassium, calcium, phosphorus, iron, vitamin A, thiamin and riboflavin were also significantly higher in HI group than in LI and MI group (p < 0.05). Daily intakes of most nutrients were less than Korean RDA except protein ed phosphorus in HI poop, and INQs of thiamin, niacin and phosphorus were higher than 1.0, while those of calcium, iron, vitamin A and riboflavin were lower than 1.0. MAR of energy and 9 nutrients was significantly higher in HI group (0.70 $\pm$ 0.04) than in LI group (0. 56 0.04) and MI poop (0.47 $\pm$ 0.03) at p = 0.000. In conclusion, quality of nutrient intakes, especially energy and protein, was significantly influenced by socioeconomic status such as education and monthly income (p < 0.05). This result suggests that it would be very helpful to develop nutritional education programs considering hemodialysis patients' education levels, and to improve public supports (e.g., medical insurance system, low-rate lease system of dialysis equipments, etc.) focusing on the patients' family income levels f3r their better nutrition and health.

• The Korean Journal of Physiology and Pharmacology
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• 제2권1호
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• pp.69-76
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• 1998

Cis-diamminedichloroplatinum II (cisplatin), an effective antitumor agent, induces acute renal failure by unknown mechanisms. To investigate direct toxic effects of cisplatin in the renal proximal tubular transport system, OK cell line was selected as a cell model and $Na^+/H^+$ antiport activity was evaluated during a course of cisplatin treatment. The cells grown to confluence were treated with cisplatin for 1 hour, washed, and incubated for up to 48 hours. At appropriate intervals, cells were examined for $Na^+/H^+$ antiport activity by measuring the recovery of intracellular pH (pHi) after acid loading. Cisplatin of less than 50 ${\mu}M$ induced no significant changes in cell viability in 24 hours, but it decreased the viability markedly after 48 hours. In cells exposed to 50 ${\mu}M$ cisplatin for 24 hours, the $Na^+-dependent$ pHi recovery (i.e., $Na^+/H^+$ antiport) was drastically inhibited with no changes in the $Na^+-independent$ recovery. Kinetic analysis of the $Na^+-dependent$ pHi recovery indicated that the Vmax was reduced, but the apparent Km was not altered. The cellular $Na^+$ and $K^+$ contents determined immediately before the transport measurement appeared to be similar in the control and cisplatin group, thus, the driving force for $Na^+-coupled$ transport was not different. These results indicate that cisplatin exposure impairs the $Na^+/H^+$ antiport capacity in OK cells. It is, therefore, possible that in patients treated with a high dose of cisplatin, proximal tubular mechanism for proton secretion (hence $HCO_3^-$ reabsorption) could be attenuated, leading to a metabolic acidosis (proximal renal tubular acidosis).

• 한국기계기술학회지
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• 제13권1호
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• pp.31-40
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• 2011

This study was conducted to research how UCD(Ultra Constant Discharge) lamp lighting affects plant cultivation. To get the results within a short time, lettuce seedling was selected as a plant and nutrient hydroponic beds were used in a dark room for 100% artificial lighting. Two beds were installed for same distance lighting condition with UCD lamp and Hi-pressure Sodium lamp each and another two beds were installed for same light intensity condition with each type of lamp. After 15 days of cultivation, for both conditions, the yields under UCD lamp were weighed more than that under Hi-pressure Sodium lamp. The result can be analyzed that the spectrum of UCD lamp having near sunlight characteristic is much superior to that of Hi-pressure Sodium lamp having a line spectrum characteristic on yellow and red wavelengths for plant cultivation.

• Journal of Microbiology and Biotechnology
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• 제34권3호
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• pp.673-680
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• 2024

Kombucha, a fermented beverage, is gaining popularity due to its numerous beneficial health effects. Various substrates such as herbs, fruits, flowers, and vegetables, have been used for kombucha fermentation in order to enhance the flavor, aroma, and nutritional composition. This study aims to investigate the potential suitability of cascara as a novel ingredient for kombucha production. Our findings suggested that cascara is a suitable substrate for kombucha production. Fermentation elevated the total phenolic and flavonoid content in cascara, which enhanced the antioxidant, antibacterial, and prebiotic characteristics of the product. Furthermore, the accumulation of acetic acid-induced the pH lowering reached 2.7 after 14 days of fermentation, which achieved the microbiological safety of the product. Moreover, 14 days of fermentation resulted in a balanced amalgamation of acidity, sweetness, and fragrance according to sensory evaluation. Our findings not only highlight the potential of cascara kombucha as a novel substrate for kombucha production but also contribute to repurposing coffee by-products, promoting environmentally friendly and sustainable agricultural development.

• 미생물학회지
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• 제21권4호
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• pp.229-237
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• 1983

Aspergillus nidulans의 tRNA 유전자의 구성과 발현기착을 연구하기 위하여 우선 Aspergillus의 총 tRNA 유전자를 cloning 하였다. Aspergillus의 핵 DNA롱 포자로 부터 분리해 내고 본질 형성에서 분리한 BamHI과 T4 DNA ligase를 사용하여 pBR322플라스미드에 재조합시켜서 cloning하였다. 15벤의 transformation을 하여 30,000개 의 transformants 얻었고, 이 중 Aspergillus DNA를 가지고 있는 colony는 5,300켜개였다. In vivo에 서 S2p로 표지 된 total tRNA를 probe로 하여 colony hybridization 실험 결과, 105개의 total tRNA유전자 clone을 얻었다. 위의 결과와 cohybridization 실험 결과를 분석해 보면, Asprgillus의 tRNA 유전자는 yeast의 그것보다는 좀 더 밀집되어 존재한다고 생각된다.

• 대한치과보철학회지
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• 제32권2호
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• pp.195-211
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• 1994

The purpose of this study was to evaluate the fracture resistance of the four kinds of dental porcelains for the all-ceramic crown(Vita In-Ceram, Vita Hi-Ceram, IPS-Empress, Vitadur-N) and one kind for the metal-ceramic non(Vita VMK 68) was used as the control group. In order to determine the fracture resistance, the hi-axial flexure strength was measured at a crosshead speed of 0.5mm/min, and the Vickers hadrness was measured at an indentation load of 1kg for 20 seconds. The results obtained were summarized as follows ; 1. The maximum Weibull modulus of 24.61 for Vitadur-N and the minimum one of 852 for IPS-Empress were observed ; the maximum characteristic strength of 353.26MPa for Vita In-Ceram and the minimum that of 63.20MPa for Vitadur-N were also observed. 2. The maximum mean bi-axial flexure strength of 339.12MPa for Vita In-Ceram and thd minimum one of 61.99MPa for Vitadur-N were calculated. Results of the Scheffe test indicated that the statistically significant difference(P<0.05) existed between Vita In-Ceram or Vita Hi-Ceram and the others ; also between IPS-Empress and Vitadur-N. 3. The maximum mean hardness of $980.55kg/mm^2$ for Vita VMK 68 appeared. Results of the Scheffe test indicated that statistically significant difference(P<0.05) existed between Vita In-Ceram or Vita Hi-Ceram and the others ; also between IPS-Empress and Vita VMK 68.