• Title/Summary/Keyword: p300

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Independent Component Analysis of the Event-Related Potential during Visual Oddball Tasks with Multiple Difficulty Levels (다중 난이도를 갖는 시각적 Oddball 작업 수행 시 사상관련전위의 독립요소분석)

  • Kim, Ja-Hyun;Yoon, Jin;Kim, Kyung-Hwan
    • Journal of Biomedical Engineering Research
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    • v.29 no.1
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    • pp.73-81
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    • 2008
  • The purpose of this study is to observe the brain activity patterns during visual oddball tasks with two difficulty levels by the analysis of high-density event-related potential (ERP). Along with conventional statistical analysis of averaged ERP waveforms, we applied independent component analysis (ICA) for the individual, single-trial analysis and verified its effectiveness. We could identify multiple ERP components such as early visual components (P1, N1), and two components which seem to be important task-related components and showed difficulty-dependent variability (P2, P300). The P2 was found around central region at $180{\sim}220ms$, and the P300 was found globally at $300{\sim}500ms$ poststimulus. As the task became difficult, the P2 amplitude increased, and the P300 amplitude decreased. After single-trial ERPs were decomposed into multiple independent components (ICs), several ICs resulting from P2 and P300 sources were identified. These ICs were projected onto scalp electrodes and the projected ICs were statistically compared according to two task difficulties. For most subjects, the results obtained from single-trial/individual analysis using ICA gave the tendencies of amplitude change that are similar to the averaged ERP analysis for most subjects. The temporal pattern and number of ICs corresponding to ${\mu}$ rhythm was not dependent on the task difficulty. It seems that the motor response was not affected by the task difficulty.

Effect of N Levels on the Herbage Yield and Quality of Orchargrass-Red Clover Mixtures (Orchargrass-Red Clover 초지의 N 시비수준이 목초의 수량과 품질에 미치는 영향)

  • 이형석;이인덕;김운영
    • Journal of The Korean Society of Grassland and Forage Science
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    • v.17 no.2
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    • pp.110-116
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    • 1997
  • The objective of this experiment was to suggest the optimum nitrogen fertilization level for orchardgrass(0G)- red clover(RC) mixtures. The field trials were conducted from 1993 to 1994 in order to evaluate the dry matter yield, botanical composition, chemical composition, dry matter digestibility(DMD), crude protein dry matter (CPDM) and digestible dry matter(DDM) yields on the nitrogen levels( 0, 50, 100, 150 and 300kgha). The results obtained were summarized as follows : 1. With increasing nitrogen levels, the DM yield of OG-RC mixttures significantly increased(P<0.05). The maximum total DM yield (7,964kgha) was obtained at N 300kgha level, However, there was no significant difference between N 150 and 300kgha. 2. With increasing the nitrogen levels, the botanical composition of OG in OG-RC mixttures was significantly increased(P< 0.05), whereas that of RC was remarkably decreased(P< 0.05). 3. The CP content was decreased by increasing nitrogen level(P

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Convergent Analysis of Old People Eye Movement Training on Change of Cognitive Ability (안구 운동이 노인의 인지능력 변화에 미치는 융합적 분석)

  • Bae, Seahyun;Kim, Kyung-Yoon
    • Journal of the Korea Convergence Society
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    • v.9 no.5
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    • pp.121-127
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    • 2018
  • The objective of the present study was to investigate the effect of eye movement on cognitive ability using Mini-Mental State Examination for Dementia Screening (MMSE-DS) and the amplitude and latency of P300 from event-related potentials after 55 elderly participants were randomly stratified into the saccadic eye movement (SEM) group and the smooth pursuit eye movement (SPEM) group, and performed eye movement for 4 weeks. As a result, P300 amplitude significantly increased and P300 latency significantly shortened in the SEM and SPEM groups. MMSE-DS showed a significant increase in both groups; upon comparing the groups, the SEM group showed a significant difference in orientation and the SPEM group in attention. In conclusion, it is thought that SEM and SPEM can improve and maintain the cognitive ability of the elderly and may be used as therapeutic tools for dementia prevention and mild dementia.

NSM00158 Specifically Disrupts the CtBP2-p300 Interaction to Reverse CtBP2-Mediated Transrepression and Prevent the Occurrence of Nonunion

  • Chen, Xun;Zhang, Wentao;Zhang, Qian;Song, Tao;Yu, Zirui;Li, Zhong;Duan, Ning;Dang, Xiaoqian
    • Molecules and Cells
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    • v.43 no.6
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    • pp.517-529
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    • 2020
  • Carboxyl-terminal binding proteins (CtBPs) are transcription regulators that control gene expression in multiple cellular processes. Our recent findings indicated that overexpression of CtBP2 caused the repression of multiple bone development and differentiation genes, resulting in atrophic nonunion. Therefore, disrupting the CtBP2-associated transcriptional complex with small molecules may be an effective strategy to prevent nonunion. In the present study, we developed an in vitro screening system in yeast cells to identify small molecules capable of disrupting the CtBP2-p300 interaction. Herein, we focus our studies on revealing the in vitro and in vivo effects of a small molecule NSM00158, which showed the strongest inhibition of the CtBP2-p300 interaction in vitro. Our results indicated that NSM00158 could specifically disrupt CtBP2 function and cause the disassociation of the CtBP2-p300-Runx2 complex. The impairment of this complex led to failed binding of Runx2 to its downstream targets, causing their upregulation. Using a mouse fracture model, we evaluated the in vivo effect of NSM00158 on preventing nonunion. Consistent with the in vitro results, the NSM00158 treatment resulted in the upregulation of Runx2 downstream targets. Importantly, we found that the administration of NSM00158 could prevent the occurrence of nonunion. Our results suggest that NSM00158 represents a new potential compound to prevent the occurrence of nonunion by disrupting CtBP2 function and impairing the assembly of the CtBP2-p300-Runx2 transcriptional complex.

Event-related Potentials of Pre- and Post-Hemodialysis in Patients with Chronic Renal Failure (만성신부전 환자에서 혈액투석 전후의 P300 인지유발전위검사)

  • Bae, Jae-Chun;Lee, Sang-Moo
    • Annals of Clinical Neurophysiology
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    • v.3 no.2
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    • pp.136-142
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    • 2001
  • Background : Nervous system dysfunction is a major complication of end stage renal disease. Although severe neurologic symptoms are partially or completely reversed by adequate hemodialysis, even optimally dialyzed patients will usually not return to normal neurocognitive function. To investigate the influence of chronic renal failure and hemodialysis on higher cognitive function electrophysiologically, we studied auditory P300 event-related potentials in 14 hemodialysis patients and 14 age- and sex-matched normal healthy controls. Methods : The subjects consisted of 14 patients(M: 6, F: 8) with chronic renal failure(CRF) for 1 to 10 years and 14 age- and sex-matched healthy controls(M: 5, F: 9). For the reliability of study, patients with diabetes mellitus, abnormal brain CT findings, or low mini-mental state score(below 20) were excluded. Event related potentials(ERPs) for hemodialysis patients were performed at pre- and post-hemodialysis. To obtain ERPs, subjects underwent 2-tone auditory discrimination test(oddball paradigm). Results : Although the age(control: $48.79{\pm}10.31years$, CRF: $51.21{\pm}7.61years$) and mini-mental state score(control: $27.00{\pm}1.71points$, predialysis CRF: $25.07{\pm}3.58points$) were not different in normal control and CRF groups significantly(P>0.05), P300 latencies at Cz(control: $288.11{\pm}17.36msec$, predialysis CRF: $332.35{\pm}42.34msec$) were significantly delayed(P<0.05)and the duration of Trail making test A was significantly prolonged(control: $64.2{\pm}24.2sec$, CRF: $118.9{\pm}101sec$) in CRF group. P300 latencies between pre- and post-hemodialysis CRF patients(predialysis CRF: $332.35{\pm}42.34msec$, postdialysis CRF: $325.82{\pm}38.69msec$) were not significantly different. The P300 latency was not related with the duration of CRF(Spearman's correlation test, r=0.25, P>0.05) and the frequency of hemodialysis(Spearman's correlation test, r=0.28, P>0.05). Conclusions : From these results, we suggest that P300 latency is valuable in evaluating cognitive brain dysfunction in patients with CRF and hemodialysis does not have a significant effect on cognitive brain dysfunction in patients with CRF.

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The effect of immediate and delayed recognition on Event-Related Potentials in a continuous recognition memory task (연속재인과제에서 즉각적 재인과 지연 재인이 사건관련전위에 미치는 영향)

  • 김명선;조상수;권준수
    • Proceedings of the Korean Society for Cognitive Science Conference
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    • 2000.05a
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    • pp.55-60
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    • 2000
  • 연속재인과제에서 자극을 즉각적으로 반복 제시하거나 지연 반복 제시할 경우 사건관련전위에 차이가 나타나는지, 만약 차이가 관찰되면 자극 제시 후 어느 시점에서 차이가 두드러지게 나타나는지를 조사하였다. 실험 결과 즉각적 재인이 지연 재인에 비해 더 높은 반응정확율과 더 빠른 반응시간을 보였고 사건관련전위에서는 P300의 진폭이 더 컸고 잠재시간도 더 빨랐다. 그리고 지연재인에서 관찰되는 N400이 즉각적 재인에서는 나타나지 않았다. 지연재인에 비해 즉각적 재인에서 P300의 진폭이 더 크고 잠재시간이 더 빠르게 나타난 것은 P300이 template matching을 통한 정보처리 과정을 반영해 준다는 주장을 지지해 준다. 즉 즉각적 재인에서는 지연 재인에 비해 template matching이 훨씬 더 정확하고 빨리 일어나며 이 결과 P300의 진폭이 커지고 잠재시간이 더 빨라진 것으로 이해된다. 즉각적 재인에서는 방금 제시된 자극(시간 간격은 2초)을 재인하기 때문에 기억의 탐색 과정이 요구되지 않는 반면 5개의 간섭 단어 후에 반복 제시되는 단어를 재인하는 지연 재인에서는 단어에 대한 탐색 과정이 필요하며, 이에 따라 N400이 초래된 것으로 여겨진다. 이 결과는 N400이 기억 탐색 과정을 반영한다는 주장을 지지해 준다. 사건관련 전위에서 즉각적 재인과 지연 재인의 차이는 자극 제시 300ms에서 450ms사이에 가장 두드러지게 나타났다.

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Effect of Rapid Mixing Intensity and Coagulant Dosages on Phosphorus Removal by Coagulation (응집을 이용한 인의 제거에 급속혼화강도 및 응집제 주입량이 미치는 영향)

  • Han, Hyun-Jin;Moon, Byung-Hyun
    • Clean Technology
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    • v.18 no.4
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    • pp.404-409
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    • 2012
  • In this study, the effects of mixing intensity and coagulant dosages on the characteristics of floc growth for phosphorus removal were investigated. The experiments were conducted under Al/P molar ratio of 1.0, 1.5 and 2.0; rapid mixing intensity with G value of 100, 300, and 500 $s^{-1}$. The characteristics of floc growth were measured by flocculation index (FSI) and the removal efficiencies of phosphorus by using different size filters. The removal efficiencies of soluble phosphorus increased as Al/P molar ratio and rapid mixing intensity increased. However, the highest removal efficiencies of T-P were observed at G value of 300 $s^{-1}$. When Al/P molar ratio was lower than 1.0, the value of FSI at G value of 500 $s^{-1}$ was the largest. However, when Al/P ratio was larger than 1.0, the value of FSI at G value 300 $s^{-1}$ was the largest. Effects of mixing intensity and Al/P molar ratio on coagulation for phosphorus removal of synthetic and real wastewater effluent were observed to be similar.

Effects of Prunella vulgaris labiatae extract on specific and non-specific immune responses in tilapia (Oreochromis niloticus)

  • Park, Kwan-Ha;Choi, Sanghoon
    • Journal of Animal Science and Technology
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    • v.56 no.1
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    • pp.3.1-3.7
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    • 2014
  • We examined the effects of Prunella vulgaris Labiatae (P. vulgaris L.) on specific and non-specific immune responses of Nile tilapia, Oreochromis niloticus. The optimal concentration without toxicity of P. vulgaris was determined to $30-40{\mu}g/ml$ in vitro and $120{\mu}g$/100 g of fish in vivo. P. vulgaris significantly elicited an antibody titer compared to FCA or ${\beta}$-glucan. ${\beta}$-glucan plus P. vulgaris group synergistically enhanced antibody production. No significant difference in antibody production was observed between P. vulgaris and P. vulgaris plus ${\beta}$-glucan group. A respiratory burst activity of head kidney (HK) leucocytes of tilapia administered with 300 or $500{\mu}g$ P. vulgaris was significantly (p < 0.05) enhanced compared with the PBS-injected control group and FCA-treated group. Maximum increase in the NBT reduction value was observed in $500{\mu}g$ P. vulgaris group but no significant difference was found between 300 and $500{\mu}g$ P. vulgaris group. The level of serum lysozyme activity was significantly (p < 0.05) higher in the 300 and $500{\mu}g$ P. vulgaris than $100{\mu}g$ P. vulgaris and FCA group. The phagocytic activities of HK leucocytes from tilapia administered with 300 and $500{\mu}g$ P. vulgaris were significantly (p < 0.05) higher than $100{\mu}g$ P. vulgaris and the control group. P. vulgaris was revealed with a good immunoadjuvant evoking the specific and non-specific immune responses of tilapia.

The Experimental Study on the Anti-allergic Effects of Samsoeum and Samsoeumgamibang (蔘蘇飮과 蔘蘇飮加味方의 抗알레르기효과에 관한 實驗的 硏究)

  • Nam, Bong-Soo;Kim, Yoon-Bum
    • The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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    • v.15 no.1
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    • pp.343-355
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    • 2002
  • Background : Although Samsoeum has been used frequently on allergic rhinitis, but there isn't any experimental research for that. Objective : This study was performed to investigate the anti-allergic effects of Samsoeum and Samsoeumgamibang. Materials and Methods : Katayama's method was used to observe the vascular permeability response induced by serotonin and histamine. Muller's method was used to observe the contact dermatitis response induced by picryl chloride. Miller's method was used to observe the delayed type hypersensitivity response to SRC. Results : 1. In the vascular permeability response to intradermal injection of serotonin, 2,600mg/kg, p.o. group of Samsoeum(蔘蘇飮), 1,300 and 2,600mg/kg, p.o. group of Samsoeumgamibang(蔘蘇飮加味方) showed significant inhibitory effects on the leakage of Evan's blue solution. 2. In the vascular permeability response to intradermal injection of histamine, 1,300 and 2,600mg/kg, p.o. group of Samsoeum, also 1,300 and 2,600mg/kg, p.o. group Samsoeumgamibang showed significant inhibitory effects on the leakage of Evan's blue solution. 3. In the contact dermatitis response induced by picryl chloride, 1,300 and 2,600mg/kg, p.o. group of Samsoeum, 1,300 and 2,600mg/kg, p.o. group of Samsoeumgamibang showed significant inhibitory effects on ear swelling formation. 4. In the delayed type hypersensitivity response to SRC. 2,600mg/kg, p.o. group of Samsoeum and 2,600mg/kg, p.o. group of Samsoeumgamibang showed significant inhibitory effects on foot swelling. Conclusion : This study shows that Samsoeum and Samsoeumgamibang may have anti-allergic effects. So Samsoeum and Samsoeurngamibang can be helpful to treat allergic rhinitis.

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An Experimental Study on Some Effects of SOYANGIN-HYEONGBANGPAEDOK-SAN (소양인(少陽人) 형방패독산(刑防敗毒散)의 효능(效能)에 관(關)한 실험적(實驗的) 연구(硏究))

  • Kim, Dae-Seong;Hong, Soon-Yong
    • Journal of Sasang Constitutional Medicine
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    • v.1 no.1
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    • pp.171-181
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    • 1989
  • We have studied some effects of the SOYANGIN-HYEONGBANGPAEDOK-SAN (S.H.P.). Several empirical remarks, depending on the different treatments, are investigated through this study as follow; 1. The Analgesic effects of S.H.P. are remarked by Acetic acid method in mice, 100 and 300mg/kg (Sample II, III), 2. The Antipyretic effect of S.H.P. are remarked by yeast method in rats, 100 and 300mg/kg (Sample II, III). 3. The inhibitory effects of S.H.P. on strychnine induced convulsion in mice is remarked. However the inhibitory effects of S.H.P. on picrotoxin induced convulsion in mice is not observed. 4. The effects of S.H.P. on muscle relaxation in mice, using the Rota-Rod test, is remarked on 1,2,3 hours by 300mg/kg (Sample III).

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