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Clinical Outcome of Pulmonary Metastasectomy in Patients with Pulmonary Metastasis (전이성 폐암에 대한 폐절제술의 성적)

  • Lee, Young-Ok;Lee, Eung-Bae;Ryu, Kyoung-Min
    • Journal of Chest Surgery
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    • v.40 no.10
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    • pp.674-679
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    • 2007
  • Background: Surgical resection is accepted widely as the standard therapy for complete resectable pulmonary metastases. The number of cases of pulmonary metastasectomy and its survival rate is increasing due to the development of the therapeutic modalities. We attempted to analyze the survival rate and prognosis factors of pulmonary metastasectomy during the last 10 years. Material and Method: We retrospectively analyzed the data of 89 patients who underwent 96 procedures of pulmonary metastasectomy between January 1996 and December 2005. The factors that may influence the long term prognosis such as completeness of resection, the type of primary cancer, the disease-free interval, the number and size of metastasis and the laterality were investigated. Result: There was no operative mortality. The mean disease free interval (DFI) was $29.6{\pm}27.9$ months and there were 3 cases of synchronous metastasis (3.4%). The overall 3, 5 and 10 year survival rate was 52.5%, 32.1% and 20.7%, respectively. The median survival time was 38 months. The 5-year survival rate according to the IRLM appraisal was 63.5%, 33.3%, 22.1% and 0% for stage I, II, III and IV, respectively Univariate analysis showed a better prognosis for patients with a disease free interval of 36 months or more, unilateral metastasis and 4 or less metastases. Conclusion: The survival rate for completely resectable pulmonary metastasectomy was favorable. The disease free interval, laterality and the number of metastasis were the prognosis factors.

Prevalence of Extended Spectrum $\beta-Lactamase-Producing$ Clinical Isolates of Escher­ichia coli in a University Hospital, Korea (국내 대학병원에서 분리된 Eschepichia coli의 Extended-spectrum $\beta-Lactamase$ (ESBL) 현황)

  • Lee Kyenam;Kim Woo-Joo;Lee Yeonhee
    • Korean Journal of Microbiology
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    • v.40 no.4
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    • pp.295-301
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    • 2004
  • Recently, the rapid increase and global spread of extended-spectrum $\beta-lactamase$ producing clinical isolates has become a serious problem. The incidence of extended-spectrum $\beta-lactamase$ producing clinical isolates of Escherichia coli in Korea and susceptibility to antimicrobial agents were investigated. Total 233 isolates of E. coli were obtained from urine from hospitalized patients in Guro hospital, Korea University in 2001. One hun­dred and eighty four isolates $(78.9\%)$ were resistant to ampicillin, 80 isolates $(34.3\%)$ were resistant to ceph­alothin, 93 isolates $(39.9\%)$ were resistant to gentamicin, and 64 isolates $(27.5\%)$ were resistant to norfloxacin. Among 233 isolates, 17 isolates $(7.3\%)$ were positive as determined by the double disk synergy test. When min­imal inhibitory concentrations were assayed with additional 6 antimicrobial agents, 13 isolates $(76.5\%)$ were multi-drug resistant to at least four different class antimicrobial agents. Extended-spectrum $\beta-lactamase$ were characterized with isoelectric focusing gel electrophoresis and DNA sequencing. They were TEM-1 in 5 iso­lates, TEM-15 in 1 isolate, TEM-20 in 1 isolate, TEM-52 in 4 isolates, TEM-1 and AmpC in 2 isolates, TEM-1 and OXA-30 in 1 isolate, TEM-1 and OXA-33 in 1 isolate, TEM-1, CTX-M-3, and AmpC in 1 isolate, but SHV was not detected. Antimicrobial resistance genes were transferred to animal isolate of E. coli (CCARM No. 1203) by the filter mating method. Extended spectrum $\beta-lactamase$ producers studied in the current study have low correlation to each other as determined by random amplified polymorphic DNA and pulsed field gel elec­trophoresis. This is a contradictory result from the general hypothesis that extended-spectrum $\beta-lactamase$ pro­ducers in one hospital is a result from a clonal spread.

Study on the Small Grain Bin for the Improvement of Grain Drying and Storage (곡물건조저장법 개선을 위한 농가용 Grain Bin에 관한 연구)

  • 김성래
    • Magazine of the Korean Society of Agricultural Engineers
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    • v.16 no.1
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    • pp.3263-3291
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    • 1974
  • Experimental work of grain bin was carried out to develop the methods of natural air in-bin drying and storage. The method is considered to be more economical, labour saving, and an effective countermeasure to grain loss. To examine the possibility of farm use of the grain bin and to analyze the related factors concerned with in-bin grain drying and storage, ambient air conditions (especially the change of air temperature and relative humidity) and grain quality during drying and storage periods were investigated. A laboratory model bin was constructed to investigate the effect of different forced air conditions on the drying characteristics of rice. In addition, a grain bin with 2.2m diameter and 1.8m height, considered to be the optimum size for the average Korean farm, was constructed and tested to examine the drying and storing characteristics of rice. The weather data analyzed in this study was the nine-year (from 1964 to 1972) record of air temperature and relative humidity in the Suweon area, and the thirty-year (from 1931 to 1960) record of pentad normal relative humidity and air temperature in the Seoul area. From the results of the weather data analyses, the adequate air delivery hours (which was arbitrary defined as the condition to give less than 75% relative humidity) to dry the rice during October were about nine hours (from approximately 10 A.M. to 7 P.M, ) a day, in which the average air temperature was about 15.9$^{\circ}C$ and average relative humidity was 66%. The occurence of days having three hours of such conditions was 1, 2, and 1-day within the 1st, 2nd add last 10-day periods for the month of October, respectively. Therefore, it may be considered that the weather condition in October was satisfactory for the forced natural air drying. The results of the laboratory model bin test were analyzed to obtain the drying curve and drying rate for different drying stages and grain layers in the bin corresponding to various conditions of forced natural air. A drying experiment with a prototype grain bin showed that an approximate 5 percent grain moisture gradient through a 1.6 meter grain deposit was observed after 80 hours of intermittent drying, giving an over dried zone in the lower grain layers and an extremely high grain moisture zone in the upper layers. This indicates that an effective measure should be taken to reduce this high moisture gradient. In order to investigate the drying characteristics of bulk grain in a layerturning operation a grain bin test was performed. This showed a significant improvement of uniform drying. In this test, approximate 107 hours were required to dry a depth of 1.6 meter of grain from an initial moisture content of 22.2 percent to a moisture content of 16.7 percent using an air delivery rate of 2.8 cubic meter per a minute per every cubic meter of grain. This resulted in a 2 percent moisture gradient from the top to the bottom of the bin. During storage period, till the end of June the average temperature of grain was 2~3$^{\circ}C$ higher than ambient air temperature. But during July when the grain moisture content went up slightly (less than 1 percent), the average temperature of the grain also increased to 3~5$^{\circ}C$ higher than ambient air temperature. It is therefore recommended that for safe grain storage, grain should not be stored in sheet metal bins after mid May. From the above results, in-bin rice drying and storage can be used effectively on Korean farms. It is strongly recommended that the use of grain-bin system should be implemented for farm use to improve farm drying and storage of rice.

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Essential Oil Composition from Leaves, Flowers, Stems, and Fruits of Vitex rotundifolia L. fil. (순비기나무(Vitex rotundifolia L. fil.)의 부위별 정유성분 조성)

  • Jang, Soo-Jung;Kim, Young-Hoi;Kim, Myung-Kon;Kim, Kei-Whan;Yun, Sei-Eok
    • Applied Biological Chemistry
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    • v.45 no.2
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    • pp.101-107
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    • 2002
  • The essential oils isolated from leaves, flowers, stems, and fruits of Vitex rotundifolia by steam distillation and extraction (SDE) method were analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). A total of 76 components detected by GC, 42 components were identified positively by GC-MS and GC co-injection with authentic standards, and 34 components were identified tentatively by mass spectral data only. They included 16 monoterpene hydrocarbons, 30 oxygenated hydrocarbons, 10 sesquiterpene hydrocarbons, 8 oxygenated sesquiterpenes, 3 diterpenes, and 9 miscellaneous components. The major components in the oil from the leaves were ${\alpha}-pinene$ (30.25%), 1,8-cineole (19.89%), sabinene (9.56%), ${\alpha}-terpineol$ (7.94%), ${\beta}-pinene$ (5.69%), and terpinen-4-ol (2.37%), and those in the flower oil were ${\alpha}-pinene$ (25.47%), 1,8-cineole (7.69%), manoyl oxide (6.21%), ${\beta}-pinene$ (4.20%), ${\alpha}-te.pineol$ (3.76%), and sabinene (2.78%). The major components in the oil from the stems were ${\alpha}-pinene$ (13.24%), ${\alpha}-terpineol$ (10.64%), 1,8-cineole (4.40%), manoyl oxide (4.02%), ${\beta}-pinene$ (2.39%), and terpinen-4-ol (2.21%) while those in the oil from the fruits were ${\alpha}-pinene$ (20.24%), 1,8-cineole (11.47%), ${\beta}P-pinene$ (9.79%), ${\alpha}-terpineol$ (7.08%), sabinene (3.68%), and limonene (2.77%). The percentage composition of monoterpenes in the oils from the leaves and the fruits were higher than in those from the flowers and the stems, whereas the oil from the flowers and the stems were characterized by a large content of sesquiterpenes, diterpenes and other unknown high molecular weight components.

Studies on the Chemical Structure of the New Polysaccharide C - (The New Polysaccharides of Gum Tragacanth. II) - (Tragacanth gum 의 신다당류(新多糖類) C 의 화학구조(化學構造) - Tragacanth gum의 신다당류(新多糖類)에 관(關)한 연구(硏究) 제2보(第二報) -)

  • Lee, Sung-Hwan
    • Applied Biological Chemistry
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    • v.3
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    • pp.25-48
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    • 1962
  • The polysaccharide C prepared from gum tragacanth powder (U. S. P. grade) by the precipitation method with 85% ethanol was a neutral polysaccharide, $[{\alpha}]^{30}_D-72.2$. The polysaccharide C consisted of L-rhamnose, D-xylose, L-arabinose and D-galactose in the molar ratio 2:1:17:9 (Table 1, 2, 3, ). The polysaccharide C was methylated with dimethylsulphate and 40% NaOH, and Purdies regent. The hydrolyzate of fully methlated product ($[{\alpha}]^{22}_D-102$ in chloroform, the methoxy content 40.6%) was composed of 2, 3, 5-tri-O-methyl-L-arabofuranose (I), 3,4-di-O-methyl-L-rhamnopyranose (II), 2,3-di-O-methyl-D-xylose (III), 2,3,4-tri-O-methyl-D-galactopyranose (IV), 2,4-di-O-methyl-L-arabopyranose (?), 2,4-di-O-methyl-D-galactose(VI), 2-O-methyl-D-arabinose (VII), and L-arabopyranose(VIII) (Table 4, 5, and Fig. 4). The first partial hydrolysis (A) of the polysaccharide C with 0.05N-HCl for 4.5 hours at $80-85^{\circ}C$ released only L-arabinose: the second hydrolysis (B) with 0.1N-HCl for 5 hours at $80-85^{\circ}C$, L-arabinose and D-galactose; and the third hydrolysis (C) with 0.3N-HCl at $90-95^{\circ}C$ in sealed tube, L-rhamnose, D-xylose, L-arabinose and D-galactose. From the unhydrolyzate A' were found L-rhamnose, D-xylose, L-arabinose, and D-galactose; from B' L-rhamnose, d-xylose, L-arabinose and D-galactose; and from C' D-xylose and D-galactose respectively (Table 6). The periodate consumption and formic acid production of the polysaccharide C were measured at various time intervals. After 120 hours periodat was consumed by 1.23 mole per $C_5H_8O_4$ and formic acid was produced 0.78 mole per $C_5H_8O_4$ (Table 7). Although a definite chemical structure for this polysaccharide C may not be formulated, experimental data, especially, from methylation, partial hydrolysie and determination of its molar ratio, and periodate analysis showed that the polysaccharide C is a highly branched polysaccharide and would be constructed of galactoaraban as a main chain residue and L-arabofuranose, D-galactopyranosyl $(1{\rightarrow}1)$-L-arabofuranose, D-xylopyranosyl $(1{\rightarrow}2)$-L-rhamnopyranosyl $(1{\rightarrow}1)$-L-arabofuranose, and L-rhamnopyranosyl $(1{\rightarrow}1)$-arabofuranose, and D-galactopyranosyl-$(1{\rightarrow}2)$-L-arabopyranosyl-$(1{\rightarrow}1)$-I-arabofuranose as a branch chain or end group (page 21).

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Simulation of Local Climate and Crop Productivity in Andong after Multi-Purpose Dam Construction (임하 다목적댐 건설 후 주변지역 기후 및 작물생산력 변화)

  • 윤진일;황재문;이순구
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.42 no.5
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    • pp.579-596
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    • 1997
  • A simulation study was carried out to delineate potential effects of the lake-induced climate change on crop productivity around Lake Imha which was formed after a multi-purpose dam construction in Andong, Korea. Twenty seven cropping zones were identified within the 30 km by 25 km study area. Five automated weather stations were installed within the study area and operated for five years after the lake formation. A geostatistical method was used to calculate the monthly climatological normals of daily maximum and minimum temperature, solar radiation and precipitation for each cropping zone before and after the dam construction. Daily weather data sets for 30 years were generated for each cropping zone from the monthly normals data representing "No lake" and "After lake" climatic scenarios, respectively. They were fed into crop models (ORYZA1 for rice, SOYGRO for soybean, CERES-maize for corn) to simulate the yield potential of each cropping zone. Calculated daily maximum temperature was higher after the dam construction for the period of October through March and lower for the remaining months except June and July. Decrease in daily minimum temperature was predicted for the period of April through August. Monthly total radiation was predicted to decrease after the lake formation in all the months except February, June, and September and the largest drop was found in winter. But there was no consistent pattern in precipitation change. According to the model calculation, the number of cropping zones which showed a decreased yield potential was 2 for soybean and 6 for corn out of 27 zones with a 10 to 17% yield drop. Little change in yield potential was found at most cropping zones in the case of paddy rice, but interannual variation was predicted to increase after the lake formation. the lake formation.

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Research of Statistical Model for Genetic Evaluation of Hanwoo Carcass Traits (한우 도체형질의 유전능력평가를 위한 통계모형 탐색)

  • Koo, Yang-Mo;Kim, Si-Dong;Kim, Jung-Il;Song, Chi-Eun;Lee, Ki-Hwan;Jeoung, Yeoung-Ho;Lee, Jae-Youn;Jang, Hyun-Gi;Park, Byoung-Ho;Choi, Te-Jong;Cho, Kwang-Hyun;Lee, Seung-Soo;Lee, Jung-Gyu;Kim, Hyo-Sun
    • Journal of Animal Science and Technology
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    • v.53 no.4
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    • pp.283-288
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    • 2011
  • This study was conducted to study the environment effects on live weight, carcass weight, dressing percentage, eye muscle area, backfat thickness, and marbling score, which are the carcass traits of Hanwoo, based on the estimates and all the possible regression for the selection of variable and significance test for 231,382 heads that underwent the carcass measurements. The average and standard deviation for the live weight, carcass weight, dressing percentage, eye muscle area, backfat thickness, and marbling score were 654.79${\pm}$91.61 kg, 362.30${\pm}$67.15 kg, 59.52${\pm}$0.03%, 81.79${\pm}$12.21 $cm^2$, 11.39${\pm}$5.40 mm, 4.38${\pm}$2.29, respectively. The live weight, carcass weight, dressing percentage, eye muscle area, backfat thickness, and marbling score for cow were 532.79${\pm}$78.38 kg, 313.40${\pm}$44.90 kg, 56.50${\pm}$0.03%, 75.24${\pm}$10.69 $cm^2$, 11.82${\pm}$5.10 mm, 4.30${\pm}$2.06, respectively, while for bull were 619.74${\pm}$93.27 kg, 376.89${\pm}$48.62 kg, 58.61${\pm}$0.02%, 85.61${\pm}$10.46 $cm^2$, 5.64${\pm}$2.71 mm, 1.41${\pm}$0.83, respectively, and for steer were 681.78${\pm}$70.72 kg, 415.23${\pm}$49.43 kg, 60.19${\pm}$0.02%, 88.29${\pm}$10.27 $cm^2$, 12.71${\pm}$5.23 mm, 5.42${\pm}$1.99, respectively. In the environmental variables selection based on the variables selection method, the examination by carcass traits suggested that the most appropriate model could be determined when five variables were selected for the live weight, carcass weight, dressing percentage, eye muscle area, and four variables for backfat thickness, and marbling score. When they were considered at a time altogether based on multiple traits, it was deemed to be desirable to insert all five variables into the variables for analysis. In addition, high significance was found by carcass traits.

Estimation of Ovulation and Optimal Breeding Time Based on Vaginal Cytology and Determination of Reproductive Hormones in Shih-tzu Bitches (Shih-tzu견에서 발정 주기 동안 질세포 검사 및 번식 호르몬 측정에 의한 교배 적기 및 배란 시기의 판정)

  • Kim, B.S.;Oh, K.S.;Kim, J.P.;Bae, C.S.;Kim, S.H.;Kim, J.T.;Park, I.C.;Park, S.G.;Son, C.H.
    • Journal of Embryo Transfer
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    • v.21 no.3
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    • pp.207-216
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    • 2006
  • Vaginal cytology was examined in 12 Shih-tzu bitches to establish the accurate basic data for estimate to the optimal mating time and ovulation time. The mean duration of proestrus and estrus were $9.09{\pm}0.83\;(mean{\pm}SD)$ days and $7.36{\pm}0.47$ days in pregnant bitches. The gestational length in the 12 pregnant bitches was $65.2{\pm}0.5$ days in pregnant bitches when Day 0 was timed from the first day of male acceptance. Characteristic features of vaginal cytology during the estrous cycle were the high proportion of large intermediate cell, superficial cell, anuclear cell and erythrocyte in proestrus, superficial cell, anuclear cell and erythrocyte in estrus, and parabasal cell, small and large intermediate cell and leukocyte in diestrus, respectively. Cornification index (CI) was the high proportion in proestrus and estrus, then it decreased in diestrus and anestrus. When Day 0 was timed from the day of the first male acceptance, the CI peak was Day 2 and maintained above 80% between Day -4 and Day 6 during 11 days, and above 90% between Day -1 and Day 5 during 7 days. In relationship between CI and reproductive hormones, CI showed peak at the first day after plasma estradiol-$17{\beta}$ concentration peak and plasma progesterone concentration was first increased above 4.0 ng/ml at Day 0 which was the first day after CI peak. In conclusion, ovulation in Shih-tzu bitches occurred at the first day after CI peak. Vaginal cytology is the simple and reliable method for estimating estrous cycle, optimal breeding time and ovulation time in Shih-tzu bitches.

Effects of Aromatherapy on Depression, Anxiety and the Autonomic Nervous System in Breast Cancer Patients Undergoing Adjuvant Radiotherapy (방사선 요법을 받는 유방암 환자에게 적용한 아로마 요법이 우울, 불안 및 자율신경계 반응에 미치는 효과)

  • Yun, Sun-Hee;Cha, Jung-Hee;Yoo, Yang-Sook;Kim, Yeong-In;Chung, Su-Mi;Jeong, Hea-Lim
    • Journal of Hospice and Palliative Care
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    • v.15 no.2
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    • pp.68-76
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    • 2012
  • Purpose: The study was designed to verify effects of aromatherapy on depression, anxiety and the autonomic nervous system in breast cancer patients who are undergoing adjuvant radiotherapy. Methods: Data were collected from November 2006 through March 2007 at the C university hospital in Seoul. The study included 33 patients and they were assigned to three groups. Group I had aroma oil inhalation for 2 minutes per time, three times a day for six weeks whereas Group II and a control group inhaled aroma oil for 2 minutes per time, once a day for six weeks. For Groups I and II, a mixture of lemon, lavender, rosewood and rose essential oils were used while control group inhaled tea tree oil. Results: Depression was significantly decreased in patients in the experimental groups only. In Groups I and II patients, anxiety level was lower than that in control patients. Patients in Groups I and II also showed stronger physical resistance to stress than control group patients. Conclusion: Aromatherapy should be considered as a method that can significantly decrease depression in breast cancer patients who are undergoing adjuvant radiotherapy.

Detection of IgY Specific to Salmonella enteritidris and S. typhimurium in the Yolk of Commercial Brand Eggs using ELISA (ELISA 방법으로 계란의 난황에 존재하는 Salmonella enteritidis와 S. typhimurium에 대한 IgY 측정)

  • 이승배
    • Food Science of Animal Resources
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    • v.23 no.2
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    • pp.161-167
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    • 2003
  • Identification of salmonellosis-infected commercial poultry flocks has become a pivotal component of efforts to reduce incidence of egg-associated transmission of S. enteritidis and S. typhimurium to humans. As a basic study for sanitary control of S. enteritidis and S. typhimurium, main food-borne pathogenic bacteria in eggs produced by domestic hens, commercial egg samples were tested for specific antibodies to whole cells of S. enteritidis and S. typhimurium and outer membrane protein(OMP) of S. typhimurium by ELISA to detect infection of S. enteritidis and S. typhimurium in various groups of hens. When the antibody titers of yolks from three commercial brand eggs were tested after diluting in the ratio from 1:100 to 1:1,600 with double dilution method, ELISA values of the specific antibodies could be shown as differences in dilution patterns by comparing with negative control egg. When the antibody titers of the yolks from two commercial brand eggs were tested after diluting in the ratio of 1:200 and 1:1,000, ELISA values of specific antibodies were different among same brand eggs. When the antibody titers of yolks from five eggs sampled randomly from twenty one commercial brand eggs were tested after diluting in the ratio of 1:1,000, ELISA value of the specific antibodies were shown generally high. ELISA values of 28.5, 30, and 28.5% of yolks from 21 brand eggs were shown low and similar to negative control egg in antibody titers to whole cells of S. enteritidis and S. typhimurium and OMP of S. typhimurium, respectively. The results demonstrated that ELISA test of egg yolk antibody could provide a highly sensitive indicator to detect contamination of S. typhimurium and S. enteritidis in poultry, and could be used effectively to reduce incidence of S. typhimurium and S. enteritidis infection in poultry.