• Title/Summary/Keyword: p-53

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The evaluation of the eutrophication for the lakes by phosphorus loading (총인부하량을 이용한 인공호의 부영양화 평가)

  • 김재윤
    • Journal of Environmental Science International
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    • v.12 no.7
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    • pp.689-695
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    • 2003
  • The purpose of this study is to evaluate and to predict of eutrophication in lakes by using Vollenweider-OECD model and total phosphorus concentration and inflow rate which were measured in 1993∼2001. The results of study were as follows. The annual total phosphorus loading from the watershed was calculated to be 55∼195tP/yr at lake Soyang, 221∼466tP/yr at lake Taechong, 123∼278tP/yr at lake Andong, 57∼109tP/yr at lake Seomjin. These are discharged, far the most parts, from population and fishfarm facility. TP loading on the surface area at lake Soyang was 3.01gP/㎡/yr, 2.82gP/㎡/yr, 2.84gP/㎡/yr, 3.03gP/㎡/yr, 2.34gP/㎡/yr, 1.78gP/㎡/yr, 0.91gP/㎡/yr, 0.89gP/㎡/yr, 0.86gP/㎡/yr, lake Taechong was 6.71gP/㎡/yr, 7.25gP/㎡/yr, 7.24gP/㎡/yr, 6.53gP/㎡/yr, 6.50gP/㎡/yr, 7.06gP/㎡/yr, 7.04gP/㎡/yr, 4.05gP/㎡/yr, 3.44gP/㎡/yr and TP loading on the surface area of lake Andong, lake Soemjin were 5.39gP/㎡/yr, 4.47gP/㎡/yr, 4.56gP/㎡/yr, 4.45gP/㎡/yr, 3.33gP/㎡/yr, 2.38gP/㎡/yr, 2.53gP/㎡/yr, 2.46gP/㎡/yr, 2.54gP/㎡/yr, 4.09gP/㎡/yr, 4.10gP/㎡/yr, 3.98gP/㎡/yr, 3.73gP/㎡/yr, 2.80gP/㎡/yr, 3.46gP/㎡/yr, 3.22gP/㎡/yr, 2.19gP/㎡/yr, 2.13gP/㎡/yr respectively. The tropic states of four lakes can be assessed as eutrophy because phosphorus leading exceeds the critical phosphorus loading by Vollenweider-OECD model.

Antioxidant Activity of Goat Meat Hot Water Extract and Effect of Extract on Expression of Apoptosis-Related Proteins (염소고기 열수추출물 처리에 따른 항산화 활성 및 암 세포주에서 항암 관련 단백질 발현량 확인)

  • Jei Oh;Yohan Yoon
    • Journal of Food Hygiene and Safety
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    • v.38 no.6
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    • pp.551-556
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    • 2023
  • This study was conducted to evaluate in vitro antioxidant activity of goat meat hot water extracts and the changes in apoptosis-related protein expression levels in the cancer cells treated with these extracts. Goat meat hot water extracts were prepared using different cuts of goat meat, including foreleg, hindleg, loin, and rib. Among these extracts, the foreleg and hindleg extracts displayed higher (P<0.05) ABTS radical scavenging activity than the other two extracts. Protein expression levels of BAX, p53, and p21 were not different in the cells treated with the extracts from different cuts, regardless of the cell type. Only p53 expression in HT-29 cells was elevated (P<0.05) after loin extract treatment. These results suggest that antioxidant activity and apoptosis-related effects of goat meat hot water extract varied with cut of meat under in vitro conditions. Because all data was obtained from the in vitro experiment, the ability to generalize conclusions is limited. Additional in vivo studies are necessary.

Activation of apoptotic protein in U937 cells by a component of turmeric oil

  • Lee, Yong-Kyu
    • BMB Reports
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    • v.42 no.2
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    • pp.96-100
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    • 2009
  • Aromatic (ar)-turmerone from turmeric oil displays anti-tumorigenesis activity that includes inhibited cell proliferation. This study investigated ar-turmerone-mediated apoptotic protein activation in human lymphoma U937 cells. Ar-turmerone treatment inhibited U937 cell viability in a concentration-dependent fashion, with inhibition exceeding 84%. Moreover, the treatment produced nucleosomal DNA fragmentation and the percentage of sub-diploid cells increased in a concentration-dependent manner; both are hallmarks of apoptosis. The apoptotic effect of ar-turmerone was associated with the induction of Bax and p53 proteins, rather than Bcl-2 and p21. Activation of mitochondrial cytochrome c and caspase-3 demonstrated that the activation of caspases accompanied the apoptotic effect of ar-turmerone, which mediated cell death. These results suggest that the apoptotic effect of ar-turmerone on U937 cells may involve caspase-3 activation through the induction of Bax and p53, rather than Bcl-2 and p21.

Awareness of Disabled Person and Analysis of Factors Related to the Awareness among Nursing Students (간호학생의 장애인에 대한 인식과 영향요인)

  • Mo, Jin-A
    • The Korean Journal of Rehabilitation Nursing
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    • v.14 no.1
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    • pp.32-38
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    • 2011
  • Purpose: The purpose of this study was to investigate the level of awareness toward disabled persons among nursing students and to identify associating factors for their awareness of disabled persons. Method: 410 nursing students completed the survey on the awareness and frequency of contacts toward disabled persons, self-efficacy, and clinical practice satisfaction. Results: The scores in awareness, contact, clinical practice satisfaction was $50.53{\pm}7.53$, $52.41{\pm}10.61$, $79.21{\pm}10.88$ and $67.04{\pm}9.47$, respectively, indicating. Awareness of disabled persons had significant positive correlations with frequency of contact (p<.001), satisfaction with nursing major (p=.045), satisfaction with clinical practice (p<.001) and self-efficacy (p=.029). Conclusion: To improve awareness of disability, we need to improve student's satisfaction with nursing major and clinical practice by modifying the curriculum. Thereby awareness toward disabled and the weak can improve naturally.

Mutational profiling of p53 gene in human breast epithelial cells (MCF10A) exposed to Benzo(a)pyrene(BaP) or N-Methyl-N'-nitro-N-nitrosoguanidine(MNNG)

  • Kim, In-Sun;Lee, Byung-Mu
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.05a
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    • pp.83-83
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    • 2003
  • Mutations of p53 tumor suppressor gene have been associated with exposure to carcinogens. Cultured human breast epithelial cells (MCF10A) were treated with Benzo(a)pyrene(BaP) or N-Methyl-N'-nitro-N-nitrosoguanidine(MNNG). MCF10A cells were grown in DMEM/F12 medium and trated for 6, 12, 24, 48 and 96h with Bap (1, 10 and 100 $\mu$M) dissolved in dimethylsulfoxide(DMSO). (omitted)

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A Study on the Arc Characteristics in Butt Joint P-GMA Welding with Acute Groove Angles (작은 그루브 각을 가지는 맞대기 P-GMA 용접에서의 용접아크에 관한 연구)

  • Kim, Ryoon-Han;Na, Suck-Joo;Kim, Cheol-Hee
    • Proceedings of the KWS Conference
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    • 2010.05a
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    • pp.53-53
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    • 2010
  • The purpose of this paper is to propose a mathematical model of welding current for the P-GMAW by modifying the well known GMAW model. Welding power circuit is simply modeled as a RL electric circuit and solved as an ODE equation. The welding current depends on the joint shape, molten pool and welding parameters. To compare the molten pool effect to the welding current, CFD numerical simulation technique was adopted. Welding experiment is also conducted with the same welding parameters as used in numerical simulations to verify the proposed welding current model. The current model which is considered molten pool shape, is more fit to experiment result.

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61 days before the Megaburst of 17P/Holmes

  • Ham, Ji-Beom
    • The Bulletin of The Korean Astronomical Society
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    • v.35 no.2
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    • pp.53.2-53.2
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    • 2010
  • A Jupiter-family comet, 17P/Holmes, suddenly underwent a spectacular outburst on 2007 October 23, about 173 days after the perihelion passage. There has been no more outstanding comet outburst than the 17P/Holmes event since the beginning of modern astronomical observations. However, little is known about the activity of the comet before the outburst because of the accidental event. We found that 17P/Holmes appeared in the AKARI all sky survey data. It was taken on 2007 August 23, 112 days after the perihelion passage and 61 days before the outburst. The 9 micron images shows obvious coma and tail. We study the dust production rate from these images and evaluate the fractional active area. We compare these results with those of data after the outburst, and discuss the aftermass.

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