• Title/Summary/Keyword: overweight and obesity

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Clinical spectrum and short-term outcomes of multisystem inflammatory syndrome in children in a south Indian hospital

  • Balagurunathan, Muruganantham;Natarajan, Thrilok;Karthikeyan, Jothilakshmi;Palanisamy, Venkateshwaran
    • Clinical and Experimental Pediatrics
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    • v.64 no.10
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    • pp.531-537
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    • 2021
  • Background: Multisystem inflammatory syndrome in children (MIS-C) is a new hyperinflammatory variant that evolved during the coronavirus disease 2019 pandemic. Although the precise pathophysiology of MIS-C is uncertain, it is thought to be due to immune dysregulation occurring after recovery from acute infection. Purpose: Our study aimed to analyze the clinical spectrum, laboratory parameters, imaging characteristics, treatment strategies, and short-term outcomes of children with a diagnosis of MIS-C. Methods: This retrospective and prospective observational study included children less than 16 years of age who were admitted to the pediatric unit of a tertiary care teaching hospital in south India between August 2020 to January 2021 with a diagnosis of MIS-C according to World Health Organization criteria. Results: Twenty-one children were included in the analysis; all had fever with variable combinations of other symptoms. The mean age was 6.9 years; 71.4% were male. Gastrointestinal (80.9%) and cardiovascular (80.9%) systems were the most commonly affected. The majority of children had elevated inflammatory markers, and 16 (76.2%) had echocardiographic abnormalities mimicking Kawasaki disease. Eleven children (52.4%) required intensive care admission, 3 (14.3%) required supplemental oxygen, and 4 (19%) required inotropes. Nine (42.9%) were treated with intravenous immunoglobulin alone, 6 (28.6%) with steroids alone, and 3 (14.3%) with steroids and immunoglobulin. The median hospital stay was 6 days; there were no fatalities. Overweight/obesity, elevated ferritin, and mucocutaneous involvement were significantly associated with a prolonged hospital stay (≥7 days). Sixteen children (76.2%) were followed up till now and all of them had no clinical concerns. Conclusion: MIS-C is an emerging disease with variable presentation. A high index of suspicion is necessary for its early identification and appropriate management. Further research is essential for developing optimal treatment strategies.

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

  • Li, Lun;Ying, Xiang-Ji;Sun, Tian-Tian;Yi, Kang;Tian, Hong-Liang;Sun, Rao;Tian, Jin-Hui;Yang, Ke-Hu
    • Asian Pacific Journal of Cancer Prevention
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    • v.13 no.5
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    • pp.2069-2079
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    • 2012
  • Background and Objective: A comprehensive overall review of gastric cancer (GC) risk and protective factors is a high priority, so we conducted the present study. Methods: Systematic searches in common medical electronic databases along with reference tracking were conducted to include all kinds of systematic reviews (SRs) about GC risk and protective factors. Two authors independently selected studies, extracted data, and evaluated the methodological qualities and the quality of evidence using R-AMSTAR and GRADE approaches. Results: Beta-carotene below 20 mg/day, fruit, vegetables, non-fermented soy-foods, whole-grain, and dairy product were GC protective factors, while beta-carotene 20 mg/day or above, pickled vegetables, fermented soy-foods, processed meat 30g/d or above, or salty foods, exposure to alcohol or smoking, occupational exposure to Pb, overweight and obesity, helicobacter pylori infection were GC risk factors. So we suggested screening and treating H. pylori infection, limiting the amount of food containing risk factors (processed meat consumption, beta-carotene, pickled vegetables, fermented soy-foods, salty foods, alcohol), stopping smoking, avoiding excessive weight gain, avoidance of Pb, and increasing the quantity of food containing protective components (fresh fruit and vegetables, non-fermented soy-foods, whole-grain, dairy products). Conclusions: The conclusions and recommendations of our study were limited by including SRs with poor methodological bases and low quality of evidence, so that more research applying checklists about assessing the methodological qualities and reporting are needed for the future.

Factors associated with paravertebral muscle cross-sectional area in patients with chronic low back pain

  • Cankurtaran, Damla;Yigman, Zeynep Aykin;Umay, Ebru
    • The Korean Journal of Pain
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    • v.34 no.4
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    • pp.454-462
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    • 2021
  • Background: This study was performed to reveal the relationships between the cross-sectional areas (CSAs) of the paraspinal muscles and the severity of low back pain (LBP), including the level of disability. Methods: This single-center cross-sectional study was conducted on 164 patients with chronic LBP. The effects of demographic characteristics, posture, level of physical activity, disc herniation type, and sarcopenia risk on the CSAs of paraspinal muscles were evaluated along with the relationship between the CSAs and severity of pain and disability in all patients. The CSAs of paraspinal muscles were evaluated using the software program Image J 1.53. Results: A negative significant correlation was found between age and the paraspinal muscle's CSA (P < 0.05), whereas a positive correlation was present between the level of physical activity and the CSA of the paraspinal muscle at the L2-3 and L3-4 levels. The CSAs of paraspinal muscles in patients with sarcopenia risk was significantly lower than those in patients without sarcopenia risk (P < 0.05). The CSAs of paraspinal muscles at the L2-3 and L3-4 levels in obese patients were significantly higher than those in overweight patients (P = 0.028, P = 0.026, respectively). There was no relationship between the CSAs of paraspinal muscles and pain intensity or disability. Conclusions: Although this study did not find a relationship between paraspinal CSAs and pain or disability, treatment regimens for preventing paraspinal muscles from atrophy may aid pain physicians in relieving pain, restoring function, and preventing recurrence in patients with chronic LBP.

Major Foods and Nutrient Intake Quality According to Body Image Perception among Korean Women: Based on the 2010 Korea National Health and Nutrition Examination Survey Data (한국 여성의 주관적 체형인식에 따른 주요 다빈도 식품 및 영양소 섭취의 질: 2010년 국민건강영양조사 자료를 이용하여)

  • Lim, Young Suk;Jeon, Soo Bin;Kim, Hee Mang;Jeong, So Yeon;Ahn, Jae Young;Park, Hae Ryun
    • Journal of the Korean Dietetic Association
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    • v.21 no.2
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    • pp.154-172
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    • 2015
  • The prevalence of obesity is continuing to increase. Self-perceived body image among women has drawn a lot of attention in Korea due to unhealthy weight control trials. This study was conducted to determine the relationship between self-perceived body image and dietary intakes among Korean women. For the analysis, 1,747 subjects were selected after eliminating those who were likely to have recently altered their diet based on the 2010 Korea National Health and Nutrition Examination Survey (KNHANES) data. The subjects were divided into three groups: underweight, normal, and obese groups according to their perception of body image. Daily nutrient intakes, NAR (Nutrient Adequacy Ratio), and food intake frequency were assessed according to age group and body image perception. Only energy intake showed differences among the three body image perception groups across all age groups, but not statistical differences. Analysis of NAR and the order of most frequently consumed food items confirmed these findings. The ratio of underweight women that perceived their body size as normal or overweight was higher with younger age. Incorrect body image perception and unhealthy weight control behaviors can cause nutritional problems. This study confirmed that nutritional knowledge is important for healthy weight control trials. Nutritional education for healthy dieting should be emphasized among Korean women.

Effects of caloric restriction with varying energy density and aerobic exercise on weight change and satiety in young female adults

  • Song, Sae-Won;Bae, Yoon-Jung;Lee, Dae-Taek
    • Nutrition Research and Practice
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    • v.4 no.5
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    • pp.414-420
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    • 2010
  • This study examines the combined effects of caloric restriction on body composition, blood lipid, and satiety in slightly overweight women by varying food density and aerobic exercise. Twenty-three women were randomly assigned to one of two groups for a four-week weight management program: the high-energy density diet plus exercise (HDE: n = 12, $22{\pm}2$ yrs, $65{\pm}7$ kg, $164{\pm}5$ cm, $35{\pm}4%$ fat) and low-energy density diet plus exercise (LDE: n = 11, $22{\pm}1$ yrs, $67{\pm}7$ kg, $161{\pm}2$ cm, $35{\pm}4%$ fat) groups. Subjects maintained a low-calorie diet (1,500 kcal/day) during the program. Isocaloric ($483{\pm}26$ for HDE, $487{\pm}27$ kcal for LDE) but different weight ($365{\pm}68$ for HDE, $814{\pm}202$ g for LDE) of lunch was provided. After lunch, they biked at 60% of maximum capacity for 40 minutes, five times per week. The hunger level was scaled (1: extremely hungry; 9: extremely full) at 17:30 each day. Before and after the program, the subjects' physical characteristics were measured, and fasting blood samples were drawn. The daily energy intake was $1,551{\pm}259$ for HDE and $1,404{\pm}150$ kcal for LDE (P > 0.05). After four weeks, the subjects' weights and % fat decreased for both LDE (-1.9 kg and -1.5%, P < 0.05) and HDE (-1.6 kg and -1.4%, respectively, P < 0.05). The hunger level was significantly higher for HDE ($2.46{\pm}0.28$) than for LDE ($3.10{\pm}0.26$) (P < 0.05). The results suggest that a low-energy density diet is more likely to be tolerated than a high-energy density diet for a weight management program combining a low-calorie diet and exercise, mainly because of a reduced hunger sensation.

The Effects of Uncooked Grains and Vegetables with Mainly Brown Rice on Weight Control and Serum Components in Korean Overweight/obese Female (현미로 주원료로 한 생식이 과체중/비만 여성의 비만도와 혈액 성분에 미치는 영향)

  • 하태열;김나영
    • Journal of Nutrition and Health
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    • v.36 no.2
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    • pp.183-190
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    • 2003
  • This study was designed to investigate the effects of weight control and changes in serum components using a commercial uncooked food diet on 36 obese women over a period of 8 weeks. The subjects had uncooked food (40 g) with milk or soymilk twice a day instead of meals. The mean body weight and height measurements of the subjects at the outset were 69.1 $\pm$ 9.3 kg and 159.5 $\pm$ 4.4 cm, respectively. Initial daily calorie intake was 103.6 % of RDA, but was significantly lower at 4 and 8 weeks. The subjects showed a significant reduction in weight, body fat mass (p<0.05), anthropo-metric value and skinfold thickness during the experimental period. Hip and upper thigh girth were 102.7 $\pm$ 6.4 cm and 61.7 $\pm$ 4.3 cm at the outset, and fell to 99.3 $\pm$ 5.0 cm and 58.8 $\pm$ 4.1 cm after 8 weeks. The most significant reduction was in abdomen skinfold thickness (p < 0.05) , which went from 32.4 $\pm$ 8.7 mm at first to 24.2 $\pm$ 8.3 mm in after 8 weeks. Serum albumin levels were higher at 4 and 8 weeks than initially but the figures for all of the subjects were within the normal range. Hemoglobin and blood glucose levels were also within the normal range during the experimental period. Initial serum triglyceride level was 110.5 $\pm$ 49.5 mg/dl but fell to 93.2 $\pm$ 48.5 mg/dl after 8 weeks. Our results show that uncooked foods are effective in the diet therapy of obese women.

A Study of Concern about Weight Control, Nutrition Knowledge, Eating Behavior and Nutrients Intake according to Weight Control Attempt among High School Girls in Seoul (서울 여고생의 체중조절 시도 여부에 따른 체중조절 관심도, 영양지식, 식행동 및 영양소 섭취 상태에 관한 연구)

  • 박선주;박양자
    • Journal of the East Asian Society of Dietary Life
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    • v.11 no.5
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    • pp.856-867
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    • 2001
  • The purpose of this study is to investigate the relationship between of weight control attempts with concern about weight control. nutrition knowledge, eating behavior and nutrients Intake among high school girls in Seoul, Korea. A self-administered questionnaire was distributed to 355 subjects. The subjects were then divided into two groups, one with experience in attempting to control their weight, and one with no experience in attempting to control their weight. The mean averages of height, weight. obesity index (OI) and BMI of the subjects were 161.1cm, 53.1kg, -5.2% and 20.4, respectively. 49% of the subjects were experienced in attempting weight control. The majority of the group that had experience in weight control expressed dissatisfaction of with their self body image (66.7%), and was concerned about weight control (94.9%). This group also had more abnormal eating habits than the group that had no experience in weight control attempts, such as missing meals, eating irregularly, not eating a variety of foods and snacking. The mean averages of perceived knowledge (PK) and correct knowledge (CK) regarding nutrition on a 30 point scale were 23.6 (78.7% of total score) and 15.8 (52.7%), respectively. There were no significant differences of the PK's and the CK's between the two groups. Nutrients intakes of the two groups were not significantly different and the mean nutrient intakes revealed adequate consumption of energy. protein, Fe, Ca. thiamin. riboflavin, niacin, vitamin A and C. The higher the dissatisfaction of their self body image, PK score. and abnormal eating habits, the higher the level of concerns about of being overweight.

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Effect of Nutrition Education on Improving Diet Behavior of University Students (식품영양관련 교양과목 수강 후 대학생들의 영양지식, 식태도, 식행동 변화에 관한 연구)

  • Park Myoung Soon;Kim Seong Ai
    • Korean Journal of Community Nutrition
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    • v.10 no.2
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    • pp.189-195
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    • 2005
  • This study was to investigate the changes in nutrition knowledge, nutrition attitude and food habit during 'meal management and diet' course to nonmajor university students by questionnaires. 280 students of Chungnam university who registered nonmajor 'meal management and diet' course in the 2003 were the subjects. The results of this study are as follows. BMIs of male and female students were 21.5 and 19.3. According to BMI, underweight subjects were $24.3\%$, normal and overweight (danger & obesity) subjects were each $62.4\%$ and $13.6\%$, respectively. The nutrition knowledge scores significantly (p < 0.001) increased from 12.1 to 14.0 after the lecture, and the uncertainty rate of nutrition know- ledge decreased significantly. Also, there were no significant differences in nutrition attitude score (39.5 to 39.8 points). Female subjects showed significantly (p < 0.05) higher nutrition knowledge scores (12.3 points) than male (11.4 points). $20\%$ of the subjects smoked and $82.9\%$ had alcohol drinks and $24.4\%$ exercised more than 3 times per week. The subjects who ate regular meals significantly increased from 9.3 to $12.5\%$ after the lecture, and smoking subjects decreased from 20 to $13\%$, but alcohol drinking subjects did not changed significantly.

A Study of the Living Habits and Results of Health Examinations of University Students according to Sasang Constitution (사상체질(四象體質)에 따른 대학생들의 생활습관과 건강검진 결과 분석)

  • Jeong, Mi-Kyung;Jung, Ki-Yong;Jun, Chan-Yong;Park, Jong-Hyeong;Choi, You-Kyung
    • Journal of Society of Preventive Korean Medicine
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    • v.16 no.3
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    • pp.1-13
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    • 2012
  • Objectives : This study aimed to analyze the living habits and results of health examinations of university students according to Sasang constitution. Methods : We measured the height, weight, body mass index, and blood pressure of 2,387 university students, performed laboratory examinations, and conducted a questionnaire survey of their eating, drinking, smoking, and exercise habits. Their Sasang constitution was diagnosed by using the Questionnaire of Sasang Constitution ClassII(QSCCII). All the data were analysed statistically by descriptive statistics, chi-square test, ANOVA, tukey's multiple comparisons Results : The Taeeumin group mostly ranged in overweight sector of the BMI, and this group showed significantly higher blood pressure and AST, ALT, GGT, LDH, CPK, Creatinine, Uric acid, total cholesterol, TG, and LDL levels than other groups, while having a lower HDL level. In the living habits survey, the Taeeumin group showed the highest proportion of "overeating", and the lowest proportion of "eating slowly". This group had the highest value of quantity of alcohol drinking, highest proportion of hazardous drinkers, and highest smoking rate of the three constitutions. Conclusions : In the results of this study, there were significant differences in the living habits behaviors, and the results of health examination, between the three constitutions. In particular, individuals of the Taeeumin group have a high possibility of getting chronic disease, such as hypertension, diabetes mellitus, hyperlipidemia, and obesity; and need to improve their living habits.

Adipose Tissue-Derived Mesenchymal Stromal Cells from Ex-Morbidly Obese Individuals Instruct Macrophages towards a M2-Like Profile In Vitro

  • Daiana V. Lopes Alves;Cesar Claudio-da-Silva;Marcelo C. A. Souza;Rosa T. Pinho;Wellington Seguins da Silva;Periela S. Sousa-Vasconcelos;Radovan Borojevic;Carmen M. Nogueira;Helio dos S. Dutra;Christina M. Takiya;Danielle C. Bonfim;Maria Isabel D. Rossi
    • International Journal of Stem Cells
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    • v.16 no.4
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    • pp.425-437
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    • 2023
  • Obesity, which continues to increase worldwide, was shown to irreversibly impair the differentiation potential and angiogenic properties of adipose tissue mesenchymal stromal cells (ADSCs). Because these cells are intended for regenerative medicine, especially for the treatment of inflammatory conditions, and the effects of obesity on the immunomodulatory properties of ADSCs are not yet clear, here we investigated how ADSCs isolated from former obese subjects (Ex-Ob) would influence macrophage differentiation and polarization, since these cells are the main instructors of inflammatory responses. Analysis of the subcutaneous adipose tissue (SAT) of overweight (OW) and Ex-Ob subjects showed the maintenance of approximately twice as many macrophages in Ex-Ob SAT, contained within the CD68+/FXIII-A- inflammatory pool. Despite it, in vitro, coculture experiments revealed that Ex-Ob ADSCs instructed monocyte differentiation into a M2-like profile, and under inflammatory conditions induced by LPS treatment, inhibited HLA-DR upregulation by resting M0 macrophages, originated a similar percentage of TNF-α+ cells, and inhibited IL-10 secretion, similar to OW-ADSCs and BMSCs, which were used for comparison, as these are the main alternative cell types available for therapeutic purposes. Our results showed that Ex-Ob ADSCs mirrored OW-ADSCs in macrophage education, favoring the M2 immunophenotype and a mixed (M1/M2) secretory response. These results have translational potential, since they provide evidence that ADSCs from both Ex-Ob and OW subjects can be used in regenerative medicine in eligible therapies. Further in vivo studies will be fundamental to validate these observations.