• 대한한방부인과학회지
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• 제31권2호
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• pp.95-102
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• 2018

Objectives: The purpose of this paper is to report the effects of herbal medicine on spontaneous pregnancy with premature ovarian failure. Methods: The 28-year-old patient who was diagnosed premature ovarian failure was treated with herbal medicine (Hyangbujapalmul-tang-gagam), acupuncture and moxibustion. Results: After the treatment, the symptoms of premature ovarian failure such as hot flushes, sweats were improved. The patient recovered menstruation and achieved spontaneous pregnancy. Conclusions: This case shows that Korean medical treatment including herbal medicine has effect on treating infertile female with premature ovarian failure.

• 대한한방부인과학회지
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• 제29권1호
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• pp.116-126
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• 2016

Objectives: The purpose of these cases is to report the effects of oriental medicine on two patients with premature ovarian failure. Methods: Two patients who had amenorrhea and hot flashes caused by premature ovarian failure were treated by oriental medicine such as herb medication. We estimated the effects of treatments by follow-up measurements of serum hormone level, menstrual cycle and symptoms. Besides, follicle and endometrium were checked by ultrasonography for academic research.Results After treatments, their symptoms of premature ovarian failure were improved and the menstrual cycle resumed. And the level of serum Follicle Stimulating Hormone decreased and the level of serum E₂ increased.Conclusions Two cases shows that oriental medicine has effects on patients with premature ovarian failure by follow-up measurements of serum hormone level, menstrual cycle and symptoms.

• 대한한방부인과학회지
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• 제33권1호
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• pp.160-167
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• 2020

Objectives: To report the Pregnancy and delivery in Premature Ovarian Failure after Korean Traditional Medicine Treatment. Methods: The patients who diagnosed as premature ovarian failure was treated with herbal medicine (Daeyeongjeon-gamibang). Results: After the treatment, symptoms of premature ovarian failure such as vaginal dryness, hot flush were improved. The patient got regular menstruation cycle and she was pregnant during the treatment. Conclusions: The case report shows that Korean medical treatment can be an effective for infertile female with premature ovarian failure.

• 대한한방부인과학회지
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• 제26권1호
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• pp.109-120
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• 2013

Objectives: The purpose of this study is to report the effects of oriental medicine on 2 patients with premature ovarian failure. Methods: The patients who had amenorrhea caused by premature ovarian failure were treated by oriental medicine such as herb medication, acupuncture and moxibustion. We evaluated the results of treatments by change of symptoms, serum hormone assay, basal body temperature and Kupperman's Index. Results: After oriental medicine, the patients could have their normal menstrual cycle. Also serum hormone assay, basal body temperature and Kupperman's Index were improved. Conclusions: This study shows that oriental medicine has effects on patients with premature ovarian failure. And serum hormone assay, basal body temperature and Kupperman's Index would be valid measurement to evaluate the effect of treatments for premature ovarian failure.

• Clinical and Experimental Reproductive Medicine
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• 제16권2호
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• pp.147-152
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• 1989

The purpose of this study is to detect certain change in peripheral blood lymphocyte subpopulations in women with premature ovarian failure. The B cells, T cells and subsets were counted in 21 women with premature ovarian failure and 30 age-matched normal control women. The B cells were measured by identifying lymphocyte with surface membrane immunoglobulin and T cells and subsets by indirect immunofluorescence technique with the monoclonal antibodies OK T3, OK T4, and OK T8. The results were as follows. 1. No significant difference in the absolute number of B cells, T cells and subsets between women with premature ovarian failure and normal control women was observed. 2. The percentage of B cells, T cells and OK T8(+) cells in women with premature ovarian failure was not significantly different from that in normal control subjects respectively. 3. The percentage of OK T4(+) cells and OK T4/0K T8(+) ratio was significantly higher in women with premature ovarian failure than in control subjects.

• 대한한방부인과학회지
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• 제21권3호
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• pp.269-278
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• 2008

Purpose: The purpose of this study is to report the effect of Traditional Korean Medicine therapy on climacteric symptoms in premature ovarian failure patient. Methods: The patient in this case was 32 years old female. She had a history of the right side ovariectomy and antituberculous chemoteraphy caused by pelvic tuberculosis. And she was diagnosed with premature ovarian failure in October, 2007. She had a climacteric symptoms when she admitted to the OBGY department of Se-Myung University in Je-Cheon. She received Korean Medicine therapies such as herbal medicine, moxibustion, acupuncture. We evaluated patient's health status by Kupperman's index and VAS. Results: After the treatment, the climacteric symptoms in premature ovarian failure patient was improved. Conclusion: This case study shows that Korean Medicine therapies have significant effect on climacteric symptoms in premature ovarian failure.

• 대한한방부인과학회지
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• 제31권2호
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• pp.113-122
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• 2018

Purpose: To report the effect of Korean medical treatments on 1 patient with secondary amenorrhea after ovarian surgery for bilateral endometriomas diagnosed as premature ovarian failure. Methods: The patient who had secondary amenorrhea was treated with Korean medical treatments such as herbal medication, herbal acupuncture and moxibustion therapy, and so forth. Results: After the Korean medical treatments, the patient could have her periods again. And high FSH level was decreased to normal. Conclusions: The case report shows that Korean medical treatment can be an effective option for treating secondary amenorrhea after ovarian surgery for bilateral endometriomas diagnosed as premature ovarian failure.

• Clinical and Experimental Reproductive Medicine
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• 제25권3호
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• pp.281-286
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• 1998

Premature ovarian failure is a condition causing amenorrhea, hypoestrogenism, and elevated gonadotropins in women younger than 40 years. Many causes of premature ovarian failure were reported, including genetic abnormalities, enzymatic defects, defects in gonadotropin secretion or action, autoimmune disorders, physical and idiopathic causes. Recently, Finnish group reported a point mutation in the follicle stimulating hormone (FSH) receptor gene in premature ovarian failure patients. But it was reported that the group from United States could not find any mutation in FSH receptor gene. So we analysed C566T point mutation of FSH receptor gene using restriction fragment length polymorphism (RFLP) and compared the result between premature ovarian failure patient with idiopathic and known causes. But we did not find 556C${\rightarrow}$T mutation in the FSH receptor gene in both groups. These findings suggest that the missense mutation in the human FSH receptor gene reported in Finnish women with premature ovarian failure is uncommon in Korean women with premature ovarian failure.

• 대한한방부인과학회지
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• 제15권4호
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• pp.193-201
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• 2002

본 증례에서는 조기난소기능부전 진단 후 여성 호르몬 대체요법을 받지 않고 에스트로겐 결핍증상과 속발성 희발월경의 양상을 보이는 환자를 적절한 변증론치(辨證論治)를 통하여 한약물 치료로 주기적인 월경의 양상과 호르몬 검사상 정상으로 개선시킬 수 있었다. 앞서의 고찰로 한약물 치료가 조기난소기능 부전에 있어 여성 호르몬 요법을 대체할 수 있는 새로운 방법이 될 수 있음을 암시해 준다. 향후 한의학계에서도 한약재의 식물성 에스트로겐으로서의 역할에 대하여 많은 연구가 필요할 것으로 사료되며 더 많은 증례의 축적으로 치료의 예후를 나타낼 수 있는 지표나 변증(辨證)에 대한 연구도 더 필요하리라 생각한다.

• Clinical and Experimental Reproductive Medicine
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• 제35권3호
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• pp.231-238
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• 2008

목 적: 조기난소부전 환자의 10$\sim$20%에서 난소기능이 회복될 수 있다고 하며 간헐적으로 배란이 되고 심지어는 임신이 가능할 수 있다는 보고가 있다. 그러나 한국의 조기난소부전 여성의 임상적 특징과 배란가능성은 논의된 적이 없다. 이 연구의 목적은 한국인 조기난소부전 환자에서 자연 난포의 발생 빈도와 배란유도의 가능성을 평가하는 것이다. 연구방법: 특발성 조기난소부전으로 진단된 15명 여성의 전체 진료기록을 후향적으로 연구하였다. 환자별로 6번 이상의 초음파 검사를 시행하였고 36개월 이상의 기간 동안 추적관찰을 하였다. 또한 4명의 환자에서 6주기의 배란유도시도를 하였다. 조사항목은 초음파 검사에서 난포의 발견율, 자연 난포 성장률과 배란유도를 시행한 경우에 그 반응을 평가하여 결과를 분석하였다. 결 과: 15명 중 6명은 초음파상 난포가 발견되었나 (40%) 초음파 검사 당 난포 발견 빈도는 7%였다 (115회 중 8회). 6명 중 한 명은 초음파 추적관찰 상 배란이 확인되었고 나머지 5명은 크기에 변화가 없었다. 배란유도를 시도한 6명 중 성공적인 난포 성장이 관찰된 예는 없었다. 결 론: 한국인 조기난소부전 환자에서 난포의 발견율은 이전 서양 연구에 비하여 낮다고 생각되지만 관찰 방법에 차이가 있어 직접비교는 불가능하다. 배란유도의 성공율은 0%로서 이전 연구에서 발표된 수준보다 낮았다.