• Asian Pacific Journal of Cancer Prevention
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• v.15 no.13
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• pp.5123-5126
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• 2014

Background: To evaluate the diagnostic performance of IOTA simple rules in differentiating between benign and malignant ovarian tumors. Materials and Methods: A study of diagnostic performance was conducted on women scheduled for elective surgery due to ovarian masses between March 2007 and March 2012. All patients underwent ultrasound examination for IOTA simple rules within 24 hours of surgery. All examinations were performed by the authors, who had no any clinical information of the patients, to differentiate between benign and malignant adnexal masses using IOTA simple rules. Gold standard diagnosis was based on pathological or operative findings. Results: A total of 398 adnexal masses, in 376 women, were available for analysis. Of them, the IOTA simple rules could be applied in 319 (80.1%) including 212 (66.5%) benign tumors and 107 (33.6%) malignant tumors. The simple rules yielded inconclusive results in 79 (19.9%) masses. In the 319 masses for which the IOTA simple rules could be applied, sensitivity was 82.9% and specificity 95.3%. Conclusions: The IOTA simple rules have high diagnostic performance in differentiating between benign and malignant adnexal masses. Nevertheless, inconclusive results are relatively common.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.5
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• pp.2003-2007
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• 2012

Purpose: E-cadherin is a transmemberane protein which is responsible for adhesion of endothelial cells. The aim of our study was to assess existing evidence of associations between reduced expression of E-cadherin and prognosis of ovarian cancer with a discussion of potential approaches to exploiting any prognostic value for improved clinical management. Methods: We conducted a meta-analysis of 9 studies (n=915 patients) focusing on the correlation of reduced expression of E-cadherin with overall survival. Data were synthesized with random or fixed effect hazard ratios. Results: The studies were categorized by author/year, number of patients, FIGO stage, histology, cutoff value for E-cadherin positivity, and methods of hazard rations (HR) estimation, HR and its 95% confidence interval (CI). Combined hazard ratios suggested that reduced expression of E-cadherin positivity was associated with poor overall survival (OS), HR= 2.10, 95% CI:1.13-3.06. Conclusion: The overall survival of the E-cadherin negative group with ovarian cancer was significant poorer than the E-cadherin positive group. Upregulation of E-cadherin is an attractive therapeutic approach that could exert significant effects on clinical outcome of ovarian cancer.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.24
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• pp.10787-10790
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• 2015

Background: Ovarian cancer is an important cause of mortality in women. The aim of this study was to evaluate the incidence and mortality rates and trends in the Iranian population and make predictions. Materials and Methods: National incidence from Iranian annual of National Cancer Registration report from 2003 to 2009 and National Death Statistics reported by the Ministry of Health and Medical Education from 1999 to 2004 were included in this study. A time series model (autoregressive) was used to predict the mortality for the years 2007, 2008, 2012 and 2013, with results expressed as annual mortality rates per 100,000. Results: The general mortality rate of ovarian cancer slightly increased during the years under study from 0.01 to 0.75 and reaching plateau according to the prediction model. Mortality was higher for older age. The incidence also increased during the period of the study. Conclusions: Our study indicated remarkable increasing trends in ovarian cancer mortality and incidence. Therefore, attention to high risk groups and setting awareness programs for women are needed to reduce the associated burden in the future.

• Korean Journal of Veterinary Research
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• v.14 no.1
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• pp.17-21
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• 1974

The experiment was carried out to determine the concentration of vitamin A by Carr-Price reaction ot fifty six sera obtained from normal cows and fourty four sera from the cows with ovarian hypofunction. The results obtained in this work were summerized as follows: 1. The mean values of vitamin A concentration of sera obtained from the cows with ovarian hypofunction were 88 IU/100 ml in summer (grazing), and in winter 79 IU/100 ml (hay) and 173 IU/100 ml (trench silage). The mean values of vitamin A concentration of sera from normal cows were 212 IU/100 ml in summer (grazing), and in winter 113IU/100 ml (hay) and 338IU/100 ml (trench silage). The differences of the concentrations of vitamin A among three groups were statistically highly significant (p<0.01). 2. The differences of vitamin A concentrations between the hay group and the trench silage group in normal cows and in cows with ovarian hypofunction were statistically highly significant (p<0.01). 3. The concentrations of vitamin A in summer group (grazing) were higher than those of the hay group in winter in normal cows and in cows with ovarian hypofunction. 4. The concentrations of vitamin A in the trench silage group in winter were higher than those of summer group (grazing) in normal cows and in cows with ovarian hypofunction.

• Tuberculosis and Respiratory Diseases
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• v.50 no.4
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• pp.499-503
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• 2001

Tracheal tumors are uncommon comprising less than 0.1% of all malignancies. Metastatic tracheal tumors, especially from the extrathoracic sites, are exceedingly rare. Ovarian cancer tends to metastasize to the serous cavities and the lymph nodes. One large autopsy study reported tracheal involvement in 1% of patients who had died from ovarian cancer. Other studies have not mentioned tracheal involvement at all. Since the main symptoms of cough, hemoptysis, or wheezing are nonspecific, patients may be initially treated for other conditions including asthma or bronchitis. Here we describe a metastatic tracheal tumor from an ovarian carcinoma that was initially treated for bronchial asthma.

• The Journal of Korean Obstetrics and Gynecology
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• v.31 no.3
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• pp.121-130
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• 2018

Objectives: The purpose of this study is to report the effects of Korean medical treatment in ovarian disorder patients resistant to controlled ovarian hyperstimulation. There are some case-reports about effectiveness of the Korean medical treatment to treat ovulation disorder and become pregnant, but cases are still deficient. Methods: The patient was diagnosed possibility of premature ovarian failure by serum hormone assay and underwent hyperstimulation to freeze oocyte. But ovary had no response to hyperstimulation. She was treated by Korean medical treatment, such as herbal medicine, acupuncture and moxibustion. Results: After the treatment, the patient recovered from irregular ovulation & menstrual cycle and became pregnant and gave birth. Conclusions: This case shows the Korean medical treatment might be effective in ovarian disorder patients resistant to hyperstimulation.

• Journal of Haehwa Medicine
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• v.17 no.1
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• pp.173-180
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• 2008

Purpose : The purpose of this paper is to report the effect of oriental medicine to primary infertility caused by polycystic ovarian syndrome. Methods : The patient in this case, 29 years-old female was treated with oriental treatment for 3 month. Before oriental treatment, she had been diagnosed as primary infertility caused by polycystic ovarian syndrome and treated medication and injection for IUI(intrauterine insemination) in 4 times. But she had failed in gestation. Results : After lasting oriental treatments, she became pregnant. Conclusion : According to this result, we concluded the oriental medicine could improve fertility rate. After this paper, further study and clinical approach based on oriental medicine will be needed about infertility caused by polycystic ovarian syndrome.

• Clinical and Experimental Reproductive Medicine
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• v.27 no.2
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• pp.151-157
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• 2000

Objective: The purpose of this study was to evaluate the effect of polycystic ovarian follicular fluid on sperm motility in human in vitro fertilization (IVF). Methods: From May, 1998 to July, 1999, 55 patients who complained of infertility were involved in this study. We obtained ovarian follicular fluids from the patients by ultrasono-guided aspiration. Subjects were divided into two groups. 20 patients who had polycystic ovarian disease were belong to study group, and 25 patients who had normal ovarian follicular fluid were belong to control group. The follicular fluid dilution was done with Ham's fluid as 10%, 20%, 50%, 100%. The sperm motility was analyzed by CASA at 6hr and 12hr after incubation in follicular fluids. Results: The levels of average path velocity (VAP) in all concentration fluid didn't show significant difference between study and control group. The other parameters including curvilinear velocity (VCL), amplitude of lateral head displacement (ALH), and linerity (LIN) were didn't show any significant difference between both groups. Conclusion: PCOD fluid had seemed to have an adverse effect on the sperm biological function. But, this study showed that PCOD fluid had no different effect on sperm motility with normal follicular fluid.

• The Journal of Korean Obstetrics and Gynecology
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• v.29 no.4
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• pp.57-68
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• 2016

Objectives: This paper aims to report the effects of Korean medical treatment on a patient who underwent abdominal surgery with hyperthermic intraperitoneal chemotherapy for ovarian cancer. Methods: An ovarian cancer patient underwent abdominal surgery and got Korean medical treatment during 7-day hospitalization. About 2 years later, with metastasis to the lymph nodes detected, she had abdominal surgery with hyperthermic intraperitoneal chemotherapy and got Korean medical treatment during 10-day hospitalization. The treatment included herbal medicine and acupuncture. Numerical Rating Scale (NRS) of symptoms was measured every morning. Results: After the treatment, sequela following surgery decreased, and general conditions improved. During 1st and 2nd hospitalization, NRS of general weakness, heartburn and dorsal chill significantly decreased (10 to 5, 10 to 5 and 10 to 2, respectively) while edema in both legs remained the same. Conclusions: This case shows that Korean medical treatment is effective for a patient who underwent abdominal surgery with hyperthermic intraperitoneal chemotherapy for ovarian cancer.

• Journal of Environmental Health Sciences
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• v.35 no.3
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• pp.235-238
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• 2009

In Korea, talc that has been widely used for a lot of consumer products as well as industrial usage until recently was found to be contaminated with asbestos. It becomes a major social issue. Critical health risk about both talc and talc contaminated with asbestos was summarized through literature review. It has been confirmed that talc can pose ovarian cancer when talc powder is used in the genital area. International Agency for Research on Cancer (IARC) already concluded that the perineal use of cosmetic talc can cause possibly carcinogenic to humane(Group 2B), although there was study reporting the lack of a consistent an established correlation between perineal dusting frequency and ovarian tissue talc concentrations and the lack of a consistent dose-response relationship with ovarian cancer risk. The association between talc exposure and ovarian cancer is as strong as in recent studies. The epidemiological studies to date provided inadequate evidence for the carcinogenicity of either inhaled or ingested talc that does not contain asbestos or asbestosiform fibers. Future studies should focus on seeking evidence in talc-exposed populations, collecting reliable information on age at initial used of body powder, exposure assessments related to talc use and dose response relationship in order to identify possible risk of talc ingested or inhaled.