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한국인 여드름 환자에서 표피성장인자가 함유된 외용제의 피부 적용에 대한 유효성 및 안전성 평가 (Efficacy and Safety of Topical Application of Epidermal Growth Factor (EGF) for Korean Acne Patient)

  • 서준혁;현무열;장성은;최선영;김명남;김범준
    • 대한화장품학회지
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    • 제42권2호
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    • pp.111-118
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    • 2016
  • 여드름은 면포, 구진, 낭종, 결절, 색소 침착 등 다양한 피부병변으로 나타나는 모낭피지선의 만성 염증질환으로 사춘기부터 성인기까지 발생 연령대가 다양해지고 있다. 한편, 약물 부작용으로 여드름이 발생하기도 하는데, 표피성장인자(epidermal grouwth factor, EGF) 수용체 억제제 항암제를 사용할 경우 75 ~ 100%에서 여드름양 모낭염이 발생된다고 보고되고 있다. 여드름의 치료로 항생제, 레티노이드 경구 복용 및 외용 약제 도포 등 다양한 방법이 이용되고 있다. 그러나 최근 들어 레티노이드 기형 유발 가능성 및 Propionibacterium acne의 항생제 내성률 증가는 기존 치료의 한계로 여겨진다. 따라서 본 연구는 최근 여드름양 발진에 효과가 있다고 알려진 EGF를 함유한 외용제가 여드름 치료에 미치는 효과와 안정성을 평가하였다. 한국 성인 10 ~ 29세 23명을 대상으로 EGF 함유 제품(트러블컨트롤 EGF)과 3종 제품(트러블컨트롤 클래리파잉 클렌징폼, 트러블컨트롤 올-클리어 필링토너, 레드롤 카밍 모이스처)을 하루 두 번 사용하도록 하였다. 사용 후 영상 피지량, 경표피수분손실량, 피부 홍조 측정, 전문가 육안 평가, 사용 후 만족도 설문조사를 평가하였다. 최종 측정 시, 피부 피지량, 경피수분손실량, 피부 홍조가 통계학적으로 감소하였으며, 전문가 육안 평가에서 여드름 병변(면포, 구진)도 통계학적으로 감소하였다. 연구동안 심각한 부작용은 관찰되지 않았다. 표피성장인자 함유 외용제는 경도의 여드름에 안전하면서도 효과적으로 사용할 수 있을 것으로 생각된다.

여드름 치료를 위한 PWM 기반 광 조사 시스템 설계 (Design of PWM-Based Photo Irradiation System for Acne Treatment)

  • 김창수;임현수
    • 한국방사선학회논문지
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    • 제6권3호
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    • pp.207-215
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    • 2012
  • 광 역학치료(Photodynamic therapy: PDT) 중 하나인 기존의 LED 광 조사는 연속파(Continuous wave: C.W) 방식의 635 nm 파장으로 여드름 치유에 가장 많이 사용되어 왔으나, 이 방식은 에너지효율이 낮고 생체조직에 열이 많이 발생하여 개선의 방안이 필요했다. 본 논문에서는 에너지효율을 높이고 여드름 치료를 위하여 생체조직에서의 열적 파괴현상을 방지하기위해 PWM(펄스 폭 변조: Pulse Width Modulation)을 활용한 여드름 치료용 LED 광 조사장치를 설계하였다. 시스템 구성은 크게 Timer 모듈, PWM 모듈, 광학전달 장치로 크게 세구성하여 설계하였으며, 여드름 치료를 위한 피부 투과 깊이를 높이기 위하여 광학전달 장치는 660 nm 파장의 1 W LED를 사용하였다. PWM 제어를 이용하여 발생된 주파수와 파형을 확인하고, 660 nm LED의 출력에너지 및 생체조직의 표면온도를 확인하여 안정적인 에너지출력과 생체조직의 안정성에 대해 평가하였다. 그 결과 여드름 치료를 위한 660 nm 파장의 1 W LED 광 에너지를 얻기 위하여 C.W 방식으로 사용하였을 경우 전력손실이 높고 생체조직에서의 열적 파괴현상을 보였으나, PWM 방식을 구현함으로써 펄스 폭 변조를 통하여 LED의 전력소모를 낮추었고, 생체조직의 열적 파괴현상이 나타나지 않아 여드름 치료를 위해 사용할 경우 C.W 방식보다 PWM 방식이 더 안전하고 효과적일 것으로 사료된다.

착지 높이와 지면 형태가 하지 관절에 미치는 영향 (The Effect on the Lower Limbs Joint as the Landing Height and Floor Pattern)

  • 김은경
    • 한국운동역학회지
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    • 제21권4호
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    • pp.437-447
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    • 2011
  • In this study, the lower limbs joints were analyzed for features based on the biomechanical characteristics of landing techniques according to height and landing on the ground type (flats and downhill). In order to achieve the objectives of the study, changes were analyzed in detail contents such as the height and form of the first landing on the ground at different angles of joints, torso and legs, torso and legs of the difference in the range of angular motion of the joint, the maximum angular difference between joints, the lower limbs joints difference between the maximum moment and the difference between COM changes. The subjects in this study do not last six months did not experience joint injuries 10 males in 20 aged were tested. Experimental tools to analyze were the recording and video equipment. Samsung's SCH-650A model camera was used six units, and the 2 GRF-based AMTI were used BP400800 model. 6-unit-camera synchronized with LED (photo cell) and Line Lock system were used. the output from the camera and the ground reaction force based on the data to synchronize A/D Syc. box was used. To calculate the coordinates of three-dimensional space, $1m{\times}3m{\times}2m$ (X, Y, Z axis) to the size of the control points attached to the framework of 36 markers were used, and 29 where the body was taken by attaching a marker to the surface. Two kinds of land condition, 40cm and 60cm in height, and ground conditions in the form of two kinds of flat and downhill slopes ($10^{\circ}$) of the landing operation was performed and each subject's 3 mean two-way RM ANOVA in SPSS 18.0 was used and this time, all the significant level was set at a=.05. Consequently, analyzing the landing technique as land form and land on the ground, the changes of external environmental factors, and the lower limbs joints' function in the evaluation were significantly different from the slopes. Landing of the slop plane were more load on the joints than landing of plane. Especially, knee extensor moment compared to the two kinds of landing, slopes plane were approximately two times higher than flat plane, and it was statistical significance. Most of all not so much range of motion and angular velocity of the shock to reduce stress was important. In the further research, front landing as well as various direction of motion of kinetic, kinetic factors and EMG variables on lower limbs joints of the study in terms of injury-prevention-approach is going to be needed.

라이다(LiDAR) 측정을 이용한 나셀전달함수의 유도 (Derivation of Nacelle Transfer Function Using LiDAR Measurement)

  • 김현구;강용혁;윤창열
    • 대한기계학회논문집A
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    • 제39권9호
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    • pp.929-936
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    • 2015
  • 풍력터빈 블레이드의 후단, 나셀 상부에 설치되는 나셀 풍속계는 블레이드 회전에 따른 후류효과 및 나셀형상 등으로 인하여 풍력터빈에 입사되는 자연풍속과는 다른 왜곡된 풍속을 측정한다. 풍력터빈 출력성능의 신뢰성 확보를 위해서는 나셀풍속을 자연풍속으로 보정하는 나셀전달함수를 유도하여 성능곡선을 보정하여야 한다. 본 연구에서는 전라남도 비금도 북부 해안에 건설된 신안풍력발전소에서 지상기반 원격탐사 장비인 라이다(LiDAR)를 설치하여 나셀 풍속계와 동일 높이에서의 자연풍속을 측정하였다. 나셀풍속을 자연풍속으로 보정하는 기존의 단순회귀분석에 의한 선형 나셀전달함수를 개선하기 위하여 다중회귀분석에 의한 비선형 나셀전달함수를 유도하였다. 나셀전달함수로 계산한 보정풍속을 풍력터빈 출력곡선에 대입하여 산출한 이론 발전량과 실제 발전량의 잔차를 비교하여 개선효과를 검증하였다. 다중회귀분석 나셀전달함수는 단순회귀분석에 비해 풍속의 표준오차는 9.4% 감소하였으며, 발전량 잔차 분포의 평균은 6.5% 감소하여 개선효과가 있음을 확인하였다.

나노웹 섬유형 전극 인터페이스와 KHU Mark2 EIT 시스템을 이용한 생체신호 동기 도전율 영상법 (Gated Conductivity Imaging using KHU Mark2 EIT System with Nano-web Fabric Electrode Interface)

  • 김태의;김현지;위헌;오동인;우응제
    • 대한의용생체공학회:의공학회지
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    • 제33권1호
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    • pp.39-46
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    • 2012
  • Electrical impedance tomography(EIT) can produce functional images with conductivity distributions associated with physiological events such as cardiac and respiratory cycles. EIT has been proposed as a clinical imaging tool for the detection of stroke and breast cancer, pulmonary function monitoring, cardiac imaging and other clinical applications. However EIT still suffers from technical challenges such as the electrode interface, hardware limitations, lack of animal or human trials, and interpretation of conductivity variations in reconstructed images. We improved the KHU Mark2 EIT system by introducing an EIT electrode interface consisting of nano-web fabric electrodes and by adding a synchronized biosignal measurement system for gated conductivity imaging. ECG and respiration signals are collected to analyze the relationship between the changes in conductivity images and cardiac activity or respiration. The biosignal measurement system provides a trigger to the EIT system to commence imaging and the EIT system produces an output trigger. This EIT acquisition time trigger signal will also allow us to operate the EIT system synchronously with other clinical devices. This type of biosignal gated conductivity imaging enables capture of fast cardiac events and may also improve images and the signal-to-noise ratio (SNR) by using signal averaging methods at the same point in cardiac or respiration cycles. As an example we monitored the beat by beat cardiac-related change of conductivity in the EIT images obtained at a common state over multiple respiration cycles. We showed that the gated conductivity imaging method reveals cardiac perfusion changes in the heart region of the EIT images on a canine animal model. These changes appear to have the expected timing relationship to the ECG and ventilator settings that were used to control respiration. As EIT is radiation free and displays high timing resolution its ability to reveal perfusion changes may be of use in intensive care units for continuous monitoring of cardiopulmonary function.

Development of an Integrated General Model (IGM) System for Comparison of Genetic Gains from Different Bull Selection Strategies for Korean Brown Cattle (Hanwoo)

  • Lee, Jeong-Soo;Kim, Hee-Bal;Kim, Si-Dong
    • Asian-Australasian Journal of Animal Sciences
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    • 제24권11호
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    • pp.1483-1503
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    • 2011
  • To advance the effectiveness of the current Hanwoo improvement system, we developed a general simulation that compared a series of breeding schemes under realistic user circumstances. We call this system the Integrated General Model (IGM) and it allows users to control the breeding schemes and selection methods by manipulating the input parameters. The Current Hanwoo Performance and Progeny Test (CHPPT) scheme was simulated with a Modified Hanwoo Performance and Progeny Test (MHPPT) scheme using a Hanwoo Breeding Farm cow population of the Livestock Improvement Main Center (LOMC) of the National Agricultural Cooperatives Federation (NACF). To compare the two schemes, a new method, the Simple Hanwoo Performance Test (SHPT), which uses ultrasound technology for measuring the carcass traits of live animals, was developed. These three models, including the CHPPT, incorporated three types of selection criteria: phenotype (PH), true breeding value (TBV), and estimated breeding value (EBV). The simulation was scheduled to mimic an actual Hanwoo breeding program; thus, the simulation was run to include the years 1983-2020 for each breeding method and was replicated 10 times. The parameters for simulation were derived from the literature. Approximately 642,000 animals were simulated per replication for the CHPPT scheme; 129,000 animals were simulated for the MHPPT scheme and 112,000 animals for the SHPT scheme. Throughout the 38-year simulation, all estimated parameters of each simulated population, regardless of population size, showed results similar to the input parameters. The deviations between input and output values for the parameters in the large populations were statistically acceptable. In this study, we integrated three simulated models, including the CHPPT, in an attempt to achieve the greatest genetic gains within major economic traits including body weight at 12 months of age (BW12), body weight at 24 months of age (BW24), average daily gain from 6 to 12 months (ADG), carcass weight (CWT), carcass longissimus muscle area (CLMA), carcass marbling score (CMS), ultrasound scanned longissimus muscle area (ULMA), and ultrasound scanned marbling score (UMS).

프랜차이즈 모기업 핵심역량 자원이 가맹점 관계결속과 재계약의도에 미치는 영향 (Effects of Core Competence and Resource Sharing on the Relational Bond among Franchisees and on Re-contract Intention in the Franchising Parent Companies)

  • 허영욱;주말찬
    • 유통과학연구
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    • 제12권4호
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    • pp.11-22
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    • 2014
  • Purpose - The domestic franchise industry has made significant contributions to industry such as investment, employment, and community economy development, facilitating growth potential. The franchise industry provides management knowhow transfer between parent companies and franchisees as per contracts addressing use of business signs, franchisees' independent position, franchisor support, and royalties to be paid to the franchisors. However, many franchisors lack management knowhow and provide insufficient support because of poor control of franchisees and not having a systematic approach to support. This results in dissatisfied franchisees and failure to establish long-term relationships. Few studies have examined relational commitment and/or re-contract intention by support resources between franchisors and franchisees, despite a considerable output of theories and studies of the growth of the franchise industry. The purpose of this study, therefore, was to examine the effects of the ability to provide resources on relational commitments and re-contract intention, and to suggest causal relationships and implications. Research design, data, and methodology - The subject was domestic franchisors registered with the Association of Franchise with more than 50 franchisees. Franchisees under contract for 2 years and considering re-contract of their franchise 2 years later were used. The subjects totaled 300 franchisees in Seoul. A questionnaire survey was used to investigate the subject of franchisees' concessions during the 10 days from November 21, 2013 to November 30, 2013. After excluding 16 surveys with poor answers, 284 responses were finally used. Four areas and 44 questions were used. A nominal scale was used for four common characteristics questions including gender, ages, educational background, and franchise managing time. Questions regarding ability, relational commitment, and re-contract intention made use of a Likert 5-point scale. Data coding and data cleaning were used. SPSS 18.0 was used as follows. First, frequency analysis was done to investigate demographic characteristics. Second, exploratory factor analysis was done to verify validity of testing tools, and Cronbach's α coefficient was used to verify reliability. Third, correlation analysis and multiple regression analysis were done. An exploratory factor analysis was done to verify validity of concepts. A correlation analysis was done to test relationships between the variables, and multiple regression analysis was done to verify franchisor's ability, franchisees' relational commitment, and re-contract intention. Results - The following were the outcomes. First, store operation management, finance operation management, and human resource management affected the calculated bond. Second, store operation management and finance operation management affected the emotional bond. Third, store operation management, finance operation management, human resource management, and marketing management affected the prescriptive bond. Fourth, calculated bond and prescriptive bond had an effect on re-contract intention. Conclusions - As stated above, in franchise management, parent companies' offer and instruction of core competence to their franchisees as an information resource could improve the relational bond by helping them grow together through the resource sharing. Consequently, core competence factors were promoting factors that could improve franchisees' re-contract intention for a long time.

Fractional-N PLL (Phase-Locked Loop) 주파수 합성기 설계 (Fractional-N PLL Frequency Synthesizer Design)

  • 김선철;원희석;김영식
    • 대한전자공학회논문지TC
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    • 제42권7호
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    • pp.35-40
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    • 2005
  • 본 논문에서는 900MHz 대역 중저속 무선 통신용 칩에 이용되는 3차 ${\Delta}{\sum}$ modulator를 사용한 Fractional-N PLL 주파수 합성기를 설계 및 제작하였다 우수한 위상노이즈 특성을 얻기 위해 노이즈 특성이 좋은LC VCO를 사용하였다. 그리고 고착시간을 줄이기 위해서 Charge Pump의 펌핑 전류를 주파수 천이 값에 따라 조절할 수 있도록 제작하였고 PFD의 참조 주파수를 3MHz까지 높였다. 또한 참조 주파수를 높이는 동시에 PLL의 최소 주파수 천이 간격을 10KHz까지 줄일 수 있도록 하기위하여 36/37 Fractional-N 분주기를 제작하였다. Fractional Spur를 줄이기 위해서 3차 ${\Delta}{\sum}$ modulator를 사용하였다. 그리고 VCO, Divider by 8 Prescaler, PFD, 및 Charge Pump는 0.25um CMOS공정으로 제작되었으며, 루프 필터는 외부 컴포넌트를 이용한 3차RC 필터로 제작되었다. 그리고 Fractional-N 분주기와 3차 ${\Delta}{\sum}$ modulator는 VHDL 코드로 작성되었으며 Xilinx Spartan2E을 사용한 FPGA 보드로 구현되었다. 측정결과 PLL의 출력 전력은 약 -11dBm이고, 위상노이즈는 100kHz offset 주파수에서 -77.75dBc/Hz이다. 최소 주파수 간격은 10kHz이고, 최대 주파수 천이는 10MHz이고, 최대 주파수 변이 조건에서 고착시간은 약 800us이다.

장거리 전송 파장분할 다중방식 수동형 광가입자망을 이용한 메트로망과 가입자망 통합 방안 (Consolidation of Metro Networks and Access Networks by using Long-reach WDM-PON)

  • 이상묵;문실구;김민환;이창희
    • 대한전자공학회논문지TC
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    • 제43권5호
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    • pp.59-67
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    • 2006
  • 외부에서 주입된 비간섭성 광원 (BLS: Broadband Light Source)에 파장 잠김된 패브리 페롯 레이저 다이오드(wavelength-locked F-P LD: wavelength-locked Fabry-Perot Laser Diode)를 광원으로 사용해서 50 GHz의 채널 간격을 갖는 양방향 장거리 저송 35 채널 고밀도 파장분할 다중방식 수동형 광 가입자망 (DWDM-PON: Dense Wavelength Division Multiplexing-Passive Optical Network)을 구현한다. 장거리 전송을 위해 F-P LD의 발진 모드를 제어하여 F-P LD에 주입이 요구되는 BLS 파워를 감소시키면서 출력 파워를 높인다. 결과적으로 광 증폭기의 사용 없이 70 km 단일 모드 광섬유를 통해 가입자당 100 Mb/s 이상의 대역폭을 제공하면서 모든 상하향 70 채널에서 손실 없이 이더넷 패킷을 전송하였다. 구현된 장거리 저송 DWDM-PON은 다수의 중앙국을 바이패스(Bypass)함으로써 메트로망과 가입자망을 통합할 수 있다. 또한, 구현한 DWDM-PON은 상용의 어븀 첨가 광섬유 증폭기를 광대역 광원으로 사용하여 80 가입자를 수용할 수 있으며, 반도체 광대역 광원을 사용하면, 100 가입자 이상의 수용이 가능하다.

Q6, Q10 어린이 인체모형의 상해치 연구 (Injury Study for Q6 and Q10 Child Dummies)

  • 선홍열;이슬;석주엽;유원재;윤일성
    • 자동차안전학회지
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    • 제8권1호
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    • pp.31-37
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    • 2016
  • The Child Occupant Safety Assessment was first introduced and carried out by Euro NCAP in 2003, with the goal of ensuring manufacturers to develop safe vehicles for passengers of all ages; the objective was to evaluate the safety and protection offered by different Child Restraint Systems (CRS) in the event of a crash. In 2013, the formerly used P child dummy series was replaced by newer and more biofidelic Q1.5 and Q3 child dummies, representing 1.5 and 3 year old children respectively. The frontal and side impact dynamic performances of the Q1.5 and Q3 were tested within all classes of vehicles assessed by Euro NCAP at the time. As an extension to that initiative, Q6 and Q10 child dummies were later developed representing children of 6 and 10 years old. Since the protection of larger children during vehicle crashes relies greatly on the interaction of vehicle restraint systems such as seat belt and the CRS, instrumented Q6 and Q10 dummies will be used to assess the protection offered in the event of front and side impact crashes. In this paper, we focused on injury criteria of Q6 and Q10 child dummies at 64 kph 40% offset frontal crash test. The whole procedure was designed with DFSS analysis. The full vehicle sled test results of both dummies were conducted with different restraint systems settled through previous sled test. It showed that several injury criteria and image data were collected as the result of the full vehicle sled test. Based on the results of these investigations, this paper describes which factor is most important and combination shows the best performance when evaluating rear seat occupant protection for Q6 and Q10 child dummies.