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Comparative Study of the Nucleotide Bias Between the Novel H1N1 and H5N1 Subtypes of Influenza A Viruses Using Bioinformatics Techniques

  • Ahn, In-Sung;Son, Hyeon-Seok
    • Journal of Microbiology and Biotechnology
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    • v.20 no.1
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    • pp.63-70
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    • 2010
  • Novel influenza A (H1N1) is a newly emerged flu virus that was first detected in April 2009. Unlike the avian influenza (H5N1), this virus has been known to be able to spread from human to human directly. Although it is uncertain how severe this novel H1N1 virus will be in terms of human illness, the illness may be more widespread because most people will not have immunity to it. In this study, we compared the codon usage bias between the novel H1N1 influenza A viruses and other viruses such as H1N1 and H5N1 subtypes to investigate the genomic patterns of novel influenza A (H1N1). Totally, 1,675 nucleotide sequences of the hemagglutinin (HA) and neuraminidase (NA) genes of influenza A virus, including H1N1 and H5N1 subtypes occurring from 2004 to 2009, were used. As a result, we found that the novel H1N1 influenza A viruses showed the most close correlations with the swine-origin H1N1 subtypes than other H1N1 viruses, in the result from not only the analysis of nucleotide compositions, but also the phylogenetic analysis. Although the genetic sequences of novel H1N1 subtypes were not exactly the same as the other H1N1 subtypes, the HA and NA genes of novel H1N1s showed very similar codon usage patterns with other H1N1 subtypes, especially with the swine-origin H1N1 influenza A viruses. Our findings strongly suggested that those novel H1N1 viruses seemed to be originated from the swine-host H1N1 viruses in terms of the codon usage patterns.

Vasorelaxant or hypotensive effects of herbal medicines belong to Umbelliferae family: a review (수종 산형과 한약재의 혈관이완 및 혈압강하 효능에 대한 문헌고찰)

  • Kim, Bumjung;Choi, Ho-Young
    • The Korea Journal of Herbology
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    • v.37 no.6
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    • pp.29-36
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    • 2022
  • Objectives : The objective of this study was to investigate the possibility for the treatment of hypertension of herbal medicines belong to Umbelliferae family. Methods : Domestic and international articles about Herbology were investigated. A review was performed via the database (DB) search engines such as Pubmed, Korean studies Information Service System (KISS), KoreaScience, and Google Scholar. Hypertension-related terms including "vasorelaxation", "vasorelaxant", "vasodilation", "vasodilatory", "vasodilative", "hypotension", and "hypotensive" were performed as search terms. Results : A list was made about herbal medicines and origin plants belonging to the Umbelliferae family in Korean Pharmacopoeia 12 and Korean Herbal Pharmacopoeia. 14 herbal medicine and 22 origin plants were searched. Ostericum koreanum root and rhizome, Notopterygium incisum root and rhizome, N. forbesii root and rhizome, Ligusticum tenuissimum root and rhizome, L. jeholense root and rhizome, Angelica gigas root, A. dahurica root, A. dahurica var. formosana root, Bupleurum falcatum root, Peucedanum japonicum root, P. praeruptorum root, A. decursiva root, Cnidium officinale rhizome, L. chuanxiong rhizome, Foeniculum vulgare fruit, and Ferula assa-foetida resin and stem showed significant vasorelaxant or hypotensive effects. Conclusion : These review results showed that Osterici seu Notopterygii Radix et Rhizoma, Ligustici Tenuissimi Rhizoma et Radix, Angelicae Gigantis Radix, Angelicae Dahuricae Radix, Bupleuri Radix, Peucedani Japonici Radix, Peucedani Radix, Cnidii Rhizoma, Foeniculi Fructus, and Ferulae Resina had vasorelaxant or hypotensive effects. The results are expected as basic data in clinical trials and experimental researches for the treatment of hypertension of herbal medicines.

The anatomical variations of median nerve in Shiraz, Iran

  • Zia Moasses;Arefeh Aryan;Ashraf Hassanpour-Dehnavi;Mohammad Zarenezhad;Alireza Dorodchi
    • Anatomy and Cell Biology
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    • v.57 no.1
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    • pp.18-24
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    • 2024
  • The origin and distribution of median nerve varies among the different individuals. The median nerve variations in axillary region were reported by many authors previously. Understanding of these variations is especially necessary for clinicians to prevent iatrogenic nerve damage. The current work aimed to evaluate the possible anatomical variations of median nerve in the axillary region in a sample of the Iranian cadavers (Shiraz, Fars). We dissected 26 upper limbs from 13 male cadavers to investigate the different variations of median and musculocutaneous nerves according to Venieratos and Anagnostopoulou classification. In 23.07% of specimens (n=6), the medial root united with 2 lateral roots and formed the median nerve proximal to the coracobrachialis muscle. In one case, a communicating branch separated from the musculocutaneous nerve distal to the coracobrachialis and connected to the median nerve in upper arm. Our results suggest that there are anatomical variations of the median nerve in terms of its origin and its communication with the musculocutaneous nerve in the population of southern Iran. The anatomical knowledge of the median nerve variations is important for clinicians to improve patient health outcome. Theses variations of the median nerve should be considered during surgical procedures of the axillary region and nerve block of the infra clavicular part of the brachial plexus.

Toxic Trace and Earth Crustal Elements of Ambient PM2.5 Using CCT-ICP-MS in an Urban Area of Korea

  • Lee, Jin-Hong;Jeong, Jin-Hee;Lim, Joung-Myung
    • Environmental Engineering Research
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    • v.18 no.1
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    • pp.3-8
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    • 2013
  • Collision cell technology-inductively coupled plasma-mass spectrometry (CCT-ICP-MS) was used to measure the concentrations of approximately 19 elements associated with airborne PM2.5 samples that were collected from a roadside sampling station in Daejeon, Korea. Standard reference material (SRM 2783, air particulate on filter media) of the National Institute of Standards and Technology was used for the quality assurance of CCT-ICP-MS. The elemental concentrations were compared statistically with the certified (or recommended) values. The patterns of distribution were clearly distinguished between elements with their concentrations ranging over four orders of magnitude. If compared in terms of enrichment factors, it was found that toxic trace elements (e.g., Sb, Se, Cd, As, Zn, Pb, and Cu) of anthropogenic origin are much more enriched in PM2.5 samples of the study site. To the contrary, the results of the correlation analysis showed that PM2.5 concentrations can exhibit more enhanced correlations with the elements (e.g., Fe, K, Si, and Ti) arising from earth's crust. The findings of strong correlations between PM2.5 and the elements of crustal origin may be directly comparable with the dominant role of those species by constituting a major fraction of even PM2.5 as well as PM10 at the roadside area.

Comprehensive Study on the Origins and Changes in Kimchi Recipe (김치의 기원과 제조변천과정에 대한 종합적 연구)

  • Park, Chae-Lin
    • Journal of the Korean Society of Food Culture
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    • v.34 no.2
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    • pp.93-111
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    • 2019
  • This paper provides a comprehensive description of previous studies of making and developing kimchi in terms of the origins of kimchi and the changes in the history of kimchi, along with newly discovered data, including the collection of works in Joseon Dynasty as well as old cookbooks discovered after the year 2000, and latest research in related disciplines, e.g., ancient history studies, archeology, and linguistics. Because new ruins and relics, such as the Liao-ho Civilization in the Northeast Asia continent, which was closely related to Dongyi tribes, have been discovered and studied, it is important to determine how to reflect the outcome of archeological studies on the origin of preserved vegetables. In addition, to describe the background and changes in the independent formation of making Korean kimchi chronologically, they were divided into the following: development from jjanji to singunji; formation of the basis for seokbakji dressed with fermented fish sauce; settlement of seokbakji culture for dressing seokbakji with fermented fish sauce and spices, including chili varieties when they were introduced; and establishment of the method for making whole cabbage kimchi, which is currently typical kimchi made by adding the seokbakji as the stuffing of the cabbage kimchi, to examine the time and specific details of the change.

Analysis of Wife Abuse Experiences of Women Who Killed their Husbands (남편살해 여성의 아내학대 경험에 대한 분석)

  • Kim, Yeong-Hee;Byoun, Soo-Jung
    • Journal of the Korean Home Economics Association
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    • v.44 no.9
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    • pp.61-76
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    • 2006
  • The purpose of this study was to examine the relationship between the abuse experience from husbands among women who killed their husbands and the husbands' characteristics, and the women's own characteristics consisting of the emotional climate in the family of origin, self-esteem and social support. The major findings were as follow. First, the subjects were divided into two groups according to the level of wife abuse experience: non-abuse group and abuse group. Second, in terms of the husbands' characteristics which consisted of economic capacity and alcohol problem, there were statistically significant group differences between non-abuse and abuse groups. Third, the women in the abuse group, compared to those in the non-abuse group, had a tendency to perceive that they received maltreatment, physical punishment, and indifference and rejection from their family of origin. However, there was no significant difference between the non-abuse and abuse groups in emotional support the women received from their family. Fourth, as for the women's characteristics consisting of self-esteem and social support, the women of both groups showed no significant difference in self-esteem, while the women in the abuse group perceived that they received a level of social support relatively lower than those in the non-abuse group.

Evaluation of consumer preferences for general food values in Korea: best-worst scaling approach

  • Chang, Jae Bong
    • Korean Journal of Agricultural Science
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    • v.45 no.3
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    • pp.547-559
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    • 2018
  • Consumers are becoming increasingly interested in what kind of value their food has. Many studies have focused on consumers' preferences and willingness to pay for specific food values. However, few studies have asked consumers to consider or rank the importance of different food values. This paper determined consumers' food values by implementing the best-worst scaling approach and segmented consumers based on the relative importance of general food values that consumers place on them. Among a list of eleven food values (taste, safety, origin, appearance, price, environmental impact, naturalness, convenience, nutrition, fairness, and habit) which was compiled from previous studies on food preferences, on average, safety, nutrition, taste, and price were the most important values to consumers, whereas fairness, habit, appearance, convenience, origin, and environmental impact were the least important values. However, significant variation exists among consumers in terms of the relative importance of food values. To investigate the heterogeneity among consumers, a Latent Class Analysis was performed to classify consumers into subgroups based on responses to questions. Two latent classes were found and characterized as 'safety-nutrition' and 'taste-price'. The 'safety-nutrition' cluster represents 61% of the sample and a group of people who find safety and nutrition centered values to be the most important. Another cluster represents about 39% of the sample, and relative to the first group, this group finds price and taste values to be more important.

The Origin, Changes and Compositive Principles of Yangkyuksanhwa-tang (양격산화탕(凉膈散火湯)의 기원(基源), 변천과정(變遷過程) 및 구성원리(構成原理))

  • Park, Byung-Joo;Lee, Jun-Hee;Lee, Eui-Ju;Koh, Byung-Hee
    • Journal of Sasang Constitutional Medicine
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    • v.23 no.2
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    • pp.184-193
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    • 2011
  • 1. Objectives: This paper investigates the origin, the progressive changes and the constructive principles of Yangkyuksanhwa-tang (凉膈散火湯). 2. Methods: Yangkyuksanhwa-tang and other related prescriptions were analyzed in terms of their pathological indications, based on previous literature including "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)", "Donguisusebowon Gabobon (東醫壽世保元 甲午本)", "Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)" and "Dongmuyugo (東武遺稿)". 3. Results and Conclusion: 1) The Yangkyuksanhwa-tang most likely originates from Sodokeum, Yangkyuksan, Baekho-tang and Indongdeung. 2) Sodoksanhwa-tang introduced in "Donguisusebowon Chobongwon (東醫壽世保元 草本卷)" progressively transformed into Chungyangsanghwa-tang ("Donguisusebowon Gabobon (東醫壽世保元 甲午本)") and ultimately into Yangkyuksanhwa-tang ("Donguisusebowon Sinchukbon (東醫壽世保元 辛丑本)"), a prescription appropriate for usage in the Sangso symptomatology (上消證). 3) Yangkyuksanhwa-tang is composed of 9 herbs. Of these, Schixonepetae herba(荊芥), Ledebouriellae Radix(防風), Forsythiae fructus(連翹), Menthae Herba(薄荷), Gardeniae fructus(梔子) scatter the Hwa-qi(火氣), and Rehmanniae Radix(生地黃), Gypsum fibrosum(石膏), Anemarrhenae(知母) put off the Stomach-heat(胃熱), whereas Lonicerae caulis(忍冬藤) support the prevention of carbunculosis(癰疽).

Bonding and Antibonding Regions (II). Origin of Barriers to Internal Rotation of $H_2O_2$ and $C_2H_6$ (결합공간과 반결합공간 (제2보). $H_2O_2$$C_2H_6$의 Internal Rotation Barrier의 원천적 요인)

  • Kim Hojing;Lee Duckhwan
    • Journal of the Korean Chemical Society
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    • v.23 no.1
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    • pp.20-29
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    • 1979
  • The origin of barriers to internal rotation of hydrogen peroxide and ethane is investigated by using the concept of Bonding and Antibonding Regions. The strong bond formations between the axial and end atoms on the same side make the real charge densities in these molecules less dependent on conformations than those in the hypothetical molecules having no axial atoms. Thus, the existence of the axial atoms should induce the migration of the transition density from the Bonding region to the Antibonding region. Barrier to internal rotation can be understood in terms of this migration of the transition density to such an extent that the change in nuclear-nuclear repulsion energy becomes the dominating part of the total perturbation energy.

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On the origin of blue straggler stars in dwarf galaxies

  • Kim, Hak-Sub;Han, Sang-Il;Joo, Seok-Joo;Yoon, Suk-Jin;Lee, Young-Wook
    • The Bulletin of The Korean Astronomical Society
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    • v.42 no.2
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    • pp.86.2-86.2
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    • 2017
  • Blue stragglers (BSs) are the objects that are brighter and bluer than the stars at main-sequence turn-off point. In this study, we present the Ca-by and VI photometry for Galactic dwarf spheroidal galaxies using Subaru/Suprime-Cam and investigate the spatial distribution characteristics of BS stars using the hk index as a photometric metallicity indicator. We compare the cumulative radial distribution of the BS stars with those of two groups of red-giant-branch (RGB) stars divided by the hk-index strength, and find that the spatial distribution of all BS stars is closer to that of hk-weak (i.e. metal-poor) RGB stars. We also find that the hk-strong BS stars are more centrally concentrated than the hk-weak ones. We will discuss the use of hk-index as a metallicity indicator for the hot BS stars and suggest possible explanations for the results in terms of the origin of BS stars in the dwarf gal.

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