• 동의생리병리학회지
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• 제23권3호
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• pp.685-694
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• 2009

This experimental study was designed to investigate the inhibitory effects of ethanol extract of modified Yukgunja-tang(mYGJT) on high-fat diet-induced obesity and hyperlipidemia in Sprague-Dawley rats, Animals were divided into normal, control, mYGJT(100 mg/kg and 200 mg/kg) treated groups. Obesity with hyperlipidemia was induced by high fat diet treatment for 6 weeks. mYGJT was given to the amimals by oral gavage for 4 weeks, starting at the high-fat diet regimen, The effect of mYGJT on the differentiation of 3T3 L1 adipocytes in vitro and serological paramamters for obesity and hyperlipidemia in vivo were evaluated, mYGJT significnatly inhibited the differentiation of 3T3 L1 adipocytes in a concentration dependent manner. mYGJT treatment siginficantly reduced body weight, abdominal and epididymal fat weight, and FER(Food Efficiency Ratio) compared with control group in a dose dependent manner. It also signficantly inhibited the levels of serum total lipid, triglyceride, phospholipid, total cholesterol, LDL, AI(Atherosclerosis Index) and returned the serum HDL to normal. Total lipids, triglycerides and cholesterols in the liver, as well as malondialdehyde(MDA) and hydroxy radical in the serum were significantly reduced. However, superoxide dismutase(SOD) activity was significantly increased in mYGJT treated group compared with control group. Finally, mYGJT treatment signficantly decreased the MDA and protein carbonyl concentrations of the hepatic homogenate but signficantly increased the activities of SOD, GSH-Px and Catalase. Taken together, these results suggest that mYGJT can be clinically useful in inhibiting high-fat diet-induced obesity and hyperlipidemia.

• 동의생리병리학회지
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• 제20권6호
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• pp.1774-1778
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• 2006

To evaluate the effects of oriental treatment on sequela of abortion patients. From January 2005 to April 2006, 12 patients in Dong-Shin university Oriental Hospital with history of sequela of abortion were selected for this study, and their medical records were reviewed retrospectively. There were 12 sequela of abortion patients who were treated with herbal medicine(Kungkuejoheolem, Kamionkyung-tang), Jokyungjongok-tang), acupuncture, moxa. 11 patients aborted below 12weeks, and 1 patient aborted above 12weeks. Those patients complained of lower abdominal pain, arthralgia, dizziness, hand and foot coldness, and lower abdominal coldness ect. after abortion. Arthralgia was treated 68.6%, lower abdominal pain and hand and foot coldness was treated 44%, dizziness was 43.5% and so no. Patients improved about 57.72%. In this study, that oriental medical therapy is significantly effective on the treatment of sequela of abortion patients.

• 동의생리병리학회지
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• 제23권1호
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• pp.232-236
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• 2009

Plantar fasciitis is most common cause of heel pain which starts anterior tubercle of calcaneus. It is chronic inflamation of plantar fascia, reduces collagen and water content of heel pain which incur the degenerative changes with elastic fiber weakness. We treated one patient after extracorporeal shock wave treatment. We diagnosed him with X-ray and treated her conservative maneuver as to oriental medical method. We measured Vas(Visual analogue scale) and thermographic picture of both leg. Visual analogue scale is from 10 to 4 and thermographic picture of both leg were improved in cases.

• 동국한의학연구소논문집
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• 제2권1호
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• pp.177-182
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• 1993

This study were performed for the effects of Panax ginseng on the side effect of Cyclophosphamide to splenic tissue in the Rats. The experimental animals were divided into control group, test group by the way of the method treatment of the drug. Each group was sacrificed and stained in accordance with the schedule and observed under light microscope. The results of this study were as follows : 1. After the ginseng extract administration rat's weight and volume were similarly increased than normal and control group. 2. The decrease of the numbers of the splenic tissue after treatment of cyclophosphamide(CP) were recovered with prescription of the ginseng extract; the decrease of white pulp, red pulp, marginal zone were recovered. 3. Increased macrophage in red pulp of splenic tissue with administration of CP were disapeared after treatment of ginseng extract.

• 동의생리병리학회지
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• 제17권4호
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• pp.1082-1091
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• 2003

To elucidate the neuroprotective effect of Kamijihwang-hwan(KSH) on nerve cells damaged by hypoxia, the cytotoxic effects of exposure to hypoxia were determined by XTT, NR, MTT and SRB asssay. The activity of catalase and SOD was measured by spectrophometry, and TNF-α and PKC activity was measured after exposure to hypoxia and treatment of Kamijihwang-hwan(KSH) water extract(KJHWE). Also the neuroprotective effect of KJHWE was researched for the elucidation of neuroprotective mechanism. The results were as follows ; Hypoxia decreased cell viability measured by XTT, NR assay when cultured cerebral neurons were exposed to 95% N2/5% CO₂ for 2～26 minutes in these cultures and KJHWE inhibited the decrease of cell viability. H₂O₂ treatment decreased cell viability measured by MTT, and SRB assay when cultured cerebral neurons were exposed to 1-80 uM for 6 hours, but KJHWE inhibited the decrease of cell viability. Hypoxia decreased catalase and SOD activity, and also TNF-α and PKC activity in these cultured cerebral neurons, but KJHWE inhibited the decrease of the catalase and SOD activity in these cultures. Hypoxia triggered the apoptosis via caspase activation and internucleosomal DNA fragmentation. Also hypoxia stimulate the release of cytochrome c form mitochondria. KJHWE inhibited the apoptosis via caspase activation induced by hypoxia. From these results, it can be suggested that brain ischemia model induced hypoxia showed neurotoxity on cultured mouse cerebral neurons, and the KJHWE has the neuroprotective effect in blocking the neurotoxity induced by hypoxia in cultured mouse cerebral neurons.

• 동의생리병리학회지
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• 제25권5호
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• pp.919-926
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• 2011

The purpose of this study is to inspect trends of the paper of Korean medical treatment on Carbon Tetrachloride-induced Hepatotoxicity and try to establish the future direction for development of Korean herbal medicine. We reviewed 79 papers which had been published from 1981 to 2010 in journals published in Korea. According to these studies, Carbon Tetrachloride-induced hepato-celluar degeneration and necrosis induced to increase in serum aspartate amintransferase (AST), alanine aminotransferase (ALT), Alkaline phosphatase (ALP), ${\gamma}$-Glutamyl transferase (${\gamma}$-GTP), lactate dehydrogenase (LDH), bilirubin, blood urea nitrogen (BUN) and albumin levels. In biochemical analyses, antioxidant enzymes such as superoxide dismutase (SOD), Glutathione S-transferase (GST) and catalase in hepatic tissue were remarkably incresed by Carbon Tetrachloride treatment. We found that some of the herbal extracts have a protective effect against Carbon Tetrachloride-induced Hepatotoxicity. More studies of oriental medicinal herbs are required for developing a treatment of hepatotoxicity.

• 동의생리병리학회지
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• 제25권6호
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• pp.1102-1107
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• 2011

This study was case report to show the good effects of korean traditional medical treatment and breathing meditation. The methods were applied to lung cancer patients. We treated one patient who scored 27 point at Beck's depression inventory(BDI) and 28 point at Hamilton rating scale for depression(HRSD) and 22 point at Beck's anxiety inventory(BAI) and 20 point at Anxiety status inventory(ASI) by korean traditional medical treatment and breathing meditation. After treatment, the clinical symptoms were improved and the score of BDI, HRSD, BAI, ASI were decreased. According to this study korean traditional medical treatment is effective for the cure of depression and anxiety disorder and breathing meditation forifies the korean traditional medical treatment.

• 동의생리병리학회지
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• 제20권4호
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• pp.1063-1067
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• 2006

The purpose of this study was to investigate the clinical application of oriental medical treatment to a patient with hypeventilation syndrome developed after traffic accident. Hypeventilation syndrome is a kind of psychosomatic disorder. Typical complaints are tachypnea, palpitation, paresthesia, muscle spasm and tetany. We treated the patient with herbal medication, physical therapy, acupuncture and moxibustion therapy, etc. In acute hyperventilation attack, we used bloodletting therapy(+宣, shihhsuan), cupping therapy(B40, B57), emergency treatment with paper bag rebreathing and herbal medication in order to tranquilize. After 2 months of oriental medical treatment, we obtained good improvement in patient's state. This results suggest that oriental medical treatment has the positive effects on a patient with hyperventilation syndrome.

• 사상체질의학회지
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• 제20권3호
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• pp.40-50
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• 2008

1. Objectives We analyze throat disease focused on Sasang constitutional medicine and find out throat disease's concept, pathology and medical treatment. 2. Methods We consider term, conceuption, symptoms, mechanism and medical treatment of throat disease in "Dongyisusebowon", "Dongyisusebowon Gabogubon", "Dongyisusebowon sasangchobongwon", "Dongyisasangshinpyun" and "Dongmuyoogo" 3. Results and conclusions 1) We find out throat disease's some concept that are refered variety in sasang constitutional medicine. 2) Throat disease's pathology are different according to sasang constitution. In Soeumin throat disease belong to taeeum syndrome and soeum syndrome, in Soyangin throat disease belong to chest heat syndrome, in Taeumin throat disease belong to dry heat syndrome, in Taeyangin throat disease belong to Yul gyuk syndrome 3) In sasang constitutional medicine, medical treatment of throat disease focus on not throat disease but human being and medical treatment of throat disease are almost internal treatment but in Soyangin and Taeumin, medical treatment of throat disease are external treatment.

• 동의생리병리학회지
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• 제24권6호
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• pp.1117-1128
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• 2010

The purpose of this study is to know recent studies about conservative treatment of osteoarthritis in knee joint. We reviewed and analyzed 71 theses published by korean research institution since 2000. These theses were classified by year, field of study and subject. The results of this study are as follows. 1. We found 24 oriental medical theses about osteoarthritis in knee joint since 2000. 2. Classified by the major field of study, the journal of korea acupuncture and moxibustion society accounted for 17 pieces in oriental medical journals. 3. In oriental medicine, the most subject is acupuncture(19 pieces). 13 pieces in it is about pharmacopuncture. 4. 47 theses are published in medical journals after 2000. 5. 35 associations dealt with this theme, the korean society of physical medicine is major. 6. Most subject is kinesitherapy, followed by pharmacotherapy, massotherapy, taping therapy, physiotherapy and insole. We found several therapies were effective through oriental and western medical theses. Combined oriental medicine and western conservative therapy like kinesitherapy make better effect on osteroarthritis of knee joint.