• 혜화의학회지
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• 제3권2호
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• pp.315-321
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• 1995

An extensive anticancer drug screening from natural resources has been carried out primarily using murine tumor model for past fourty years. Recently a new screening program from NCI, so called disease-oriented screening system. has been estabished to detect anticancer drugs that show selective growth inhibition toward variety of tissue specific human solid tumors originated from leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate amd breast. To develope the anticancer drugs from oriental medicinal herbs, we investigated the cytotoxic effects against human tumor cell panels with 23 kinds of MeOH extract of medicinal herbs. Evodiae Fructus, Meliae Toosendan Fructus, Saussureae Radix and Pharbitidis Semen showed strong activities against several tumor cell lines.

• 한국자원식물학회지
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• 제23권2호
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• pp.138-144
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• 2010

최근 한약추출박은 배출되는 양이 많아 쓰레기화 되어 환경을 크게 오염시키고 있다. 이러한 한약추출박을 퇴비로 재활용하기 위한 기초시험으로 첩약(貼藥)인 '연령고본단(延齡固本丹)'의 한약추출박 성분을 분석하였고, 여기에 배초향을 재배하여 비료로 시용한 후 생육특성과 전초 수량을 조사한 결과는 다음과 같다. 1. 한약추출박의 분석 성분 중 유기물은 89.6%가 함유되어 있었고, 염분은 0.1%로 약초의 생장에 지장이 없는 공정규격(1.0%)이하의 범위였다. 약초의 생장에 직접적으로 필요한 비료 3요소 중 질소는 2.8%가 함유되어 있었고, 인산은 0.6%, 그리고 칼륨은 0.5%가 함유되어 있었다. 미량성분으로 식물체의 영양분이 될 수 있는 성분은 아연과 구리 등이 함유되어있었다. 이러한 분석결과, 한약추출박 성분은 유기물과 질소, 인산, 가리, 미량요소 등이 골고루 함유되어 유기질 비료로 사용 될 수 있을 것으로 본다. 2. 한약추출박의 시용에 따른 배초향의 생육은 한약추출박 시용이 무시용보다 초장과 경직경이 크고, 엽수와 가지수가 많아 생장이 양호 하였고, 수량도 전초 1주중이 무거워 증수되는 경향이었다. 한약추출박의 시용농도는 30~50 g의 시용에서 효과가 인정되었으므로 추출박 30 g의 농도가 적정 시용 농도로 판단된다. 이상의 결과를 종합하여 볼 때 한약추출박은 배초향과 같은 전초이용 약초에 유기질 비료로 재활용 할 수 있을 것으로 본다.

• 대한한의학원전학회지
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• 제24권2호
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• pp.109-149
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• 2011

Objectives : The study contains formulas, medicinal herbs, how to make of paste preparations in "Dongeuibogam". Methods : I will try to find paste preparations in "Dongeuibogam" using a word, paste(膏). Results : Paste preparations are categorized into two types: the external and the internal medicine. Paste preparations were used not only in the dermatology disease but in the internal disease. The same formula name to have different information was written by other people. Various kinds of medicinal herbs, minerals, animals were used and type of oil or juice was used to dissolve these. Methods to process paste preparations were to grind medicines or extract from medicinal materials. Paste preparations for the external was used to put in eyes or to push into wound and apply them to the skin. Paste preparations for the internal was used to take with wine, water and herbal tea. Some paste preparations were used both external and internal. Conclusion : These results explain that Paste preparations were variously used in "Dongeuibogam".

• 한국응용약물학회:학술대회논문집
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• 한국응용약물학회 2005년도 춘계학술대회
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• pp.97-128
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• 2005

• Archives of Pharmacal Research
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• 제26권7호
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• pp.516-520
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• 2003

A reversed-phase high performance liquid chromatographic method was developed to determine the contents of psoralen and angelicin from some medicinal herbs. The optimum eluent for chromatography was 20 v/v% acetonitrile in water on a Zorbax 300SB $C_{18}$ column. The identification was carried out by comparing the retention time and mass spectra of the relevant peaks with their standards. The variation of the concentration of psoralen and angelicin was wide between different species. The seeds of Psoralea corylifolia showed the highest contents of psoralen (7.8 mg/g) and angelicin (2.3 mg/g) among the tested herbs.

• Journal of Life Science
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• 제10권1호
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• pp.51-56
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• 2000

In many cases of human cancer, the appearance of hypersialylated glycan structures is related to a precise stage of the disease ; this may depend on the elebated sialyltransferase activity during carcinogenesis. The aim of this study was to investigate the inhibitory effects of Oriental medicinal herbs on enzymatic activities of two kinds ofsialyltransferase, Gal $\beta$ 1,3GalNAc$\alpha$2,3-sialyltransferase(ST3Gal I) and Gal $\beta$ 1,4GlcNAc $\alpha$2,6-sialyltransterases(ST6Gal I), which are well known as glycosyltransterases associated with cancer. The aqueous extracts of Scutellaria Baicalensis Georgi, Coptidis Rhizoma, Glycyrrhiza urlensis Fisch, Bupleuri Radix and Platycodi Radix were prepared and tested, respectively. At concentration of 100$\mu$g, Glycyrrhiza uralensis Fisch showed the highest inhibitory effects(about 42% and 57%, respectively) on ST3Gal Iand ST6Gal Iactivities. ST3GAl I was inhibited about 23% by Scutellaria baicalensi G댁햐, but not by the other samples, whereas ST6Gal I was inhibited about 20% and 40%,respectively, by Scutellaria baicalensis Georgi and Bupleuri Radix. All inhibitory effects were obtained in a concentration-dependent manner.

• 대한한의학방제학회지
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• 제7권1호
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• pp.183-188
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• 1999

Though development of diverse and highly value-added commodities in Artemisia Iwayomogi, we can expect such effects as procurement of secure farm's production bases and promotion of consumer's demands. Thus, as a first step for development of funtional foods of Artemisia Iwayomogi, solids yield, physical properties and scopoletin contents which is main component of Artemisia Iwayomogi, were investigated according to extration solvents and temperatures. The main result of this experiment were as following: solid yield in 50% ethanol extracts showed higher than those of water extracts at the same temperature. In condition of 50% ethanol extracts, solid yield, degree of browing and scopoletin contents showed increasing, but turbidities which mean transmittance(%T) showed decreasing sa temperature rise. In water extracts, pH values showed increasing as temperature rise.

• 한국식품과학회지
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• 제40권3호
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• pp.277-282
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• 2008

본 연구는 홍삼, 인진쑥, 형개, 회향으로부터 기능성 성분을 분리 및 검출하는 것을 목적으로 하였다. 홍삼의 열수 추출물에 함유된 maltol과 adenosine을 HPLC를 이용하여 분리할 수 있었다. 그 중 maltol은 그 분획을 얻어 UV-visible 흡광도의 측정과 MS를 이용한 분자량 측정을 통하여 maltol 임을 재확인하였다. 그리고 인진쑥, 형개, 회향을 여러 가지 용매로 추출하여 그 추출물을 GC-MS로 분석한 결과, 인진쑥에는 limonene, menthone, anethole 등의 성분이 미량 검출되었고 회향에는 limonene 외의 성분은 거의 검출이 이루어지지 않았다. 본 실험 중 형개 추출물의 추출 효율이 가장 우수했는데 목적 성분 중 limonene, menthone, pulegone을 고농도로 얻을 수 있었다. 본 연구 결과로서 천연 약용 식물에서 기능 성분의 분리, 정제 시 각 성분에 대한 화학적 안전성을 확보할 수 있었으며, 한방 약초로부터의 기능성 화학성분의 정량분석을 HPLC, GC-MS 등의 분석방법으로 수행하였다. 본 실험의 결과는 향후 목적하는 phytochemicals을 함유한 복합체 기능성 연구에 사용하고자 한다. 약용식물 유래의 유용화합물과 안정성이 확보된 고분자 형성물질에 의해 만들어진 복합체는 새로운 기능을 나타낼 수 있으며, 식품, 화장품, 의약품 등에 다양한 이용가능성이 예상된다.

• 대한한의학회지
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• 제44권4호
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• pp.121-135
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• 2023

Objectives: This study aimed to establish and provide reliable information for general public, based on expert consensus, on the risks of misuse of medicinal herbs for food and pure food ingredients for the fetus during pregnancy. Methods: A panelist of seven traditional Korean medicine (TKM) gynecologists responded to a questionnaire summarizing the fetal safety literature for twenty-five medicinal herbs for food and pure food ingredients derived from medicated diet (藥膳, Yaksun) recipes during three online Delphi rounds anonymously. Results: Ginkgonis Semen (Ginkgo nut), Illici Veri Fructus (Star anise), lavender, bitter gourd, and parsley were agreed at the level 1 of "Do not consume". These five ingredients were recognized as having significant risks both in the literature evidence and in expert opinion. Rosemary, Citri Unshius Pericarpium, Discoreae Rhizoma, lemongrass, Schisandrae Fructus, Cassiae Semen, Foeniculi Fructus, Mori Fructus, Cinnamomi Cortex, and Astragali Radix were agreed at the level 2 of "consultation with TKM practitioner is required". Conclusion: Based on the consensus of a seven-member expert panel of TKM gynecologists, consumption of Ginkgonis Semen (Ginkgo nut), Illici Veri Fructus (Star anise), lavender, bitter gourd, and parsley should be avoided by pregnant women. For Rosemary, Citri Unshius Pericarpium, Discoreae Rhizoma, lemongrass, Schisandrae Fructus, Cassiae Semen, Foeniculi Fructus, Mori Fructus, Cinnamomi Cortex, and Astragali Radix, the level 2 advisory may be recommended to use with caution and to consult a TKM practitioner for advice on consumption, dose, and duration.

• 한국식생활문화학회지
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• 제28권4호
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• pp.339-347
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• 2013

Yaksun, a medicinal diet, has been traditionally prepared and applied (based on theories in oriental medicine) for the modulation of disease symptoms and signs. However, restaurants that serve and claim Yaksun mainly focus on stamina foods. A consistent definition of Yaksun has not been provided, which can confuse the public interpretation of Yaksun. The purpose of this study was to investigate the perception of Yaksun in Korean adults living in Seoul, Gyeonggi, and Chungbuk regions. Among the participants (M=55, F=168, 25y), only 10.4% understood the definition of Yaksun (mainly through the broadcast media). The frequency of Yaksun consumed when eating out was 2~3 times per month in 50.2% of participants. The main reason for choosing a Yaksun menu (46.3% of participants) when eating out was for health. The mean satisfaction score of Yaksun was $3.5{\pm}0.8$ on the five point Likert scale. Participants highly agreed ($3.8{\pm}0.8$) that Yaksun is composed of nutritious foods combined with oriental medicinal herbs for the treatment of disease, which was significantly higher in groups with learning experience on Yaksun (p<0.05). Interestingly, participants showed neutral to the description, that a diet without oriental medicinal herbs is not Yaksun ($3.1{\pm}1.0$), which was significantly different between genders (p<0.05). Men recognized more than women that Yaksun should be based on oriental medical theory (p<0.05) and should be prepared for the prevention or treatment of diseases (p<0.05). In conclusion, the concept and terminology of Yaksun need to be defined and publicized in modern diet.