• 대한한방체열의학회지
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• 제5권1호
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• pp.1-13
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• 2006

Objectives : This study was designed to analyze basic data for cold hypersensitivity patients with a questionnaire and investigate correlation between cold hypersensitivity and Heart Rate Variability(HRV). Methods : 49 patients who complain of cold hypersensitivity on hands and feet in ambulatory care were investigated in Oriental Gynecology, Kyunghee Oriental Medical Center and Women medical center, Kangnam Koreana hospital from May 1, 2006 to October 20, 2006. All patients were asked to answer a questionnaire. After careful I examination to rule out other disease which may affect Digital Infrared Thermal Imaging(DITI) and HRV data, patients were taken thermography for the diagnosis of cold hypersensitivity Based on the result of thermography, the patients were divided into two groups(Objective cold hypersensitivity and Subjective cold hypersensitivity). Then, these two groups were compared using HRV data which was measured in the supine position for 5 minutes. Results: 1. For most patients, cold hypersensitivity first developed during puberty. 2. The parts of the body that felt cold first time were hands and feet. 3. The cold sensation was increased in winter or at bedtime Showing that the sensation can be changed according to the level of coldness. 4. Among women who sufferfrom cold hypersensitivity, very few of them were treated. 5. More than half of cold hypersensitivity patients's family member also had a cold hypersensitivity. 6. The decrease in mean values of LF/HF ratio was observed in objective cold hypersensitivity group than subjective cold hypersensitivity group and the decrease was significant(P=0.014) when examined by Student t-test. Conclusions : It is necessary that the cold hypersensitivity patients should be treated carefully considering the facts mentioned above. And it can be suggested that dysautinomia be related with cold hypersensitivity and be evaluated by HRV.

• 한국한의학연구원논문집
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• 제17권2호
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• pp.115-120
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• 2011

Objectives : The purpose of this study is to develop an apparatus which can take a facial image by self-operated capturing technique. The user can obtain one's facial image immediately after adjusting facial tilt and focusing distance. The system has been designed for classifying Sasang typology based on facial image. Methods : The system is composed of a Webcam, one-way glass mirror and mini LCD. The Webcam takes a facial image which is displayed on the mini LCD. Then the user can see and adjust to the right position in the real time through the image mirror-reflected from the mini LCD. The optical sensor is used to estimate the proper focusing distance. To verify the performance of the system, 11 characteristic points on the facial image are used and compared with high performance DSLR camera(D700) by applying the coefficient of variance and Bland-Altman Plot. Results : The developed system and D700 show enough agreement with the small coefficient of variance to analyse constitutional types with a facial im mage. However, the result of Bland-Altman plot shows that the width parameters have distortions owing to short focusing distance. Conclusions : The system is expected to be utilized on u-healthcare services for home environment after improving the distortion in the width parameters.

• 대한한의학회지
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• 제30권1호
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• pp.163-172
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• 2009

Objectives: The purpose of this study is to report the improvement after oriental medical treatment of partial tear of supraspinatus tendon. Method: We treated 2 patients having shoulder pain due to partial tear of supraspinatus tendon with Oriental medical treatment, including Sa-am acupuncture DaeJang-Jeonggyeok, A-shi point(阿是穴) and herbal medicine. We checked visual analog scale (VAS) score and range of movement (ROM). Results: We treated shoulder pain. Thereafter ROM improved and V AS score dropped to the level of 2 to 4 points from 10 points at onset. Conclusion: This report shows Oriental medical treatment has effectiveness on partial tear of supraspinatus tendon. Follow-up study is needed.

• 대한한의학회지
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• 제28권1호통권69호
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• pp.87-93
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• 2007

Objectives : This study was to assess the effectiveness of Oriental medical treatment on carpal tunnel syndrome, comparing its outcome with that of Western medical treatment. Methods : After being diagnosed with carpal tunnel syndrome by electromyography, subjects were enrolled in Kyung Hee Medical Center from March 2006 to January 2007. We prescribed Kejibokryung-hwan to the Oriental medical therapy group (OM group) and NSAIDS to the Western medical therapy group (WM group). Effectiveness was assessed by degree of pain using visual analog scale (VAS) before and after 3 weeks' treatment. Adverse effects were also monitored. Results : There were 21 patients in the OM group and 19 in the WM group. No statistical significant difference was detected at the baseline assessment. After 3 weeks of medication, pain was reduced about 26% in the OM group and 46% in the WM group. These findings might be explained by that more than half of the WM group received local steroid injection, which has been known to have more rapid analgesic effect that oral medication. Although pain reduction rate was higher in the WM group than in the OM group, we suggest that Oriental medical treatment is still effective, faking into consideration the fact that completely recovered cases were found only in the OM group. No adverse effect was found in either of the groups. Conclusion : This work could help us to understand the effectiveness of Oriental medical treatment on carpal tunnel syndrome.

• 동의신경정신과학회지
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• 제19권3호
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• pp.245-254
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• 2008

This study was designed to evaluate the effects of an Schultz's autogens traning and herbal medicine with various scales on symptoms of UL-syndrom(鬱證). We treated UL-syndrom(鬱證) with Schultz's autogens traning, including herbal medicine and we evaluated the clinical progress of the patient using BDI. After treatment about 2-month, the chief complaint and most of symptoms were subsided and improved. BDI score were decreased 32 to 10. This study suggests that Schultz's auto gens traning and herbal medicine is significantly effective in the treatment of UL-syndrom(鬱證).

• 동의신경정신과학회지
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• 제17권2호
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• pp.167-177
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• 2006

Objective : We aimed to study the relationship between the post-stroke depression and acceptance of the stroke. Method : For this study, 80 stroke patients were surveyed by using questionnaires for CES-D, acceptance for stroke, and social support. Result & Conclusion : 1. Acceptance for stroke varied inversely as the post-stroke depression. 2. The acceptance for the stroke appeased the negative influence caused by the stress of the stroke, and the post-stroke depression was biggest predictable variant. And location of the stroke were the predictable variants of the post-stroke depression. 3. When the gender, location of the stroke, motor power, age, period of stroke, and social support were controlled, the group with depression and the one without depression had a significant difference in the acceptance of the stroke.

• Molecular & Cellular Toxicology
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• 제5권1호
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• pp.1-6
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• 2009

Microglial cells constitute the first line of defense against infection and injury in the brain. This study was conducted to evaluate the protective mechanisms of Agrimonia pilosa (AP) on LPS-induced activation of BV-2 microglial cells. The effects of AP on gene expression profiles in activated BV-2 microglial cells were evaluated using microarray analysis. BV-2 microglial cells were cultured in a 100 mm dish ($1{\times}10^7/mL$) for 24 hr and then pretreated with 1 g/mL AP or left untreated for 30 min. Next, 1 g/mL LPS was added to the samples and the cells were reincubated at $37^{\circ}C$ for 30 min, 3 hr and 6 hr. The gene expression profiles of the BV-2 microglial cells varied depending on the AP. The microarray analysis revealed that MAPK signaling pathway-related genes were down-regulated and IL10 gene was up-regulated in AP-treated BV-2 microglial cells. AP can affect the inflammatory response and MAPK pathway in BV-2 microglial cells.

• Molecular & Cellular Toxicology
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• 제5권1호
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• pp.44-50
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• 2009

This study was conducted to evaluate the inflammation mechanisms of tumor necrosis factor-$\alpha$ (TNF-$\alpha$), interleukin-4 (IL-4), and IL-$1{\beta}$-induced stimulation of A549 human epithelial cells. In the present study, A549 cells were stimulated with TNF-$\alpha$, IL-4 and IL-$1{\beta}$ to induce expression of chemokines and adhesion molecules involved in eosinophil chemotaxis. The effects of TNF-$\alpha$, IL-4 and IL-$1{\beta}$ on gene expression profiles in A549 cells were evaluated by oligonucleotide microarray and Real time RT-PCR. The gene expression profiles for the A549 cells varied depending on the cytokines. Also, the results of the microarray and Real time RT-PCR revealed that inflammatory-related genes were up-regulated in cytokine stimulated A549 cells. Cytokines can affect inflammation in A549 cells. A microarray-based genomic survey is a high-throughput approach that enables evaluation of gene expression in cytokine stimulated cell lines.

• 동의신경정신과학회지
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• 제19권2호
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• pp.241-250
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• 2008

Depressive Disorders are widespread and increasing recently. Somatic-symptom Group in Major Depressive Disorders are treated with current medical treatment but the results are not satisfactory. We tried to apply more effective and satisfactory oriental medical treatment. We treated 2 depression patients accompanying somatic-symptom treated with herbal medication and Meditation of the retaining needle. The Meditation of the retaining needle(鐵膜想), which combines Meditation and Acupuncture is a kind of medical meditation originating from Oriental Medicine. After our treatments, various somatic-symptoms were improved and Beck's depression Inventory(BDI) decreased from 28 and 27 to 14 and 12. This result suggests that meditation of the retaining needle(鐵膜想) is effective on somatic symptom and able to be developed as a useful way of oriental medical psychological care.

• 대한중풍순환신경학회지
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• 제11권1호
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• pp.36-45
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• 2010

Objective : The aim of this study was to examine the characteristics of the acute stroke patient who took Chungpyesagan-tang, and provide the basis of Chungpyesagan-tang prescription. Method : We studied hospitalized patients within 4 weeks after their occur who were admitted at Kyunghee University Oriental Medical Center, Kyunghee University East-West Neo Medical Center, Kyungwon University Oriental Medical Center, Semyung University Oriental Medical Center from February 2010 to July 2010. We compared the general characteristics of acute stroke patient with herbal medicine. Result : The patient who took Chungpyesagan-tang showed significant difference for age, family history of hypertension, ALT, coffee drinking, fastfood eating, stool, Oriental Medical Diagnosis. Conclusion : The above result show that Chungpyesagan-tang can be prescribed to stroke patient whose stool is hard, whose Oriental Medical Diagnosis is fever type. Further studies will be needed to better understand the difference between Chungpyesagan-tang group and Other herbal medicine among acute stroke patients.