• Journal of Korean Medicine Rehabilitation
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• 제20권4호
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• pp.147-157
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• 2010

Objectives : The study is performed to investigate the influence of psychological stress on neck muscles tone and heart rate variability(HRV). Methods : This study was carried out with the data from stress response index score(SRI), surface electromyography(sEMG) and HRV. First subjects were divided into two group according to the SRI points. Subjects in group A had points of SRI in which lower than 30 points. Subjects in group B had points of SRI in which higher than 30 points. Then we investigated how to difference of the index of sEMG and HRV according to each groups. Results : In this study, the muscle contraction of both upper trapezius muscle in stress group were higher than non-stress group significantly. Complexity, root mean square of successive differences of R-R intervals(RMSSD), standard deviation difference between adjacent normal to normal intervals(SDSD), high frequency oscillation power(Ln(HF)), normalized HF(Norm HF) in stress group were lower than non-stress group significantly and normalized LF(Norm LF) was higher. Conclusions : This results show that the stress was associated with neck muscle condition and autonomic nervous system.

• Journal of Physiology & Pathology in Korean Medicine
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• 제24권3호
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• pp.380-384
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• 2010

The present paper attempts to investigate the factors which may affect the attitude toward Oriental Medicine among the university students in Korea and China. The research on determining factors that may influence the attitude toward the Oriental Medicine can provide the answers for the question how the traditional things can acquire their present position and make a development in modern society. The East Asian countries such as Korea and China have promoted the western-style changes and development, thinking that modernization means the westernization. Given this, the research on the attitude toward Oriental Medicine can be a good case study that shows how tradition sustains its place and develops. The present study makes two hypotheses in order to analyze the factors which make the influence on the attitude toward the Oriental Medicine: Hypothesis there will be no significant difference between the socio-demographic variables and attitude toward Oriental Medicine. Hypothesis there will be significant differences between traditionalism, modernity, nationalism, and attitude toward Oriental Medicine. The statistical results show that hypothesis 1 was confirmed in the case of the gender of the participants, whereas it was not confirmed in the case of the birthplace, economic status, and nationality. And hypothesis 2 was not confirmed in the relations between nationalism and modernity and the attitude toward Oriental Medicine, whereas it was confirmed in the relations between traditionalism and the traditional medical concept and attitude toward Oriental Medicine.

• Journal of Pharmacopuncture
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• 제6권2호
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• pp.137-147
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• 2003

Objective : This study was carried out to investigate the progress of bilateral simultaneous facial palsy and the effect of Hominis Placenta herbal-acupunture and the other oriental medical therapies. Method : We used two methods to research the progress of disease. 1. Diagnosis - Facial muscle test, Taste test, Hearing test, Photographies, Lab-finding 2. Treatment - Acupuncture, Herbal-acupuncture, Electroacupuncture, Herb-med Edema rate, Pain endurance, WBC, Hemoglobin, Platelet, Total protein, Albumin, Globulin, RA factor, CRP Results : The onset of Rt. facial palsy was earlier than Lt. facial palsy 3days. The reaction on the treatment of Rt. facial palsy was more dull than Lt. facial palsy. In terms of treatment period, Rt. facial palsy was very longer than Lt. facial palsy. Conclusion : According to the above results, we discoveried that Hominis Placenta herbal-acupunture and the other oriental medical therapies had good influence on the bilateral simultaneous facial palsy. In the future, we should endeavor to know influence between Rt. and Lt. face in case of bilateral simultaneous Bell's palsy.

• The Journal of Korean Medicine
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• 제42권4호
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• pp.10-24
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• 2021

Objectives: Yongdamsagan-tang (YST) and Paljung-san (PJS) in traditional medicine and finasteride in modern medicine are used to treat benign prostatic hyperplasia (BPH). In recent, the use of combination herbal remedies with conventional drugs has been increasing. Therefore, we investigated the anti-inflammatory effects of these drugs to treat BPH and the influence of herbal formulas on finasteride metabolism. Methods: The inhibitory effects of the herbal formulas and finasteride on the production of inflammatory mediators and cytokines were determined in lipopolysaccharide (LPS)-treated RAW 264.7 cells. Additionally, the influence of herbal formulas on activities of human drug metabolizing enzymes (DMEs) was assessed using human microsomal enzymes. Results: We observed that YST, PJS and finasteride inhibited the production of nitric oxide (NO), prostaglandin E₂ (PGE₂) and interleukin-6 (IL-6) in RAW 264.7 cells. The half maximal inhibitory concentration (IC₅₀) of YST on PGE₂ production was calculated to be below 25 ㎍/mL. YST inhibited the activity of uridine diphosphate-glucuronosyltransterase (UGT) 1A4 with an IC₅₀ value of 49.35 ㎍/mL. The activities of cytochrome P450 (CYP) 1A2, CYP2B6, CYP2C19, CYP3A4, and UGT1A1 were inhibited by PJS (IC₅₀ < 100 ㎍/mL, each). Although PJS and YST inhibited the activities of CYP3A4 and UGT1A4, respectively, these formulas may not influence the metabolism of finasteride because the IC₅₀ values of herbal formulas on DMEs are too high to affect metabolism. Conclusions: Our results suggest that the combination of finasteride and YST or PJS might not influence their drug metabolism and that the drugs may have synergistic effects against BPH.

• Journal of the Korean Society of Food Science and Nutrition
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• 제41권7호
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• pp.881-887
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• 2012

This study was designed to examine influence of bacteria and herbal applications of Lonicerae Flos on the permeability of intestinal epithelial cells. The HCT-116 human intestinal cell was used as an in vivo model of "leaky gut". Dextran sodium sulphate (DSS) was used to induce an increase in the permeability of epithelial cell tight junctions. Probiotics including Lactobacillus acidophilus, Lactobacillus plantarum, Salomonella spp. and Staphylococcus aureus were used to evaluate bacterial influence on the intestinal epithelial cells. Herbal extract Lonicerae Flos was also assessed to find out what kind of effects it has when used alone or fermented with Lactobacillus plantarum. The permeability of intestinal cell lines was assessed using transepithelial electrical resistance (TEER) and horseradish peroxide (HRP) assessments. This data provides evidence for the probiotic benefits of intestinal permeability. The data also provides promising evidence of herbal effects on reducing intestinal permeability, especially when fermented with probiotics.

• Journal of Physiology & Pathology in Korean Medicine
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• 제21권6호
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• pp.1631-1636
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• 2007

The purpose of this study was done to investigate the influence of social risk factors on each stroke type. We recruited at the Stroke Medical Center in Daejeon University Oriental Medical Hospital from July 2005 to March 2007 for this study. We divided 217 patients with acute stroke within 2 weeks as the case group(Cases), 146 people without major risk factor as the healthy control group(Normals), and 160 people as the general control group(Controls). We analyzed general characteristics such as age, sex, with or without spouse, education periods, religion, psychologic stress, and the odds ratio of each social risk factors by multivariate logistic analysis. As a result of reviewing the influence of social risk factors upon each stroke type, without spouse may be risk factor of ischemic stroke, and the undereducated may be risk factor of hemorrhagic stroke and ischemic stroke. But religion and psychologic stress had no significant relation with stroke.

• The Journal of Korean Obstetrics and Gynecology
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• 제23권1호
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• pp.72-82
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• 2010

Purpose: This study was conducted to estimate the annual socioeconomic costs of menopausal syndrome treated with oriental medicine in Korea 2008. Methods: Study subjects selected were patients aged 40 years or older who had national health insurance(NHI) claims record with menopausal syndrome(KCDO codes: K04, K04.0, K04.2, K04.3, K04.4) for oriental medicine treatment in 2008. Direct medical cost of oriental medicine treatment for menopausal syndrome were measured from NHI claims records. Direct non-medical costs were estimated as transportation costs incurred when visiting hospitals. Indirect costs were defined as patients' productivity loss associated with office visits or hospitalization. Also, the costs of unpaid-household chores were calculated. Results: The total cost for the oriental medicine treatment of menopausal syndrome in the nation was estimated to be 743,091,219 Korean won(KRW) which included direct costs at 442,971,637 KRW and indirect costs at 300,119,583 KRW. Conclusion: This study provides an important perspective of socioecnomic influence due to menopausal syndrome treated with oriental medicine. And this results can be used as elementary data for menopausal syndrome-related health policy of oriental medicine.

• Journal of Acupuncture Research
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• 제28권1호
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• pp.117-124
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• 2011

Objectives : Bell's palsy is the most common acute facial paralysis but its causes still unclear. At present, one of the most widely accepted cause is viral infections, and generally socioeconomic factors influence the viral infections. The purpose of this study is to investigate the relationship of incidence of facial palsy with socioeconomic factors. Methods : Seventeen patients with a acute facial palsy, who volunteered and completed all of the assessment measures participated. Using data on 17 participants, we examined the independent contribution of education, income, and occupation to a risk factor of severe facial palsy. Severity of global facial impairment was assessed by the facial disability index (FDI), the house-brackmann facial nerve grading system, WHO quality of life - bref (WHOQOL-BREF) and visual analogue scale (VAS) about discomfort of life. Results : There was no correlation between severity of facial palsy and gender, marriage, education, or occupation. Age greater than 60 years (p<0.05), and low monthly income(p<0.05), poor self-rated health was associated with greater severity of idiopathic facial paralysis. Conclusions : The number of subjects with facial palsy in our study (n-17) was small, and therefore generalization to larger patient populations might be unwarranted. But according to the outcome, we suggest that socioeconomic factors, especially low monthly income influence severity of bell's palsy.

• The Journal of Korean Medicine
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• 제29권4호
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• pp.104-113
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• 2008

Objectives: The aim of this study was to investigate the influence of five herbal medicines on cytochrome P450 (CYP) 3A4 drug-metabolizing enzymes in human liver microsomes. Methods: By using of human liver microsomes, we extracted Cnidium officinale Makino, Rhus verniciflua Stokes, Prunus persica Batsch, Corydalis remota Fisch, Carthamus tinctorius Linne, which are called Hwalhyulgeoouhyak(活血祛瘀藥). Then they were incubated and measured for relative enzyme activity under incubation conditions compared to ketoconazole, which is known as a representative inhibitor of CYP 3A4. Results: We showed that all of five traditional herbal medicines had no inhibition effect of CYP 3A4 at 10, 20, 30, 40, and 50${\mu}g/m{\ell}$ doses in human liver microsomes, although Rhus verniciflua Stokes (RVS) showed a little inhibition as about 95% enzyme activity of control. However, this result was not enough to prove that RVS has a CYP 3A4 inhibition effect. Moreover, we can't confirm that those rates have significant induction effect on CYP 3A4. Conclusions: The result of this study could support that those herbal medicines are more reliable than chemical drugs, even if this is a basic step to prove that result.

• The Journal of Korean Medicine Ophthalmology and Otolaryngology and Dermatology
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• 제25권2호
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• pp.20-37
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• 2012

Objectives : The primary purpose of present study is to evaluate the effect of a supplement of Bee Larva on tinnitus. the second is to comparatively evaluate safety of this supplement. Methods : Among those patients who visited Semyung Oriental Medical Center from January 11st, 2010 to February 20th, 2010, we screened 45 patients considered suitable for this study after some examinations and consent of the patients. they were devided into 2 groups. Group A took 5 tablets of this supplement everyday for 4 weeks, group B, placebo, in the same way. for 4 weeks, we checked changes in intensity, duration, extent of tinnitus on daily life and sleep and THI(Tinnitus Handicap Inventory) score. to evaluate safety of this supplement, adverse events, assessment of vital sign, hematologic examination were recorded. Result : Through 4 weeks of the clinical trial, we found that this supplement is effective on tinnitus and it improves intensity, duration and extent (its influence on daily life) of tinnitus, influence of tinnitus on sleep and THI score more effectively than the placebo drug. Also, in the assessment of the safety of the study the supplement of bee Larva and placebo drug, there were no adverse events and side effects over the average which need treatment for it. Moreover, there were not any abnormal findings in change of blood pressure and hematologic examination. Conclusion : According to this experiment, we confirmed that the supplement of bee Larva can be used effectively and safely on tinnitus.