• 정보관리연구
• /
• 제39권4호
• /
• pp.173-186
• /
• 2008

본 연구에서는 다양한 Open API를 이용한 매쉬업 검색서비스를 통해 한의 분야의 약재 정보를 검색하는 약재 검색 매쉬업 시스템을 구축하였다. 특히 본 논문에서는 일반적인 Open API외에도 현재 서비스되고 있는 한의 분야의 논문과 연구개발과제 서비스에 대한 2개의 Open API를 개발하고 공개하여 전문적인 지식을 쉽게 공유하고 검색할 수 있도록 하였다. 한의 분야의 약재 정보는 다른 분야와는 다르게 정보의 출전이 어디냐에 따라 다양한 이름과 설명들을 가지기 때문에 일반적인 검색 방법과 같이 한 두 개의 검색어를 이용해서는 원하는 검색 결과를 얻기 힘들다. 본 연구에서는 이러한 문제를 해결하기 위해서 기존에 한의 약재 100건의 정보를 온톨로지로 구축한 약재 온톨로지를 이용해서 검색어를 확장하고 이를 여러 Open API를 통해 검색하는 시스템을 구축함으로써 정확하고 포괄적인 검색이 이루어질 수 있도록 하였다.

• 혜화의학회지
• /
• 제22권1호
• /
• pp.79-90
• /
• 2013

Objectives : With increasing interests in hair cosmetic to keep their scalp and hair healthy we must have much more information about the oriental medical cosmetic goods. Methods : Shampoos which contain herbal ingredients are commonly used to stopping their hair loss, alopecia. On the basis of oriental pharmacology, we analyzed several shampoos which have herbal ingredients and thought about the oriental cosmetic methods for a hair loss. Results : We found that many herb based shampoos are developed on the basis of the principle of oriental medicine. In addition, the interest in oriental medical cosmetic methods that used the principles of the oriental medical science has been increased and cosmetic goods based on the oriental medicine have a positive market. Conclusions : With many possibilities for the oriental medical cosmetic methods, clinical records to prove scientific facts are urgently needed. In addition, the oriental medical cosmetic methods based on oriental medicine to examine scalp and hair should be offered.

• 한국한의학연구원논문집
• /
• 제2권1호
• /
• pp.129-145
• /
• 1996

According to the Medical Product Safety Administration Guidelines for safety assessment guinea pigs, mice and rats were used for antigenicity test, rabbits for pyrogenic test and hymolytic test. The results were summarized as follows; 1. The antigenicity test of Red-ginseng radix extract solution for herb-acupuncture did not show any anaphylatic shock but produced IgE in high dose group. 2. The result of the pyrogen test of Red-ginseng radix extract solution for herb-acupuncture was negative. 3. The result of the hemolytic test of Red-ginseng radix extract solution for herb-acupuncture were negative in low and middle dose group but was positive in high dose group.

• 혜화의학회지
• /
• 제10권1호
• /
• pp.375-383
• /
• 2001

Clinically the arthritis occupies much part of musculoskeletal diseases. The arthrits is subordinate to Bi-jeung in the oriental medicine. The causes of Bi-jeung are almost proposed as Pung-Han-Sup-Yeol, and various herb medication were composed following this standard. In this paper, herb medications corresponded with Bi-jeung of Bangyakhappyeon(方藥合編) were anlysed. And the results are as follws. 1. Herb medications of Bi-jeung were composed with 4 parts, Sangtong(8 medications), Jungtong(7), Hatong(6) and Jeungbobang(7). 2. Herb medications of Bi-jeung were almost composed with Geopungsupyak, Haepyoyak(解表藥), Onryyak(溫裏藥), Boyikyak(補益藥), Yigiyak(理氣藥), and Hwalhyeol-geouhyak. 3. Analysed with a source book, Dongeuibogam was the most quotational literature.

• 혜화의학회지
• /
• 제20권2호
• /
• pp.91-98
• /
• 2012

Objective : This is a comprehensive review summary of anticancer effect through autophagy using herb. Method : Data were retrieved from pubmed and authorized texts concerning anticancer effect through autophagy using herb.g its ant Results : A total of 5 potentially relevant studies were identified with including 4 in vitro papers. All papers were related to single herb extract or its compound providini-cancer effect through autophagy mechanisms of up-regulated pro-autophagy proteins and down-regulated anti-autophagy proteins. Conclusion : We can search five potentially relevant studies with anticancer treatment through enhancing autophagy mechanism. Autophagy will be a good pathway mechanism to explore novel experimental therapeutics in herb.

• 동의신경정신과학회지
• /
• 제23권3호
• /
• pp.161-174
• /
• 2012

Objectives : The purpose of this study is to study as reference for practical application in clinics, examine the procedure of historical changes and compare components and their doses of herb medicines, which are recorded in the chapter, Sinmun Jeonkwang of "Donguibogam". Methods : I examined 19 Herb Medicines (Ed note: no need to capitalize the 'h' and 'm') in Chapter Sinmun Jeonkwang of "Donguibogam". Fourteen books, which were noted in Chapter Sinmun Jeonkwang of "Donguibogam" and 16 books in Jeonkwang part of "The Eastern Medical Textbook of neuropsychiatry" and 25 books were mentioned in same part of "Uibujeonrok", were selected as reference. Results and Conclusions : Fourteen documents were referred to the 19 Herb Medicines in Chapter Sinmun Jeonkwang of "Donguibogam". Seventeen Herb Medicines were recorded in the source book but 2 Herb Medicines were not recorded. Fourteen Herb Medicines among 19 were recorded in the source book, which were directly quoted from the firstly appeared books, and 3 Herb Medicines were re-quoted from the other books that succeeded the source books. I suspect that the components and dosages of the Herb Medicines were revised, according to the author's clinical experience and circumstances.

• 대한한방내과학회지
• /
• 제21권1호
• /
• pp.65-73
• /
• 2000

Objectives : The effects of cotreatment of adriamycin and ethanol extract of herb (Palgin-tang hab Hwajuck-hwan a traditional medicine for cancer treatment in oriental medicine) on the induction of apoptotic cell death were investigated in human liver origin cell lines, Chang. Methods : Chang(ATCC) liver cells were cultured in RPMI-1640(Gibco SRL Co, Gaithersburg, MD) badge including 10% fetal bovine serum. Chang liver cells were treated with various concentrations(from 10 to $0.16{\mu}l$) of adriamycin and herb extract(from 500 to $31.25{\mu}l$) After 48h later, the cells were tested for viability by Crystal violet staining assay. Adriamycin and Herb extract induced ladder pattern of DNA fragmentation in Chang cells. Genomic DNA was isolated and separated on 1.5% agarose gels. The DNA was stained with ethidium bromide and visualized under UV light. Results : The death of Chang cells was synergistically induced by the cotreatment of adriamycin and ethanol extract of herb. In addition, the cotreatment-induced cell death of Chang cells was mediated by apoptotic death signal processes. The phosphotransferase activity of JNK1 remained in a basal level in Chang cells which was treated individually with the adriamycin and ethanol extract of herb. However, it was markedly increased in Chang cells which was cotreated with adriamycin and ethanol extract of herb. In addition, the expression of Fas and FasL was markedly induced by the cotreatment of adriamycin and herb extract. For a while, the expression of Sax was a eminently increased by the ethanol extract of herb. However, Scl2 expression was not affected by the individual or cotreatment of adriamycin and herb extract. Conclusions : our results suggest that the cotreatment of adriamycin aM ethanol extract of herb induces synergistic apoptotis of human liver origin Chang cells via the upregulation of JNK, Fas, FasL and Bax.

• 동의생리병리학회지
• /
• 제25권3호
• /
• pp.389-397
• /
• 2011

This study tried to integrate the traditional oriental medical theories and results of experimental studies of herbaceous plants on anti-diabetes. And I tried to analyze recent experimental study trend on the anti-diabetic herb. I searched anti-diabetic herb studies on 4 korean databases and 10 korean journals by keywords, 'diabetes', 'blood glucose', 'glycometabolism', 'pancreatic ${\beta}$-cell', etc. In order to see detail review, searching was performed from 2000 to 2010. And I searched 125 study cases concerning anti-diabetic herb and 72 varieties herbaceous plants used in study of anti-diabetes. and I analyzed the choice motives of each herb for anti-diabetic study, the extract methods and anti-diabetic evaluation contents. And I analyzed anti-diabetic herbs from a traditional oriental medical point of view. When the researchers chose herb for anti-diabetic experiment, just 8.8% of the choice was based on the oriental medical evidences. I found that 60.6% of the herb shown to be effective in diabetes experimentally had oriental medical theory-based Properties(性). There were studies with whole plants(16.8%), aqueous extract(45.6%), methanol extract(8.0%), ethanol extract(8.0%) and comparative studies of more than 2 types of extracts or various fractions(18.4%). The most frequent experimental diabetic models was diabetic mouse induced by streptozotocin(STZ)(87.8%). And there were db/db mouse(6.7%), ob/ob mouse(1.1%), etc. 33.6% of all studies just measured hematological indices of diabetes, and 66.4% researches analyzed details. To improve herbaceous plants study on diabetes, we oriental medical scientists have to integrate the oriental medical theories and results of experimental studies.

• 동의신경정신과학회지
• /
• 제23권3호
• /
• pp.175-190
• /
• 2012

Objectives : The purpose of this study is To to study as reference (Ed note: 'study as reference' is awkward and unclear) for practical application in clinics, examine the procedure of historical changes and compare components and their doses of herbal medicines, which are recorded in Chapter Sinmun Jeongan of "Donguibogam". Methods : I examined 23 Herb Medicines in Chapter Sinmun Jeongan of "Donguibogam". Fourteen books, which were noted in Chapter Sinmun Jeongan of "Donguibogam" and 14 books were mentioned in the same part of "Uibujeonrok", which were selected as reference. Results and Conclusions : Fourteen documents were referred to as the 23 Herb Medicines in Chapter Sinmun Jeongan of "Donguibogam". A total of 21 Herb Medicines were recorded in the source book, but 2 Herb Medicines were not recorded. Eleven Herb Medicines among 21 were recorded in the source book, which were directly quoted from the firstly appeared books and 10 Herb Medicines were re-quoted from other books that succeeded the source books. I suspect that the components and dosages of the Herb Medicines were revised, according to the author's clinical experience and circumstances.

• 동의신경정신과학회지
• /
• 제8권1호
• /
• pp.111-125
• /
• 1997

This study was done in order to investigate Oriental Medicine's meaning on stress, the stress is due to animal experiments.Methods:This research was done by animal experiments's results based on 41 animal experiment treatises carried out by 24 prescriptions about stress control. Each experiments were compared with same conditions, minimizing the experiments differences. The results were analyzed by p-value and Increas e·Decrease percentage of experiments result's numerical value. Results:1. Inquire into frequency in use of each stress stimulus and measuring items, the restriction stimulus stress and measuring the content of catecholamines are numerous.2. Significance of stress stimuluses based on experments's results is good by restriction stimulus.3. Oriental Medicine's meaning for stress is pathological phenomenon of Seven Emotion(七情). Stagnant the Energy(氣鬱), the Fire(火), Dam(痰), Lack of the general Blood thing(血虛), and reaction of an individual body.4. Inguire into the effects of frequency in use of experiments's Herb drugs, Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛痰) are numerous.5. From a Sasang Medical point of view, experimental use of Herb Drugs are Soeum-in(少陰人) Herb Drugs are numerous.According to above results, it is considered that Herb Drugs of Tonifing the general Blood thing depend on stabilized Mind(補血安神), Circulated the Energy and Digest(理氣消導), Tonifing the general Blood thing(補血), Clearing the Mind(淸心), Removing the Dam(祛淡), and Soeum-in(少陰人) Herb Drugs are used to prevent stress and related diseases.