• Journal of Pharmaceutical Investigation
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• v.40 no.1
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• pp.15-21
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• 2010

Sibutramine is an orally administered centrally-acting antiobesity agent and inhibits both noradrenaline(norephinephirine) and serotonin(5-HT) reuptake. These effects are contributed by its active metabolites, M1 and M2. However, as the free base form of sibutramine is an oil form in room temperature, it had the problem of handling and stability. Thus, this drug should be used in the form of acid salt form in the pharmaceutical application. Unfortunately, anhydrous sibutramine hydrochloride is highly hygroscopic and unstable. In order to solve the hygroscopicity of the anhydrous salt form, another sibutramine acid salt form must be developed as a hydrate form. In this study. to overcome these problems, various of sibutramine acid salt forms were prepared with the pharmaceutically available salts such as maleate, esylate, mandelate, camsylate, besylate, salicylate, tartrate, isethionate and malate forms, and their physicochemical properties were investigated. Sibutramine malate was selected for excellent solubility and stability among the listed salt forms above. Its pharmacokinetic parameters were evaluated in rats comparing with sibutramine HCl, resulting in similar parameters. In vitro dissolution study of sibutramine malate-loaded capsule was performed comparison with commercial product ($Reductil^{(R)}$) in pH 1.2, pH 4.0, pH 6.8 and water medium. Our results indicated that there were no significant differences in their dissolution profiles were similar in all tested medium. Thus, sibutramine malate-loaded capsule should be a potential candiate due to its excellent solubility, good stability and biosimilar absorption.

• Bulletin of the Society of Naval Architects of Korea
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• v.27 no.1
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• pp.3-10
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• 1990

Hull form can be described numerically by two approaches, one is to describe a hull form with a set of curves("curve approach"), and the other is to describe it with surfaces directly("surface approach"). This paper describes the numerical definition scheme of hull form using curve approach method which defines the hull form by a set of curves consisting of 2-dimensional transverse section curves and 3-dimensional longitudinal curves. A set of curves in the hull form definition scheme is described by the modified cubic spline which modified the general parametric cubic spline in order to ensure a very smooth curvature distribution within the curve segment even though a curve segment has large tangent angle at its end points. Illustrative examples are given showing the application of the method to represent the hull form of SWATH ship and oceanographic research vessel. Also, examples for hull form transformation are shown by using this method connected with transformation technique.

• Journal of the Korean Society of Costume
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• v.57 no.8
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• pp.75-88
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• 2007

Nowadays, geometrical form expressed on costume is recognizing as a part of modeling art, at the same time is working to develop it. Also the geometrical form is affording the coinciding lifestyle and sensitivity of customers keeping their pace. As a result, our study is researching on the geometrical form that is used in the pattern, silhouette, and detail of the costume to show the texture in sense of touch and the effect of optical illusion used in variable designs, in order to present the expansion our capability of infinite development included in the study of costume. Specially, geometrical form included in sports wear is very effective since the geometrical form includes short and simple beauty as well as practical design. Thus, this study is wishing to know if satisfying the practical and psychological urge of present human beings may be applied to the golf wear market, which is a type of sport that geometrical form is sent in the fastest way in domestic market. Also we are urged to know what type of design technique is the geometrical form nowadays used and changed to discriminate the artificial commerce and improve the identity of such unique brand. The source of this thesis is wishing to investigate the specialization and the most effective geometrical shape and preference of each type in domestic golf wear goods that applied geometrical goods in $2002{\sim}2006$ and analyze its way of expression.

• Fashion & Textile Research Journal
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• v.20 no.6
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• pp.722-732
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• 2018

This study was to develop a dress form that is highly representative of the body shapes of senior men in their 50s and 60s. And this research was compared the measurements and forms of three different dress forms available in the market, in order to analyze the body type and suitability and provide a standard for developing and utilizing the dress forms. After extracting the body shapes of the senior men's 3D shape, the body type that is curvature on the back prevalent among senior men, was chosen. The dress form was created as follows: 3D modeling and rendering, printing with a FDM-type 3D printer. The dress forms were 3D-scanned and the 3D data was analyzed - classification drop value, area deviation, compared horizontal section and vertical section. The results were as follows: This suggested that the area deviation amount at the chest and hip circumference levels was larger in the commercial products than in the dress form in this study, while that at the waist circumference level was larger in the dress form in this study. The vertical length of the lateral shoulder point-waist circumference was smaller, the side shape showed severe curvature on the back, and the waist circumference was larger in the senior men dress form than the commercial products. The dress form developed in this study reflected the body type of senior men and, therefore, were suitable for fitting when creating clothes for senior men.

• 제어로봇시스템학회:학술대회논문집
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• 1992.10a
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• pp.171-175
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• 1992

In this paper, we derive the optimal input-constrained control law which minimizes predictive control objective function subject to input constraints. In order to obtain the closed form of control law, three suboptimal methods are proposed and evaluated by simulation.

• Journal of the Korean Society of Safety
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• v.17 no.1
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• pp.87-93
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• 2002

In this thesis using FTA technique, the author proposes a new method of analysis of some accidents in construction work. Some efficient plans of safe facility investment are made out. For this study, I referred to 'The Death Accident in Construction Works', which have been published by Korea Industrial Safety Corporation from 1993 to 1999 for 6 years. I selected some of apartment constructions which have caused many deaths for the purpose of analysis in the study. I found that the concrete work using ferro-deck takes more deaths than the conventional construction. After finding this, I selected GANG FORM works using ferro-concrete which is the most widely used but causes many accidents. On the basis of the classification, I try to do some quantitative analyses by adding the death frequency and material factors. In order to draw up the most efficient investment plan, it is imperative that FT diagram be made out and that factors. In order to draw up the most efficient investment plan, it is imperative that FT diagram be made out and that minimal Cut Set be needed. It requires a great deal to labor and time to get Minimal Cut Set. The Minimal Cut Set which is formed of these process is the main factor to analyze disaster in the work. It is desirable that we add calculated percentage of accidents to these factors to these factors in value order, that is to say, from the high cost to low cost.

• Journal of the Korea Concrete Institute
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• v.22 no.6
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• pp.761-768
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• 2010

When cracks occur in reinforced concrete structures, a steel carries all tensile force at crack section, while the concrete between cracks carries a part of the tensile force due to bond, so that the steel is less elongated. This is called the tension-stiffening effect, that plays an important role in verification of a serviceability limit state. But it is a complicated work to use a complex strain distribution between cracks, therefore an average strain is used to calculate deflection and crack width. In Eurocode 2, tension-stiffening effect expressed in the first order form or the second order form is used in calculating an average curvature for deflection. In this study for a flexural member deflection and crack width are calculated using various models for the tension-stiffening effect and the results are compared with the values of Eurocode 2 and KCI provisions. As results, the predicted values using the second order form are appeared to be well agreed with the experimental values and it could secure more analytical consistency.

• Journal of the Korean Society of Costume
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• v.58 no.7
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• pp.13-30
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• 2008

Visual language is 'a form of communication without text'. Visual language is one of the strongest methods to spread knowledge. Uniforms could be interpreted as a symbolic language that establishes order in this complicated modern society by placing identity and responsibility on each members of various different organizations. In light of the above, the purpose of this research paper will be to analyze police uniforms of U.S.A, Great Britain, Italy, France and Korea as a form of visual language and interpreting them in terms of visual design in order to understand the fundamental ideas behind the designs and the effective applications thereof. Upon analysis of traffic police uniforms of each individual county mentioned above by separating each uniform's distinctive design, pattern, color, material and decoration based on visual factor, three characteristics of authority, dynamic functionality and friendliness were derived from comparing and analyzing each country's distinctive uniform design. The traditional unique role of police in our society was to maintain social order as their nature inherently possesses characteristic of authority and preservation, but has since undergone transition in many countries to appeal to the broader public by incorporating friendliness and dynamic functionality. Analyzing police uniforms in terms of visual linguistic sense requires a much more profound process of understanding beyond simple interpretation of configurative shapes. In conclusion, the true purpose of uniforms is to include and portray images of mankind's desire toward expressing ideas like 'mankind's bias toward existence beyond theirselves and the exercise of force through authority' and materializing such ideas into a physical form.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.12 no.3
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• pp.33-48
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• 2009

A palustrine wetland is a type of a wetland that prevails in Korea as well as an ecosystem that provides various ecological functions and has affluent biodiversity. This study was conducted to understand the characteristics of vegetation in a palustrine wetland by analyzing a life form and naturalized plants, in order to present the maintenance and utilization plan of a small wetland. A total of 249 taxa including 76 families, 188 generics, 209 species, 38 varieties and 2 forma were found at six investigated wetlands. As a result of the appearance ratio analysis, Therophytes (37.8%) with 94 taxa and Hemicryptophytes (31.3%) with 78 taxa were in order of life form, and Gramineae (14.1 %) with 35 taxa and Compositae (11.2 %) with 28 taxa were in order of family level. These were deemed representative vegetation in a palustrine wetland. Equosetum arvense, Phragmites communis, Commelina communis, Persicaria thunbergii, Arenaria serpyllifolia, Stellaria media, Erigeron annuus, Erigeron canadensis and Artemisia princeps var, orientalis were found continuously for a period of investigation in all sites. Equosetum arvense, Phragmites communis and Persicaria thunbergii were species with high appearance frequency. Especially, Persicaria thunbergii was construed high in a cover ratio in May as it develop first among Hydrophytes and form a canopy sooner than anything else. We found that a degree of naturalization and an urbanization index appear comparatively high in Yeongok-ri, Cheonan, Gangjang-ri, Asan and Yodang-ri, Hwasung, which is construed due to artificial interference, such as fanning, fishing, swimming and green-tour program. These results would be used to utilize in restoring a deserted and damaged wetland and to provide fundamental data in creating a wetland as follows.

• 제어로봇시스템학회:학술대회논문집
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• 2005.06a
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• pp.694-699
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• 2005

This paper deals with a control technique of eliminating the transient vibration of a geared mechanical system. This technique is based on a model-based control with a rotational speed sensor in order to establish the damping effect at the driven machine part. A rotational speed sensor is installed in a driven gear, namely a bull gear. A control model is composed of a reduced-order mechanical part expressed as a transfer function between the rotational speed of the motor and that of the bull gear. This control model estimates a load speed after the rotational speed of the bull gear is acted on the transfer function. The difference between the estimated load speed and the motor speed is calculated dynamically and it is added to the velocity command to suppress the transient vibration generated at the load. This control technique is applied to a dies driving spindle of a form rolling machine. In this paper, the performance of this control method is examined by simulations. The settling time of the residual vibration generated at the loading inertia can be shortened down to about 1/2 of the uncompensated vibration level.