• 한국임상약학회지
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• 제19권2호
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• pp.105-109
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• 2009

In July 2008, The National Police Hospital has developed the CPOE system(Computerized Physician Order Entry system) which links the medicine master and introduced the new program for the injectable antimicrobial agents. After introducing new system, we wanted to check the management of oral antimicrobial agents. Because new system has limitation that new system control only the use of the injectable antimicrobial agents. So we tried to evaluate the use of oral levofloxacin, which was chosen by a medical specialist of the infection. We retrospectively analyzed the appropriateness of oral levofloxacin through EMR(Electric Medical Record) of 72 inpatients who received oral levofloxacin in National Police Hospital in December 2008. We applied the modified ASHP(American Society of Health- System Pharmacists) DUE(Drug Use Evaluation) criteria, which is composed of justification of drug use, critical indicators, complications and outcome measures. Acceptable cases of use of levofloxacin were 67(93.01%) and 57cases(79.2%) showed good outcome. However critical indicators were not performed very well. We want to suggest the new system for the management of the medical therapeutics by the pharmacist in charge.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제48권2호
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• pp.94-100
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• 2022

Objectives: This study aimed to compare the effects of systemic administration of levofloxacin or cephalexin on fracture healing in rats. Materials and Methods: In this animal study, tibial fractures not requiring fixation were artificially induced in 30 male Wistar albino rats using a 1.1 mm surgical bur. The rats were randomly divided into 6 groups (n=5). Groups 1 and 2 received daily subcutaneous saline injections. Groups 3 and 4 received subcutaneous injections of 25 mg/kg levofloxacin twice daily. Groups 5 and 6 received daily subcutaneous injections of 20 mg/kg cephalexin. The rats in Groups 1, 3, and 5 were sacrificed after 1 week, while the rats in Groups 2, 4, and 6 were sacrificed after 4 weeks. The score of fracture healing was determined through histological assessment of sections from the fracture site according to Perry and colleagues. Data were analyzed by Kruskal-Wallis and Mann-Whitney tests. Results: The mean score of fracture healing at 4 weeks was significantly higher than that at 1 week in the saline, levofloxacin, and cephalexin groups (P<0.001). At 1 week, no significant difference was noted among the three groups of saline, levofloxacin, and cephalexin in the mean score of fracture healing (P=0.360). However, this difference was significant at 4 weeks (P=0.018), and the mean score in the saline group was significantly higher compared to that in the levofloxacin group (P=0.015). Conclusion: It is recommended not to prescribe levofloxacin for more than 1 week after surgical management of bone fractures due to its possible adverse effects on fracture healing.

• 대한안과학회지
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• 제59권12호
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• pp.1195-1200
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• 2018

목적: 상직근 비대가 동반된 환자에서 상직근 및 하직근 수술 이후 발생한 전안부허혈을 경험하였으며, 현재까지 두 개의 직근수술 이후 발생한 전안부허혈은 국내에서 보고된 바 없어 이를 보고하고자 한다. 증례요약: 80세 남자 환자가 3년 전부터 발생한 복시를 주소로 내원하였다. 제일눈위치에서 30프리즘디옵터의 우안 상사시를 보였고, 눈운동검사에서 우안의 하전운동장애가 관찰되었다. 안와 전산화단층촬영검사에서 우안 상직근 비대 소견이 관찰되었다. 우안 상직근 후전술 및 하직근절제술을 시행하였다. 수술 후 2일째 전안부 검사상 우안의 미만성 각막부종과 데스메막주름이 관찰되었고, 전방 방수흐림 및 동공산대가 관찰되었다. 전안부허혈 진단하에 경구 스테로이드 45 mg으로 치료를 시작하였으며, 1% prednisolone acetate와 0.5% levofloxacin 점안약을 사용하였다. 수술 후 1개월째 제일눈위치에서 정위를 보였고 각막부종, 동공이상이나 전방의 염증은 관찰되지 않았다. 결론: 본 증례를 통해 두 개의 직근을 수술할 때도 전안부허혈의 발생 가능성을 항상 염두에 두어야 함을 알 수 있으며, 고령의 환자에서 수직근수술을 시행할 때 더욱 주의할 것을 권유한다.