• Title/Summary/Keyword: oral application

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Membranes for the Guided Bone Regeneration

  • Lee, Sang-Woon;Kim, Seong-Gon
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.36 no.6
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    • pp.239-246
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    • 2014
  • Many kinds of membrane have been used for the guided bone regeneration (GBR) technique. However, most membranes do not fulfill all requirements for the ideal membrane for the GBR technique. Among them, collagen membrane has been most widely used. However, its high price and weak tensile strength in wet condition are limitations for wide clinical application. Synthetic polymers have also been used for the GBR technique. Recently, silk based membrane has been considered as a membrane for the GBR technique. Despite many promising preclinical data for use of a silk membrane, clinical data regarding the silk membrane has been limited. However, silk based material has been used clinically as vessel-tie material and an electrospun silk membrane was applied successfully to patients. No adverse effect related to the silk suture has been reported. Considering that silk membrane can be provided to patients at a cheap price, its clinical application should be encouraged.

A Safety Test on Grapefruit Seed Extract (Grapefruit 종자추출물의 안전성 검사)

  • 조성환;고경혁;이근희
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.24 no.5
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    • pp.690-694
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    • 1995
  • Effects of grapefruit seed extract on the lethality, the primary skin irritation, and the acute eye irritation potentials were evaluated in rats. The acute oral $LD_{50}$ of GFSE for Sprague-Dawley derived rats was 3.75g/kg with 95% confidence limits of 2.55 and 5.52g/kg. Patch application to the intact and abraded skin of rabbits led to mild to moderate erythema and no or mild edema. Application to the eyes of rabbits led to severe corneal opacity, iritis, conjunctival erythema, edema, and discharge.

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Effect of pH on the Formation of Lysosome-Alginate Beads for Antimicrobial Activity

  • Park, Hyun Jung;Min, Jiho;Ahn, Joo-Myung;Cho, Sung-Jin;Ahn, Ji-Young;Kim, Yang-Hoon
    • Journal of Microbiology and Biotechnology
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    • v.25 no.2
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    • pp.234-237
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    • 2015
  • In this study, we developed lysosome-alginate beads for application as an oral drug delivery system (ODDS). The beads harboring lysosomes, which have antimicrobial activity, and various concentrations of alginate were characterized and optimized. For application as an ODDS, pH-dependent lysosome-alginate beads were generated, and the level of lysosome release was investigated by using antimicrobial tests. At low pH, lysosomes were not released from the lysosome-alginate beads; however, at neutral pH, similar to the pH in the intestine, lysosome release was confirmed, as determined by a high antimicrobial activity. This study shows the potential of such an ODDS for the in vivo treatment of infection with pathogens.

Evaluation of Bleeding After Denal Extraction in Patients Taking Single Antiplatelet Treatment

  • Kim, Jae Jin;Kim, Hak Kyun
    • International Journal of Oral Biology
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    • v.40 no.3
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    • pp.147-150
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    • 2015
  • The purpose of this study was to evaluate the effect of single antiplatelet treatment on delayed bleeding, in patients undergoing dental extraction. A total of 154 teeth were extracted in 94 patients with ongoing antiplatelet treatment, who were taking single antiplatelet of either aspirin or clopidogrel. All patients underwent simple dental extraction; local hemostasis was performed with gauze-biting, suturing, and/or application of a local hemostatic agent. Delayed bleeding was recorded in 5 teeth out of a total of 154 teeth after extraction, the incidence of postoperative delayed bleeding being 3.2%. The bleeding was controlled by the patients themselves, through application of pressure with additional gauze-biting. No one visited the doctor or emergency room for hemostasis. These results confirmed that patients taking single antiplatelet drugs may have teeth extracted safely without interruption of the antiplatelet treatment.

CAD/CAM splint based on soft tissue 3D simulation for treatment of facial asymmetry

  • Tominaga, Kazuhiro;Habu, Manabu;Tsurushima, Hiroki;Takahashi, Osamu;Yoshioka, Izumi
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.38
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    • pp.4.1-4.6
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    • 2016
  • Background: Most cases of facial asymmetry involve yaw deformity, and determination of the yaw correction level is very difficult. Methods: We use three-dimensional soft tissue simulation to determine the yaw correction level. This three-dimensional simulation is based on the addition of cephalometric prediction to gradual yaw correction. Optimal yaw correction is determined visually, and an intermediate splint is fabricated with computer-aided design and computer-aided manufacturing. Application of positioning devices and the performance of horseshoe osteotomy are advisable. Results: With this procedure, accurate repositioning of jaws was confirmed and patients obtained fairly good facial contour. Conclusions: This procedure is a promising method for a widespread, predictable treatment of facial asymmetry.

Clinical Effectiveness of Bone Grafting Material Using Autogenous Tooth: Preliminary Report (자가치아를 이용한 골이식재의 임상적 유용성: 일차 보고)

  • Lee, Jeong-Hoon;Kim, Su-Gwan;Moon, Sung-Young;Oh, Ji-Su;Kim, Young-Kyun
    • Maxillofacial Plastic and Reconstructive Surgery
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    • v.33 no.2
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    • pp.144-148
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    • 2011
  • Purpose: The purpose of this study was to evaluate the effectiveness of a novel bone grafting material using an autogeneous tooth (AutoBT) and provide the basis for its clinical application. The AutoBT contains organic and inorganic mineral components and is prepared from autogenous grafting material, thus eliminating the risk of immune reactions that may lead to its rejection. AutoBT can be used as bone material as is has both osteoinduction and osteoconduction activities at guided bone regeneration for implant placement and maxillary sinus graft. Methods: In a total of 63 patients, guided bone regeneration surgery was performed at the time of implant placement, and tissue samples were harvested at the time of the second surgery with the patient's consent. Results: There were no complications in guided bone regeneration using autogeneous tooth. Conclusion: We concluded that AutoBT underwent gradual resorption and was replaced by new bone of excellent quality via osteoinduction and osteoconduction.

RECONSTRUCTION OF INTRAORAL JAW DEFECTS WITH CORTICOCANCELLOUS BLOCK OF MANDIBULAR SYMPHYSIS (하악골 정중부에서 채취한 피질해면골블록을 이용한 구내 골결손부의 재건: 증례보고)

  • Kim, Young-Kyun;Kim, Hyoun-Tae;Cho, Chang-Uk
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.26 no.6
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    • pp.666-671
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    • 2000
  • Objectives: This study evaluated the availability of mandibular symphysis corticocancellous block grafts in patients treated for reconstruction of intraoral jaw defects. Materials & Methods: 8 patients with mandibular and maxillary bony defects were treated with corticocancellous block of symphysis. The types of defects included 4 pathologic jaw defects and 4 vertical and/or horizontal alveolar deficiencies. The age ranged from 13 to 45 years. Additional treatments such as plate fixation, alloplastic bony substitutes, and/or barrier membrane application were perfomred. They were evaluated for complications and healing of defects. Follow-up period ranged from 6 to 15 months. Results: 2 patients experienced complications such as wound dehiscence and mild resorption of exposed bone. None of the patients needed secondary operation. Paresthesia of lip, chin, and teeth were recovered completely by 6 months postoperatively. Reconstructed wound showed favorable healing and bony consolidation. Conclusion: Corticocancellous block of mandibular symphysis can be used for the reconstruction of a variety of intraoral local jaw defects selectively. Advantages were easy fixation of graft, possibility of restoration of original alveolar contour, and decreased donor site morbidity.

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Identification of Actinobacillus actinomycetemcomitans Using Species-Specific 16S rDNA Primers

  • Kim Su Gwan;Kim Soo Heung;Kim Mi Kwang;Kim Hwa Sook;Kook Joong Ki
    • Journal of Microbiology
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    • v.43 no.2
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    • pp.209-212
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    • 2005
  • The purpose of this study was to develop species-specific PCR primers for use in the identification and detection of Actinobacillus actinomycetemcomitans. These primers target variable regions of the 168 ribosomal RNA coding gene (rDNA). We assessed the specificity of the primers against 9 A. actinomycetemcomitans strains and 11 strains (3 species) of the Haemophilus genus. Primer sensitivity was determined by testing serial dilutions of the purified genomic DNAs of A. actinomycetemcomitans ATCC$ 33384^$T Our obtained data revealed that we had obtained species-specific amplicons for all of the tested A. actinomycetemcomitans strains, and that none of these amplicons occurred in any of the other species. Our PCR protocol proved able to detect as little as 4 fg of A. actinomycetemcomitans chromosomal DNA. Our findings suggest that these PCR primers are incredibly sensitive, and should prove suitable for application in epidemiological studies, as well as the diagnosis and monitoring of periodontal pathogens after treatment for periodontitis.

Comparison of oral hygiene status by clinical dental hygiene care performance (임상치위생관리과정 수행 전·후에 따른 구강위생 상태 비교)

  • Park, Ran-Jeong;Lee, Yeun-Kyung;Son, Hwa-Kyung;Hong, Min-Hee
    • Journal of Korean society of Dental Hygiene
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    • v.14 no.1
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    • pp.25-32
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    • 2014
  • Objectives : The purpose of this study was to investigate the oral hygiene status before and after the dental hygiene care performance to patients by the dental hygienists. Methods : Subjects were 55 adults visiting to dental clinics in Chungnam. The patients agreed to undergo a dental hygiene care performance. A skilled dental hygienist provided dental hygiene care performance including periodontal status, halitosis and oral hygiene status. Results : The periodontal pocket depth was compared before and after the performance. The depth dropped from 4.02 mm to 2.81 mm, and the value of halitosis dropped from 45.78 bbv to 35.76 bbv. The O'Leary index of the patients dropped form 49.37 to 32.84, and all the differences were statistically significant. Conclusions : Proper use of oral hygiene supplies and regular dental checkup can prevent periodontal diseases. This study will provide the useful information of the effective application of dental hygiene care performance.

BONE FORMATION USING INJECTABLE TISSUE-ENGINEERING MATERIALS (주사형 조직공학재료를 이용한 골형성)

  • Choi, Byung-Ho;Park, Dong-Joon;Zhu, Shi-Jiang;Huh, Jin-Young;Kim, Byung-Young;Lee, Seoung-Ho
    • Journal of the Korean Association of Oral and Maxillofacial Surgeons
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    • v.29 no.6
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    • pp.374-378
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    • 2003
  • Aim : Several injectable materials have been used in the application of osteogenic bone substitute; however, nothing has won universal acceptance. This study was performed to investigate whether chitosan-alginate gel/MSCs/BMP-2 composites are potentially injectable materials for new bone formation. Material and Methods : The composites were injected into the subcutaneous space on the dorsum of the nude mouse to investigate whether new bone would be tissue engineered in the mouse. The composites were examined histologically over a 12-week period. Results : The composites implanted in the mouse were able to tissue engineer new bone, and the newly formed bone consisted of trabecular bone and calcified bone matrix. Conclusions : The present study shows that chitosan-alginate gel/MSCs/BMP-2 composites have the potential to become real injectable materials for new bone formation.