• Title/Summary/Keyword: optical coherence tomography(OCT)

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Complex Conjugate Resolved Retinal Imaging by One-micrometer Spectral Domain Optical Coherence Tomography Using an Electro-optical Phase Modulator

  • Fabritius, Tapio E.J.;Makita, Shuichi;Yamanari, Masahiro;Myllyla, Risto A.;Yasuno, Yoshiaki
    • Journal of the Optical Society of Korea
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    • v.15 no.2
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    • pp.111-117
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    • 2011
  • Full-range spectral domain optical coherence tomography (SD-OCT) with a 1-${\mu}m$ band light source is shown here. The phase of the reference beam is continuously stepped while the probing beam scans the sample laterally (B-scan). The two dimensional spectral interferogram obtained is processed by a Fourier transform method to obtain a complex spectrum leading to a full-range OCT image. A detailed mathematical explanation of the complex conjugate resolving method utilized is provided. The system's measurement speed was 7.96 kHz, the measured axial resolution was $9.6{\mu}m$ in air and the maximum sensitivity 99.4 dB. To demonstrate the effect of mirror image elimination, In vivo human eye pathology was measured.

Evaluation of sealant microleakage using Swept-Source Optical Coherence Tomography (치면열구전색치아의 미세누출 평가를 위한 Swept-Source Optical Coherence Tomography의 타당도 평가)

  • Nam, Sang-Mi;Ku, Hye-Min;Lee, Eun-Song;Kim, Baek-Il
    • The Journal of the Korean dental association
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    • v.56 no.12
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    • pp.686-694
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    • 2018
  • Purpose: The aim of this study was to evaluate the validity of swept-source optical coherence tomography (SS-OCT) for detecting sealant microleakage. Materials and Methods: A total of 31 extracted sound human molar, assigned as suitable for sealant application, were chosen and divided into two groups: (1) no microleakage group and (2) microleakage group by applying sealant using the different methods. All specimens were immersed in 1% methylene blue for 24 h and sectioned to confirm the absence or presence of sealant microleakage as a gold standard method. Subsequently, all the sectioned specimens were digitally photographed using a microscope with a magnification of ${\times}50$. Presence of microleakage was evaluated on a 2-point rating scale. The association of histological method with conventional methods (visual and tactile assessment) and SS-OCT was assessed using a chi-squared test. The intra- and inter-examiner reliability was calculated using Cohen's Kappa. Results: The SS-OCT showed a sensitivity of 0.73 and a specificity of 1.00, while visual and tactile assessment showed a sensitivity of 0.67 and a specificity of 0.86. The inter-examiner reliability of SS-OCT was 0.79, whereas that of the visual and tactile assessment was 0.53. Conclusions: SS-OCT can be used to non-invasively detect sealant microleakage and to monitor pit and fissure sealant in the clinics.

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Development of Real-time Screening System for Superior Melon Seeds Using Optical Coherence Tomography (광간섭 단층촬영법을 이용한 우량 참외 종자 실시간 감별 시스템 개발)

  • Han, Seunghoon;Lee, Changho;Lee, Seung-Yeol;Jung, Hee-Young;Kim, Jeehyun
    • Journal of Sensor Science and Technology
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    • v.22 no.4
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    • pp.262-267
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    • 2013
  • We developed a real-time screening system using optical coherence tomography (OCT) to distinguish the fruitful melon seeds efficiently. Cross-section images of melon seeds infected with Cucumber green mottle mosaic virus (CGMMV) showed an additional layer that did not appear in normal seeds. Additional layer appeared under $100{\sim}300{\mu}m$ from the surface of the seed. OCT can visualize the micro-structural and morphological changes of the internal seed structure. Real-time OCT seed screening system provided the real-time, non-destructive, cross-section image and quantitative information such as A-scan analysis of selected region in the cross-section image. We can distinguish the viral infection seeds while monitoring the averaged A-scan analysis graph in real-time by considering the second peak value of the graph which refers to the layer that occurred owing to the virus. Real-time OCT seed screening system could assist to distinguish the disease caused by CGMMV.

Acquirement of in vivo epidermal cross-sectional image by using swept source optical coherence tomography (SS-OCT 방식을 이용한 생체의 표피단면 영상 획득)

  • Kim, Hoon-Sup;Lim, Hae-Jin;Eom, Jin-Seob
    • Journal of Industrial Technology
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    • v.28 no.A
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    • pp.163-166
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    • 2008
  • In this paper, the swept source optical coherence tomography system has realized using a free-space interferometer based on a beam splitter. Personal computer has completed the control for tunable wavelength laser digitally and the B-scan motor as well. From each experiment for an onion and a salmon egg, we confirmed that the in vivo epidermal cross-sectional images for them can be obtained appropriately.

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Post-tuning of Sample Position in Common-path Swept-source Optical Coherence Tomography

  • Park, Jae-Seok;Jeong, Myung-Yung;Kim, Chang-Seok
    • Journal of the Optical Society of Korea
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    • v.15 no.4
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    • pp.380-385
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    • 2011
  • Common-path interferometers are widely used for endoscopic optical coherence tomography (OCT) because an arbitrary arm length can be chosen for the endoscopic imaging probe. However, the scheme suffers from the limited range of the sample position distance from the end of the imaging probe because the position between the reference reflector and the sample is limited by the optical path-length difference (OPD) to induce an interference signal. In this study, we developed a novel method for compensating the arbitrary sample position in common-path swept-source OCT by adding an extra Mach-Zehnder interferometer in the post-path of the interfered optical signal. Theoretical analysis and an experimental demonstration of imaging depth tuning for the flexible sample position of an endoscopic OCT image are discussed. After post-tuning of sample position distance, the positioning limitation between the reference reflector and the sample can be solved for various sample positions over a range of 26 mm for the cross-sectional images of a fish eye sample.

A case of Candida albicans-induced fungal keratitis in a Chihuahua dog - with a focus on optical coherence tomographic features

  • Heejong Cho;Manbok Jeong;Sukjong Yoo
    • Journal of Veterinary Science
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    • v.24 no.2
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    • pp.30.1-30.6
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    • 2023
  • A 4-year-old Chihuahua dog was referred for bilateral corneal ulcers. Slightly raised white fluorescein-positive plaque-like corneal lesions in both eyes appeared as intense hyperreflective areas with posterior shadowing on optical coherence tomography (OCT). Based on corneal cytology and culture, Candida albicans-induced fungal keratitis was diagnosed. Despite treatment, on OCT, endothelial plaques, increased stromal infiltration thickness, vertical shapes of the ulcer edge, and necrotic stromal space were judged to be aggravation of the disease, and surgery was performed. Conjunctival grafting surgery with topical 1% voriconazole effectively resolved fungal keratitis. OCT can provide detailed and objective information related to the disease prognosis.

A Study on the Interferometer Configuration for Improvement of Signal-to-Noise Ratio of Optical Coherence Tomography System (OCT 시스템의 SNR 향상을 위한 간섭계 개선에 관한 연구)

  • Yang, Sung-Kuk;Park, Yang-Ha;Chang, Won-Suk;Oh, Sang-Ki
    • Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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    • v.18 no.5
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    • pp.126-131
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    • 2004
  • As a noninvasive imaging method, optical coherence tomography system has been extensively studied because it has some advantages such as imaging of high resolution, low cost, and compact size configuration. In order to improve the SNR of OCT system, two types of interferometers were configured and then, we compared simulation with measurement of reference sample. In the OCT system is configured with Michelson interferometer, the contrast of cross-sectional image is reduced with low SNR detection which is due to loss of feedback interference signal from light source part. Also, in order to image measured data with real time, image processing program is constructed. From results of simulation, it is confirmed that improved Michelson interferometer is improved about 10[dB] with a 50 : 50 fiber coupler. And from the measurement of reference sample, about 5[dB] is improved with a 50 : 50 fiber coupler. It is confirmed that the OCT system is configured with the improved Michelson interferometer which has a good distinctive cross-sectional image due to higher contrast.

Broadband Wavelength-swept Raman Laser for Fourier-domain Mode Locked Swept-source OCT

  • Lee, Hyung-Seok;Jung, Eun-Joo;Jeong, Myung-Yung;Kim, Chang-Seok
    • Journal of the Optical Society of Korea
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    • v.13 no.3
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    • pp.316-320
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    • 2009
  • A novel broadband wavelength-swept Raman laser was used to implement Fourier-domain mode locked (FDML) swept-source optical coherence tomography (SS-OCT). Instead of a conventional semiconductor optical amplifier, this study used broadband optical fiber Raman amplification, over 50 nm centered around 1545 nm, using a multi-wavelength optical pumping scheme, which was implemented with the four laser diodes at the center wavelengths of 1425, 1435, 1455 and 1465 nm, respectively, and the maximum operating power of 150 mW each. The operating swept frequency of the laser was determined to 16.7 kHz from the FDML condition of 12 km optical fiber in the ring cavity. The OCT images were obtained using the novel broadband wavelengthswept Raman laser source.

A Handheld Probe Based Optical Coherence Tomography System for Diagnosis of Dental Calculus (치석 진단용 소형 프로브 기반 광간섭단층촬영 시스템)

  • Lee, Chang-Ho;Woo, Chai-Kyoung;Jung, Woong-Gyu;Kang, Hyun-Wook;Oh, Jung-Hwan;Kim, Jee-Hyun
    • Journal of Sensor Science and Technology
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    • v.21 no.3
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    • pp.217-222
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    • 2012
  • Optical coherence tomography(OCT) is a noninvasive optical imaging tool for biomedical applications. OCT can provide depth resolved two/three dimensional morphological images on biological samples. In this paper, we integrated an OCT system that was composed of an SLED(Superluminescent Light Emitting Diode, ${\lambda}_0$=1305 nm bandwith= 141 nm), a reference arm adopting a rapid scanning optical delay line(RSOD) to get high speed imaging, and a sample arm that used a micro electro mechanical systems(MEMS) scanning mirror. The sample arm contained a compact probe for imaging dental structures. The performance of the system was evaluated by imaging in-vivo human teeth with dental calculus, and the results indicated distinct appearance of dental calculus from enamel, gum or decayed teeth. The developed probe and system could successfully confirm the presence of dental calculus with a very high spatial resolution($6{\mu}m$).

Realization of Swept Source Optical Coherence Tomography with Loop Mirror Reference Arm (루프 미러로 구성된 기준팔을 가지는 파장 스위핑 OCT 구현)

  • Kim, Hoon-Sup;Namgoong, Myung-Woo;Lee, Jung-Ryul;Eom, Jin-Seob
    • Journal of Industrial Technology
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    • v.27 no.B
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    • pp.121-123
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    • 2007
  • As a reflector of reference arm in OCT systems, a coated fiber reflector has mostly used. Instead, this paper has realized the swaept source optical coherence tomography system using a loop mirror within a reference arm. Through the experiments for a tilted thin glass plate, we found that the loop mirror is better than the coated fiber typed mirror for obtaining the clear image.

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