• 약학회지
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• 제50권6호
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• pp.429-435
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• 2006

The antidepressant effects of Cirsium japonicum compositae was investigated using open field test and forced swimming test. Total extract of Cirsium japonicum (CJ) was orally administered at dose of 20, 100, 300, 500 mg/kg bodyweight. Supplementation of CJ increased dose-dependently movement, rearing frequency and total turn angle in the center area of open field in mice. Treatment of Cirsium japonicum's extract (300 mg/kg, CJ) decreased immobile duration and increased mobile and strong mobile duration significantly; and it is comparable to that of imipramine and fluoxetine. These results indicate that CJ has antidepressant effect. Treatment of CJ did not induced any impairment in motor coordination and myorelaxation. These results indicate that the constituents or its complex of Cirsium japonicum could be a candidate of new antidepressant drug.

• 대한물리의학회지
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• 제9권3호
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• pp.249-253
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• 2014

PURPOSE: This study intends to examine the effects of change of anatomical position of the ankle joint in open kinematic chain, an appropriate position for selective muscle training, on vastus lateralis obliques, rectus femoris, vastus medilais obliques, and rectus abdominalis muscle activation and to present an effective method of muscle training for patients and normal people. METHODS: The participants of this study were Korean healthy adult in their 20s. The 8 channel surface electromyography was used to measure muscle activation while the subjects raised their legs under each condition. Under each condition, while the subjects raised the leg to hip joint flexion at $60^{\circ}$ along the arch. RESULTS: The analysis result of muscle activation by each section and position during leg rising. There were significant differences. CONCLUSION: For independent strengthening of each muscle, muscle activation was measured according to leg raising angles and the result differed according to each section and position. If this study result is applied to muscle training for patients who need selective muscle training, more effective muscle strengthening will be made possible.

• 설비공학논문집
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• 제26권4호
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• pp.163-168
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• 2014

The plate heat exchanger has been widely used in water heating systems due to high efficiency, simple structure, and easy maintenance. However, the studies on the effects of fouling on the heat transfer performance under various operation and maintenance conditions are very limited in the open literature. The objective of this study is to investigate the effects of fouling with calcium carbonate ($CaCO_3$) on the heat transfer characteristics of the plate heat exchanger under various operating and geometric conditions. The heat transfer coefficient and pressure drop in the plate heat exchangers were measured under accelerated fouling conditions with $CaCO_3$ by varying geometric and operational parameters. The fouling resistance increased with the decrease in the flow rate, and the increase in the chevron angle and the concentration.

• 한국운동역학회지
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• 제21권1호
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• pp.31-38
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• 2011

This study aimed to determine the effects of the blockage of visual feedback on joint dynamics of the lower extremity. Fifteen healthy male subjects(age: $24.1{\pm}2.3\;yr$, height: $178.7{\pm}5.2\;cm$, weight: $73.6{\pm}6.6\;kg$) participated in this study. Each subject performed single-legged landing from a 45 cm-platform with the eyes open or closed. During the landing performance, three-dimensional kinematics of the lower extremity and ground reaction force(GRF) were recorded using a 8 infrared camera motion analysis system (Vicon MX-F20, Oxford Metric Ltd, Oxford, UK) with a force platform(ORG-6, AMTI, Watertown, MA). The results showed that at 50 ms prior to foot contact and at the time of foot contact, ankle plantar-flexion angle was smaller(p<.05) but the knee joint valgus and the hip flexion angles were greater with the eyes closed as compared to with the eyes open(p<.05). An increase in anterior GRF was observed during single-legged landing with the eyes closed as compared to with the eyes open(p<.05). Time to peak GRF in the medial, vertical and posterior directions occurred significantly earlier when the eyes were closed as compared to when the eyes were open(p<.05). Landing with the eyes closed resulted in a higher peak vertical loading rate(p<.05). In addition, the shock-absorbing power decreased at the ankle joint(p<.05) but increased at the hip joints when landing with the eyes closed(p<.05). When the eyes were closed, landing could be characterized by a less plantarflexed ankle joint and more flexed hip joint, with a faster time to peak GRF. These results imply that subjects are able to adapt the control of landing to different feedback conditions. Therefore, we suggest that training programs be introduced to reduce these injury risk factors.

• 생명과학회지
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• 제26권2호
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• pp.181-189
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• 2016

본 연구에서는 발아전처리 제초제인 Dithiopyr (DTP)를 시험물질로 사용하여 급성 독성시험을 평가하고, zebrafish의 행동에 미치는 영향을 연구하였다. 급성 독성시험 결과 zebrafish에서의 DTP의 LC₅₀값은 14.49 μM이었다. 또한 DTP 노출이 유영 패턴에 미치는 영향을 관찰하기 위하여 아치사농도(2.5-20 μM)에서 novel tank test (NTT)와 open field test (OFT)의 두 가지 행동실험을 실시하였다. NTT를 실시한 결과, 하층부의 머무는 시간 및 최초로 상층부에 들어간 시간, 회전각, 부동 시간의 경우 control 그룹과 비교하여 통계적으로 유의성 있게 농도 의존적으로 증가하였다(p<0.05). 또한 상층부에 진입한 횟수 및 평균 유영속도에서 통계적인 유의성 있는 감소현상이 확인되었다(p<0.05). OFT를 실시한 결과, 총 이동 거리 및 평균 유영속도에서 유의성이 있는 감소현상이 확인되었다(p<0.05). 부동 시간 및 회전각, 굴곡유영에서는 유의성 있는 증가 현상이 확인되었다(p<0.05). 또한 Whole-body cortisol level 측정 결과, 저농도 노출 그룹에서만 유의성 있는 증가가 관찰되었으나(p<0.05), 5와 10 μM에서는 유의성 있는 차이가 관찰되지 않아 농도의존적으로 감소하는 것을 확인하였다.

• Restorative Dentistry and Endodontics
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• 제27권6호
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• pp.577-586
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• 2002

본 연구는 엔진구동형 Ni-Ti 합금 파일의 삭제날 각의 차이가 근관 성형 후 근관 내 절삭 면에 형성되는 도말층의 분포, 형태 및 상아세관 내로의 침투 정도 등에 어떤 차이를 보이는가를 알아보기 위함이다. 건전한 36개의 단근관을 갖는 발치된 사람의 단근치를 선택하고 positive cutting angle을 갖는 HEROShaper 파일과 negative cutting angle로 된 ProFile 파일을 이용하여 근관성형 후 절단면에서의 도말층의 양, 분포 형태 및 상아세관내로의 침투 빈도를 주사전자 현미경을 이용하여 사진촬영 후 다음과 같은 결과를 얻었다. 1. 사용된 엔진구동형 합금 파일의 삭제날 각의 차이에 관계없이 모든 군에서 도말층이 형성되었다. 2. 근관 성형 후 절삭면상에 나타난 도말층 형태는 삭제날 각의 차이에 따라 형태학적인 차이를 보였으며, positive cutting angle과 radial land가 없는 니켈-티타늄 전동통파일에서 상대적으로 적은 양의 도말층 형성을 보였다(p < 0.05). 결론적으로, 본 연구는 삭제날의 각이나 radial land의 유무에 관계없이 사용된 모든 엔진구동형 파일에서 도말층이 형성된 것으로 미루어 근관 성형 시 liquid EDTA와 같은 chealting agent의 사용의 필요성을 시사한다.

• 한국해안·해양공학회논문집
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• 제25권6호
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• pp.349-356
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• 2013

본 연구에서는 만 또는 도서지역과 같이 지형적으로 차폐되어 외해로부터 직접적인 파랑전파가 어렵고 바람에 의해 발달된 파랑의 영향이 클 것으로 판단되는 지역에 사용되는 기존 만내설계파 모델의 문제점을 분석하고 개선방안을 검토하였다. 기존 만내설계파 모델은 바람을 고려할 수 있고 타 모델에 비해 복잡한 지형에도 비교적 간편하게 사용할 수 있는 장점을 지니는 반면 인근 대형 구조물 또는 지형에 의한 파랑의 회절 및 반사 등의 고려가 곤란하다. 기존모델의 단점을 극복하기 위해 회절 및 반사각, 수심변화 등의 고려가 가능한 개량된 만내설계파 모델을 현지에 적용하고 기존 모델과 비교 검토한 결과 구조물 주변에서 설계파고의 값에 신뢰성이 향상되는 것을 확인하였다. 따라서 개선된 만내설계파 모델은 차폐되어 있는 해역에서 항만 구조물 설계 시 기존의 방법에 비해 보다 고정도의 설계파를 산정하는 방법으로서 이용될 수 있을 것으로 판단된다.

• The Korean Journal of Physiology and Pharmacology
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• 제28권4호
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• pp.345-359
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• 2024

Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-induced increase in IOP and increase the TM expression of ECM proteolytic enzymes; however, its effects on the deposition of ECM components by TM and its associated pathways, such as TGF-β-SMAD signalling remain uncertain. This study, therefore, explored the effects of trans-resveratrol on the expression of ECM components, SMAD signalling molecules, plasminogen activator inhibitor-1 and tissue plasminogen activator in dexamethasone-treated human TM cells (HTMCs). We also studied the nature of molecular interaction of trans-resveratrol with SMAD4 domains using ensemble docking. Treatment of HTMCs with 12.5 µM trans-resveratrol downregulated the dexamethasone-induced increase in collagen, fibronectin and α-smooth muscle actin at gene and protein levels through downregulation of TGF-β1, SMAD4, and upregulation of SMAD7. Downregulation of TGF-β1 signalling by trans-resveratrol could be attributed to its effect on the transcriptional activity due to high affinity for the MH2 domain of SMAD4. These effects may contribute to resveratrol's IOP-lowering properties by reducing ECM deposition and enhancing aqueous humour outflow in the TM.

• Steel and Composite Structures
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• 제21권2호
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• pp.395-409
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• 2016

Nonlinear vibration characteristics of composite laminated trapezoidal plates are studied. The geometric nonlinearity of the plate based on the von Karman's large deformation theory is considered, and the finite element method (FEM) is proposed for the present nonlinear modeling. Hamilton's principle is used to establish the equation of motion of every element, and through assembling entire elements of the trapezoidal plate, the equation of motion of the composite laminated trapezoidal plate is established. The nonlinear static property and nonlinear vibration frequency ratios of the composite laminated rectangular plate are analyzed to verify the validity and correctness of the present methodology by comparing with the results published in the open literatures. Moreover, the effects of the ply angle and the length-high ratio on the nonlinear vibration frequency ratios of the composite laminated trapezoidal plates are discussed, and the frequency-response curves are analyzed for the different ply angles and harmonic excitation forces.

• JSTS:Journal of Semiconductor Technology and Science
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• 제9권2호
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• pp.91-97
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• 2009

The performance of GaInP/GaAs tandem solar cells with AlInP growth temperatures of 680$^{\circ}C$ and 700 $^{\circ}C$ on n-type GaAs (100) substrate with 2$^{\circ}$ and 6$^{\circ}$ tilt angles has been investigated. The series resistance and open circuit voltage of the fabricated tandem solar cells are affected by the substrate tilt angles and the growth temperatures of the window layer when zinc is doped in the tunnel diode. With carbon doping as a p-type doping source in the tunnel diode and the effort of current matching between top and bottom cells, GaInP/GaAs tandem solar cell has been exhibited 25.58% efficiency.