• 대한의생명과학회지
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• 제28권4호
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• pp.260-275
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• 2022

Sterile alpha motif (SAM) domains bind to various proteins, lipids, and RNAs. However, these domains have not yet been analyzed as prognostic biomarkers. In this study, SAM domain containing 13 (SAMD13), a member of the SAM domain, was evaluated to identify a novel prognostic biomarker in various human cancers, including hepatocellular carcinoma (HCC). Moreover, we identified a correlation between SAMD13 expression and immune cell infiltration in HCC. We performed bioinformatics analysis using online databases, such as Tumor Immune Estimation Resource, UALCAN, Kaplan-Meier plotter, LinkedOmics, and Gene Expression Profiling Interactive Analysis2. SAMD13 expression in HCC samples was significantly higher than that in normal liver tissue; additionally, SAMD13 was higher in primary tumors, various stages of cancer and grades of tumor, and status of nodal metastasis. Higher SAMD13 expression was also associated with poorer prognosis. SAMD13 expression positively correlated with CD8+ T cells, CD4+ T cells, B cells, neutrophils, macrophages, and dendritic cells. In the analysis of SAMD13 co-expression networks, positively related genes of SAMD13 were associated with a high hazard ratio in different types of cancer, including HCC. In biological function of SAMD13, SAMD13 mainly include spliceosome, ribosome biogenesis in eukaryote, ribosome, etc. These results suggest that SAMD13 may serve as a novel prognostic biomarker for HCC diagnosis and provide novel insights into tumor immunology in HCC.

• 한국ITS학회 논문지
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• 제22권3호
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• pp.116-130
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• 2023

고속도로는 중장거리 지역 간을 연결하는 자동차 전용도로로 철도 및 항공 수단보다 접근성과 이동성이 우수하여 화물 수송의 중추적인 역할을 담당하고 있다. 그러나 기존의 고속도로를 이용하는 화물수송실적은 차종 구분의 혼재, 개별 화물차량의 화물적재량 파악의 어려움으로 정확한 산정에 한계가 있다. 따라서 본 연구에서는 고속도로 온라인 데이터의 분석을 통하여 보다 신뢰성있는 화물수송실적 산정 방법론의 틀을 제시하고자 하였다. 자동요금징수시스템로부터 수집된 데이터를 활용하여 고속도로 구간별 통행실적(대·km/일)을 도출하였으며 차량제원정보데이터와 고속 및 저속축중기 데이터로부터 차종별 화물 적재 원단위(톤/대)를 도출하였다. 본 연구는 기존에 제시되고 있지 않은 고속도로 구간별, 차종별 화물수송실적을 산정하는데 주요 목적이 있으며, 개방식 영업소, 민자고속도로 등을 모두 연계한 수송실적산정방법을 제시하였다는데 기존 연구와의 차별성을 가진다.

• 한국수자원학회:학술대회논문집
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• 한국수자원학회 2022년도 학술발표회
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• pp.209-209
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• 2022

Reservoirs play a key role in the carbon cycle between terrestrial and marine systems and are pathways that release greenhouse gases(GHGs), CO₂, CH₄, and N₂O, into the atmosphere by decomposing organic matters. Developed countries have been actively conducting research on carbon emission assessment of dam reservoirs for over 10 years under the leadership of UNESCO/IHA, but associated research is very rare in Korea. In particular, the GHGs footprint evaluation, which calculates the change in net carbon emission considering the watershed environment between pre- and post- impoundment, is very important in evaluating the carbon emission of hydroelectric dams. The objective of this study was to estimate the GHG emissions and footprints in Daecheong Reservoir using the G-res Tool, an online platform developed by UNESCO/IHA. The G-res Tool estimates CO₂ and CH₄ emissions in consideration of diverse pathway fluxes of GHGs from the reservoir and characterizes changes in GHG fluxes over 100 years based on the expected lifetime of the dam. The input required to use the G-res Tool include data related to watersheds, reservoirs, and dams, and most were collected through the government's public portal. As a result of the study, the GHG footprint of Daecheong Reservoir was estimated to be 93 gCO₂eq/m²/yr, which is similar to that of other reservoirs around the world in the same climate zone. After impoundment, the CH₄ diffusion emission from the reservoir was 73 gCO₂eq/m²/yr, also similar to those of the overseas reservoirs, but the CH₄ bubbling emission, degassing emission, and CO₂ diffusion emissions were 44, 34, 252 gCO₂eq/m²/yr, respectively, showing a rather high tendency. Since the dam reservoir carbon footprint evaluation is essential for the Clean Development Mechanism evaluation of hydroelectric power generation, continuous research is needed in the future. In particular, experimental studies that can replace the emission factors obtained from the overseas dam reservoirs currently used in the G-res Tool should be promoted.

• 지능정보연구
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• 제22권1호
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• pp.43-61
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• 2016

온라인 쇼핑몰의 상품에 대한 고객 리뷰는 구매자들의 구매 의사결정에 영향을 미치고 있으며 중요한 구전효과의 원천과 의사결정의 정보 원천의 역할을 하고 있다. 한 제품에 대한 리뷰가 무척 많기에 온라인 쇼핑몰들은 고객 리뷰 평가 방안을 도입하였고, 이를 통해 고객들에게 유용하리라고 판단되는 리뷰들을 걸러서 보여주거나 강조할 수 있게 되었다. 리뷰 평가 방안은 해당 리뷰가 도움이 되었는지 혹은 도움이 되지 않았는 지를 리뷰를 읽은 고객이 평가하게 하는 방안이다. Amazon.com은 고객 평가를 바탕으로 총 투표 수 중에서 유용하다는 투표 수의 비율을 리뷰 유용성 지표로 삼고 있으며, Yelp.com은 유용하다는 투표 수 자체를 유용성 지표로 삼고 있다. 본 연구는 고객 리뷰의 감성과 독해 용이성이 리뷰의 유용성에 미치는 영향을 파악하고자 한다. Amazon.com의 고객 리뷰 자료를 활용하여 비율형 유용성 지표를 종속변수로 하는 유사한 연구들이 수행되어 왔다. 본 연구에서는 Yelp.com의 리뷰 자료를 활용하여 가산형 리뷰 유용성 지표인 경우에도 동일한 효과가 존재하는지를 검토하고자 한다. Yelp.com의 음료와 음식 카테고리에 해당하는 업종에 대한 리뷰를 자료로 활용하였으며, 점포의 명성과 인기도 데이터를 파악할 수 있는 170,294개의 리뷰를 분석에 활용하였다. 분석결과는 리뷰의 긍정 정도는 유용 투표수를 늘리는데 음의 영향을 미쳤다. 평가가 긍정적인 리뷰에서는 음의 영향관계가 유의 하였으나, 평가가 부정적인 리뷰에서는 리뷰의 긍정 정도가 유용 투표 수에 미치는 영향은 유의하지 않았다. 독해 용이성은 리뷰가 읽기 어려울 수록 높은 값을 갖으며, 독해의 어려운 정도는 유용 투표수 획득에 음의 영향을 미쳤다. 독해 용이성은 긍정 리뷰, 부정 리뷰 관계없이 모두 음의 영향을 미치는 것으로 분석되었다. 이 결과는 유용 투표수가 0인 리뷰를 포함하여 영과잉 음이항 회귀분석을 수행한 경우와 유용 투표수가 0인 리뷰를 제외하고 음이항 회귀분석을 수행한 경우 모두 동일하게 파악되었다.

• 한국공간정보시스템학회 논문지
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• 제10권4호
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• pp.67-75
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• 2008

본 연구에서는 u-City 인력양성 현황을 토대로 국토해양부의 u-City 관련 인력양성에 대한 실천 계획이 효율적으로 실행될 수 있는 방안을 제시하였다. u-City를 추진하는 지자체, 개발사업자마다 공통적으로 제기하는 문제점은 u-City 관련 고급 및 산업 인력의 절대적인 부족이다. u-City 전문 인력은 u-City건설의 특성상 도시계획.개발, 정보통신망, IT 등 다양한 분야에 대한 전문지식을 갖추어야하나 이러한 고급인력이 배출되고 있지 않다. 따라서 본 연구에서는 인력양성방안의 목표를 'u-City의 성공적인 추진에 부합하는 전문 인력 양성'으로 설정하였으며, 수요자 중심의 교육, 지역 균형적인 전문 인력 양성, u-City 관련분야의 융.복합교육, u-City 관련 교육인프라 구축을 추진전략으로 수립하였다. u-City 인력양성의 추진목표 및 전략을 실행하기 위한 중점추진과제로는 'u-City건설 전문 인력 교육 관련 수요전망', '지역별 거점대학 선정을 통한 전문 인력의 양성', 'u-City 인력양성센터 건립추진', '교육포탈을 통한 온라인 교육', '교육인프라 구축' 등 5개를 선정하였다. u-City 인력양성을 위한 추진전략의 성공적 실행을 위해서는 중점 추진과제들 간의 유기적인 연계가 필수적이다.

• Asia pacific journal of information systems
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• 제17권4호
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• pp.113-132
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• 2007

Price rigidity involves prices that do not change with the regularity predicted by standard economic theory. It is of long-standing interest for firms, industries and the economy as a whole. However, due to the difficulty of measuring price rigidity and price adjustments directly, only a few studies have attempted to provide empirical evidence for explanatory theories from Economics and Marketing. This paper proposes and validates a research model to examine different theories of price rigidity and to predict what variables can explain the observed empirical regularities and variations in price adjustment patterns of Internet-based retailers. I specify and test a model using more than 3 million daily observations on 385 books, 118 DVDs and 154 CDs, sold by 22 Internet-based retailers that were collected over a 676-day period from March 2003 to February 2005. I obtained a number of interesting findings from the estimation of our logit model. First, quality seems to play a role-I find that both price levels as proxies for store quality, and information on the quality of a product consumers have, affect online price rigidity. Second, greater competition(i.e., less industry concentration) leads to less price rigidity(i.e., more price changes) on the Internet. I also find that Internet-based sellers more frequently change the prices of popular products, and the sellers with broader product coverage change prices less frequently, which seem due to economic forces faced by these Internet-based sellers. To the best of my knowledge, this research is the first to empirically assess price rigidity patterns for multiple industries in Internet-based retailing, and attempt to explain the variation in these patterns. I found that price changes are more likely to be driven by quality, competitive and economic considerations. These results speak to both the IS and economics literatures. To the IS literature these results suggest we take economic considerations into account in more sophisticated ways. The existence and variation in price rigidity argue that simplistic assumptions about frictionless and completely flexible digital prices do not capture the richness of pricing behavior on the Internet. The quality, competitive and economic forces identified in this model suggest promising directions for future theoretical and empirical work on their role in these technologically changing markets. To the economics literature these results offer new evidence on the sources of price rigidity, which can then be incorporated into the development of models of pricing at the firm, industry and even macro-economic level of analysis. It also suggests that there is much to be learned through interdisciplinary research between the IS, economics and related business disciplines.

• 대한가정학회지
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• 제45권4호
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• pp.1-16
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• 2007

The purpose of this study was to explore the identity of home economics(HE) education by assessing perceptions of HE teacher, students, and general adults regarding the images and characteristics of HE education. Respondents in this study were 234 HE teachers, 505 students, and 264 general adults. Questionnaires were collected through both online and offline. The image and the characteristics of HE education were the factors of the identity that were also the byproducts of HE education operation of the past and present, and had the characteristics in changing in accordance with the change of time. The current image of HE education was shown to positive recognition as the curriculum helpful to the actual living and future living for the HE teacher, students, and the general adults. For the HE teacher, it had strong emotionally warm image similar to the image of 'home', and it was connected to the curriculum image to be acknowledged as good problem solving teachers in terms of competence and conservative image. However, on the images of the HE curriculum and HE teacher, the HE teachers had the most positive recognition, and on the image of the HE curriculum, the students had the most negative recognition while the image of the HE teacher, the general adults had the most negative recognition. The general adults among the three groups recognized the HE curriculum as the most technical oriented curriculum while the students recognized as interesting curriculum, curriculum contributing on society. In the meantime, for the characteristic of the HE education, the HE teachers recognized that it had weak female curriculum characteristics and strong living functional curriculum characteristics, and the practical curriculum characteristics would be important in the future. Accordingly, the identity of the HE education formulated might be considered as the practical curriculum that was helpful to problem solving in actual living of the family and family members with the connection to the concept of 'home'. However, depending on the definition on implication of practice and issue of actual living, the characteristics and appearance of the HE education had been changed and might interpret as changing according to the above.for the fertility policy and the methods for the estimation of the child cost were suggested based on the results.

• Asian Pacific Journal of Cancer Prevention
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• 제15권8호
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• pp.3403-3410
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• 2014

Context: Interest exits in whether TNF-alpha antagonists increase the risk of breast cancer and total malignancies in patients with rheumatoid arthritis (RA). Objectives: To analyze the risk of malignancies, especially breast cancer, in patients with RA enrolled in randomized control trials (RCTs). Methods: A systematic literature search for RCTs from 1 January 1998 to 1 July 2013 from online databases, such as PubMed, WILEY, EMBASE, ISI web of knowledge and Cochrane Library was conducted. Studies included RCTs that compared the safety of at least one dose of the five TNF-${\alpha}$ antagonists with placebo or methotrexate (MTX) (or TNF-${\alpha}$ antagonists plus MTX vs placebo plus MTX) in RA patients for more than 24 weeks and imported all the references into document management software EndNote${\times}6$. Two independent reviewers selected studies and extracted the data about study design, patients' characteristics and the type, number of all malignancies. Results: 28 RCTs from 34 records with 11,741 patients were analyzed. Of the total, 97 developed at least one malignancy during the double-blind trials, and breast cancer was observed in 17 patients (17.5% of total malignancies). However, there was no statistically significant increased risk observed in either the per protocol (PP) model (OR 0.65, 95%CI [0.22, 1.93]) or the modified intention to treat (mITT) model (OR 0.75, 95%CI [0.25, 2.21]). There were also no significant trend for increased risk of total malignancies on anti-TNF-${\alpha}$ therapy administered at approved doses in either model (OR, 1.06, 95%CI [0.64, 1.75], and OR, 1.30, 95%CI [0.80, 2.14], respectively). As to the two models, modified intention to treat model analysis led to higher estimation than per protocol model analysis. Conclusions: This study did not find a significantly increased risk of breast cancer and total malignancies in adults RA patients treated with TNF-${\alpha}$ antagonists at approved doses. However, it cannot be ignored that more patients developed malignancies with TNF-${\alpha}$ antagonists therapy compared with patients with placebo or MTX, in spite of the lack of statistical significance, so that more strict clinical trials and long-term follow-up are needed, and both mITT and PP analyses should be used in such safety analyses.

• 한국ITS학회 논문지
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• 제14권6호
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• pp.50-59
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• 2015

본 연구에서는 가치추정방법의 하나인 조건부 가치측정법(Contingent Valuation Method : CVM)을 이용하여 교통사고 긴급통보시스템 도입을 위한 지불의사액을 산정하고자 하였다. 분석을 위해 이중양분선택법 질문양식을 이용하여 긴급통보시스템에 대한 이용자들의 지불의사액(Willingness to Pay : WTP) 추정방안을 제시하였다. 기존 연구들의 경우 지불의사액 산정에 사용되는 질문 유형별 분석 모델별로 지불유무에 따른 절단데이터가 다르게 처리되고 있음을 알 수 있었다. 이에 따라 본 연구에서는 이중양분 선택법으로 구성된 절단 데이터를 처리하는 방법으로 모형별 지불의사액의 차이를 비교하였다. 연구에 사용된 설문지는 약 500부 수준으로 응답자의 지역적인 편차(bias)가 반영되지 않도록 온라인과 오프라인에서 동시에 진행하였으며, 연령대별 편차를 고려하기 위해 2010년 인구주택 총 조사 결과를 참조하여 자료를 구성하였다. 최종적으로 더 나은 자료의 해석을 위해 생존분석, 다중회귀분석, 토빗분석 등 다양한 통계기법을 적용하여 결론을 도출하였다.

• 대한의생명과학회지
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• 제25권4호
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• pp.381-389
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• 2019

The physiological function test is the only patient contact area in the field of clinical laboratory. We need to recruit and encourage the experts due to requiring the expertise and long time for examination. However, there is currently no rule for estimating optimal workforce in the field of physiological function tests. The purpose of this study is to establish the basis of the studies for mid- to long-long term job creation in the field of ultrasound by evaluating the number of appropriate tests and appropriate workforce. We calculated the quantitative and qualitative workload for the number of appropriate tests and appropriate workforce using online questionnaire. All statistical analyses were performed using SPSS version 18.0 (SPSS Inc., Chicago, IL, USA). A total of 216 respondents were 48 (22.2%) male and 168 (77.8%) female. A total of 157 laboratories were 62 (39.5%) for echocardiography, 91 (58.0%) for the transcranial Doppler (TCD) and 4 (5.7%) for the carotid ultrasound. The mean number of appropriate tests was 10 ± 2 in the echocardiography, 9 ± 2 in TCD and 11 ± 2 in the carotid ultrasound. In addition, the number of laboratories required to recruit employees for appropriate workforce was 19 in echocardiography, 18 in TCD, and 0 in carotid ultrasound. The number of hospital required to recruit workforce were 7 primary hospitals, 22 secondary hospitals, 7 third hospitals. This study can be used as an important data as the first study at present time when the data on the workforce status and work environment of the ultrasonic laboratories is insufficient. Based on the quantitative and qualitative workloads, the number of appropriate tests and appropriate workforce can support mid- to long-long term job creation in the field of ultrasound.