• 한국독성학회:학술대회논문집
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• 한국독성학회 2003년도 추계학술대회
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• pp.190-191
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• 2003

We investigated the effects of gestational and lactational exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differential induction of CYP1A1 in the levels of protein and gene expression in the liver and brain regions of offspring rats. For this study, pregnant Sprague Dawley rats were orally exposed to TCDD (1 or 10 ng/kg body weight/day) starting at Day 1 of gestation up to Day 20 of postpartum. (omitted)

• 한국동물학회:학술대회논문집
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• 한국동물학회 2000년도 공동 춘계학술대회
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• pp.91.2-91
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• 2000

No Abstract, See Full Text

• 한국사회복지학회:학술대회논문집
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• 한국사회복지학회 2006년도 춘계학술대회
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• pp.113-115
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• 2006

• 한국동물학회:학술대회논문집
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• 한국동물학회 1999년도 한국생물과학협회 학술발표대회
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• pp.42.2-42
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• 1999

No Abstract, See Full Text

• Asian-Australasian Journal of Animal Sciences
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• 제17권9호
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• pp.1223-1226
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• 2004

Previously candidate gene approach revealed estrogen receptor (ESR) locus was associated with increased litter size. In this study, PvuII polymorphisms of ESR gene was detected by PCR-RFLP, and ESR locus was evaluated for its association with reproductive tracts components in the Large $White{\times}Meishan$ ($LW{\times}M$) F2 offspring. Ninety seven gilts with reproductive tracts components records and 136 offspring with performance traits records were genotyped and the results were used to estimate allele substitution effects. The results showed that two alleles (A and B) were identified, and 121 bp fragments were observed for the AA genotype and 65 bp and 56 bp fragments for the BB genotype; the length of uterine body (LUB) of BB gilts were significantly shorter than AA gilts', the additive effect was -1.762 cm; the uterine weight (UW) of AB gilts were significantly lighter than AA gilts' with the additive effect -18.058 g; no significant associations of ESR alleles with ovulation rate (OR), length of uterine horn (LUH), length of uterine cervix (LUC), weight of two ovaries (OW), volume of uterine lumen (VUL), length of oviduct (LO) were observed. BB genotypes gilts need significantly less days to 100 kg ($D_{100kg}$) than AA genotypes (p<0.01), the additive effect was per copy of B allele. Allele B is also favorable for average daily gain (ADG), with additive effect 0.015 kg/d (p<0.05). There was no difference between genotypes for backfat thickness at the 13th rib (SF13), loin meat height (ELMH), and loin meat percentage was estimated (ELMP), individual birth weight (IBW) and teat number (TN).

• 한국환경성돌연변이발암원학회지
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• 제21권2호
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• pp.77-81
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• 2001

Kamijadowhan (KMD), an oriental herbal medicine used for anti-angiogenic effect, was extracted with 80% ethanol from mixture of source materials and lyophilized. KMD was orally administered to plugpositive pregnant rats from gestational days 12 to 20, dividing into three groups including vehicle-treated control, 0.5 g/kg or 3 g/kg KMD-treated groups. Dam weight during gestation and post-gestation, weight of pre- and post-weaning offsprings in male and female, and reproductive and developmental endpoints including incisor eruption, eye opening and testes descent were measured. No significant alterations in development of physical landmarks in offspring, maternal weight gain during gestation and post-gestation, and offspring weight were observed in KMD-treated group. The measurement of organ weight at post-gestational days 21 was not changed in dams. In 0.5 g/kg KMD-treated rats, kidney weights in male and female offsprings were significantly increased, and the body weight in male offspring was also increased. Liver and brain weights were not changed. Taken together, these data suggest that KMD may not significantly cross the placenta and produce no reproductive and developmental toxicity at maternally non-toxic dosages.

• 농촌지도와개발
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• 제16권3호
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• pp.503-532
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• 2009

This study aims at identifying any difference in the quality of life according to the patterns of living together in the family for the aged women who live in the rural areas. The findings of this study can be summarized in brief. First, those aged women who live alone showed a higher ratio of works like farming with less average income and less perception of living standards but better ADL than those of the aged women who live together with their family. Second, as a result of logistic regression analyses to identify factors to predict the patterns of living together in the family for the aged women in the rural areas, those aged women who live alone showed more cases of farming, higher ADL level, higher degree of economical preparations and more perception of intimacy with their offspring than those of aged women who live together with their family. Unlike these results, those aged women who live together with their family have less average income, more phone calls with their neighbor and higher quality of life that those of aged women who live alone. Third, as a result of impact variables in the quality of life by the pattern of living together in the family for the aged women in the rural areas, those aged women who live together their family showed higher quality of life with better preparations for the health, emotion and economy for their aged life, and with less number of offspring and more frequency of phone calls with their neighbor. In addition, those aged women who live along in the rural areas showed higher quality of life with better emotional preparations, better economic preparations, more number of offspring, more friendly with their neighbor and more emotional supports.

• 한국환경보건학회:학술대회논문집
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• 한국환경보건학회 2005년도 국제학술대회
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• pp.73-83
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• 2005

Higher methylmercury (MeHg) accumulation and susceptibility to toxicity in the fetus than in the mother at parturition is well known. However, the difference in MeHg exposure to fetus and offspring throughout gestation and suckling is not well established. In the human, the effects of MeHg exposure on pregnant and breast-feeding women remain an important issue for elucidation, especially those of continuous uptake in high-fish-consumption populations. The purpose of this paper was to evaluate the difference in MeHg exposure to fetus and offspring throughout gestation and lactation using our recent animal and human studies data. In the animal study, adult female rats were given a diet containing 5 ${\mu}$g/g Hg (as MeHg) for 8 weeks. Then they were mated and subsequently given the same diet throughout gestation and suckling. On embryonic days 18, 20, 22 and at parturition, the concentrations of Hg in the brains of fetus were approximately 1.5-2.0 times higher than those in the mothers. However, during the suckling period Hg concentrations in the brain rapidly declined to about 1/10 of that during late pregnancy. Hg concentrations in blood also decreased rapidly after birth. In human study, Hg concentrations in red blood cells (RBCs-Hg) in 16 pairs of maternal and umbilical cord blood samples were compared at birth and 3 months of age after parturition. RBCs-Hg concentration in the umbilical cords was about 1.6 times higher than those in the mothers at parturition. However, all the infants showed declines in Hg concentrations throughout the breast-feeding period. The Hg concentration in RBCs-Hg at 3 months of age was about half that at birth. Both the animal and human studies indicated that MeHg exposure to the fetus might be especially high but it dramatically decreases during the suckling period. Therefore, close attention should be paid to the gestation rather than the breast-feeding period to avoid the risk of MeHg to human infants.

• 한국정보과학회논문지:소프트웨어및응용
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• 제28권11호
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• pp.833-841
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• 2001

본 논문에서는 진화프로그래밍에서 레비 확률분포(Levy probability distribution)를 사용한 돌연변이 연산의 유용성을 레비 돌연변이 연산 후의 변수의 평균변화율(mean square displacement) 및 유일성(distinctness) 등을 통하여 분석하였다. 레비 확률분포는 무한의 분산(infinite second moment을 가지는 확률분포로 쪽거리(fractal)와 연계되어 최근 연구가 활발히 진행되고 있는 확률분포이다. 레비 확률분포를 사용한 레비 돌연변이 연산은 변화가 작은 자손(offspring)뿐만 아니라 기존의 정규분포를 사용한 돌연변이 연산에 비하여 상대적으로 변화가 큰 자손을 생성할 수 있다. 이러한 사실에 기초하여 레비 돌연변이 연산은 보다 넓은 탐색 공간을 효율적으로 조사할 수 있음을 평균변화율 및 유일성 등의 조사를 통하여 수학적으로 증명하였다. 이를 통하여 진화 프로그래밍에서 레비 확률분포에 기초한 돌연변이 연산이 정규분포를 사용한 돌연변이 연산보다 다변량 함수의 최적화의 경우 일반적으로 효율적인 연산임을 알 수 있었다.

• Fisheries and Aquatic Sciences
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• 제11권2호
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• pp.82-87
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• 2008

Marine fisheries are important natural resources and must be maintained, especially fish species that are important sources of food. Despite the increase in stocking programs to maintain fisheries with artificially raised fish, the genetic impact stocking has on the wild fry population has not been addressed. Genetic variation in rock bream, Oplegnathus fasciatus, within and between wild-caught parents and the $F_1$ generation produced by them in 1 day was assayed using nine highly variable micro satellite markers. The nine micro satellite loci used in this study displayed diverse polymorphisms, and in total, 98 different alleles were observed over all loci. Differences in genetic variability of the $F_1$ offspring compared to their wild-caught parents (brood stock) were observed in terms of allele frequency, gene diversity, and heterozygosity. Although the $F_1$ generation of rock bream was missing 16% of the micro satellite alleles, no significant reduction was found in mean heterozygosity of the $F_1$ population compared to the brood stock. Eight of nine loci showed significant Hardy-Weinberg equilibrium (HWE) deviations in the $F_1$ population, while the brood stock deviated from HWE at three micro satellite loci (KOF85, KOF360 and KOF374). These deviations showed mostly a deficit of heterozygotes. Our results provide evidence for genetic differences in the $F_1$ hatchery offspring compared to their wild-caught parents and reinforce the need for a series of consecutive egg collections to avoid the loss of genetic variability. This also further underscores the importance of monitoring genetic variability of hatchery populations for the conservation of natural rock bream resources.