Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Tissue-Specific Splicing and Expression of Cyp1A1 in the Liver and Brain of Offspring Rats after Gestational Exposure to 2,3,7,8-Tetrachlorodibenzo-P-Dioxin

  • Lim, Hak-Seob (Institute of Genetic Engineering, Changwon National University) ;
  • Lee, Chul-Won (Institute of Genetic Engineering, Changwon National University) ;
  • Kim, Yong-Hoon (Institute of Genetic Engineering, Changwon National University) ;
  • Joo, Woo-Hong (Department of Biology, Changwon National University) ;
  • Yong-Kweon (Department of Biochemistry and Health Science, College of Natural Sciences, Changwon National University) ;
  • Moon, Ja-Young (Department of Biochemistry and Health Science, College of Natural Sciences, Changwon National University)
  • Published : 2003.10.01
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Abstract

We investigated the effects of gestational and lactational exposures to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the differential induction of CYP1A1 in the levels of protein and gene expression in the liver and brain regions of offspring rats. For this study, pregnant Sprague Dawley rats were orally exposed to TCDD (1 or 10 ng/kg body weight/day) starting at Day 1 of gestation up to Day 20 of postpartum. (omitted)

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