• 한국산업보건학회지
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• 제30권3호
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• pp.249-255
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• 2020

Objective: The purpose of this study was to provide technical information about the management of occupational exposure limits(OELs) for substances with completely revised ACGIH TLVs. Methods: The history of ACGIH TLVs for aluminum compounds, the reason for the complete revision of the related ACGIH TLV in 2008, and OELs for them in respective countries were reviewed. In addition, the results of a 2019 work environment assessment for aluminum compounds in Korea were reviewed. Results: In 1979, the ACGIH set up the TLVs for aluminum compounds considering types of compounds such as metal dust, pyro powders, welding fumes, soluble salts, alkyls, and aluminum oxide. However, in 2008 the ACGIH withdrew the TLVs for all types of aluminum and its compounds and adopted new TLVs for aluminum metal and insoluble compounds. This can cause confusion in many countries in the management of exposure to aluminum compounds because they adopt or refer to the ACGIH TLVs. Conclusion: Although Korea is setting occupational exposure limits by referring to the ACGIH's TLVs, it is necessary to sufficiently review whether it is necessary to accept the TLVs as they are if a TLV is completely changed, like took place with the revision of aluminum compounds in 2008.

• 한국산업보건학회지
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• 제25권1호
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• pp.45-57
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• 2015

Objectives: This study aims to compare the physicochemical characteristics, toxicological data with Occupational Exposure Limits (OELs) of chemicals under the Occupational Safety and Health Act(OSHA) regulated by the Ministry of Employment and Labor of Korea. Methods: Information on chemicals which have OELs on physicochemical characteristics and toxicological data was collected using Material Safety Data Sheet(MSDS) from Korea Occupational Safety and Health Agency(KOSHA) and the Korea Information System for Chemical Safety Management(KISChem) in 2014. Statistical analyses including correlation and simple regression were performed to compare the OELs with chemical characteristics including molecular weight, boiling point, odor threshold, vapor pressure, vapor density, solubility and octanol-water partition coefficient(OWPC) and toxicological data such as median lethal dose($LD_{50}$) and median lethal concentration($LC_{50}$). Results: A total of 656 chemicals have OELs under OSHA in Korea. The numbers of chemicals which have eight-hour time weighted average(TWA) and short term exposure limits(STEL) are 618 and 190, respectively. TWA was significantly correlated with boiling point and STEL was only correlated with vapor pressure among physicochemical characteristics. Solubility and OWPC between "skin" and "no skin" substances which indicate skin penetration were not significantly different. Both $LD_{50}$ and $LC_{50}$ were correlated with TWA, while the $LC_{50}$ was not with STEL. As health indicators, health rating and Emergency Response Planning Guidelines(ERPG) rating as recommended by the National Fire Protection Association(NFPA) and American Industrial Hygiene Association(AIHA) were associated with OELs and reflect the chemical hazards. Conclusions: We found relationships between OEL and chemical information including physicochemical characteristics and toxicological data. The study has an important meaning for understanding present regulatory OELs.

• 한국산업보건학회지
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• 제30권2호
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• pp.87-98
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• 2020

Objective: The purpose of this study was to propose a sequential procedure for the simultaneous analysis of soluble and insoluble metal compounds. Methods: Methods for sampling and analyzing metal compounds such as ISO standards, NIOSH methods, HSE methods, and OSHA methods were reviewed. Results: Some metals have different OELs depending on the solubility of the compound. Therefore, we should take into account these characteristics and perform an exposure assessment. Soluble metal compounds are first extracted from the filter, and then the filter is digested by acids to analyze residual insoluble components. The extraction of soluble compounds can be completed by agitation for about 60 minutes with a leach solution (water) in a water bath at 37℃. For the analysis of insoluble compounds, the sample filter and the filtration filter remaining after the extraction of the soluble compounds are analyzed. This allows simultaneous determination of soluble and insoluble metal compounds. For hexavalent chromium compounds, soluble hexavalent chromium can first be extracted from the filter by using sulfate buffer. The insoluble hexavalent chromium remaining in the filter can then be extracted using carbonate buffer. Conclusion: Workers are often exposed to many hazardous substances with different exposure limits at industrial sites. The OELs for compounds of the same metal can be set differently depending on solubility. This study can help evaluate a worker's exposure to metal compounds by suggesting methods for the simultaneous determination of soluble and insoluble metal compounds.

• 한국산업보건학회지
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• 제23권2호
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• pp.148-155
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• 2013

Objectives: This study was performed in order to compare the average levels and similarity of occupational exposure limits in South Korea, the U.S., the E.U., Germany, Japan and Finland. Methods: In this study, occupational exposure limits (OELs) for one hundred and seventy seven hazardous substances which are managed in the workplace by the Occupational Safety and Health Act in South Korea were matched with those of other countries. The units for the exposure limits of the same substance (identical CAS number) were unified and the exposure limits in each country were compared with threshold limit values (TLVs) of the American Conference of Governmental Industrial Hygienists (ACGIH) using a geometric mean method. Geometric similarity was calculated to assess the association by each country. Results: The exposure limits according to ACGIH TLVs in South Korea, the E.U., Germany, Japan, and Finland were 148, 37, 76, 90, and 110, respectively. When using TLVs of ACGIH as a standard, the geometric mean ratios of Germany, Finland, the E.U., South Korea, and Japan were 0.79, 0.80, 0.82, 1.19, and 1.27, respectively. Geometric similarity with TLVs of ACGIH was highest in South Korea (0.75) followed by Japan (0.56), the E.U. (0.52), Finland (0.50), and Germany (0.46). Conclusions: Through the comparison of levels of OELs and similarities among South Korea, the U.S., the E.U., Germany, Japan, and Finland, we could better understand the characteristics of occupational exposure limits by country.

• 한국산업보건학회지
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• 제31권3호
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• pp.255-265
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• 2021

Objectives: The purpose of this study is to analyze the exposure characteristics of inorganic acids. Methods: We analyzed exposure data (n = 363,146) for six inorganic acids (hydrogen fluoride, hydrogen bromide, hydrogen chloride, phosphoric acid, nitric acid, and sulfuric acid) collected between 2017 and 2019 in South Korea. Measurement characteristics and exposure levels (ELs) were analyzed by inorganic acid, industry category, enterprise size, and measurement year. Results: Measurement percentage dominated in time-weighted average (TWA, 91%) compared to short term exposure limit (STEL) and Ceiling. Most of the measurements (79.7%) were collected from the manufacturing category of industry. Medians of ELs were mostly low (≤3% of the threshold limit), with the exception of sulfuric acid (4.6% of TWA and 10.5% of STEL). The percentages of exceeding 1% of the occupational exposure limits (OELs) in TWA were relatively high for sulfuric acid (35.8%) and hydrogen chloride (16.5%) compared to the other acids (4.2%-6.6%). In addition, the percentages of exceeding 1% of OELs in STEL or Ceiling were higher for sulfuric acid (22.9%), hydrogen chloride (12.3%), and nitric acid (8.2%) compared to the other acids (1.2%-1.9%). The small-sized enterprises showed higher ELs in TWA; contrarily, the large-sized enterprises had higher ELs in STEL or Ceiling. Conclusions: The measurement characteristics and ELs identified in this study could be useful for establishing safety and health policies for inorganic acids.

• 한국산업보건학회지
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• 제25권4호
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• pp.482-492
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• 2015

Objectives: Exposure Assessment for workplace hazards where the exposure level is below occupational exposure limits(OELs) has been performed without considering either the degrees of risk or exposure levels and has failed to lead to intervention in many cases. The objective of this study was to suggest and test an application framework for risk assessment methodology under the current exposure assessment system in Korea. Materials: First, we investigated the exposure assessment systems in Korea and other countries. To adopt some risk assessment techniques, we also analyzed risk assessment systems and compared them to exposure assessment systems. A few suggestions were made. We held a public hearing during an industrial hygiene conference and took surveys using a questionnaire. Results: The first suggestion was to implement the risk assessment and exposure assessment through a "one-stop" system. In that case, one expected question would be who has been doing the jobs so far. In most cases, industrial hygiene consulting services or laboratories have been performing exposure assessment for business owners. Business owners are required to perform risk assessment. As two different groups of people will be required to implement two things in a one-stop system, they need to share information. As an information vehicle to share information, commonly filed survey checklists were suggested. The second suggestion was to categorize exposure level into four groups instead of the current binary divisions based on OELs. In the risk assessment system, exposure level is divided into four groups utilizing the cut-points of 10%, 50%, and 100% of OELs. The same schema can be adopted in the exposure assessment system and different levels of requirements can be assigned for each group. The third suggestion was regarding the regulation system. To provide the suggestions some thrust toward being implemented in the field, changes should be made in the legal system. Two different types of new exposure assessment result reporting forms were suggested. Some investigations such as an ergonomic survey are officially accepted as risk assessment under the current legal system. A few items were suggested to be included in the exposure assessment result reporting to be accepted as risk assessment. A pilot study in two small factories was performed and pointed out the strengths and weakness of our suggestions. Conclusions: Discussions and studies on the improvement of the exposure assessment system have been held for decades and no tangible changes have yet been made. We hope this result can help realize healthy lives for workers in Korea.

• 한국산업보건학회지
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• 제28권1호
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• pp.80-90
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• 2018

Objectives: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for HCFC-123, which caused an acute hepatotoxicity incident. Methods: An acute hepatotoxicity incident due to the fire extinguishing agent HCFC-123 was investigated. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for HCFC-123. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: An OEL for HCFC-123 of 10 ppm($62.5mg/m^3$), which considered the $RfC_{worker}$ value, 5.56 ppm, produced in dose-response assessment and the exposure level of 19.1-20.9 ppm measured as an eight-hour TWA(time-weighted average) in the incident place, is recommended. HCFC-123 is urged to be included as a chemical requiring legal management in the Occupational Safety and Health Regulations. In addition, it is recommended that a peak exposure of ACGIH be adopted in the Notice of the Ministry of Employment and Labor.

• 한국환경과학회지
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• 제25권4호
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• pp.505-516
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• 2016

With the development of nanotechnology, nanomaterials are used in various fields. Therefore, the interest regarding the safety of nanomaterial use is increasing and much effort is diverted toward establishment of exposure assessment and management methods. Occupational exposure limits (OELs) are effectively used to protect the health of workers in various industrial workplaces. This study aimed to propose an OEL for domestic multi-walled carbon nanotubes (MWCNTs) based on animal inhalation toxicity test. Basic procedure for development of OELs was examined. For OEL estimation, epidemiological study and quantitative risk assessment are generally performed based on toxicity data. In addition, inhalation toxicity data-based no observed adverse effect level (NOAEL) and benchmark dose (BMD) are estimated to obtain the OEL. Three different estimation processes (NEDO in Japan, NIOSH in USA, and Baytubes in Germany) of OELs for carbon nanotubes (CNTs) were intensively reviewed. From the rat inhalation toxicity test for MWCNTs manufactured in Korea, a NOAEL of $0.98mg/m^3$ was derived. Using the simple equation for estimation of OEL suggested by NEDO, the OEL of $142{\mu}g/m^3$ was estimated for the MWCNT manufacturing workplace. Here, we used test rat and Korean human data and adopted 36 as an uncertainty factor. The OEL for MWCNT estimated in this work is higher than those ($2-80{\mu}g/m^3$) suggested by previous investigators. It may be greatly caused by different physicochemical properties of MWCNT and their dispersion method and test rat data. For setting of regulatory OELs in CNT workplaces, further epidemiological studies in addition to animal studies are needed. More advanced technical methods such as CNT dispersion in air and liquid should be also developed.

• 한국산업보건학회지
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• 제26권2호
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• pp.109-118
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• 2016

Objectives: To review reference levels by the international and domestic management and provide the basis for setting occupational exposure limits(OELs) of radon in Korea Methods: Government's organizations with laws and systems for monitoring radon exposure were investigated and compared. There are five laws governing Indoor Air Quality(IAQ) control such as Occupational Safety and Health Act, Indoor Air Quality Control in Public Use Facilities, Etc. Act, School Health Act, Public Health Control Act and Parking Lot Act in Korea. It was surveyed that a total of 32 countries including 24 countries in the European Union(EU), six countries in Asian and two countries in North America setting the reference levels for radon in the world. Results: In Korea, there are set guidelines for radon in the Ministry of Environment and the Ministry of Education. Reference levels of radon for existing dwellings were $150{\sim}400Bq/m^3$ for Western European countries, and $200{\sim}1,500Bq/m^3$ in Eastern European countries. Approximately 67% of those EU countries were set up $400Bq/m^3$ to the standards for existing dwellings. EU countries such as Luxembourg, Finland, Norway, Sweden and Russia had adopted mandatory level for radon. Radon guidelines for new dwellings were set more strictly reference level($200Bq/m^3$) than existing dwellings. Conclusions: International organizations such as ICRP, UNSCEAR and NCRP, etc. had recommended the guidelines for radon. It was calculated the relation of the dose conversion factors with the annual effective doses. the OELs of radon suggest to need to establish $150Bq/m^3$ for office room and $400{\sim}1,000Bq/m^3$ for the workplace.

• 한국산업보건학회지
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• 제29권1호
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• pp.13-20
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• 2019

Objective: This study was performed to propose a domestic occupational exposure limit(OEL) following a health hazard assessment, calculation of a non-carcinogenicity reference concentration worker($RfC_{worker}$) value, and examination of international agencies' exposure limits. It also recommends legal management within the Occupational Safety and Health Act for PHMG-Phosphate(CAS No. 89697-78-9), It is a humidifier disinfectant that generated many lung injuries. Methods: We have investigated the recommendation or guidelines of foreign OEL for PHMG-Phosphate and the actual state of legal management in Korea. To examine the procedures and methods for recommendation OEL. Toxicological hazard and health hazard classifications were examined and a non-carcinogenicity $RfC_{worker}$ value was calculated for PHMG-Phosphate. An OEL and the necessity of legal management were recommended as well. Results and Conclusions: The OEL for PHMG-Phosphate is recommended to be $0.01mg/m^3$. The recommended OEL is close to 10 times the RfCworker value of $0.000833mg/m^3$ calculated from the chemical dose-response hazard assessment, which is a 2017 study. The CMIT/MIT(3:1) mixture, which was a social issue as a humidifier disinfectant substance, was also exposed to the same ratio in March 2018, establish the OEL. It is recommended to establish OEL for PHMG-Phosphate to prevent worker health hazards and for chemical safety management.