• 대한한방부인과학회지
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• 제26권4호
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• pp.213-222
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• 2013

Purpose: The purpose of this study is to evaluate the effects of Gyejigabuja-tang on a menopausal female patient complained of excessive sweating after bilateral salpingo-oophorectomy (BSO). Methods: We studied one menopausal female patient complained of excessive sweating who visited OO University Hospital from 10th July 2013 to 23th July 2013. We only treated her with Gyejigabuja-tang. The climacteric symptoms of the patient had been estimated with Numeric Rating Scale (NRS) and Menopause Rating Scale (MRS). Results: After treatment, climacteric symptoms were improved and the score of MRS was reduced from 20 to 10 during 12days. NRS score of sweating was reduced from 10 to 2. NRS scores of fatigue, hot flush, thirst, anorexia, dyspepsia, back pain and cramp of calves also reduced after treatment. Conclusions: This study suggests that Gyejigabuja-tang significantly reduced the climacteric symptoms of patient.

• Asian Pacific Journal of Cancer Prevention
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• 제14권6호
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• pp.3641-3645
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• 2013

Background: Assessment of the nursing staff knowledge, attitude and practices about cervical cancer screening in a tertiary care teaching institute of rural India. Materials and Methods: A cross sectional, descriptive, interview-based survey was conducted with a pretested questionnaire among 262 staff nurses of a tertiary care teaching and research institute. Results: In this study 77% respondents knew that Pap smear is used for detection of cervical cancer, but less than half knew that Pap smear can detect even precancerous lesions of cervix. Only 23.4% knew human papilloma virus infection as a risk factor. Only 26.7% of the respondents were judged as having adequate knowledge based on scores allotted for questions evaluating knowledge about cervical cancer and screening. Only 17 (7%) of the staff nurses had themselves been screened by Pap smear, while 85% had never taken a Pap smear of a patient. Adequate knowledge of cervical cancer and screening, higher parity and age >30 years were significantly associated with self screening for cervical cancer. Most nurese held a view that Pap test is a doctor procedure, and nearly 90% of nurses had never referred a patient for Pap testing. Conclusions: The majority of nursing staff in rural India may have inadequate knowledge about cervical cancer screening, and their attitude and practices towards cervical cancer screening could not be termed positive.

• Journal of Microbiology and Biotechnology
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• 제19권9호
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• pp.1051-1054
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• 2009

This cross-sectional study examined the distribution of HPV 58 sequence variation in Korean women for the first time. Among 1,750 Korean women, 53 women were positive for HPV 58 single infection, of whom 26 were without disease, 20 were with cervical intraepithelial neoplasia (CIN) 1, and 7 with CIN 2 or 3. Altogether, 36 different nucleotide sequence variations were identified with the L1, 20 within E2, 5 within E6, and 10 within E7. Further studies on variants of oncogenic HPVs are necessary, particularly for the purpose of developing more predictive HPV detection methods.

• 대한한방부인과학회지
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• 제26권1호
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• pp.121-134
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• 2013

Objectives: The purpose of this study is to evaluate the effects of Shihogayonggolmoryo-tang on climacteric symptoms. Methods: We studied 5 climacteric symptoms patients who visited Oriental Hospital of OO University from March 2012 to September 2012. We treated them with Shihogayonggolmoryo-tang, acupuncture and moxibustion. The patients of climacteric symptoms had been estimated with Kupperman's index. Results: After treatment, climacteric symptoms were improved and mean score of Kupperman's index was reduced(the first case reduce from 82 to 13 during 3 months, the second case reduce from 81 to 19 during 2 months, the third case reduce from 80 to 21 during 2 months, the fouth case reduce from 50 to 9 during 2 months, the fifth case reduce from 66 to 17 during 1 month). Conclusions: This study suggests that Shihogayonggolmoryo-tang is significantly effective on climacteric symptoms patients.

• 대한한방부인과학회지
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• 제21권3호
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• pp.99-110
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• 2008

Purpose: Premenstrual syndrome(PMS) is a collection of physical, psychological and emotional symptoms related to a women's menstrual cycle. The symptoms are related with Autonomic Nervous system. The purpose of this study is to investigate the activity of Autonomic Nervous system in women with premenstrual syndrome(PMS) by using Heart Rate Variability(HRV). Methods: We studied 26 patients visiting ㅇㅇ hospital from 26th December 2005 to 26th April 2006. Activity of Autonomic Nervous system was assesed by means of Heart Rate Variability(HRV). The subjects were categorized in two groups, PMS group(10) and non-PMS group(16). We studied the difference of HRV between two groups by Mann-Whitney U-test using SPSS for windows (version 12.0). Results: SDNN of PMS group was non-significantly lower than non-PMS group. RMS-SD of PMS group was significantly lower than non-PMS group. Mean PR of PMS group was non-significantly higher than non-PMS group. TP, VLF, LF, HF norm of PMS group was non-significantly lower than non-PMS group. HF of PMS group was significantly lower than non-PMS group. LF norm, LF/HF ratio of PMS group was non-significantly higher than non-PMS group. Conclusion: The results suggest that PMS can be related to decreased activity of parasympathetic nervous system. HRV can be useful to diagnose PMS. The more studies to diagnose PMS would be needed.

• Clinical and Experimental Reproductive Medicine
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• 제26권3호
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• pp.457-465
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• 1999

Objective: The presence of Y chromosome in patients with gonadal dysgenesis is related to the risk of gonadoblastoma. Since the patients with abnormal sexual differentiation may have cryptic Y mosaicism, it is important to detect the presence of Y material in these patients. But sometimes it is difficult to detect Y material only with karyotyping. This study was performed to evaluate the usefulness of the SRY gene screening in blood and gonad by using PCR in detecting the presence of Y material and possible tissue mosaicism in patients with gonadal dysgenesis as Turner syndrome and 46,XY pure gonadal dysgenesis (PGD, Swyer syndrome). Method: In 26 patients with gonadal dysgenesis, we screened for Y material by using PCR for SRY gene in peripheral leukocytes and in gonadal tissues of some patients. They were 22 cases of Turner syndrome (7 45,XO, 2 46,Xi(Xq), 3 45,XO/46,XX, 5 45,XO/46,Xi(Xq), 1 45, XO/46,XY, 1 45,XO/46,Xi(Yq), 1 45,XO/47,XYY, 1 46,XX,del(X)(q24) and 1 46,X,+mar) and 4 cases of 46,XY pure gonadal dysgenesis. PCR for SRY gene in the gonadal tissue was performed in 5 Turner syndrome and 2 PGD to determine the cryptic Y mosaicism between blood and gonad. Results: By using PCR analysis for SRY, Y chromosome material was detected in the blood of 4 of 22 Turner syndrome patients (45,XO/46,Xi(Xq), 45,XO/46,Xi(Yq), 45,XO/46,XY, and 45, XO/47,XYY), 3 of 4 46,XY pure gonadal dysgenesis. Discrepancy between karyotyping and blood PCR for SRY was noted in 1 Turner syndrome (45,XO/46,Xi(Xq)) and 1 PGD. Laparoscopic gonadectomy was performed in Y containing or SRY positive cases. In addition, PCR analysis for SRY in the gonads of 5 Turner syndrome and 2 PGD showed discrepancy between blood and gonad or between both gonads in 3 Turner syndrome (45,XO/46,Xi(Xq), 45,XO/46,Xi(Y q), 45,XO/46,XY) and 2 PGD patients. Conclusion: In gonadal dysgenesis, PCR analysis for SRY gene is useful to detect the cryptic Y mosaicism that is sometimes undetected by karyotyping. And since there may be tissue mosaicism, it is necessary to evaluate Y mosaicism in various tissues even in the case without Y chromosome on karyotyping.

• Clinical and Experimental Reproductive Medicine
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• 제26권3호
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• pp.339-344
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• 1999

Objective: To evaluate incidence of microbial growth from the tip of the embryo transfer catheter after embryo transfer in relation to clinical pregnancy rate following in-vitro fertilization and embryo transfer. Method: This study was performed prospectively at the time of transcervical embryo transfer following conventional in-vitro fertilization and intracytoplasmic sperm injection procedures. Sixty three patients were enrolled in this study. Microbiological cultures were performed on endocervical swabs and embryo transfer catheter tips. Results: Positive microbial growths were observed from endocervical swabs in 45 (71.4%) women and from catheter tips in 30 (47.6%) women. There was no statistically significant difference seen in the mean number of oocytes fertilized or number and grade of embryos transferred between the group of patients without growth and the group of patients with positive microbial growth from catheter tips. The clinical pregnancy rate were 30.3% in the group of patients without growth and 13.3% in the group with positive microbial growth from catheter tips. This difference in clinical pregnancy rates was statistically significant. Conclusion: Our finding is that microbial contamination at embryo transfer may influence implantation rates. The major questions arising from our finding are whether eradication of endocervical micro-organisms is possible and whether their eradication will improve implantation rates.

• 사상체질의학회지
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• 제26권1호
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• pp.110-121
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• 2014

Objectives The purpose of this study was to report the effects of Korean medical treatment (acupuncture, moxibustion, herb medicine) combined with intense pulsed light (IPL) on three postpartum patients with freckles worsened during pregnancy. Methods and Results The postpartum patients with freckles were treated with acupuncture, moxibustion, herbal medication and IPL. The energy density of IPL was selected modified according to skin types classified by Sasang constitutional medicine. This efficacy of treatment was evaluated with observation. After treatment, freckles as well as various postpartum symptoms are improved. Conclusions This case report shows that the Korean medical treatment combined with IPL is effective in the treatment of postpartum patient's freckles. However further studies are still necessary.

• 대한한방부인과학회지
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• 제22권1호
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• pp.41-52
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• 2009

Purpose: This study was designed to investigate the anti-tumor metastasis by immunomodulating effects of extracts of Prunellae Spica. Methods: Antimetastatic experiment was conducted in vivo by using colon 26-M3.1 carcinoma. And we observed cytotoxicity of Prunellae Spica on colon 26-M3.1 carcinoma, L5178Y-R lymphoma cell, hela cell and macrophage. To observe the immnomodulating effects of Prunellae Spica, we estimated IL-6, IL-10, IL-12, TNF-${\alpha}$ from peritoneal macrophages. And we evaluated the activation of NK cell by using anti-asialo-GM1 serum. Results: We found that the administration of Prunellae Spica extracts significantly inhibited tumor metastasis in vivo. In an in vitro cytotoxicity analysis, cell growth are closer to 100% in case of colon 26-M3.1 carcinoma, L5178Y-R lymphoma cell, hela cell at low concentration. In case of macrophage, cell proliferation is closer to 100% less than $62.5{\mu}g/m{\ell}$ of Prunellae Spica extracts. The level of cytokine such as IL-6, IL-10, IL-12 which stimulates Prunellae Spica extracts was increased in dose-dependent manner compared to the control group. TNF-${\alpha}$ is hardly secreted less than $250{\mu}g/m{\ell}$ The depletion of NK cells by anti-asialo GM1 serum partly abolished the inhibitory effect of Prunellae Spica on tumor metastasis. Conclusion: Prunellae Spica appears to have considerable activity on the anti-metastasis by activation the immune system such as macrophage and NK cell.

• 대한한방부인과학회지
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• 제26권3호
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• pp.59-72
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• 2013

Objectives: The aim of this study was to assess the duration of lochia in women hospitalized at Korean medical postpartum care center and to identify factors that influence duration of lochia. Methods: On the obstetric variables of 315 cases, the duration of lochia was analyzed. In the postpartum care center, the obstetric variables were asked of 315 cases of women, and who examined a body composition. After discharge, women were surveyed for the duration of lochia by telephone. Results: The median duration of lochia was 30 days and the range was 18~53 days. Maternal age, parity and mode of delivery were associated with its duration. So, its duration was longer on women over the age of 35, multipara and women had a Cesarean section. Its duration was correlated with gestational age and BMI before pregnancy, but not neonatal gender, birth weight, maternal BMI change during pregnancy, maternal body weight gain, BMI before delivery. Conclusions: It was 30 days that the median duration of lochia of women who had been got Korean medical postpartum care management, and which was slightly different from previous studies. And it was influenced by maternal age, parity, mood of delivery, gestational age and BMI before pregnancy. In future more studies or surveys for the duration of lochia of women with no treatment, lochial pattern and so on should be done.