• 사상체질의학회지
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• 제21권2호
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• pp.107-114
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• 2009

1. Objectives : We analyzed the case reports published by the journal of Sasang Constitutional Medicine, to study Sasang Constitution diagnosis and characteristic of clinical practice. 2. Methods : It has been examined 138 case reports of Sasang Constitution society published from 1994 to 2008. We analyzed. patient's number, publication year, distribution of Sasang Constitution, title's characteristics and bases of constitution diagnosis. 3. Results and conclusions : 1) In the analysis of patient's number, 1 case report was almost part of the case reports, and the case reports ware many published after 2001. 2) In the analysis distribution of Sasang Constitution, Soyangin was the most Sasang Constitution, and Tae-umin was the next one and Soeumin, Taeyangin followed them. 3) In the analysis of the journal's title, Sasang Constitution, disease and symptom of Sasang Constitution were more important than prescription recently. 4) In the analysis of the journal's purpose, unique disease and response of treatment were almost part of the case reports. 5) In the analysis of diagnosis bases, subjective bases were more important than objective bases and Sasang Constitutional drug response. therefore we should do researches in objective bases and drug response in the future.

• 대한기계학회논문집B
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• 제28권7호
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• pp.879-886
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• 2004

A numerical optimization has been carried out to determine the shape of the three-dimensional channel with oblique ribs attached on both walls to enhance turbulent heat transfer. The response surface based optimization is used as an optimization technique with Reynolds-averaged Navier-Stokes analysis of fluid flow and heat transfer. Shear stress transport (SST) turbulence model is used as a turbulence closure. Numerical results fur heat transfer rate show good agreements with experimental data. four dimensionless variables such as, rib pitch-to-rib height ratio, rib height-to-channel height ratio, streamwise rib distance on opposite wall to rib pitch ratio, and the attack angle of the rib are chosen as design variables. The objective function is defined as a linear combination of heat-transfer and friction-loss related coefficients with a weighting factor. D-optimal method is used to determine the training points as a means of design of experiment. Sensitivity of the objective parameters to each design variable has been analyzed. And, optimal values of the design variables have been obtained in a range of the weighting factor.

• Communications for Statistical Applications and Methods
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• 제15권1호
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• pp.125-136
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• 2008

많은 실제적인 공학 설계문제에 있어서, 목적함수의 형태는 설계변수들에 의하여 정확하게 주어지지 않는다. 이러한 환경 하에서, 구조해석, 유체 역학 해석, 열역학 분석과 같은 등과 같은 문제에서 설계변수들의 값이 주어졌을 때 목적함수들의 값은 실제 실험이나 계산상의 실험을 통하여 얻어지게 된다. 일반적으로, 이러한 실험들은 많은 비용이 든다. 이런 경우에는 실험의 횟수를 가능한 적게 하기위하여, 목적함수의 형태를 예측하는 것과 병행하여 최적화를 수행하게 된다. 반응표면분석(Response Surface Methodology, RSM)은 이러한 접근 방법에서 잘 알려져 있다. 본 논문에서는 목적함수의 예측을 위하여 서포트 벡터 기계(Support Vector Machines, SVM)의 방법을 적용할 것이다. 이러한 접근에서 가장 중요한 과제들 중의 하나는 가능한 실험의 횟수를 적게 하기 위하여 적절하게 표본자료들을 배치하는 것이다. 이러한 목적에 서포트 벡터의 정보들이 효과적으로 사용되어짐을 보이고 제안한 방법의 효율성은 공학 설계문제에서 잘 알려진 수치 예제를 통하여 보인다.

• 대한기계학회논문집A
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• 제31권12호
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• pp.1165-1172
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• 2007

The spacer grid set is a part of a nuclear fuel assembly. The set has a spring and the spring supports the fuel rods safely. Although material nonlinearity is involved in the deformation of the spring, nonlinearity has not been considered in design of the spring. Recently a nonlinear response structural optimization method has been developed using equivalent loads. It is called nonlinear response optimization equivalent loads (NROEL). In NROEL, the external loads are transformed to the equivalent loads (EL) for linear static analysis and linear response optimization is carried out based on the EL in a cyclic manner until the convergence criteria are satisfied. EL is the load set which generates the same response field of linear analysis as that of nonlinear analysis. Shape optimization of the spring is carried out based on EL. The objective function is defined by minimizing the maximum stress in the spring while mass is limited and the support force of the spring is larger than a certain value. The results are verified by nonlinear response analysis. ABAQUS is used for nonlinear response analysis and GENESIS is employed for linear response optimization.

• 대한불안의학회지
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• 제11권1호
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• pp.33-37
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• 2015

Objective : Impaired response inhibition has been suggested to play an important role in the pathophysiology of obsessive-compulsive disorder (OCD). The aim of this study was to evaluate the response inhibition in patients with OCD, by using the Go/NoGo paradigm, and to better understand its associations with clinical symptoms. Methods : The participants included 63 OCD patients and 80 healthy volunteers matched in age and sex. response inhibition was evaluated using computerized Go/NoGo task, in which their commission error rates, omission error rates, and mean response times were measured. The severity of clinical symptoms in the OCD patients was assessed using Montgomery-Asberg Depression Scale and Yale-Brown Obsessive Compulsive Scale. Result : OCD patients showed significantly impaired inhibition and higher omission errors rates despite their slower response time, compared to normal controls. Clinical symptoms were not correlated with commission errors and omission errors. Conclusion : The present results indicate that impairment in response inhibition may play a critical role in the pathophysiology of OCD as a trait. These findings suggest that deficit of response inhibition may contribute to developing and maintaining clinical symptoms such as compelling need to repeat certain actions in patients with OCD.

• 한국지진공학회논문집
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• 제11권6호
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• pp.1-14
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• 2007

인접 구조물의 지진응답 제어를 위한 비선형 감쇠시스템의 최적 설계 방법에 관하여 연구하였다. 최적 설계를 위한 목적 함수로는 구조물의 응답과 감쇠기의 총 사용량을 고려하였으며, 상충하는 두 목적함수를 합리적인 수준에서 동시에 최소화하는 해를 구하기 위하여 유전자 알고리즘에 기반한 다목적 최적화 방법을 도입하였다. 또한, 최적화 과정에서 요구되는 비선형 시간이력해석을 수행하지 않고도, 비선형 이력감쇠기로 연결된 구조물의 지진응답을 효율적으로 평가하기 위하여 추계학적 선형화 방법을 접목하였다. 제시하는 방법의 효율성을 검증하기 위한 수치 예로서 20층과 10층의 인접 빌딩을 고려하였으며, 두 빌딩을 연결하는 비선형 감쇠시스템으로는 입력전압의 크기에 따라 변화하는 감쇠성능을 보이는 MR 감쇠기를 도입하였다. 제시하는 방법을 통하여 MR 감쇠기의 각 층별 최적 개수 및 감쇠용량을 결정할 수 있었으며, 이는 일반적인 균등분포 시스템에 비해 유사한 제어성능을 보이면서도 훨씬 경제적이었다. 또한, 인접구조물간 충돌에 대하여도 확률적으로 안정적인 거동을 보임을 검증하였으며, 제시하는 방법이 준능동 제어시스템의 최적 배치를 결정하기 위한 설계문제에도 적용할 수 있음을 보였다.

• Journal of Acupuncture Research
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• 제21권2호
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• pp.183-203
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• 2004

Objective : Tension-type headache is the most common headache. The objective of this study is to find the clinical manifestation of tension-type headache and correlation with autonomic bioelectric response. Methods : This observation was carried out on 60 patients with tension-type headache. We used headache questionnaire and the Autonomic Bioelectric Response recoder(ABR-2000) for this study. Results : 1. Distribution of sex & age : male : female=5 : 7, 50s&60s group (28.3%) 2. Duration of onset : over 5years(50%), over one years(83.4%) 3. Causes of illness : stress(58.3%), severe fatigue(53.5%), tension(33.3%) 4. Time of attack : irregular(56.7%), day time(16.7%) 5. Pattern of pain: heavy(31 people), stiffness of occipital region (27 people) tightening around the head(25 people) 6. Curve : 40%, 56.7%, 35.0% SL(Slope low) at peak 1, 2, 3/ SH&SI not found 7. Regulation : 16.7% RR(Regulation reverse) at peak 1, 25% RH(Regulation high) at peak 2, 15% RR(Regulation reverse) at peak 3 8. Graph : Activity-60.0%, 70.0%, 63.3% lowered reaction(L, LR, L!) at peak 1, 2, 3 Reactivity-83.3%, 95.0%, 93.3% lowered reaction at peak 1, 2, 3 Conclusion : We find tension-type headache has remarkable relativeness with autonomic bioelectric response.

• 전자공학회논문지SC
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• 제49권2호
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• pp.38-45
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• 2012

선천성 난청으로 태어난 아이를 조기에 진단하여 가능한 빨리 적절한 치료를 해줌으로써 치료 효과를 극대화하고, 이후에 발생되는 사회적 비용을 최소화할 수 있기 때문에 신생아로부터 난청 이상 유무를 객관적으로 판별하는 검사 장비가 필요하다. 대표적인 것으로 청성뇌간반응(auditory brainstem response, ABR) 검사가 있으나 클릭음(click sound)에 대한 반응으로 주파수 특이성이 없고 고주파수 대역에 대한 청력을 주로 반영하는 단점이 있다. 청성지속반응(auditory steady-state response, ASSR) 검사는 주파수 특이도는 좋으나 오진의 가능성이 조금 높다. 이러한 단점을 보완하여 청성뇌간반응 검사와 청성지속반응 검사를 하나의 시스템에서 측정하고, Fsp와 F-test 분석을 통하여 객관적 지표를 보여주는 시스템을 제안하였다. 하드웨어 구성요소를 최소화하고 소프트웨어 역할을 강화하여 추후 하드웨어 수정 없이 소프트웨어의 수정만으로 다양한 검사가 가능하도록 설계하였다. 제안한 시스템의 객관적 평가 기능은 정상인 10명을 대상으로 한 실험을 통하여 검증하였다.

• 한국시뮬레이션학회:학술대회논문집
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• 한국시뮬레이션학회 1994년도 추계학술발표회 및 정기총회
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• pp.1-2
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• 1994

With the prevalence of computers in modern organizations, simulation is receiving more atention as an effectvie decision -making tool. Simualtion is a computer-based numerical technique which uses mathmatical and logical models to approximate the behaviror of a real-world system. However, iptimization of synamic stochastic systems often defy analytical and algorithmic soluions. Although a simulation approach is often free fo the liminting assumption s of mathematical modeling, cost and time consiceration s make simulation the henayst's last resort. Therefore, whenever possible, analytical and algorithmica solutions are favored over simulation. This paper discussed the issues and procedrues for using simulation as a tool for optimization of stochastic complex systems that are dmodeled by computer simulation . Its emphasis is mostly on issues that are speicific to simulation optimization instead of consentrating on the general optimizationand mathematical programming techniques . A simulation optimization problem is an optimization problem where the objective function. constraints, or both are response that can only be evauated by computer simulation. As such, these functions are only implicit functions of decision parameters of the system, and often stochastic in nature as well. Most of optimization techniqes can be classified as single or multiple-resoneses techniques . The optimization of single response functins has been researched extensively and consists of many techniques. In the single response category, these strategies are gradient based search techniques, stochastic approximate techniques, response surface techniques, and heuristic search techniques. In the multiple response categroy, there are basically five distinct strategies for treating the responses and finding the optimum solution. These strategies are graphica techniqes, direct search techniques, constrained optimization techniques, unconstrained optimization techniques, and goal programming techniques. The choice of theprocedreu to employ in simulation optimization depends on the analyst and the problem to be solved. For many practival and industrial optimization problems where some or all of the system components are stochastic, the objective functions cannot be represented analytically. Therefore, modeling by computersimulation is one of the most effective means of studying such complex systems. In this paper, after discussion of simulation optmization techniques, the applications of above techniques will be presented in the modeling process of many flexible manufacturing systems.

• Asian Pacific Journal of Cancer Prevention
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• 제17권12호
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• pp.5315-5320
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• 2016

Purpose: Tumor cell growth and sensitivity to chemotherapy depend on many factors, among which insulin-like growth factors (IGFs) may play important roles. The aim of the present study was to evaluate the levels of insulin-like growth factors (IGFs) and IGF binding proteins (IGFBPs) in primary tumors and ascites as predictors of response to neoadjuvant chemotherapy in ovarian cancer (OC) patients. Materials and Methods: Tumor tissue samples and ascitic fluid were obtained from 59 patients with advanced OC. The levels of IGF-I, IGF-II, IGFBP-3, IGFBP-4 and PAPP-A were determined using ELISA kits. Taking into account the data on expression of these IGF-related proteins and outcome, logistic regression was performed to identify predictors of response to neoajuvant chemotherapy. Results: Human ovarian tumors expressed IGFs, IGFBP-3, IGFBP-4 and PAPP-A and these proteins were also present in ascites fluid and associated with its volume. IGFs and IGFBPs in ascites and soluble PAPP-A might play a key role in ovarian cancer progression. However, levels of proteins of the IGF system in tumors were not significant predictors of objective clinical response (oCR). Univariate analysis showed that the level of IGF-I in ascites was the only independent predictor for oCR. Conclusion: The level of IGF-I in ascites was shown to be an independent predictor of objective clinical response to chemotherapy for OC patients treated with neoadjuvant chemotherapy and debulking surgery.