• BMB Reports
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• v.50 no.12
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• pp.601-609
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• 2017

Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrientrich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.

• Clinical and Experimental Pediatrics
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• v.63 no.3
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• pp.110-114
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• 2020

Background: Subclinical hypothyroidism (SH) is a common condition in obese children. However, its effect on glucose and lipid metabolism in obese children remains controversial. Purpose: The present study aimed to investigate the association between SH and metabolic parameters. Methods: A total of 215 obese children and adolescents aged 6-18 years were included in this retrospective cross-sectional study. The patients' anthropometric measurements such as thyrotropin (TSH), free thyroxine (fT4), fasting plasma glucose, and insulin levels, as well as homeostasis model assessment for insulin resistance (HOMA-IR) index, and lipid profiles were evaluated. The patients were allocated to the SH group (fT4 normal, TSH 5-10 mIU/L) (n=77) or the control group (fT4 normal, TSH<5 mIU/L) (n=138). The glucose and lipid metabolisms of the 2 groups were compared. Results: SH was identified in 77 of 215 patients (36%). Mean body mass index was similar in both groups. The mean serum insulin, HOMA-IR, and triglyceride (TG) levels were higher and the mean high-density lipoprotein cholesterol level was lower in the SH group than in the control group (P=0.007, P=0.004, P=0.01, and P=0.02, respectively). A positive correlation was observed between TSH level and insulin level, HOMA-IR, and TG level. Conclusion: SH was identified in some of the obese children and adolescents. A clear association was observed between SH, insulin resistance, and dyslipidemia in obese children.

• Clinical and Experimental Pediatrics
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• v.54 no.2
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• pp.55-63
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• 2011

Prader-Willi syndrome (PWS) is a complex multisystem genetic disorder that is caused by the lack of expression of paternally inherited imprinted genes on chromosome 15q11-q13. This syndrome has a characteristic phenotype including severe neonatal hypotonia, early-onset hyperphagia, development of morbid obesity, short stature, hypogonadism, learning disabilities, behavioral problems, and psychiatric problems. PWS is an example of a genetic condition caused by genomic imprinting. It can occur via 3 main mechanisms that lead to the absence of expression of paternally inherited genes in the 15q11.2-q13 region: paternal microdeletion, maternal uniparental disomy, and an imprinting defect. Over 99% of PWS cases can be diagnosed using DNA methylation analysis. Early diagnosis of PWS is important for effective long-term management. Growth hormone (GH) treatment improves the growth, physical phenotype, and body composition of patients with PWS. In recent years, GH treatment in infants has been shown to have beneficial effects on the growth and neurological development of patients diagnosed during infancy. There is a clear need for an integrated multidisciplinary approach to facilitate early diagnosis and optimize management to improve quality of life, prevent complications, and prolong life expectancy in patients with PWS.

• Proceedings of the Plant Resources Society of Korea Conference
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• 2018.10a
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• pp.120-120
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• 2018

Intestinal microbiota is strongly connected to health of host. It has been reported that not only metabolic disease like diabetes and obesity, but psychological diseases are affected by composition of intestinal microbiota. To figure it out the importance of the composition and relationship between disease and microbiota, intensive researches have done with human and experimental animals. But, the composition of the intestinal microbiota could be affected by several factors such as experimental environments, feeding, water, and bedding. As a result, the data from each experimental group might be diverse. It also affects experiments about biological activities of plant materials. In this study, mouse intestinal bacteria were isolated from fresh feces and identified by 16S rRNA gene to use in biological activities of natural medicines. The fecal supernatant was anaerobically incubated at $37^{\circ}C$ for 48 hours. Colonies were picked up separately and incubated again in same condition to increase quantity to analyze and stock. The bacteria strains were listed up and could be used for many researches including biological activities of plant materials and change in composition of intestinal bacteria itself.

• Korean Journal of Health Education and Promotion
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• v.22 no.1
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• pp.41-54
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• 2005

Purpose : This study was undertaken in order to find out the actual condition and barriers of health education in elementary school after introduction of 7th curriculum modification. Method: A questionaire was sent by mail on November 1, 2003, and received a total of 230 till November 30, 2003. Among them, 198 were included in fmal analysis. The collected data was analyzed through frequency, percentage, mean and standard deviation. Results : The results of this study were as follows: Among of the school health task, the most time spending task was emergency treatment and medication. The health education content which now being taught was sex education and prevention of drug abuse in the 6th grade, prevention of obesity in the 5th grade, emergency treatment, safety education in the 4th grade and prevention of disease of teeth in the 3rd grade. The most difficult problem in health education was pointed to no subject, no hour about health education by policy. Conclusion : It was necessary to formalize the health education subject, to ensure of health education hour by policy and to establish of extra health education room to improve health education at elementary school.

• Journal of Korean society of Dental Hygiene
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• v.15 no.3
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• pp.399-410
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• 2015

Objectives: The purpose of the study is to investigate the influencing factors of metabolic syndrome on the periodontal disease in the Korean adults over 40 years old. Methods: The data were extracted from the Fifth National Health Nutrition Survey 2010. The subjects were adults over 40 years old. The periodontal diseases were examined by direct survey. The questionnaire consisted of the general characteristics of the subjects, oral health behavior, metabolic syndrome, and relation to periodontal diseases. CPI(community periodontal index) was measured. CPI indicates periodontal condition and classified into alveolar arch of the upper jaw and the lower jaw. A periodontal disease is defined as $CPI{\geq}3$(over 4 mm). The variables for metabolic diseases included hypertension, diabetes mellitus, dyslipidemia, and obesity measured as BMI. Results: Diabetes mellitus is closely related to periodontal diseases prevalence. Low level of HDL increase the periodontal diseases. Number of toothbrushung, use of dental floss and interdental toothbrush as for the number of toothbrushing, more than twice toothbrushing a day, and use of dental floss and interdental toothbrush reduced periodontal diseases. Conclusions: The risk factors of periodontal disease in Korean adults over 40 years old were sex, age, residence, monthly income, education level, smoking, diabetes and low HDL cholesterol.

• Korean Journal of Health Education and Promotion
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• v.27 no.4
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• pp.153-163
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• 2010

Objectives: Analysis and understanding on the health trend of college and university students are paramount to creating healthy campus communities. We evaluated the change of health status, health behavior, and influencing factors among them in the last ten years. Methods: Using the results of the ACHA-National College Health Assessment from 2000 to 2009, we reanalyzed the trend of health condition, health behavior, and health risk factors in linear regression model. Results: In general health of college and university students, major health problem were allergy problems, back pain, and sinus infection. Academic impacts were stress, sleep difficulties, cold/flu, concern for troubled friend or family member, relationship difficulty, and internet use or computer games. Although regular exercise was decreasing among them, it were more likely to have never smoking, no sexual partner, and eating of fruits/vegetables as time passed (p<0.05, p<0.01). Obesity and sleeping difficulty were increasing, while it were less likely to have feeling very sad, feeling hopelessness, and considering attempting suicide (p<0.05, p<0.01). Conclusion: These data expand the understanding of the health needs and capacities among young adults. For Korean college and university students, it is necessary to standardize the data-collection survey to set the college health and healthy campus.

• Journal of the Korean Home Economics Association
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• v.36 no.4
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• pp.1-18
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• 1998

The purpose of this study was to investigate relationship between the eating behavior, physical and mental health. For this purpose, the data was collected by using questionnaires and intervews distibuted to 293 the elderly residing in Seoul. This study was designed to observe the eating behavior(eating habit, healthy food preference, smoking, drinking), physical health(weight, height, desease and heath of the current and past, self-awareness of the health) and mental health(weight, height, desease and heath of the current and the past, self-awareness of the health) and mental health(meeting, excursion, exercise, service, activi ty, depression). The major results are: 1. The heathy elderly had the better eating habit and the non healthy tried to stop smoking and drinking for their own health. 2. There were many elderly with neuralgia and arthralgia, especially women were worse. The sleep disorder related to many disease. When physical health was bad, so was mental health. 3. More than 50 percentage of subjects had light depression, especially women and the elderly at 60-75age were more serious. The depressive elderly had no meetings, excursion, exercise, service activity and showed a hight tendency for under-weight or obesity. In conclusion, the relationship between the eating behavior and physical and mental health wa very significant, so it was necessary to provide comfortable living condition to the elderly.

• Women's Health Nursing
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• v.10 no.4
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• pp.291-300
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• 2004

Purpose: This study attempted to show the implications of obese female college students' weight control experiences and to use this as primary data for developing a nursing intervention. Method: The participants were 7 obese students who had tried losing weight at C College on Jeju Island. Their average age was 22 and BMI was $25.6kg/m^2$ on average. The data were collected from May 17th to July 6th 2004, and in-depth interviews were conducted with open-ended questions. Result: The analysis was conducted by Colaizzi's phenomenological method, and the analyzed results were categorized into 9 criteria, 22 theme clusters and 50 themes. The 9 criteria include withdrawal, desperation, self-restraint, relief, satisfaction, distraction, depression, regaining self-control and negligence of health. They tended to go through a weight gain loss cycle in a repetitive manner, and were faced with great physical and mental difficulties. In addition, they often went on a severely-strict diet without taking their health condition into consideration, which, in effect, causes various health problems. Conclusion: This study gives insights into the weight control experiences of obese female college students, and it shows developing more practical and effective nursing interventions are urgently needed.

• CELLMED
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• v.10 no.1
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• pp.5.1-5.6
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• 2020

In the present highly changing era, every dimension from Technology to Education, Environment to Sanitation and from Agriculture to our Food basket is getting changed. Our experiences say that the most affected ethnic group from this rapidly changing pattern of our food intake, lifestyle are our adolescent. This is also a fact that our adolescent passes their 2/3 of time of a day in their schools. In this regard our school system needs to formulate their comprehensive approach to Health for our adolescents. On other hand Ayurveda, the ancient Indian system of Medicine had expressed views on a concept of Holistic Health thousand years ago. This research article is an attempt of borrowing this valuable concept from Ayurveda and suggesting to introduce them into our comprehensive school health programme such as concept of wellness, quality of life, Holistic Health and measures related to diet and lifestyle for preservation, promotion of health and prevention of disorders etc. This manuscript also evaluates the existing approaches of school health programmes towards current scenario. Now a day's our food habits, dietary intake and the life style are not at the level of satisfactory condition this lead to early onset of metabolic chronic disorder especially in our adolescents because on the basis of age-immunity relationship they are easily targeted. The chronic metabolic disorders results into overweight, obesity, anxiety, mental trauma, distress, over- fatigued, incapable for physical work, getting tired soon. This article provides a space to rethink and reformulate our school health programmes in light of our ancient tradition of medicine.