• IMMUNE NETWORK
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• v.9 no.6
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• pp.255-264
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• 2009

Background: Chronic low grade inflammation is closely linked to type II diabetes, obesity, and atherosclerosis. Macrophages play a key role in the regulation of pro- or anti-inflammatory actions at the lesion sites of disease. Components of cordyceps militaris, cordycepin and adenosine, have been used for the modulation of inflammatory diseases. The effects of cordycepin in the modulation of macrophages have yet to be be elucidated. We investigated the effects of cordycepin and adenosine on the morphological changes of macrophages under the inflammatory condition of LPS and an anti-inflammatory condition involving high concentrations of adenosine. Methods: We confirmed the mRNA levels of the M1/M2 cytokine genes through RT-PCR and morphological change. Results: LPS-activated macrophages returned to their inactivated original shape, i.e., they looked like naive macrophages, through the treatment with high concentrations of cordycepin ($40{\mu}g/ml$). LPS and adenosine activated macrophages also returned to their original inactivated shapes after cordycepin treatment; however, at relatively higher levels of cordycepin than adenosine. This change did not occur with relatively low concentrations of cordycepin. Adenosine down-regulated the gene expression of M1 cytokines (IL-$1{\beta}$, TNF-${\alpha}$) and chemokines (CX3CR1, RANTES), such as cordycepin. Additionally, M2 cytokines (IL-10, IL-1ra, TGF-${\beta}$) were up-regulated by both cordycepin and adenosine. Conclusion: Based on these observations, both cordycepin and adenosine regulated the phenotypic switch on macrophages and suggested that cordycepin and adenosine may potentially be used as immunomodulatory agents in the treatment of inflammatory disease.

• Korean Journal of Oriental Medicine
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• v.16 no.3
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• pp.115-121
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• 2010

Objectives : Quality control of the needle tips and prevention of pollutions are important factor for safe and effective acupuncture treatment. Ear acupuncture needle is made by 3 companies in Korea, and used to treat for obesity or smoking in clinic frequently, but the Korean industrial Standard is proposed most recently. In spite of the importance, there has been little study about that. Moreover, there was no study about ear acupuncture needle. Methods : We investigated the current condition of needle shape and pollution about the tips and body of the ear acupuncture needle under the stereoscopic microscope. Samples are selected 100 pieces from 300 pieces randomly in each company. Results : The substandard needles are classified into four groups and counted 1. Normal condition (55.3%), 2. Scratch on the surface (14.0%), 3. Malformation of tips (19.3%), 4. Pollution of body (4.3%), 5. Multiple Substandard (7.0%). In the case of including type 2 as a standard needle, normal rate of A company was 81% when B was 76%, and C was 51%. Conclusion : The substandard ear acupuncture needles can induce local side effects such as needling pain or itching. Furthermore, it can disturb the proper effect of acupuncture treatment. We hope that this study can help to improvequality of ear acupuncture and reduce substandard rate for safe and effective ear acupuncture treatment.

• Journal of Nutrition and Health
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• v.35 no.1
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• pp.124-136
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• 2002

As the elderly population has increased in recent years in Korea chronic degenerative diseases prevalent in the aged have garnered attention in relation to food behavior. In general, dietary intakes of elderly Koreans were inadequate in quality as well as in quantity. Especially, intakes of Ca, vitamin A, and riboflavin along with total energy were insufficient. They tended to consume high carbohydrate and low fat energy rates which may be resulted from long standing vegetable-based flood patterns. Relationships between dietary intakes and indices of cardiovascular diseases revealed that blood pressures and serum lipids patterns tended to be poor in individuals having high abdominal fat accumulations which seemed to be related with dietary consumption of high carbohydrate and insufficient intake of many nutrients. These results suggested that a nutritionally balanced diet including animal sources floods is needed in order to prevent an abdominal obesity and cardiovascular diseases. The bone health status of the Korean elderly appeared poor. It was more serious in women recording a higher prevalence rate of osteopenia and osteoporosis than in men. There were strong associations between dietary factors and bone health status. Bone mineral density was found to be higher with higher intakes of protein energy rate, the total amount of feeds, and many nutrients including Ca and p, indicating that a good quality diet is essential in maintaining healthy bone status in later life. mental health condition of the elderly as measured by cognitive function and the degree of depression was also inadequate and had strong association with dietary consumption. The positive results were obtained in individuals having an adequate dict. Therefore, it could be summarized that the physical as well as mental health in elderly Koreans are highly related with their dietary patterns. Thus, the older adults need te consume nutritionally well balanced diet in sufficient amount, which contains various flood items including significant amounts of animal source floods in a daily diet in order to maintain healthy condition.

• Journal of Society of Preventive Korean Medicine
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• v.7 no.2
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• pp.1-12
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• 2003

The study was conducted to evaluate the difference of life style, subjective symptoms and health cognition depending on the Sasang Constitution in the industrial workers. The results were as follows ; Constitutional distribution among exposed group were Tae-eum In(38.4%), So-eum In(35.2%), and So-yang In(26.4%) and it was turned out that Tae-eum In took a higher portion of Sasang constitution than other constitutions in technician workers. 'Exercise' and 'Obesity' were found most in Tae-eum In, In So-eum In there were many 'Normal' weight and 'Having digestive disorders' were found most in So-eum In. There were no significant difference in the health cognition among the constitutions. The closer to 'normal' weight, the higher prevalence in 'having' concern about health condition and the more 'normal' condition in sleeping, the higher prevalence of 'having' self-confident in present health.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.12 no.7
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• pp.3123-3129
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• 2011

Deep-frying pork cutlets contains high fat and calories and can cause obesity, even though it has a high preference among young consumers in Korea. In this study, we have investigated the use of oven cooking method and is studying quality characteristics of pork cutlets for the contribute to improving national health. For the replace the deep-frying method, the pork cutlet was using canola oil added brown crumbs and optimization the oven cooking time, temperature, relative humidity, fan speed. The fat content and calories of oven pork cutlet reduced by 55.4% and 28.6% respectively(P<0.05), when compared to frying method. In a color experiment, texture characteristics and separation ration of batter, oven pork cutlet has no difference(P>0.05), in a sensory characteristics, overall taste has no different (P>0.05) with frying pork cutlet. Therefore, if pork cutlet cooking by oven with optimized condition, without impoverishment of consumer's preference because of the taste similarity with frying pork cutlet and these results may be helpful to people who need dietary treatment.

• Journal of Korean Physical Therapy Science
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• v.30 no.3
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• pp.72-83
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• 2023

Background: Normal-weight obese women have a normal weight with relatively low muscle mass resulting from high body fat. We aimed to investigate the effects of core exercise on body composition, abdominal muscle thickness, trunk muscular endurance, and psychological factors in normal-weight obese women. Design: One group pre-, mid-, and post-test design. Methods: A total of 20 normal-weight obese women were recruited voluntarily. Core exercises were performed for 30 minutes, three times a week for 4 weeks. InBody measurements, ultrasound imaging, and clinical tests were used to assess body composition, abdominal muscle thickness, trunk and core muscular endurance, and psychological condition(satisfaction with appearance and self-esteem). The dependent variables were measured three times: before the intervention (pre-test), 2 weeks after the intervention (mid-test), and 4 weeks after intervention (post-test). One-way repeated measures ANOVA and Friedman test were used for statistical analysis. Results: Although there was no change in the body composition (p>0.05), thickness of the transversus abdominis and internal and external oblique muscles, endurance of the trunk flexors and extensors and core muscles, and psychological condition showed significant differences after the intervention (p<0.05). Conclusion: Our findings will help develop exercise programs for normal-weight obese individuals that utilize the beneficial effect of core exercises.

• The International Journal of Costume Culture
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• v.4 no.2
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• pp.77-85
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• 2001

The purpose of this study was to classify the somatotype around a upper body of 30's men. The subjects were 202 working men aged from 30 to 39 and the data of 33 items including computed items were analysed by factor analysis and cluster analysis. Re results were as follows: As a factor of somatotype in evaluating males in 30's, the horizontal area represented the chest circumference at scye and the breadth items, the vortical region indicated hit length posterior, front length, back length, the breadth difference and the length difference. The somatotype by cluster analysis was classified with 3 type. Type I as the Roher's index 1.21 indicating the smallest in the circumference and weight item was classified as the thin and long featuring bending somatotype. Type 2 with the Rohrer's index 1.35 showing the mid-group between type 1 and 3 had the highest distribution rate as the balanced featuring the standard somatotype. Type 3 as the rohrer's index 1.40 was the largest physical condition group in the obesity featuring the turning over somatotype.

• Journal of Korean Academy of Nursing
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• v.41 no.3
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• pp.411-422
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• 2011

Purpose: The aim of this study was to clarify the actual condition of elders with dementia who were registered in the Seoul Dementia Management Project. Methods: Data were collected from 5,312 elderly patients with dementia. Demographic included characteristics, comorbidity, and healthy lifestyle habits; data from the Seoul Dementia Management Project. Results: First, demographic characteristics were as follows; mean age at the time of definite diagnosis was 78.0 yr. There were slightly more women (69.3%), and 4.55 yr was the average length of education with 41.4% being illiterate or uneducated patients. Second, there were several comorbidities including hypertension (61.7%), diabetes mellitus (31.8%), hypercholesterolemia (10.2%), heart disease (11.1%), obesity (4.2%), and stroke (21.4%). Third, alcoholic history was found in 11.8% of the patients, and smoking in 9.8%. Regular exercise was done by only 29.1% of the patients with dementia. Finally, significant differences between men and women were found for the following; age, education, medical security, hypertension, diabetes mellitus, stroke, alcoholic consumption, smoking, and regular exercise. Conclusion: Authors expect that the present data will be used for establishment of dementia associated projects and policies.

• Journal of the East Asian Society of Dietary Life
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• v.21 no.1
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• pp.146-153
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• 2011

For the purpose of carrying out nutrition counseling effectively and efficiently, this study assessed the nutrition counseling practice, perception and nutrition knowledge of elementary school children in Gyeongbuk province. Survey questionnaires were distributed between November 2009 and December 2009 to 100 nutrition counseling experienced children (participants) and 110 nutrition counseling non-experienced children (non-participants) and were completed with nutrition teachers' assistance. According to the survey results, girls and overweight/obese children showed higher tendency of participation in nutrition counseling (p<0.001). Participants who took nutrition counseling according to their own intentions showed satisfaction after counseling on diverse subjects such as obesity, unbalanced diet, and weight control. Particularly, 'lack of counseling session time', 'unfavorable counseling condition' or 'difficult explanation' caused participants unsatisfaction after counseling. Participants usually perceived the meaning of nutrition counseling more correctly than non-participants and showed positive intentions for taking further counseling in the future(p<0.001). Diet good for weight control, good food to fix unbalanced diet and diet good for growing stature were the top three subjects of nutrition counseling chosen by subjects (p<0.001). Participants also showed higher nutrition knowledge scores than non-participants. Therefore, it is critically important to apply nutrition counseling in the proper environment (counseling room, time, teaching materials, etc) to elementary school students to fix healthy food habits. Therefore, nutrition teachers need to be provide professional nutrition counseling skills and knowledge.

• BMB Reports
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• v.50 no.12
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• pp.601-609
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• 2017

Mammalian target of rapamycin complex 1 (mTORC1) plays a major role in cell growth, proliferation, polarity, differentiation, development, and controls transitioning between anabolic and catabolic states of the cell. It collects almost all extracellular and intracellular signals from growth factors, nutrients, and maintains cellular homeostasis, and is involved in several pathological conditions including, neurodegeneration, Type 2 diabetes (T2D), obesity, and cancer. In this review, we summarize current knowledge of upstream signaling of mTORC1 to explain etiology of T2D and hypertriglyceridemia, in which state, the role of telomere attrition is explained. We discuss if chronic inhibition of mTORC1 can reverse adverse effects resulting from hyperactivation. In conclusion, we suggest the regulatory roles of telomerase (TERT) and hexokinase II (HKII) on mTORC1 as possible remedies to treat hyperactivation. The former inhibits mTORC1 under nutrientrich while the latter under starved condition. We provide an idea of TOS (TOR signaling) motifs that can be used for regulation of mTORC1.