• 생명과학회지
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• 제26권6호
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• pp.651-656
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• 2016

벌 화분은 꿀벌로부터 생산되며 자연으로부터 얻을 수 있는 가장 균형 잡힌 영양 식품으로 받아들여지고 있다. 역사적으로도 벌 화분은 질병치료와 에너지 보충의 목적으로 사용되어 왔다. 최근의 연구 결과에서는 벌 화분의 항산화, 항염증, 심지어 항암작용과 같은 다양한 생리활성이 과학적으로 규명되고 있다. 그러나 벌 화분은 exine이라는 외피로 둘러싸여 있어 강산이나 고압 그리고 소화효소 등에 매우 저항성이 강한 것으로 밝혀졌고, 이로 인하여 생체이용률이 낮아 영양공급과 임상적 이용에 제한을 받고 있다. 본 연구는 벌 화분의 외피를 분쇄할 수 있는 습식분쇄기술을 개발하여 벌 화분의 생리활성을 분석하고자 기획되었다. 먼저 습식분쇄를 통해 벌 화분의 외피가 효과적으로 분쇄됨을 현미경을 통해 확인하였다. 게다가 습식분쇄에 의해 벌 화분의 활성성분으로 잘 알려진 polyphenol 화합물의 양이 약 11배 증가하였고 ABTS 항산화 분석법과 DPPH 라디칼 소거능 시험을 통해 항산화 효과가 증가함을 확인하였다. 이러한 결과는 습식분쇄기술을 통해 벌 화분을 임상적 및 향장 목적으로 사용할 수 있음을 증명한다.

• 한국식품영양과학회지
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• 제24권4호
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• pp.510-516
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• 1995

체지방이 30% 이상으로 비만이라 판정되는 20~62세의 지원자들에게 저열량 균형식, 무리하지 않은 유산소 운동 및 개인별 비만의 원인을 교정하고 평생체중을 조절하기 위한 영양상담과 교육을 포함한 행동수정을 통해 5주 동안 비만을 치료하고 성인병과 관련된 위험 요인들의 변화를 살펴보았다. 활동량, 식습관, 식이섭취조사를 실시하여 개인별 비만의 원인을 진단한 후 잘못된 식생활을 교정할 수 있도록 주 3회의 영양상담과 매주 1회의 영양교육을 실시하였다. 식이요법은 1일 1끼의식사와 3회의 조제식이를 통해 열량이 1200kcal 정도가 되고, 양질의 단백질, 비타민, 무기질은 성인 권장량의 100~150% 이상이 되도록 하였다. 식전에 식이섬유와 물을 복용하고 식사 기간은 20분 이상으로 천천히 섭취하도록 하였으며, 투긴음식, 가공식품, 패스트 푸두, 술, 청량음료, 달고 기름진 음식, 짜고 자극적인 음식 등은 제한하였다. 주당 3~5일간 1시간 정도의 가벼운 유산소 체조를 실험대상자 저원이 모여서 실시하였다. 먹은 식품, 활동, 운동, 감정상태, 피로여부 등을 일지로서 기록하게 하여 삼담을 통해 교정하고 관찰하여 긍정적인 내적동기를 갖도록 교육하였다. 비만치료 기간 중 탈락한 수는 총 16명 중 5명 (31.3%)이었으며, 비만도는 대상자의 대부분이 경증이고, 불규칙적인 식사, 빨리 먹는 습관, 과식, 짜게 먹는 습관, 야식, 음주 등의 비만의 원인이 되는 습관들을 가지고 있어 식습관 점수는 개선이 요구된다고 진단되었다. 5주동안의 비만치료로 체중은 평균 4.8kg(주당 0.96kg)이 감량 되었으며, 체지방, body mass index, 허리, 팔, 둔부의 둘레가 유의적으로 감소되었다. 혈압, 공복시의 혈당, 혈액증의 중성지방, 총콜레스테롤, HDL-콜레스테롤은 변화가 없었으나, LDL-콜레스테롤은 유의적으로 감소하였다.

• Journal of Nutrition and Health
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• 제50권5호
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• pp.437-446
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• 2017

'계피' 건조분말 및 물추출물의 혈당 개선 기능성을 평가하기 위하여 메타 분석을 실시하였다. 2017년 5월을 기준으로 DB 검색을 통해 4,688건의 자료를 수집하여, 선정/제외 기준에 따라 선별한 결과 총 14건 (n = 709)의 연구가 분석에 포함되었다. 건조분말의 경우 하루 1~6 g씩 섭취하였을 때, 공복혈당은 -1.55 mmol/L, 식후 혈당의 곡선하면적은 $-51.8mmol/L{\cdot}min$ 수준으로, 물추출물은 하루 0.1~0.5 g씩 섭취시 공복혈당이 -0.76 mmol/L 수준으로 개선시켰으며, 당화혈색소에는 영향이 없는 것으로 분석되었다.

• 대한지역사회영양학회지
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• 제28권4호
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• pp.302-316
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• 2023

Objectives: The study aim was to identify changes in the nutritional status of older adults during the COVID-19 pandemic according to household income and demographic characteristics. Methods: Study participants were 2,408 adults aged 65 and over who participated in the 2019-2020 Korea National Health and Nutrition Examination Survey (KNHANES). To examine changes in nutrient intake levels resulting from COVID-19, data of 2019 and of 2020 were compared. Study participants were divided into three groups based on household income level to compare these changes. The changes were compared according to household income level, age group, and household type. Results: Percentages of recommended intakes for energy, protein, and most micronutrients were the lowest for the low-income group of both males and females in 2020. The Mean Adequacy Ratio (MAR) score was the lowest for the low-income group in both years. When comparing nutrient density for 2019 and 2020 by income group, the male low-income group experienced a decrease in nutrient densities of vitamin A, thiamine, calcium, and iron. For the same group, a decreased percentage for energy intake from protein was noted. Fruit intake was lowest in the low-income group for both males and females. Low-income males had the lowest intake levels for meat, fish, eggs, and legumes in both 2019 and 2020 and the lowest milk and milk product intake levels in 2020. Older adults living alone or single older adults with children had lower MAR scores than those living with a spouse. Older adults living alone experienced decreases in energy and thiamine and iron intake levels in 2020 compared to their intake levels in 2019. Conclusions: Because of the COVID-19 pandemic, nutrition intake levels worsened for older adult males in the low-income group and older adults living alone. This finding shows the need for a more systematic nutritional support strategy for the vulnerable older adults population in national disaster situations.

• 한국가금학회지
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• 제37권1호
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• pp.69-80
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• 2010

대두단백질(ISP)이 혈액 콜레스테롤 농도에 미치는 영향을 확인하기 위하여, 카제인, 어분, 쌀단백질, 옥수수 단백질(글루텐 밀) 등과 함께 이들을 각각 함유한 반정제(semi-purified) 사료를 2주간 병아리에게 급여하였다. 병아리는 쥐에 비해 혈액 콜레스테롤에 예민하게 반응하며, 인체의 지질 실험 모델로 더 적합한 동물이다. 각 단백질 사료 마다 NRC 요구량을 기준하여 부족한 필수아미노산(lysine, arginine 등)을 첨가하였다. 모든 실험 사료는 강제 급이 방식으로 1일 3회 급여하여 아미노산을 제외한 모든 영양소의 섭취량을 동일하게 하였다. 실험 2에서는 모든 사료에 콜레스테롤을 0.3% 수준으로 첨가하여 급여하였다. 카제인군의 병아리 증체량이 두 실험 모두 가장 저조하였고(P<0.05), 대두단백질과 어분군의 성장률이 가장 좋았다. 카제인군은 실험 1, 2에서 혈액 총콜레스테롤, non-HDL 콜레스테롤, TG 함량이 유의하게 가장 높았고, 대두단백질 군은 다른 단백질군(쌀 옥수수단백질, 어분)과 대체로 비슷한 수준을 보였다. 어분군은 실험 2에서 혈액 콜레스테롤이 대두 쌀 옥수수단백질군 보다 유의하게 더 높았다. 카제인군은 간 중량이 두 실험 모두 가장 무거웠고 간의 콜레스테롤 및 총지질 함량 도 가장 많았다. 반면에 어분군은 콜레스테롤 함량을 제외하고 대두 쌀 옥수수단백질 군과 같은 수준을 보였다. 카제인군에서 나타난 고콜레스테롤혈증(hypercholesterolemia)은 전형적인 Lys- Arg 길항 작용에 의한 결과이며, 카제인을 섭취한 대부분의 동물에서 나타나는 현상이다. 반면에 대두단백질과 쌀단백질, 옥수수단백질 및 어분군의 혈중 콜레스테롤 함량이 비슷하게 나타나는 것은 사료 Lys/Arg 비율이 카제인 만큼 심하게 높지 않기 때문이라고 생각된다. 결론적으로 대두단백질군의 저콜레스테롤 혈증(hypocholesterolemia)은 카제인에 비교할 때만 나타나는 상대적인 현상으로, 대두단백질 자체가 혈중 콜레스테롤을 저하시킬 수 있는 독자적인 기능을 갖고 있지 않다고 판단된다.

• Fisheries and Aquatic Sciences
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• 제23권6호
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• pp.15.1-15.14
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• 2020

Background: Large rivers are ecological treasures with high human value, but most have experienced decades of degradation from industrial and municipal sewage, row-crop agricultural practices, and hydrologic alteration. We reviewed published analyses of long-term fish diversity publications from three intensively managed large river ecosystems to demonstrate the conservation potential of large river ecosystems. Results: We show how the incorporation of recent advances in river concepts will allow a better understanding of river ecosystem functioning and conservation. Lastly, we focus on the Wabash River ecosystem based on high conservation value and provide a list of actions to maintain and support the ecosystem. In the Wabash River, there were originally 66 species of freshwater mussels, but now only 30 species with reproducing populations remain. Although there were multiple stressors over the last century, the largest change in Wabash River fish biodiversity was associated with rapid increases in municipal nutrient loading and invasive bigheaded carps. Conclusions: Like similarly neglected large river systems worldwide, the Wabash River has a surprising amount of ecological resilience and recovery. For instance, of the 151 native fish species found in the 1800s, only three species have experienced local extinctions, making the modern assemblage more intact than many comparable rivers in the Mississippi River basin. However, not all the changes are positive or support the idea of recovery. Primary production underpins the productivity of these ecosystems, and the Wabash River phytoplankton assemblages shifted from high-quality green algae in the 1970s to lower less nutritional blue-green algae as nutrient and invasive species have recently increased. Our recommendations for the Wabash River and other altered rivers include the restoration of natural hydrology for the mainstem and tributaries, nutrient reductions, mechanisms to restore historical hydrologic patterns, additional sediment controls, and improved local hydraulics.

• Nutritional Sciences
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• 제5권3호
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• pp.123-128
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• 2002

Physical activity is a primary cancer control strategy that has received little attention to date. However, an Increasing number of epidemiological studies have proposed that physical exercise may be beneficial by enhancing anticancer immune system responses. We investigated the effects of acute exercise on changes in nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) expression. The amounts of NO generated by abdominal macrophages in mice were measured after exercise. Thirty-two mice, which were challenged with thioglycollate broth to activate peritoneal macrophages, were randomly assigned to control, exercise and recovery groups. The mice exercised on a motor-driven treadmill for 3 consecutive days, either moderately (18m/min, 30 min/day, 5％ grade) or severely (18-35m/min, 60 min/day, 5％ grade). The mice were killed immediately after exercise or after 6 hrs of recovery. Nitric oxide was quantified by the Griess assay. The exercised mice showed higher levels of NO generation than those of the control mice, but the intensity of exercise had no significant effect on NO generation. Mice allowed six hours of recovery after exercise showed higher levels of NO generation than that of animals sacrificed immediately after exercise, but there were no significant differences in NO generation with variations in the intensity of exercise. Increased levels of iNOS were found in the exercised groups, and this was greatest in the groups allowed six hours of recovery compared to those groups sacrificed immediately after exercise. The results of this study suggest that acute exercise may enhance an immune response by inducing macrophage-derived NO generation; these results support the epidemiological findings which support the benefits of exercise in the prevention and control of cancer. Further study is needed to determine the physiological significance of these findings, which could be applied to the use of therapeutic exercises to assist in the prevention and control of cancer.

• Journal of Genetic Medicine
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• 제18권1호
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• pp.64-69
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• 2021

Primary cilium has a signal transduction function that is essential for brain development, and also determines cell polarity and acts as a mediator for important signaling systems, especially the Sonic Hedgehog (SHH) pathway. TBC1D32 is a ciliary protein, implicated in SHH signaling. Biallelic mutations in the TBC1D32 gene causes a kind of ciliopathy, heterogeneous developmental or degenerative disorders that affect multiple organs, including the brain. Here we report a boy who carried compound heterozygous variants in TBC1D32. The patient showed hypotonia, respiratory difficulty, and multiple anomalies at his birth. He was diagnosed with congenital hypopituitarism and treated with T4, hydrocortisone, and growth hormone. Despite the hormonal replacement, the patient needed long-term respiratory support with tracheostomy and nutritional support with a feeding tube. His developmental milestones were severely retarded. Hydrocephalus and strabismus developed and both required surgery, during the outpatient follow-up. Whole-exome sequencing indicated compound heterozygous variants, c.2200C>T (p.Arg734^*) and c.156-1G>T, in TBC1D32 gene. This is the first Korean case of TBC1D32-related ciliopathy and we reported detailed and sequential clinical features. This case demonstrated the utility of whole-exome sequencing and provided valuable clinical data on ultra-rare disease.

• 대한지역사회영양학회지
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• 제27권4호
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• pp.273-285
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• 2022

Objectives: This study compared the nutritional intakes of early and late preterm infants in a neonatal intensive care unit (NICU) and at home. The dietary problems and the need for community care services for premature infants were further investigated. Methods: This is a cross-sectional and descriptive study on 125 preterm infants and their parents (Early preterm n = 70, Late preterm n = 55). The data were collected by surveying the parents of preterm infants and from hospital medical records. Results: No significant differences were obtained between the early and late preterm infant groups when considering the proportion of feeding types in the NICU and at home. Early preterm infants were fed with a greater amount of additional calories at home and had more hours of tube feeding (P = 0.022). Most preterm infants had feeding problems. However, there was no significant difference between early and late preterm infants in the mental pain of parents, sleeping, feeding, and weaning problems at home. Many parents of preterm babies had no external support, and more than half the parents required community care to take care of their preterm babies. Conclusions: Regardless of the gestational age, most preterm infants have several problems with dietary intake. Our study indicates the need to establish community care services for preterm infants.

• 대한지역사회영양학회지
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• 제25권3호
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• pp.189-203
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• 2020

Objectives: This study was performed to identify the current barriers of obesity management for children using Community Child Care Centers and their caregivers (parents and teachers working in the Centers). Further, this study explored the possibility of utilizing a mobile phone application for tailored obesity prevention and management programs to overcome the current difficulties associated with children's obesity management. Methods: The qualitative data were collected through in-depth interviews with 20 obese and overweight children or children who wanted to participate in this study using Community Child Care Centers, 12 teachers working at the Centers, and a focus group interview with five parents of children using the Centers. Data were analyzed with a thematic approach categorizing themes and sub-themes based on the transcripts. Results: The current barriers of obesity management of obese and overweight children using Community Child Care Centers were lack of self-directed motivation regarding obesity management (chronic obesity-induced lifestyles and reduced self-confidence due to stigma) and lack of support from households and Community Child Care Centers (latchkey child, inconsistency in dietary guidance between the Center and household, repetitive pressure to eat, and absence of regular nutrition education). Mobile phone applications may have potential to overcome the current barriers by providing handy and interesting obesity management based on visual media (real-time tracking of lifestyles using behavior records and social support using gamification), environmental support (supplementation of parental care and network-based education between the Community Child Care Center and household), and individualized intervention (encouragement of tailored and gradual changes in eating habits and tailored goal setting). It is predicted that the real-time mobile phone program will provide information for improving nutritional knowledge and behavioral skills as well as lead to sustainable children's coping strategies regarding obesity management. In addition, it is expected that environmental factors may be improved by network-based education between the Community Child Care Centers and households using the characteristics of mobile phones, which are free from space and time constraints. Conclusions: The tailored education program for children using Community Child Care Centers based on mobile phones may prevent and reduce childhood obesity by overcoming the current barriers of obesity management for children, providing environmental and individualized support to promote healthy lifestyles and quality of life in the future.