• 대한약학회:학술대회논문집
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• 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.1
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• pp.243.1-243.1
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• 2003

Extensive efforts in the search of therapeutically useful carbocyclic nucleosides have resulted in a wealth of their synthetic methodologies in racemic and optically active forms. The classical one-directional methods such as linear synthesis and convergent synthesis are the approaches most frequently seen in the literature for the preparation of carbocyclic nucleosides, and their advantages and limitations are well known. (omitted)

• 대한약학회:학술대회논문집
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• 대한약학회 2002년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2
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• pp.345.2-345.2
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• 2002

Recently. 4'${\alpha}$-C homologated furanose nucleosides. especially alkyl branches. are molecules of considerable current interest. One of reasons for this prominence arises from the notable biological activities as antiviral and antitumor agents. as shown in 4'${\alpha}$-C-methyl-2-deoxythymidine (EC$_{50}$ = 7.2$\mu$M against HIV in MT-4 cell), 4'${\alpha}$-C-fluoromethyl-2-deoxycytidine. 4'${\alpha}$-C-hydroxymethylthymidine and 4'${\alpha}$- -C-azidomethyl-thymidine. (omitted)omitted)

• 대한화학회지
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• 제45권4호
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• pp.312-317
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• 2001

7'-Aldehyde-nucleoside 유사체(2a, 2c)을 6-N-benzoyl-2',3'-O-isopropylideneadenosiner과 uridine으로부터 합성하였다. 2와 Wittig reagent인 ethoxycarbonylmethylene을 축합시켜 ethoxycarbonyl group을 갖는 탄소수를 증가시킨 공액 이중 결합을 지닌 nucleosi de 유사체, ethyl-1',5',6',7',8'-pentadeoxy-1'-(adenin-9-yl)-$\beta$-D-ribo-nnona-5'(E).7'(E)-dienofuranuronate(4b), ethyl-1',5',6',7',8'-pentadeoxy-1'-(uracyl-1-yl)-$\beta$-D-ribo-nona-5'(E),7'(E)-dienofuranuronate(4c)을 얻었다. 또한 2와 CBr4, Ph3P을 반응시켜 공액 이중 결합을 지닌 9-[8',8'-dibromo-5',6',7',8'-tetradeoxy-$\beta$-D-ribo-octa-5'(E),7'(E)-diene]nucleosides (6b,6c) 유사체를 각각 합성하였다.

• 한국식품영양과학회지
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• 제12권1호
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• pp.1-6
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• 1983

인삼(人蔘)과 오가피중(五加皮中)의 핵산계(核酸系) 성분(成分)을 HPLC로 분리(分離) 정량(定量)하여 다음과 같은 결과를 얻었다. 1. 동일한 원료수삼에서 제조한 백삼(白蔘)과 홍삼(紅蔘)의 핵산유리염기(核酸遊離鹽基)와 nucleoside의 조성이 거의 같았다. 2. 인삼(人蔘)과 오가피(五加皮)중의 nucleosides 함량에서 adenosine, guanosine, cytidine 등이 특징적(特徵的)인 차이(差異)를 나타냈으며 인삼속(人蔘屬)이 약(約) 3배(倍)이상 많게 나타났다. 그러나 tymidine과 inosine은 오가피속(五加皮屬)이 다소 많았다. 3. nucleobase 함량면에서는 인삼(人蔘)이나 오가피간(五加皮間)에 비슷한 함량으로 1~2mg/100g를 함유했다.

• Bulletin of the Korean Chemical Society
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• 제20권6호
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• pp.731-733
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• 1999

• Bulletin of the Korean Chemical Society
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• 제10권6호
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• pp.614-617
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• 1989

• Bulletin of the Korean Chemical Society
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• 제10권3호
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• pp.317-319
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• 1989

• 대한약학회:학술대회논문집
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• 대한약학회 2000년도 춘계총회 및 학술대회
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• pp.165.2-165.2
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• 2000

• Biotechnology and Bioprocess Engineering:BBE
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• 제4권1호
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• pp.17-20
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• 1999

Facile synthetic methods of 2',5'-dideoxy-, 2',3'-dideoxy- and 3'-deoxy-1, N6-ethenoadenosine nucleosides by either an enzymatic dideoxyribosyl transfer reaction or a simple chemical reaction were proposed. The synthesis products were isolated and purified by preparative HPLC and their structures were confirmed by 1H NMR (500 MHz) and FAB-MS including high resolution mass measurement. These modified nucleoside analogs have not been reported yet. Therefore, these modified nucleoside analogs are of potential value to be studied further for biological activity such as anticancer or antiviral.

• Natural Product Sciences
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• 제21권1호
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• pp.25-29
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• 2015

In a continuation of our studies to discover bioactive secondary metabolites from marine sources, we further investigated samples from a tryptamine and phenyl-alkane producing sponge, which resulted in the isolation of four uncommon small molecules and five nucleosides. Their structures were determined to be 7,8-dihydroimidazo[1,5-c]pyrimidin-5(6H)-one (1), 5-chlorocavernicolin (2), maleimide-5-oxime (3), 3-methylmaleimide-5-oxime (4), uridine (5), 2'-deoxyuridine (6), thymidine (7), adenine (8), and adenosine (9) by spectroscopic analyses. The isolated compounds were evaluated for inhibitory activity against soluble epoxide hydrolase (sEH) as well as the Wnt/${\beta}$-catenine signaling pathway.