• Journal of Life Science
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• v.29 no.9
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• pp.941-948
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• 2019

Colorectal cancer is a major health problem in industrialized countries. Ziyuglycoside II ($3{\beta}-3-{\alpha}$-1- arabinopyranosyloxy-19-hydroxyurs-12-en-28-oicacid), a triterpenoid saponin isolated from the roots of Sanguisorba officinalis L., possesses antioxidant, antiangiogenic, and anticancer properties. However, the therapeutic function of ziyuglycoside II in colitis-associated colorectal carcinogenesis is undefined. In the present study, the effect of ziyuglycoside II on colitis-associated colon cancer induced in mice using azoxymethane (AOM)/dextran sulfate sodium (DSS) was explored. The AOM model recapitulates many features of human colon cancer, but it lacks an inflammatory component. DSS induces colitis and promotes AOM-induced colon cancer in mice. BALB/c mice were injected with AOM and administered 2% DSS in drinking water. The mice were given ziyuglycoside II (1 or 5 mg/kg) orally three times per week, and colonic tissue was collected at 64 days. Administration of ziyuglycoside II markedly diminished the formation of colonic tumors. Western blot and immunohistological analyses showed that ziyuglycoside II noticeably decreased nuclear factor kappa-B-positive cells and levels of inflammation-related proteins, such as inducible nitric oxide synthase, cyclooxygenase-2, tumor necrosis factor-${\alpha}$, and interleukin-6 in colon tissue. It also prompted apoptosis. Ziyuglycoside II treatment augmented cleaved forms of caspase-3, caspase-7, and poly (ADP-ribose) polymerase in colonic tissues. In conclusion, ziyuglycoside II could defend against colitis-associated tumorigenesis in mice by inhibiting inflammation and inducing apoptosis. This shows a promising chemopreventive potential for its use in colitis-associated colon cancer.

• Journal of the Korea Convergence Society
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• v.10 no.4
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• pp.123-130
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• 2019

The Study aims at carrying out basic research on the future housing culture plan by the aging and low fertility phenomenon which is the most serious problem that Korean society faces today. In the future, the housing culture will be transformed into a 'convergence housing complex's residential culture' that can be coexisted with households with various members, rather than a housing type represented by apartments today, due to the phenomenon of nuclear family and the increase of one resident. In this regard, this study is a basic study on the housing complex culture of Korea. It is not that the hosing complex culture has been imported from the western society today, but the Korean traditional housing complex's culture proposed by Korean first developer Segwon Jeong has already existed in Korea urban and architectural perspective. In the early 20th century, Segwon's improved Hanok planned to complement the disadvantages of the existing hanok and the modernization of hanok such as the standardization of hanok, moreover the most important point is the beginning of the Korean style housing complex by modernization of the inner space of hanok. It is expected that this study for Segwon's housing complex of improved hanok will provide important basic data for the Korean-style convergence residential culture plan needed for our society in the future.

• Nuclear Engineering and Technology
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• v.27 no.6
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• pp.859-869
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• 1995

The present study is to understand the physical phenomena anticipated during the accident with RHR loss under mid-loop operation in a PWR and, at the same time, to examine the prediction capability of RELAP5/MOD3.1 on such an accident, by simulating an integral test relevant to this accident for reliable analysis in an actual PWR. The selected experiment, i.g. BETHSY Test 6.9a, represents the configuration with the pressurizer manway open and steam generators unavailable during the accident. Accordingly, the results of this ok are sure to contribute to understanding both the key events as well as the sensitive parameters, anticipated in the accident, for validity of the actual analysis. In the simulation result overall behavior as well as major phenomena observed in the experiment have been predicted reasonably by RELAP5/MOD3.1, however, the problem associated with enormous computing time .due to small time step size has been encountered. Besides, the code prediction of higher swollen level in the pressure vessel has given rise to overestimation of both pressurizer level and RCS pressure. Subsequently, overprediction of the break flow through the manway has led to earlier core uncovery than that in the experiment by about 400 seconds. As a whole, it is demonstrated from both the experiment and the analysis that gravity feed has not been sufficient to recover the core level and thus additional forced feed has been necessary in this configuration.

• The Korean Journal of Nuclear Medicine Technology
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• v.20 no.2
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• pp.62-68
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• 2016

Purpose In a cyclosporine experiment using a robotic liquid handing system has found a deviation of its standard curve and low reproducibility of patients's results. The difference of the test is that methanol is mixed with samples and the extractions are used for the test. Therefore, we assumed that the abnormal test results came from using methanol and conducted this test. In a manual of a robotic liquid handling system mentions that we can choose several setting parameters depending on the viscosity of the liquids being used, the size of the sampling tips and the motor speeds that you elect to use but there's no exact order. This study was undertaken to confirm pipetting ability depending on types of liquids and investigate proper setting parameters for the optimum dispensing ability. Materials and Methods 4types of liquids(water, serum, methanol, PEG 6000(25%)) and $TSH^{125}I$ tracer(515 kBq) are used to confirm pipetting ability. 29 specimens for Cyclosporine test are used to compare results. Prepare 8 plastic tubes for each of the liquids and with multi pipette $400{\mu}l$ of each liquid is dispensed to 8 tubes and $100{\mu}l$ of $TSH^{125}I$ tracer are dispensed to all of the tubes. From the prepared samples, $100{\mu}l$ of liquids are dispensed using a robotic liquid handing system, counted and calculated its CV(%) depending on types of liquids. And then by adjusting several setting parameters(air gap, dispense time, delay time) the change of the CV(%)are calcutated and finds optimum setting parameters. 29 specimens are tested with 3 methods. The first(A) is manual method and the second(B) is used robotic liquid handling system with existing parameters. The third(C) is used robotic liquid handling system with adjusted parameters. Pipetting ability depending on types of liquids is assessed with CV(%). On the basis of (A), patients's test results are compared (A)and(B), (A)and(C) and they are assessed with %RE(%Relative error) and %Diff(%Difference). Results The CV(%) of the CPM depending on liquid types were water 0.88, serum 0.95, methanol 10.22 and PEG 0.68. As expected dispensing of methanol using a liquid handling system was the problem and others were good. The methanol's dispensing were conducted by adjusting several setting parameters. When transport air gap 0 was adjusted to 2 and 5, CV(%) were 20.16, 12.54 and when system air gap 0 was adjusted to 2 and 5, CV(%) were 8.94, 1.36. When adjusted to system air gap 2, transport air gap 2 was 12.96 and adjusted to system air gap 5, Transport air gap 5 was 1.33. When dispense speed was adjusted 300 to 100, CV(%) was 13.32 and when dispense delay was adjusted 200 to 100 was 13.55. When compared (B) to (A), the result increased 99.44% and %RE was 93.59%. When compared (C-system air gap was adjusted 0 to 5) to (A), the result increased 6.75% and %RE was 5.10%. Conclusion Adjusting speed and delay time of aspiration and dispense was meaningless but changing system air gap was effective. By adjusting several parameters proper value was found and it affected the practical result of the experiment. To optimize the system active efforts are needed through the test and in case of dispensing new types of liquids proper test is required to check the liquid is suitable for using the equipment.

• The Journal of Korean Society for School & Community Health Education
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• v.8 no.2
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• pp.19-34
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• 2007

Background & Objectives: The current study aims to convey correct knowledge of dementia that is be on the rise as the most significant social problem and provide basic data for implementing immediate school health education for dementia which is the basis of improving quality of life for patients with dementia, their family and the society by analyzing recognition level for dementia among male and female students in the 2nd grade of middle school and the necessity of school health education for dementia. Methods: The current study conducted a survey with a total of 150 students. 25 male and female students respectively selected from three middle school taking into account regional characteristics. The study also processed the survey results using SPSS-PC Program 12.0 and gained the following results by implementing Frequency Analysis. Cross-tabulation Analysis and ANOVA Analysis. Results: As for respect for grandparents, 55.3% of the respondents said they respect their grandparents. while 39.3% answered so-so and 5.3% said they don't respect their grandparents. As for the number of they meet grandparents, 36.0% of the respondents said they meet grandparents once or twice a month, which was the most frequent answer. On the other hand, 24.7% are once or twice every six months, 13.3% are once or twice a year and a week, respectively, and 6.7% said that they seldom meet their grandparents. In a question about whether they had recognized dementia after explaining dementia in detail, 82.7% said' yes' while 17.3% said' no'. But few students recognized it when they were asked using a terminology' dementia' first. The average score of knowledge level integrating the most fundamental 16 questions about dementia was $11.20{\pm}1.73$. Also 83.3% of the respondents answered that they had no experience in health education about dementia while 16.7% said presented positive answers. In the necessity of health education about dementia, 73.3% of them said' necessary' while 21.3% said' so-so' and 5.3% said 'not necessary. Conclusions: From the above study results, it was found that it is time to emphasize the necessity and importance of school health education for improving respect for the old and a sense of responsibility for support and converting recognition for dementia in Korea that has social structure of the trend toward the nuclear family and heads for an aged society. However, the fact that the above things are not implemented at all in reality can expand disparate views among family members in the future and further can cause even more serious problem by neglecting senior problems. Therefore, the government, social organizations, especially school organizers should recognize the necessity and importance of school health education and actively begin cultivations of students' character by implementing the education about dementia at the early stage.

• Journal of Radiation Protection and Research
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• v.17 no.1
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• pp.43-56
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• 1992

As one of the methods to ameliorate the ray effects which are the nature of anomalous computational effects due to the discretization of the angular variable in discrete ordinates approximations, a computational program, named TWODET (TWO dimensional Discrete Element Transport), has developed in 2 dimensional cartesian coordinates system using the discrete elements method, in which the discrete angle quadratures are steered by the spatially dependent angular fluxes. The results of the TWODET calculation with K-2, L-3 discrete angular quadratures, in the problem of a centrally located, isotropically emitting flat source in an absorbing square, are shown to be more accurate than that of the DOT 4.3 calculation with S-10 full symmetry angular quadratures, in remedy of the ray effect at the edge flux distributions of the square. But the computing time of the TWODET is about 4 times more than that of the DOT 4.3. In the problem of vacuum boundaries just outside of the source region in an absorbing square, the results of the TWODET calculation are shown severely anomalous ray effects, due to the sudden discontinuity between the source and the vacuum, like as the results of the DOT 4.3 calculation. In the probelm of an external source in an absorbing square in which a highly absorbing medium is added, the results of the TWODET calculation with K-3, L-4 show a good ones like as, somewhat more than, that of the DOT 4.3 calculation with S-10.

• Journal of Christian Education in Korea
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• v.72
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• pp.49-70
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• 2022

The purpose of this study is to suggest a response and solution through Christian educational care to the crisis and change of the era of low birth rate faced by Korean society and the Korean church. This study proposes to find an alternative to the biblical aspect of pregnancy, childbirth, and parenthood as God's blessing for the demographic cliff and low birth rate problem that have become a reality in Korean society and churches. Being a parent in an age of low birth rate is very difficult, but on the other hand, it gives happiness and joy. Being a parent is a blessing from God, and is the most important and valuable thing in life. However, modern society emphasizes the right and necessity to choose one's own parenthood status. In the nuclear family, the decrease in the number of children, and the development of child research, parents feel more responsibility and economic burden for raising children than ever before. Therefore, it is a reality that the number of people who delay becoming parents or voluntarily do not have children is gradually increasing. To improve the perception of becoming a parent due to a decrease in responsibility for raising children, it is necessary to shed light on marriage, pregnancy, childbirth, and childrearing from a Christian educational point of view. In addition, it is necessary to understand the recognition of being a parent and the characteristics of childbirth and rearing, and to analyze past and present value changes. This study will also discuss the causes of low birthrate and try to provide Christian educational care for childcare including solving the low birthrate problem.

• Tunnel and Underground Space
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• v.19 no.1
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• pp.11-18
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• 2009

Use of nuclear energy inevitably brings the problem of radioactive waste disposal. Repositories for disposing radioactive waste use underground space that is unconnected with the outside and the diagonal system, which allows the waste to be deposited. Ventilation if necessary because high-level radioactive waste generates heat. In this study, the air velocity through diagonal branches with regulators of different sizes and in different locations, was measured. The air velocity is determined by the size of the first and last regulators, regardless of the size of other regulators. In the diagonal system. Consequently, once the desired total airflow rate has been achieved by installing the appropriate first and last regulators, the other regulators fan be evenly installed to maintain the minimum air velocity needed.

• Asian-Australasian Journal of Animal Sciences
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• v.16 no.7
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• pp.1071-1086
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• 2003

Reproductive biotechnologies continue to be developed for genetic improvement of both river and swamp buffalo. Although artificial insemination using frozen semen emerged some decades back, there are still considerable limitations. The major problem appears to be the lack of efficient methods for estrus detection and timely insemination. Controlled breeding experiments in the buffalo had been limited and similar to those applied in cattle. Studies on multiple ovulation and embryo transfer are essentially a replica of those in cattle, however with inherent problems such as lower number of primordial follicles on the buffalo ovary, poor fertility and seasonality of reproduction, lower population of antral follicles at all stages of the estrous cycle, poor endocrine status and a high incidence of deep atresia in ovarian follicles, the response in terms of transferable embryo recovery has remained low with 0.51 to 3.0 per donor and pregnancy rates between 15 to 30%. In vitro production of buffalo embryos is a valid alternative to recovery of embryos by superovulation. This aspect received considerable attention during the past decade, however the proportion of embryos that develops to the blastocyst stage is still around 25-30% and hence the in vitro culture procedures need substantial improvement. Embryo cryopreservation procedures for direct transfer post thaw need to be developed for bubaline embryos. Nuclear transfer and embryo cloning is a technique that has received attention in various species during recent years and can be of immense value in buffaloes as they have a low rate of embryo recoveries by both in vitro and in vivo procedures. Gender pre-selection, genome analysis, gene mapping and gene transfer are a few of the techniques that have been studied to a limited extent during recent years and are likely to be included in future studies on buffaloes. Very recently, reproductive biotechnologies have been applied to feral buffaloes as well, but the results obtained so far are modest. When fully exploited they can play an important role in the preservation of endangered species.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.20 no.1
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• pp.27-33
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• 2020

Recently, visual object detection and tracking has become a vital role in many different applications. It spans various applications like robotics, video surveillance, and intelligent vehicle navigation. Especially, in current situation where the use of UAVs is expanding widely, detection and tracking to soot down illegal UAVs flying over the sky at airports, nuclear power plants and core facilities is becoming a very important task. The remarkable method in object tracking is correlation filter based tracker like KCF (Kernelized Correlation Filter). But it has problems related to target drift in tracking process for long-term tracking. To mitigate the target drift problem in video surveillance application, we propose a tracking method which uses KCF, adaptive thresholding and Kalman filter. In the experiment, the proposed method was verified by using monochrome video sequences which were obtained in the operational environment of UAV.