• Journal of Chest Surgery
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• 제38권1호
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• pp.13-22
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• 2005

배경 : 심장수술과 같은 체외순환(Extracorporeal circulation)이 요구되는 상황에서 조직관류에 우월할 것으로 보이는 박동성 혈류장치를 이용하려는 시도가 계속되어 왔다. 본 연구에서는 체외순환 조건에서 박동 혈류가 비박동 혈류보다 조직관류에 우월하다는 가설을 직접 증명하기 위해 치근 개발된 조직관류측정기($QFlow^{TM}-500$ Perfusion Measurement System, Thermal Technologies Inc.,Cambridge, MA, USA)의 열확산 탐침(Thermal Diffusion Probe)으로 조직 관류량을 실시간 및 연속적으로 직접 측정함으로써, 체외순환에서 박동 혈류와 비박동 혈류가 신장에 미치는 영향을 직접 관찰하고자 하였다. 대상 및 방법: 몸무게가 25 kg에서 40 kg 사이의 돼지를 암수 구별 없이 총 12마리를 각각 6마리씩 두개 군으로 나누어 실험을 진행하였다. 동물의 심장을 노출시킨 후, 좌측 측하복부를 절개하여 좌신장을 노출하여 관류측정기의 열확산 탐침을 신장의 피질내에 $2\~3$ cm 깊이로 거치하였다. 9볼트의 배터리로 심정지를 유도하면서 대동맥 차단을 하여 총심폐우회술을 시행한 후, 1군(n=6)은 Biopump에, 2군(n=6)은 박동식 혈류를 제공하는 T-PLS (Twin-Pulse Life Support System)에 연결하였다. 실험 동안 pump flow는 2 L/min로 유지하였다. 체외순환 전과 시작 후 10분마다 심박수, 혈압, 및 신장 관류치를 측정하여 60분까지 측정하고, 동맥혈가스분석, 전혈구 계산, 혈액 뇨질산, 크레아티닌 및 혈장 용혈헤모글로빈을 체외순환 시작 전과 60분 후에 측정하였다. 결과: 두 군 사이에 기초치는 유사하였다. 평균 혈압은 체외순환 전에는 두 군 간에 차이가 없었으나, 체외순환 20분 이후부터는 2군에서 높은 경향이 있었고(1군 $39.84\~45.5$ mmHg, 2군 $48.7\~52$ mmHg), 특히 60분에서의 평균혈압은 통계적으로 유의한 차이를 보였다(1군$\;41.2{\pm}4.3\;mmHg,\;48.7{\pm}5.4\;mmHg,\;p=0.023$). 체외순환 전 측정한 신장 관류치는 두 군간에 차이가 없었으나, 체외순환을 시작한 이후부터는 2군에서 지속적으로 더 높은 경향이 있었으며(1군 $48.5\~64$ mL/min100 g, 2군 $65.8\~88.3$ mL/min/100 g), 특히 30분에서의 측정값은 통계적으로 유의한 차이를 보였다(1군$47.5{\pm}18.3\;mL/min100\;g,$ 2군$83.4{\pm}28.5\;mL/min100\;g,\;p=0.026$). 혈액 뇨질산, 크레아티닌, 그리고 혈장 용혈헤모글로빈의 변화는 두 군간에 차이가 없었다. 결론: 일정한 펌프 혈류 조건에서 박동성 혈류의 평균 혈압이 더 높다는 것은, 비박동성 혈류보다 조직관류압(Tissue Perfusion Pressure) 측면에서 우수하여 말초장기의 조직관류 효과에 유리한 요인이라고 볼 수 있다. 본 연구를 토대로 장시간의 체외순환에서는 신장기능을 대표하는 수치들에도 영향을 미칠 수 있으리라 예상되며, 신장 이외에 다른 주요 장기에 미치는 영향에 대한 연구를 더 진행할 필요가 있을 것으로 생각한다.

• Journal of Advanced Marine Engineering and Technology
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• 제8권1호
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• pp.17-36
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• 1984

Since 1973, the competition on the development of fuel saving type internal combustion engines has become severe by the two times oil shock, and new type engines are reported every several months. Whenever these new type engines are developed, new designs are required and they will be offered in the market after performing the endurance test for a long time. But the engine market is faced with a heavy burden of finance, as the developing of a new engine requires tremendous expenses. For this reason, the computer simulation method has been lately developed to cope with it. The computer simulation method can be available to perform the reasonable research works by the theoretical analysis before carrying out practical experiments. With these processes, the developing expenses are cut down and the period of development is curtailed. The object of this study is the development of simulation computer program for the small naturally aspirated four-stroke diesel engine which is intended to product by the original design of our country. The process of simulation is firstly investigated for the ideal engine cycle, and secondly for the real engine cycle. In the ideal engine cycle, each step of the cycle is simulated by the energy balance according to the first law of thermodynamics, and then the engine performance is calculated. In the real cycle imulation program, the injection rate, the preparation rate and the combustion rate of fuel and the heat transfer through the wall of combustion chamber are considered. In this case, the injection rate is supposed as constant through the crank angle interval of injection and the combustion rate is calculated by the Whitehouse-Way equation and the heat transfer is calculated by the Annand's equation. The simulated values are compared with measured values of the YANMAR NS90(C) engine and Mitsubishi 4D30 engine, and the following conclusions are drawn. 1. The heat loss by the exhaust gas is well agree with each other in the lower load, but the measured value is greater than the calculated value in the higher load. The maximum error rate is about 15% in the full load. 2. The calculated quantity of heat transfer to the cooling water is greater than the measured value. The maximum error rate is about 11.8%. 3. The mean effective pressure, the fuel consumption, the power and the torque are well agree with each other. The maximum error is occurred in the fuel consumption, and its error rate is about 7%. From the above remarks, it may be concluded that the prediction of the engine performance is possibly by using the developed program, although the program needs to reform by adding the simulation of intake and exhaust process and assumping more reliable mechanical efficiency, volumetric efficiency, preparation rate and combustion rate.

• 대기
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• 제29권4호
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• pp.481-499
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• 2019

National Institute of Meteorological Sciences has conducted a total 54 cloud seeding experiments with a silver iodide and calcium chloride using aircrafts from 2008 to 2018. The goal of the experiments is to improve the techniques of precipitation enhancement in Korea. The cloud seeding experiments using the silver iodide and calcium chloride were 36 and 18 times, respectively. During the cloud seeding experiments of the silver iodide and calcium chloride, the average values of total cloud amount for two kinds of seeding materials were 9.6 for and 8.1, respectively. The cloud type with the highest occurrence was Nimbostratus (Ns)-Stratus (St) (58%) in the silver iodide cloud seeding experiment. It was Altostratus (As)-Stratocumulus (Sc) (44%) in the calcium chloride cloud seeding experiment. Compared to probability of obtaining cloud seeding effect of the experiments using a leased aircraft, the probability using an atmospheric research aircraft increased from 43% to 63% in the silver iodide cloud seeding experiment and from 29% to 75% in the calcium chloride cloud seeding experiment. However, the increasing tendency was only shown during the one year experiment (2018). To get the meaningful statistical tendency of the cloud seeding effects, it is needed to implement many experiments in several years. Further we have to more clearly understand the characteristics of clouds developing in Korea and implement the cloud seeding experiments under a variety of weather conditions in order to develop the optimized precipitation enhancement technology in Korea.

• 대한핵의학회지
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• 제26권1호
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• pp.72-81
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• 1992

Pharmacologic coronary vasodilation in conjunction with myocardial scintigraphy has become an accepted alternative to dynamic exercise testing for the diagnosis of coronary artery disease. Although dipyridamole has traditionally been used for this purpose, it causes frequent side effect, which at times can be life-threatening. Moreover, dipyridamole dose not elicit maximal coronary vasodilation in a substantial number of patients receiving the usual i.v. dose. Adenosine is an endogenously produced compound that has significant effects as a coronary vasodilator and rapid onset action and extremely short half-life (< 10 seconds). The diagnostic accuracy and safety profile of adenosine $^{99m}Tc-MIBI$ myocardial scintigraphy were evaluated and comparison with exercise $^{99m}Tc-MIBI$ was performed. Twenty-eight subjects underwent $^{99m}Tc-MIBI$ imaging after adenosine infusion and exercise $^{99m}Tc-MIBI$ imaging. Adenosine was infused intravenously at a dose of 0.14mg/kg/body weight per minute for 6 min and MIBI was injected at 3 minute. Adenosine caused an incerease in heart rate ($64{\pm}12$ at baseline versus $74{\pm}16$ beats/min at peak effect, p<0.001), a mild decrease in systolic and diastolic blood pressure and a slightly increase in PR interval(p; NS). Side effects were reported in 92% of patients and were mostly mild in nature and promptly resolved within 1 or 2 minutes of termination of adenosine infusion. Facial flushing (53%), chest pain (36%), mild dyspnea (39%), headache (21%), throat discomfort (21%) were frequent symptoms. ST segment depression (> 1 mm) and second degree AV block in electrocardiography occured in 11% of the patients, respectively. The overall sensitivity and specificity for individual coronary stenoses in 16 patients underwent coronary angiography were 88% and 95%, respectively. The agreement ratio of segmental perfusion between adenosine and exercise images was 92% (Kappa index=0.82). In conclusion, $^{99m}Tc-MIBI$ myocardial perfusion scintigraphy with intravenous adenosine is a feasible, safe and highly accurate noninvasive technique for the detection of coronary artery disease and results are at least comparable with those of exercise $^{99m}Tc-MIBI$ scintigraphy.

• 대한방사선치료학회지
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• 제11권1호
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• pp.53-59
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• 1999

The aim of this study is to improve the accuracy of field placement and junction between adjacent fields and block shielding through the use of a computed tomography(CT) simulator and virtual simulation. The information was acquired by assessment of Alderson Rando phantom image using CT simulator (I.Q. Xtra - Picker), determination of each field by virtual fluoroscopy of voxel IQ workstation AcQsim and colored critical structures that were obtained by contouring in virtual simulation. And also using a coronal, sagittal and axial view can determine the field and adjacent field gap correctly without calculation during the procedure. With the treatment planning by using the Helax TMS 4.0, the dose in the junction among the adjacent fields and the spinal cord and cribriform plate of the critical structure was evaluated by the dose volume histogram. The pilot image of coronal and sagittal view took about 2minutes and 26minutes to get 100 images. Image translation to the virtual simulation workstation took about 6minutes. Contouring a critical structure such as cribriform plate, spinal cord using a virtual fluoroscopy were eligible to determine a correct field and shielding. The process took about 20 minutes. As the result of the Helax planning, the dose distribution in adjacent field junction was ideal, and the dose level shows almost 100 percentage in the dose volume histogram of the spinal cord and cribriform plate CT simulation can get a correct therapy area due to enhancement of critical structures such as spinal cord and cribriform plate. In addition, using a Spiral CT scanner can be saved a lot of time to plan a simulation therefore this function can reduce difficulties to keep the patient position without any movements to the patient, physician and radiotherapy technician.

• 한국의료질향상학회지
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• 제8권1호
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• pp.10-21
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• 2001

Background : The Clostridium difficile is the most important identifiable cause of nosocomial infectious diarrhea and colitis, which lengthens hospital stay. Recently incidence of C. difficile has been increasing in an university hospital, and an intervention for prevention and control of C. difficile associated diarrhea (CDAD) was in prompt need. Methods : Subjects were the patients in the neurosurgical intensive care unit(NCU) where C. difficile was most frequently isolated. To increase participation of various departments, we used the CQI method, because management of CDAD requires a wholistic approach including control of antibiotics, barrier precaution and environmental cleaning and disinfection. Duration of the CQI activities was 9 months from April to December 1999. Results : The identified problems were misuse and overuse of antibiotics, lack of consciousness of medical personnels and the possibility of transmission from the contaminated environment and tube feeding. Education for proper use of antibiotics and management of C. difficile infection, use of precaution stickers, supplement of handwashing equipments, emphasis on environmental disinfection, and the change of the process of tube feeding were done. The CDAD rate in NCU was significantly decreased after the CQI program (8.6 case per 1,000 patient days from January to April 1999 vs 4.8 from May to December 1999). The distribution of neurosurgical wards including NCU among the total number of isolated C. difficile from the clinical specimens dropped from 49.4% in January to April to 33,7% in May to December. The average hospital stay of the neurosurgical department changed from 19.6 days to 15.2 days. Also, the effect of the CQI activities for C. difficile may have affected the incidence of vancomycin resistant enterococci (VRE). Duration and dosage of certain antibiotics used in the NS department were decreased. The distribution of neurosurgical department in the number of VRE isolated patients declined from 18.4% to 11.1%. Conclusion : Infection control of resistant organisms such as C. difficile is likely to be successful when management of environmental contamination an collaborative efforts of decreasing the patients' risk factors such as antibiotics management and decreasing the length of hospital stay come simultaneously. For this work, related departments need to actively participate in the entire process under a common target through discussions for identifying problems and bringing up solutions. In this respect, making use of a CQI team is an efficient method of infection control for gathering participation and cooperation of related departments.

• 한국정보과학회논문지:정보통신
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• 제34권6호
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• pp.435-445
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• 2007

Snoop 프로토콜은 유 무선 혼합망에서 무선 링크에서 발생하는 TCP 패킷 손실을 효과적으로 보상하여 TCP 전송률을 향상시킬 수 있는 효율적인 프로토콜이다. 하지만, 무선 링크에서 연집한 패킷 손실이 발생하는 경우에는 지역 재전송을 효과적으로 수행하지 못하여 전송 효율이 떨어진다는 문제점이 있다. 이러한 Snoop 프로토콜의 문제점을 개선하기위해 무선 구간에서 TCP-SACK의 장점을 활용한 SACK-Aware-Snoop, SNACK 메커니즘 등이 제안되었다. SACK-Aware-Snoop, SNACK 메커니즘은 연집한 패킷손실 환경에서도 Snoop 프로토콜보다 높은 전송률을 보장하지만 전송 계층의 ACK 패킷을 기반으로 재전송을 수행한다는 점은 ACK 패킷의 손실에 심각한 전송 성능 저하를 가져오며, 무선 구간에서 SACK 옵션의 사용은 무선망의 대역폭과 이동 단말의 한정된 에너지 자원을 불필요하게 낭비하는 문제를 초래하게 된다. 본 논문에서는 이러한 문제점을 개선하기 위해 Cross-layer 기법을 적용한 지역 재전송 기법인 C-Snoop(Cross-layer Snoop) 프로토콜을 제안한다. C-Snoop 프로토콜은 현재 유 무선 혼합망에서 가장 널리 사용되는 IEEE 802.11 MAC 프로토콜 기반의 지역 재전송 메커니즘으로서, MAC 계층의 ACK 패킷과 새로이 제안된 지역 재전송 타이머에 의해 효율적인 지역 재전송을 수행한다. ns-2 시뮬레이터를 이용한 실험을 통해 C-Snoop의 지역 재전송 기법은 무선 구간의 연집적인 패킷 손실에 대해 효율적인 보상을 수행하며, 이동 단말의 에너지 효율성을 향상시키는 것을 확인할 수 있었다.

• 사상체질의학회지
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• 제23권3호
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• pp.351-360
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• 2011

1. Objective: This study was designed to analyze the characteristics of each Sasang constitutional type using the Temperament and Character Inventory (TCI). 2. Methods: A total of 135 healthy subjects (age 19-30) participated in this study, consisting of 35 Soyang-type, 66 Taeeum-type, 30 Soeum-type, and 4 Taeyang-type subjects. A Sasang Constitutional Medicine specialist determined each subject's Sasang constitutional type based on the Two Step Questionnaire for Sasang Constitution Diagnosis (TS-QSCD) and comprehensive constitutional assessment. The subjects were also asked to complete the TCI. 3. Results: Among the four temperament dimensions, the Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Novelty Seeking (NS). The Soeum-type subjects showed significantly higher scores than the Taeum- and Soyang-type subjects in Harm Avoidance (HA) (Soeum type > Taeeum type > Soyang type). The Soyang-type subjects showed significantly higher scores than the Soeum-type subjects in Reward Dependence (RD). The Soyang- and Taeeum-type subjects showed significantly higher scores than the Soeum-type subjects in Persistence (P). Among the three character dimensions, the Soyang-type subjects showed significantly higher score than the Taeeumand Soeum-type subjects in Self-Directedness (SD) (Soyang type > Taeeum type > Soeum type). The Soyang-type showed significantly higher scores than the Taeeum-type in Cooperativeness (C). 4. Conclusions: Differences in temperament and character were discovered across the Sasang constitutional types. The Sasang constitutional characteristics should be investigated in larger studies in the future. Similar studies could add to the growing knowledge of Sasang constitutional typology and contribute to a more accurate Sasang constitutional diagnosis.

• 대한전자공학회논문지TC
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• 제43권10호
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• pp.79-89
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• 2006

TCP는 신뢰성을 보장하는 전송 프로토콜로서 인터넷 등에서 가장 널리 사용되고 있는 전송 방식이다. 하지만 TCP는 유선망에 적합하도록 설계되었기 때문에 무선망에서 TCP를 사용할 경우 성능 저하가 발생된다. TCP의 성능 저하 원인으로는 MAC 계층에서의 무선 매체 경쟁, hidden-terminal 문제와 exposed terminal 문제, 링크 계층에서의 패킷 손실, 불공정성의 문제들과 노드의 이동에 의한 경로 단절시 발생되는 패킷 순서 바뀜 문제와 경로의 단절로 인한 재전송 타이머의 exponential backoff에 의한 대역폭의 낭비 등이 있다. 특히 이동 ad-hoc 망에서는 전송 범위(transmission range)와 간섭범위(interference range)의 불일치로 인해 발생되는 hidden terminal 문제로 인해 동시에 전송할 수 있는 노드의 수가 제한되며 이로 인해 성능저하가 크게 발생된다. 본 논문에서는 IEEE 802.11 기반 이동 ad-hoc 망에서 발생되는 hidden terminal 문제로 인해 노드가 전송을 하지 못하고 CW(contention window)만 크게 증가되는 문제를 해결하기 위한 MAC 알고리즘을 제안한다. 기존의 802.11 MAC의 DCF(distributed coordination function)에서는 전송에 실패할 경우 CW를 지수적으로 증가시키지만 본 논문에서 제안하는 기법은 노드가 전송 실패를 하였을 경우 그 원인에 따라 CW를 적절하게 변화시킴으로 성능 향상을 얻을 수 있다. 이 기법을 사용하면 hidden terminal에 의해 전송을 실패하는 노드에게 공정한 전송 기회를 부여함으로써 TCP 성능 향상을 얻을 수 있음을 시뮬레이션을 통해 보였다.

• 전자공학회논문지
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• 제51권9호
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• pp.11-20
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• 2014

IETF CoRE WG은 IoT (Internet of Things) 환경에서 웹기반 응용 서비스를 지원하기 위해 CoAP (Constrained Application Protocol)를 표준화하고 있다. 하지만, CoAP 표준에서는 CoAP 센서 노드의 이동성에 대해서는 고려하지 않았다. 본 논문에서는 IoT 환경에서의 제한된 네트워크의 특징을 고려한 CoAP 센서 노드의 이동성 관리를 제공 할 수 있는 이동성 관리 프로토콜을 제안한다. 제안된 CoAP 센서를 위한 이동성 관리 프로토콜은 CoAP 센서 노드가 서로 다른 네트워크로 움직이는 동안에 웹 클라이언트가 CoAP 센서 노드로부터 신뢰성 있는 센싱 정보를 전송 받을 수 있게 된다. 이를 위해, 본 논문에서는 CoAP 센서 노드의 IP 주소를 별도로 관리하는 이동성 관리 구조를 설계하였고, 신뢰성 있는 센싱 정보 전달을 위해, 홀딩 (Holding Mode) 및 바인딩 모드 (Binding Mode)을 사용한 이동성 관리 프로토콜을 제시했다. 마지막으로, 핸드오버 지연과 패킷 손실 성능에 대해 제안된 CoAP 센서 노드의 이동성 관리 프로토콜과 기존의 이동성 관리 프로토콜간 수학적 분석과 네트워크 시뮬레이션 툴을 활용한 성능 분석을 수행하였다. 성능결과는 제안된 이동성 관리 프로토콜이 기존의 이동성 관리 프로토콜에 비해 패킷손실 없이 센싱 데이터를 신뢰성있게 전송 할 수 있다는 것을 보여준다.