• 한국식생활문화학회지
• /
• 제36권1호
• /
• pp.103-109
• /
• 2021

The study was conducted to identify the anti-inflammatory and anti-cancer effects in sprouts of mouse-eyed bean (Rhynchosia nulubilis), ginseng (Panax ginseng), perilla (Perilla frutescens), broccoli (Brassica oleracea var. italica), and lettuce (Lactuca sativa) grown with organic germanium concentrate. Western blot analysis was performed to assess the anti-inflammatory activity of the extract. All extracts exhibited noticeable anti-oxidant activity, indicating a significant correlation between the germanium content and anti-oxidant activity (p<0.05). In particular, rat-eyed bean sprouts with the highest germanium content showed significant anti-inflammatory activity (p<0.05) by significantly inhibiting the expression of the inflammatory complexes, NLRP3, cytokines IL-1β and caspase-1. Ginseng and broccoli sprouts showed strong anti-cancer properties and had high anti-oxidant effects (p<0.001). Germanium-concentrated water allows the mass production of agricultural products containing high concentrations of organic germanium. Agricultural produce grown with germanium concentrate add organic germanium to various physiological active ingredients, increasing the anti-oxidant and anti-cancer effects. These results strongly suggest that agricultural products containing high germanium concentrations can be used as novel health supplements to improve health.

• 한국식품영양과학회:학술대회논문집
• /
• 한국식품영양과학회 2004년도 Annual Meeting and International Symposium
• /
• pp.37-42
• /
• 2004

The relatively new concept of functional foods is supportive of sales of food products that deliver isolated 'nutrient' or 'food compound' substances, much as is done by dietary supplements. Whether such isolated substances have benefit must be investigated in each instance; such investigations can be complex. At the same time, simply prepared natural plant foods contain a myriad of substances that, in accord with the concept of food synergy, are beneficial for health. Whole grain foods are an example of such healthy fare, based on strong epidemiologic and experimental evidence. If the concept of functional foods is to be of use for the public health, it should support the consumption of healthy traditional foods as well as promoting 'novel' foods; in this sense, whole grain foods, which have great functionality, should be regarded as functional foods.

• Journal of Plant Biotechnology
• /
• 제49권4호
• /
• pp.316-324
• /
• 2022

Hair loss causes psychological stress due to its effect on appearance. Therefore, the global market for hair loss treatment products is rapidly growing. The present study demonstrated that ginseng berry-derived and sequence-modified peptides promoted the proliferation rate of dermal papilla (DP) cells and keratinocytes, in addition to having antioxidant properties. Moreover, the potential role of these ginseng berry peptides as TGF-β2 antagonists was confirmed through in silico computer docking. In addition to promoting the growth of ,the ginseng berry-derived peptides also promoted the proliferation of keratinocytes experimental Particularly, an unmodified ginseng berry-derived peptide (GB-1) and two peptides with sequence modifications (GB-2 and GB-3) decreased ROS generation and exhibited a protective effect on damaged HaCaT keratinocytes. Computer-aided peptide discovery was conducted to identify the potential interactions of important proteins with transforming growth factor-beta 2 (TGF-β2), a key protein that plays a crucial role in the human hair growth cycle. Our results demonstrated that MAGH, an amino acid sequence present in herbal supplements and plant-based natural compounds, can inhibit TGF-β2.

• 한국응용과학기술학회지
• /
• 제36권4호
• /
• pp.1164-1171
• /
• 2019

Dietary supplements derived from natural sources are an essential factor in optimizing athletic performance. It has been proposed that the extract of Momordica charantia (M. charantia) that is known as a bitter melon can be potentially used as a novel supplement for health promotion. This pilot study aimed to examine the effects of the M. charantia extract when administered in the form of a sports drink, and we evaluated changes in body composition and metabolic factors in tennis players after 4-week consumption of the extract. Eight male college tennis players were instructed to consume an M. charantia extract 6 times per day (3 in the morning and 3 in the afternoon, and the total daily intake was 600 ml). Collected data were analyzed using paired t-tests to examine the changes over time after consumption of the M. charantia extract. The results revealed a significant increase in the trunk muscle mass, basal metabolic rate, and daily calorie intake (p < 0.05). Levels of protein, minerals, and total body water showed an increased tendency (not statistically significant), whereas intracellular water and extracellular water showed a decreased trend. Furthermore, fat-free mass, skeletal muscle mass, and muscle mass showed an increased tendency. In conclusion, consumption of the M. charantia extract caused an increase in parameters related to protein, muscle mass, and metabolism. It seems that follow-up studies related to fatigue, inflammation, and stress hormones related to the M. charantia extract consumption would be needed.

• Journal of Microbiology and Biotechnology
• /
• 제28권11호
• /
• pp.1800-1805
• /
• 2018

Inflammatory bowel disease, including Crohn's disease and ulcerative colitis (UC), is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Intestinal epithelial cells (IECs) constitute barrier surfaces and play a critical role in maintaining gut health. Dysregulated immune responses and destruction of IECs disrupt intestinal balance. Dextran sodium sulfate (DSS) is the most widely used chemical for inducing colitis in animals, and its treatment induces colonic inflammation, acute diarrhea, and shortening of the intestine, with clinical and histological similarity to human UC. Current treatments for this inflammatory disorder have poor tolerability and insufficient therapeutic efficacy, and thus, alternative therapeutic approaches are required. Recently, dietary supplements with probiotics have emerged as promising interventions by alleviating disturbances in the indigenous microflora in UC. Thus, we hypothesized that the probiotic Bifidobacterium animalis subsp. lactis strain BB12 could protect against the development of colitis in a DSS-induced mouse model of UC. In the present study, oral administration of BB12 markedly ameliorated DSS-induced colitis, accompanied by reduced tumor necrosis factor-${\alpha}$-mediated IEC apoptosis. These findings indicate that the probiotic strain BB12 can alleviate DSS-induced colitis and suggest a novel mechanism of communication between probiotic microorganisms and intestinal epithelia, which increases intestinal cell survival by modulating pro-apoptotic cytokine expression.

• 생명과학회지
• /
• 제19권1호
• /
• pp.138-146
• /
• 2009

마늘은 역학조사에 의하면 각종 질환의 예방과 치료에 효능이 있는 것으로 알려져 있다. 마늘의 주요 성분인 알리신 성분은 매우 불안정하여 쉽게 분해되어 새로운 형태의 유황 화합물로 만들어져 이들 성분들이 상승적으로 작용하여 중요한 생리황성을 갖는 것으로 알려져 있다. 시판되고 있는 여러 종류의 마늘제품 중에서 숙성마늘제품이 다른 제품에 비하여 생리활성이 높은 것으로 보고되었다. 숙성마늘제품은 마늘을 일정한 조건으로 숙성시킬 때 수용성 성분인 S-allylcysteine, S-allylmercaptan, steroid saponins, te-trahydro-${\beta}$-caboline derivatives 및 fructeosyl-arginine 등이 많이 증가하여 그 효능이 상승적으로 높아지는 것으로 알려져 있다. 따라서 시판 마늘가공품의 품질을 표준화하기 위하여 이들 수용성 성분을 biomarker로서 규격기준을 정해야 할 것이다.

• 정보처리학회논문지:소프트웨어 및 데이터공학
• /
• 제9권9호
• /
• pp.259-266
• /
• 2020

본 논문에서는 온라인 고객 리뷰를 활용하여 건강 보조제, 화장품 등 현재의 상태를 개선하기 위해 사용되는 제품을 대상으로 그 효과를 알아보기 위한 제품 효과 분석 기법을 제시하였다. 제안하는 제품 효과 분석 기법은 블로그 포스팅에 존재하는 광고를 자동 제거하고, 효과 분석을 위한 증상, 효과, 증가, 및 감소로 이루어진 단어 사전을 구축하며, 제안하는 알고리즘을 통해 제품의 효과를 측정한다. 제품 효과 분석 기법을 검증하기 위해 정답 레이블이 존재하는 네이버 쇼핑 리뷰 데이터셋을 대상으로 성능평가를 실시하였으며, 전통적인 긍부정 사전과 RNN 모델과 성능을 비교하였다. 실험 결과, 본 논문에서 제안하는 효과 분석 기법이 다른 두가지 방법보다 정확도가 뛰어남을 보여주었다. 또한, 아토피 피부염, 여드름 치료제에 제안하는 기법을 적용하여 소셜 미디어에 나타난 효과적인 치료법을 소개하였다. 본 논문에서 제시한 알고리즘은 블로그를 포함한 여러 매체의 리뷰로부터 제품의 효과를 점수화할 수 있으므로 다양한 제품군과 소셜 미디어에 적용될 수 있을 것으로 보인다.

• Journal of Microbiology and Biotechnology
• /
• 제33권9호
• /
• pp.1149-1161
• /
• 2023

Changes in the gut microbiome cause recolonization by pathogens and inflammatory responses, leading to the development of intestinal disorders. Probiotics administration has been proposed for many years to reverse the intestinal dysbiosis and to enhance intestinal health. This study aimed to evaluate the inhibitory effects of two newly designed probiotic mixtures, Consti-Biome and Sensi-Biome, on two enteric pathogens Staphylococcus aureus and Escherichia coli that may cause intestinal disorders. Additionally, the study was designed to evaluate whether Consti-Biome and Sensi-Biome could modulate the immune response, produce short-chain fatty acids (SCFAs), and reduce gas production. Consti-Biome and Sensi-Biome showed superior adhesion ratios to HT-29 cells and competitively suppressed pathogen adhesion. Moreover, the probiotic mixtures decreased the levels of pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin (IL)-6 and IL-1β. Cell-free supernatants (CFSs) were used to investigate the inhibitory effects of metabolites on growth and biofilms of pathogens. Consti-Biome and Sensi-Biome CFSs exhibited antimicrobial and anti-biofilm activity, where microscopic analysis confirmed an increase in the number of dead cells and the structural disruption of pathogens. Gas chromatographic analysis of the CFSs revealed their ability to produce SCFAs, including acetic, propionic, and butyric acid. SCFA secretion by probiotics may demonstrate their potential activities against pathogens and gut inflammation. In terms of intestinal symptoms regarding abdominal bloating and discomfort, Consti-Biome and Sensi-Biome also inhibited gas production. Thus, these two probiotic mixtures have great potential to be developed as dietary supplements to alleviate the intestinal disorders.