• The Journal of Korean Obstetrics and Gynecology
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• v.23 no.2
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• pp.71-84
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• 2010

Purpose: In the theory of traditional medicine, Glenditsia spina(GS) can resolve carbuncle, relive swelling, dispel wind and destroy parasites. This study was designed to investigate the effects of GS on gene expression of ovarian tissue in polycystic ovary syndrome(PCOS) rats. Methods: In this experiment, female rats injected with a single dose of 2 mg estradiol valerate(EV) and GS was given for 5 weeks. The genetic profile for the effects on ovarian tissue in PCOS rats was measured using microarray technique, and the functional analysis on these genes was conducted. Results: 985 genes were increased in control and restored to normal level in GS group. (B), 733 genes were decreased in control group and restored to normal level in GS group. (F). Metabolic pathways related in B group genes were Graft-versus-host disease, Allograft rejection, Autoimmune thyroid disease, Cytokine-cytokine receptor interaction, Small cell lung cancer, Type I diabetes mellitus. Metabolic pathways related in F group genes were Antigen processing and present, Adipocytokine signalling pathway, Focal adhesion, ECM-receptor interaction, Pancreatic cancer, Notch signalling pathway, Tight junction. The network of total protein interactions was measured using cytoscape program, and some key molecules, such as c-Fos, c-Myc, ABL1 related in B group, MAPK8, RASA1, CALR related in F group that can be used for elucidation of therapeutical mechanism of medicine in future were identified. Conclusion: These results suggest possibility of GS as anti-cancer and anti-hyperplasia drug in PCOS. In addition, the present author also suggests that related mechanisms are involved in suppression of proto-oncogene such as c-Fos, c-Myc and ABL1, and in regulation of cell cycle such as RASA1.

• Transactions of Materials Processing
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• v.17 no.4
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• pp.240-248
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• 2008

The effect of alloying elements(Mn, S, Mo, B) on the high temperature deformation behavior of Fe-29%Ni-17%Co (Kovar) alloy were investigated. And the effect of high temperature oxidation on the hot ductility was also studied. The hot ductility of Kovar alloy was drastically increased with the addition of Mn and lowering of S content. It has been found that the brittle intergranular fracture at high temperature cracking is closely associated with the FeS sulfide along the grain boundary. When Mn was added, the type of sulfide was changed to MnS from FeS and ductile intergranular fracture and transgranular fracture were promoted. The formation of oxide layer was found to have minimized the hot ductility of the Kovar alloy significantly. Grain boundary micro-cracks in the internal oxide region were noted following deformation due to high temperature, one of which acting as a notch that caused the poor hot workability of the oxidized specimen. The addition of Mo to the Kovar alloy could also retard the decrease in the hot ductility of the oxidized specimen through the prevention of notching due to internal oxidation. Hot ductility was remarkably improved by the addition of Boron. The improvement of hot ductility results from the grain boundary migration mainly due to the dynamic recrystallization at lower temperature range ($900{\sim}1000^{\circ}C$).

• Journal of the Korean Ceramic Society
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• v.44 no.7
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• pp.343-348
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• 2007

Alumina/silver nanocomposites were fabricated using a soaking method through a sol-gel route to construct an intra-type nanostructure. The pulse electric-current sintering (PECS) technique was used to sinter the nanocomposites. Several specimens were annealed after sintering. The microstructure, mechanical properties, critical frontal process zone (FPZ) size, and thermo-mechanical properties of the nanocomposites were estimated. The relative densities of the specimens sintered at 1350 and $1450^{\circ}C$ were 95% and 99%, respectively. The maximum value of the three-point bending strength was found to be 780 MPa for the $2{\times}2{\times}10 mm$ specimen sintered at $1350^{\circ}C$. The fracture toughness of the specimen sintered at $1350^{\circ}C$ was measured to be $3.60 MPa{\cdot}m^{1/2}$ using the single-edge V-notched beam (SEVNB) technique. The fracture mode of the nanocomposites was transgranular, in contrast to the intergranular mode of monolithic alumina. The fracture morphology suggested that dislocations were generated around the silver nanoparticles dispersed within the alumina matrix. The specimens sintered at $1350^{\circ}C$ were annealed at $800^{\circ}C$ for 5 min, following which the maximum fracture strength became 810 MPa and the fracture toughness improved to $4.21 MPam^{1/2}$. The critical FPZ size was the largest for the specimen annealed at $800^{\circ}C$ for 5 min. Thermal conductivity of the alumina/silver nanocomposites sintered at $1350^{\circ}C$ was 38 W/mK at room temperature, which was higher than the value obtained with the law of mixture.

• The KIPS Transactions:PartC
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• v.13C no.7 s.110
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• pp.881-888
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• 2006

The position of the bridged tap is determined by that of the outlet in most modern apartments, since most of the indoor wiring utilizes the bus wiring structure when deploying the indoor communication line. These bridged taps deteriorate transmission performance in the specific frequency at the time of high-speed multimedia communication, which uses a high frequency bandwidth, since the duality of return loss worsens and line attenuation increases rapidly. As a result, analysis on this phenomenon is required. In this study, the test model is created by modeling the intercommunication facility of the apartment that is the most representative residential house type, and by understanding the structure and the environment of the indoor wiring. Also, how the bridge tap affects performance is analyzed when the VDSL service is provided, so that problems of intercommunication lines can be identified and methods for improving the proper intercommunication line can be suggested, which is suitable for accommodating high-speed multimedia service of the future.

• Parasites, Hosts and Diseases
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• v.59 no.3
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• pp.235-249
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• 2021

Leptin is a type of adipokine mainly produced by adipocytes and reported to be overproduced in prostate cancer. However, it is not known whether it stimulates the proliferation of prostate cells. In this study, we investigated whether benign prostatic hyperplasia epithelial cells (BPH-1 cells) infected with Trichomonas vaginalis induced the proliferation of prostate cells via a leptin signaling pathway. To investigate the effect of crosstalk between adipocyte leptin and inflamed epithelial cell in proliferation of prostate cells, adipocytes 3T3-L1 cells were incubated in conditioned medium of BPH-1 cells infected with T. vaginalis (T. vaginalis-conditioned medium, TCM), and then the adipocyte-conditioned medium (ATCM) was identified to cause proliferation of prostate cells. BPH-1 cells incubated with live T. vaginalis released pro-inflammatory cytokines, and conditioned medium of these cells caused migration of adipocytes. When prostate stromal cells and BPH-1 cells were incubated with adipocyte conditioned medium containing leptin, their growth rates increased as did expression of the leptin receptor (known as OBR) and signaling molecules such as JAK2/STAT3, Notch and survivin. Moreover, blocking the OBR reduced this proliferation and the expression of leptin signaling molecules in response to ATCM. In conclusion, our findings show that inflamed BPH-1 cells infected with T. vaginalis induce the proliferation of prostate cells through leptin-OBR signaling. Therefore, it is likely that T. vaginalis contributes to prostate enlargement in BPH via adipocyte leptin released as a result of inflammation of the prostate.

• Journal of Chest Surgery
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• v.31 no.5
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• pp.466-471
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• 1998

Purpose: The safety and efficacy of minimally invasive techniques in congenital heart surgery were tested in this study. Materal and method: Between July 1997 and November 1997, a total of 46 children were underwent minimally invasive cardiac operations at Seoul National University Children's Hospital. Age and body weight of the patients averaged 34.6${\pm}$41.8 (Range: 1∼148) months and 14.5${\pm}$9.9(Range: 3.0∼40.0) kg, respectively. Twenty eight patients were male. Preoperative surgical indications included 15 atrial septal defects, 25 ventricular septal defects, 1 foreign body in aorta, 3 partial atrioventricular septal defects, 1 total anomalous pulmonary venous connection(cardiac type), and 1 tetralogy of Fallot. After creating a small lower midline skin incision starting as down as possible from the sternal notch, a vertical midline sternotomy extended from xyphoid process to the level of the second intercostal space, where one of the T-, J-, I- or inverted C-shaped lower lying mini-sternotomy was completed with a creation of unilateral right or bilateral trap door sternal opening. A conventional direct aortic and bicaval cannulation was routine. Result: A mean length of skin incision was 6.1${\pm}$1.0(range: 4.0∼9.0) cm. A mean distance between the suprasternal notch and the upper most point of the skin incision was 4.0${\pm}$1.1 (range: 2.0∼7.0) cm. Mean cardiopulmonary bypass time, aortic cross-clamp time, and the operation time were 62.9${\pm}$20.0(range: 28∼147), 29.8${\pm}$12.8(range: 11∼79), and 161.1${\pm}$34.5 (range: 100-250) minutes. A mean total amount of postoperative blood transfusion was 71.0${\pm}$68.1 (range: 0∼267) cc. All patients were extubated mean 11.3${\pm}$13.8(range: 1∼73) hours after operation. A mean total amount of analgesics used was 0.8${\pm}$1.8(range: 0∼9) mg of morphine. The mean duration of stay in intensive care unit and hospital stay were 35.0${\pm}$32.2 (range: 10∼194) hours and 6.2${\pm}$2.0(range: 3∼11) days. There were no wound complications and hospital deaths. Conclusion: This short-term experience disclosed that the minimally invasive technique can be feasibly applied in a selected group of congenital heart disease as well as is cosmetically more attractive approach.

• Magazine of the Korea Concrete Institute
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• v.6 no.2
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• pp.97-107
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• 1994

The objective of this study is to develop polymer-impregnated concrete(PIC), which is a newly developed composite material made by impregnating polymer impregnanls into hardened normal concrete, and to develop analytical techniques for its proper applications. Crystalline methyl methacrylate(MMA) is chosen as a monomer of polymer impregnants. The corrlpositions of polymer impregnants and producing processes are developed by analyzing the effects of penetration, polymerization, thermal safety, and strengthening characteristics. On t he basis of experimental results of this study, various strength characteristics and stress strain constitutive relations are formulated in terms of the compressive strength of normal concrete and the polymer loadings, which can be applied for analysis and design of PIC members. In order to provide a model for fracture analysis of flexural members, fracture toughness, fracture energy, critical crack width, and tension softening relations near crack tip are also formulated in terms of member depth, initial notch depth, and the flexural strength of normal concrete. The structural analysis procedure and the finite element computer program developed in the study are applicable to evaluate elastic behavior, ultimate strength, and tension softening behavior of MMA type PIC structural members subject to various loading conditions. The accuracy and effectiveness of the developed computer program is examined by comparing the anal ytical results with the experimental results. Therefore, it is concluded that the developed structural analysis procedure and the finite element computer program are applicable to analysis and design of in-situ and precast PIC structural members.

• Korean Journal of Soil Science and Fertilizer
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• v.31 no.3
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• pp.211-215
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• 1998

Soil loss and runoff were investigated in a small watershed located in Sangeo-ri, Yeoju-eup, Yeoju-gun, Kyonggi-do. The watershed with the area of 35 ha consists of forest, grassland, uplands and mulberry. V-notch type water tank. flow-meter, automatic water sampler and rain gauge were installed at the main outlet stream. Out of $1.037.9Mg\;35ha^{-1}$ of total annual rainfall. 17.9% was lost via run-off. The total amount of soil eroded was $152.2Mg\;35ha^{-1}$, of which $78.6Mg\;35ha^{-1}$ was suspended load and $73.6Mg\;35ha^{-1}$ ha was sediment load. The soil losses under different land uses were $16.02Mg\;ha^{-1}$ for upland annual Crops. $2.69Mg\;ha^{-1}$ for mulberry field, $0.58Mg\;ha^{-1}$ for grassland and $0.55Mg\;ha^{-1}$ for forest. The predicted soil loss by Universal Soil Loss Equation was approximately 20% underestimated in forest, grassland and uplands, and 32% underestimated in mulberry field.

• 대한공업교육학회지
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• v.31 no.1
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• pp.200-210
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• 2006

This C-ring test, normally employed for evaluating susceptibility to stress-corrosion cracking, was determined to be a suitable small scale test to evaluate PWHT(Post-Weld Heat Treatment) cracking susceptibility. This test is possible to incorporate an actual weld, to introduce a notch into the coarse grained HAZ(Heat Affected Zone), to load the coarse grained HAZ any level of stress ad, most importantly, since the C-ring is an approximately constant strain type test, the stress decreases with time at temperature in a manner similar to that of an actual steel weldment. The procedure employed in making the C-ring was presented in the experimental procedure section, however, several points deserve further discussion. The walls of the weld groove are made along radial lines form the center of th var in order to obtain an HAZ which is oriented perpendicular to the walls of the machined C-ring. Therefore, the plane of maximum stress will be aligned through the HAZ and, therefore, crack propagation will not be forced to deviate form the plane of maximum stress in order to remain in the coarse grained HAZ as is the case with the Y groove test.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.15 no.2
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• pp.447-454
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• 2011

Power-line interference(PLI) can distort certain regions in analysing the ECG signal. In particular, the regions such as P and R wave that are important element in diagnosing with arrhythmia is expressed as different type of noise according to the case whether power-line frequency is multiples of sampling frequency and or not. Noise characteristics is also divided into linearity and non-linearity. In this paper, adaptive subtraction method for removing variable PLI of ECG signal is proposed. We classify the multiple relationship between power line and sampling frequency as Multiple and Non-multiple. PLI of Linear segment is extracted through moving average filter, PLI of non-linear segment is extracted through the interference component that is extracted in the linear segment and stored in the temporary buffer. The performance of P wave and R wave detection is evaluated by using 119 data record of MIT-BIH arrhythmia database. The achieved scores indicate P wave detection rate of 97.91%, R wave detection rate of 96.66% and P wave detection rate of 99.01%, R wave detection rate of 97.93% accuracy respectively for Notch filter and proposed subtraction method.