• 대한유전성대사질환학회지
• /
• 제3권1호
• /
• pp.86-93
• /
• 2003

Background : The SCL began screening of newborns and high risk group blood spots with tandem mass spectrometry (MS/MS) in April 2001. Our goal was to determine approximate prevalence of metabolic disorders, optimization of decision criteria for estimation of preventive effect with early diagnosis. This report describes the ongoing effort to identify more than 30 metabolic disorders by MS/MS in South Korea. Methods : Blood spot was collected from day 2 to 30 (mostly from day 2 to 10) after birth for newborn. Blood spot of high risk group was from the pediatric patients in NICU, developmental delay, mental retardation, strong family history of metabolic disorders. One punch (3.2 mm ID) of dried blood spots was extracted with $150{\mu}L$ of methanol containing isotopically labelled amino acids (AA) and acylcarnitines (AC) internal standards. Butanolic HCl was added and incubated at $65^{\circ}C$ for 15 min. The butylated extract was introduced into the inlet of MS/MS. Neutral loss of m/z 102 and parent ion mode of m/z 85 were set for the analyses of AA and AC, respectively. Diagnosis was confirmed by repeating acylcarnitine profile, urine organic acid and plasma amino acid analysis, direct enzyme assay, or molecular testing. Results : Approximately 31,000 neonates and children were screened and the estimated prevalence (newborn/high risk group), sensitivity, specificity and recall rate amounted to 1:2384/1:2066, 96.55%, 99.98%, and 0.73%, respectively. Confirmed 28 (0.09%) multiple metabolic disorders (newborn/high risk) were as follows; 13 amino acid disorders [classical PKU (3/4), BH4 deficient-hyperphenylalaninemia (0/1), Citrullinemia (1/0), Homocystinuria (0/2), Hypermethioninemia (0/1), Tyrosinemia (1/0)], 8 organic acidurias [Propionic aciduria (2/1), Methylmalonic aciduria (0/1), Isovaleric aciduria (1/1), 3-methylcrotonylglycineuria (1/0), Glutaric aciduria type1 (1/0)], 7 fatty acid oxidation disorders [LCHAD def. (2/2), Mitochondrial TFP def. (0/1), VLCAD def. (1/0), LC3KT def. (0/1). Conclnsion : The relatively normal development of 10 patients with metabolic disorders among newborns (except for the expired) demonstrates the usefulness of newborn screening by MS/MS for early diagnosis and medical intervention. However, close coordination between the MS/MS screening laboratory and the metabolic clinic/biochmical geneticists is needed to determine proper decision of screening parameters, confirmation diagnosis, follow-up scheme and additional tests.

• 한국가스학회지
• /
• 제16권6호
• /
• pp.67-72
• /
• 2012

본 연구에서는 압축천연가스 자동차용으로 사용하는 CNG 충전니플의 밀봉성과 밀봉내구 안전성에 관련된 접촉법선응력 및 등가진응력을 유한요소법으로 해석하였다. 기존의 원형 오링과 새로운 더블립 오링에 초기압축률 15%를 가한 상태에서 밀봉력을 해석한 결과에 의하면, 두 곳에서 밀봉작용을 하는 더블립 오링이 한곳에서 밀봉작용을 하는 기존의 원형 오링보다 41% 더 높게 나타남을 알 수 있다. 오링에 초기압축력 15%와 가스압축압력 8MPa을 작용한 상태에서 가스누출 차단 안전성을 비교하면, 기존의 원형 오링보다는 더블립 오링에서 5% 향상된 해석결과를 제시하고 있다. 또한, 오링의 밀봉내구 안전성을 비교한 FEM 해석결과에 의하면, 원형 오링보다는 더블립 오링에서 발생된 최대등가진응력이 10.2%나 더 높게 발생한 것으로 나타났다. 이것은 더블립 오링이 기존의 원형 오링보다는 장수명을 보장할 수 있다는 것이다.

• 대한한의학회지
• /
• 제16권1호통권29호
• /
• pp.132-140
• /
• 1995

Object : This study is designed to evaluate the correlation between the data of DITI(Digital Infrared Thermographic Imaging)examination and the changes of clinical symptom after the therapy of acupuncture in the patients with herniated cervical intervertebral disc. Content : The conservative therapy with acupuncture was performed during $4{\sim}5$ weeks, The acupuncture points of SI3, B62, TE3, G34, LI4, S36, GV26, G21, SII5 were used. In the pre- and post therapy, DITI examinations were performed in patients who had HIVD and were treated by acupuncture simultaneously, and then tried to correlate the results of clinical symptoms with the difference of thermographic findings at pre-acupuncture and post-acupuncture. Setting : The standard routine thermoghaphic examinations were performed with thermography(DITI) in the 15 patients with lumbar disc herniations at pre- and post acupuncture. Patient : Thermographic imaging of 15 cases were analyzed. They has disc herniations in X-ray, CT scan and MRI and they were treated by acupuncture theraphy in our hospital from March, 1994 to January, 1995. Result : 1) The causes were trauma(60%), retention of phlegm and fluid(8.7%) and cold & moisture(33.3%) 2) Levels of herniated cervical disc are C2/3(1 case). C3/4(2 cases), C5/6 & C6/7 (2 cases), C6/7(4 cases), Normal(6 cases). 3) Classifications of thermographic pattern are radiculopathy(80%), spot(13.3%), and nonspecific(6.7%) in order. 4) In evaluation Results of clinical symptom are Excellent(80%), Good(6.7%), and Poor(6.7%). Data of DITI are Excellent(80%), Good(6.7%), Fair(6.7%), and Poor(6.7%). Conclusion ; Acupuncture showed good results over 86.7% in clinical evaluation and 86.7% in DITI. Thermographic examination was valuable in the evaluation of therapeutic effect of acupuncture treatment.

• Structural Engineering and Mechanics
• /
• 제53권5호
• /
• pp.881-896
• /
• 2015

In this study, a method for fatigue performance estimation of deepwater steel catenary riser (SCR) under short-term vortex-induced vibration was investigated for selected S-N curves. General tendency between S-N curve capacity and fatigue performance was analysed. SCRs are generally used to transport produced oil and gas or to export separated oil and gas, and are exposed to various environmental loads in terms of current, wave, wind and others. Current is closely related with VIV and it affects fatigue life of riser structures significantly. In this regards, the process of appropriate S-N curve selection was performed in the initial design stage based on the scale of fabrication-related initial imperfections such as welding, hot spot, crack, stress concentration factor, and others. To draw the general tendency, the effects of stress concentration factor (SCF), S-N curve type, current profile, and three different sizes of SCRs were considered, and the relationship between S-N curve capacity and short-term VIV fatigue performance of SCR was derived. In case of S-N curve selection, DNV (2012) guideline was adopted and four different current profiles of the Gulf of Mexico (normal condition and Hurricane condition) and Brazil (Amazon basin and Campos basin) were considered. The obtained results will be useful to select the S-N curve for deepwater SCRs and also to understand the relationship between S-N curve capacity and short-term VIV fatigue performance of deepwater SCRs.

• 대한화장품학회지
• /
• 제27권1호
• /
• pp.119-131
• /
• 2001

Exposure of the human skin to UV-light can cause sun-tanning, photoaging and even photo-carcinogenesis. Melanin is important in protecting the skin against UV damage, but excessive or uneven melanin production can lead to the formation of freckles and aged spot. Control of hyperpigmentation is becoming even more important as aged population continues to grow. These needs led us to develop effective and safe depigmenting-agent, kojyl 3-aminopropyl phosphate (kojyl-APPA), called Whitegen. The development of whitegen was based on the fact that phosphate group of 3-aminopropyl phosphate can make kojic acid more compatible to the skin membrane and more stable. Instability of kojic acid has been a problem in cosmetic use. The insertion of phosphoester group has been recognized as a powerful tool to improve such physical properties as solubility and stability, because the phosphodiester residue is well characterized as a non-toxic moiety, having a high affinity for cell membranes. Kojyl-APPA showed no tyrosinase inhibition effect compared to kojic acid in vitro, but showed tyrosinase inhibition effect in situ. It means that kojyl-APPA is converted to kojic acid enzymatically in cells. Kojyl-APPA showed the inhibitory activity on melanin synthesis in mouse melanoma and normal humal melnaocytes and also showed long-lasting stability in comparison with its original form (kojic acid). Kojyl-APPA showed depigmenting effects when applied to UVB-induced hyperpigmentated region of guinea pig skin. Based on these results, kojyl 3-aminopropyl phosphate can be used as a safe and effective ingredient for the brightness and cleanness of skin.

• 한국산업보건학회지
• /
• 제3권2호
• /
• pp.188-193
• /
• 1993

Toluene in air and blood and hippuric acid in urine were checked for the 41 female workers who are exposed to toluene and have normal liver function in shoe making factories in July, 1993. Toluene in air was sampled with charcoal by personal air sampler at least 4 times and analyzed by gas chromatography. At the end of shift, blood and spot urine were collected with a vacuum tube containing EDTA and a polyethylene bottle for detecting blood toluene and urine hippuric acid and analyzed by gas chromatography and high performance liquid chromatography. Means of air and blood toluene and urine hippuric acid concentrations were 34.35ppm, 0.360mg/L, and 1.78g/g creatinine, respectively. Toluene in air showed a good correlation with hippuric acid in urine(r=0.4503) and toluene in blood(r=0.4596). The hippuric acid in urine and toluene in blood corresponded 10 exposure of 100ppm toluene in air were 2.628g/g creatinine and 0.481mg/L. Blood toluene and urine hippuric acid expected ratio were not correlated to the obesity index and working duration, however increased with age.

• 한국방사선학회논문지
• /
• 제2권1호
• /
• pp.23-29
• /
• 2008

본 연구에서는 웨이블릿 변환과 경계선 검출 필터를 이용하여 초음파영상의 다해상도 분해를 한 후 경계선 검출 필터링을 통해 초음파 영상의 화질을 개선하는 방안을 제안하였다. 제안된 방법에서는 잡음을 줄이고 에지를 강화하기 위해 웨이블릿 변환된 영상으로부터 얻어진 저해상도 영상에서 고해상도 영상으로 단계적으로 영역별 선택계수 조정과 방향성을 고려한 에지 필터링을 수행하였다. 이를 통해 반점영역의 픽셀은 웨이블릿 계수를 줄여 에지를 제외한 영역에서 선택적 저역통과 필터링 효과를 만들고, 에지에서는 접선 방향으로 평활화를 하여 연속성을 향상시키고, 법선 방향으로는 세선화를 하여 contrast를 높였다. 실험을 통해 단일해상도에서 비선형적 이방성의 확산모델을 이용한 필터링 방법과 웨이블릿 수축구조를 이용한 필터링 방법에 대해 비교하였다.

• 한국학교ㆍ지역보건교육학회지
• /
• 제11권2호
• /
• pp.89-102
• /
• 2010

Objectives: This study was conducted to compare health behavior between obese children and those with standard body weight, analyzing the correlation in their health behavior, and further making it useful data for the development of programs for a better education on health. Methods: To achieve the goal of this survey as mentioned, we have carried out a research targeting on a total of 636 elementary school students, 505 children of standard body weight and 131 children of obesity, all of whom belong to elementary school students in Seoul, the capital city of Korea. And we have itemized the research into 'eating habits', 'physical activity, 'dieting experience in the past', and 'stress and release management' in order to spot the specific health behavior leading to obesity. Results: 1. Factors for diseases mainly from obesity were statistically significantly differentdepending on degree of the subjects' self-respect and a history of obesity in their families, father($x^2$=7.172, p=.007), mother($x^2$=9.011, p=.003), and siblings($x^2$=12.431, p=.000). 2. Regarding the subjects' eating habits, some items were statistically significantly different: taking algae($x^2$=3.324, p=.043), eating breakfast($x^2$=6.070, p=.010), and eating fast($x^2$=8.551, p=.002). 3. There were some statistically significant differences in the subjects' dieting experience. For the latest 1 year, they made some attempts for that: fasting($x^2$=4.229, p=.040), reduction of eating($x^2$=25.377, p=.000), eating one meal a day($x^2$=5.582, p=.018) 4. OR(Odd Ratio)of Percieued obesity was 0.15 in the subjects' under weight than normal weight. And there was OR(Odd Ratio) 11.72 in the subjects' over weight. We can witness obese children think that they are over weight(p=.000).

• 정보관리연구
• /
• 제43권3호
• /
• pp.1-21
• /
• 2012

이 연구에서는 대학도서관의 연구지원서비스를 정의하고, 국내외 주요 대학도서관에서 제공하는 연구지원서비스를 비교 분석하였다. 분석 결과, 국내 대학도서관은 일반적으로 온라인상에서 도서관 서비스제공 빈도가 상대적으로 저조하였다. 또한 상대적으로 국외대학도서관에서 제공하는 연구지원 전문서비스보다는 서지교육과 원문제공서비스, 상호대차서비스 등과 같은 일반적인 도서관 서비스만을 제공하였다. 또한 연구윤리 관련 정보서비스가 상대적으로 부족하였다. 그리고 연구단계별 연구지원서비스는 자료수집단계에 집중된 경향이 있으며, 그 외 연구계획단계와 논문작성단계의 서비스는 미흡한 것으로 나타났다. 미국 대학도서관은 대학 소속 연구자와 학자 간의 커뮤니케이션을 위한 공간을 도서관 홈페이지를 통해 제공하고 있었다.

• 한국육종학회지
• /
• 제40권4호
• /
• pp.507-511
• /
• 2008

녹두 신품종 소현은 전라남도농업기술원에서 수원28호와 KM94004를 인공교배하여 2006년에 육성되었다. 소현의 생육습성은 직립, 잎 모양은 심장형, 백축색은 녹색, 성숙기에 꼬투리는 검고 곧으며, 종피는 광택이 없는 녹색이다. 천립중은 42 g이고, 녹두나물 수량은 표준품종인 어울보다 9% 많다. 소현은 vitexin과 isovitexin을 각각 12.0, 12.4 mg/g 함유하여 표준품종보다 각각 38, 31% 많다. 바이러스, 갈색무늬병, 흰가루병 및 도복에 대한 포장저항성은 강하고 평균 수량은 1.62 ton/ha으로 표준품종보다 많다.