• 환경정책연구
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• 제6권2호
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• pp.47-70
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• 2007

최근 들어 환경생태의 중요성 인식과 풍요롭고 환경적으로 안정된 생활을 영위하고자 하는 국민들의 욕구가 증대하고 있다. 이에 따라 물을 대하는 국민의 요구도 수질 및 수량관리에서 한 걸음 더 나아가 하천의 생태계를 보전하고 하천의 정상적인 기능을 회복시켜 건전한 하천환경 유지에 대한 수요도 증가하고 있다. 이러한 국민의 요구에 부응할 수 있도록 환경유량에 대한 개념을 정립하여 하천관리는 환경유량과 연계하여 취수를 허락하고, 자연에 가깝게 생태계를 보전하고 관리하여야 한다. 우리나라에서 환경유량은 하천관리 측면에서의 하천유지용수 개념으로 도입되었다. 우리나라에서 하천유지용수 산정은 아직도 인간 위주의 용수이용기능을 중점적으로 고려한 것으로 순수한 환경유량의 의미로서 환경생태적 관점에서 정의되고 강조되지 못했다. 환경유량은 하천유지용수에서 더 발전하여 생태계의 건전성 유지에 강조를 둔 새로운 개념으로 전환되어야 한다. 즉, 환경유량은 하천의 기능과 하천이 가지는 본래의 가치를 유지하기 위해 필요한 유량으로 정의하고 이는 각종 경제활동 유지를 위한 용수 공급, 위락, 심미, 수질, 수력발전, 주운 등을 위한 용수와 동일가치 또는 그 이상에서 고려하여야 한다.

• 대한예방한의학회지
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• 제12권2호
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• pp.101-114
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• 2008

The current study was conducted to produce basic data for the policy establishment to improve the life satisfaction of residents in regional communities. The study subjected total 1,400 residents living in youngnam province in our nation for the survey by using convenience sampling. The survey took about 4 months started from March 1, 2007 to June 30, 2007. The abstract and conclusion of the result could be summarized as in below. 1. In subjective health status, 45.4% responded as normal, and the health status scored $2.68{\pm}0.67$ in 5 point scale(53.6 in 100 point scale). 2. The level of life satisfaction was found to show the score of $19.57{\pm}3.39$ in 30 point scale(65.2 in 100 point scale). Characteristically, the highest score was found in male in both age groups younger than 19 and in 20s, but lowest score was found in the age group in 40s(p<0.001). In the level of life satisfaction, 29.6% responded as satisfactory and 11.9% responded as not satisfactory. 3. In reviewing the life satisfaction by the health related characteristics, 65.7% of whom responded as very healthy answered satisfactory in life, and the life satisfaction was significantly high in peoples who do not smoke. However, the level was significantly higher in alcohol drinker than no alcohol drinker. People who have enough sleep tended to satisfy in their life, and the life satisfaction level of whom have leisure turned out to show superiorly high satisfaction level. 4. As the variables affecting on the life satisfaction, sex, age, education level, marital status, health status, stress level, life satisfaction level, healthy life activities and depression level were found, and the influence of these variables was 19.6%. As the above results demonstrate, the life satisfaction of residents in regional community was proportional to health status and highly affected by daily health life. So, the more attentions have to be made on health management and the self effort should not be neglected. Especially, since stress, depression level and leisure life did have effects on life satisfaction, more attentions have to be made on stress solving and on the development of leisure life programs. For the goal, the governments, related private organizations and specialized workforces have to make integrated efforts along with the health improvement project in large perspectives.

• 대한의용생체공학회:의공학회지
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• 제24권4호
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• pp.267-273
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• 2003

본 연구에서는 일반 공기 중의 산소 농도 (21%) 환경에 비해 외부에서 고 농도 (30%)의 산소 공급이 공간 지각 능력에 어떠한 변화를 유발하는지 관찰하고자 한다. 8명의 남자 대학생 (평균 23.5세)을 뇌기능 연구의 실험 참여자로 선정하였고. 21%와 30% 산소 농도를 각각 8L/min의 양으로 일정하게 공급할 수 있는 장치를 개발하였다. 공간 지각 능력 측정을 위해 20 문항을 포함하는 두 개의 문제지를 제작하였고, 과제 수행 결과로부터 정답률을 산출하였다. 실험 패러다임은 30%의 산소 농도에서 과제를 수행하는 회기와 21%의 산소 농도에서 과제를 수행하는 회기로 각각 이루어져 있다. 각 회기는 네개의 black으로 구성되고, 각 block은 통제 과제 8문항. 공간지각 과제 5문항을 포함한다. 3T MRI기기를 사용하였고, single-shot EPI 방법으로 뇌기능 영상을 획득하였다. 산소 농도 21%에 비해 30% 상태에서 양측 후두엽 영역, 양측 상두정엽, 양측 하두정엽, 양측 쐐기앞소엽, 양측 중심후이랑 등의 두정엽 영역, 그리고 양측 중간전두이랑, 양측 하전두이랑, 양측 내측전두이랑 양측 상전두이랑, 양측 대상회 등의 전두엽 영역의 활성화가 증가하였고, 과제 수행 결과에서도 산소 농도 21%에 비해 30% 상패에서 정답률이 증가였다. 본 연구의 결과로부터 외부에서의 고농도의 산소 공급이 공간 지각 능력 증가에 긍정적인 영향을 미친다는 결론을 도출할 수 있다.

• 스마트미디어저널
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• 제6권1호
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• pp.16-21
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• 2017

컴퓨터가 상용화되면서 일반인들은 문서를 작성하기 위해 컴퓨터를 이용하는 방법을 자주 사용하게 되었다. 컴퓨터를 이용하여 문서를 작성하는 방법은 작성 속도가 빠르고 손의 피로가 적지만 철자오류가 발생할 확률이 매우 높다. 보통 철자오류는 발견하기 쉽기 때문에 곧바로 수정이 가능하지만, 사용자의 지식 부족 혹은 눈에 잘 띄지 않는 철자오류도 존재하기 때문에 철자오류가 존재하지 않는 문서를 작성하기 어렵다. 온라인상에서는 문서 작성에 대한 규칙 및 예절이 미비하기 때문에 철자오류에 의한 문제가 적지만 중요문서에서 발생하는 철자오류는 신뢰도 하락과 같은 큰 문제를 일으킨다. 철자오류 교정은 전문가 또한 완벽하게 수행하기 힘들기 때문에 비전문가인 일반인들을 위한 교정방법연구가 필요하다. 본 논문에서는 한글 편집거리 알고리즘을 이용해 철자오류를 교정하는 연구를 진행한다. 이전 연구를 통해 검출한 철자오류를 수집한 말뭉치 사전에서 등장하는 단어 중 철자오류 단어와 가장 유사한 단어를 발견하여 주위 단어와의 동시등장빈도를 계산하는 것으로 철자오류 교정을 수행하게 된다.

• Journal of Preventive Medicine and Public Health
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• 제39권2호
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• pp.141-148
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• 2006

Objectives : We wanted to evaluate the medical underutilization for benign prostatic hyperplasia (BPH) and lower urinary tract symptoms (LUTS) among Korean elderly men and we wanted to determine their associated factors. Methods : This study was conducted on 239 men with LUTS and 116 men with BPH who were compatible with the diagnostic criteria from a total of 641 participants. These participants were over 50 years old and they were randomly chosen in a community-based study for estimating the prevalence of BPH. Using a self-reported questionnaire, we surveyed the sociodemographics, health status, quality of life, lower urinary tract symptoms, medical utilization and reasons for not seeking treatment. Results : Only 27.6% of the men with LUTS and 31.0% of the men with BPH reported having visited a doctor for urinary symptoms. The reasons for not visiting a doctor were, in order of responses from the group with LUTS: 'considered the symptoms as a part of the normal ageing process', 'not enough time to visit a doctor', 'financial difficulty' and 'the symptoms were not severe or bothersome'. Regarding BPH, the responses were the same as those of the group with LUTS however, 'financial difficulty' placed second. Among the men with experience of visiting a doctor for urinary symptoms, 33.3% of those with LUTS and 28.1% of those with BPH were not treated. The most common reason in both groups was 'the symptoms were not severe to be treated'. On a multiple logistic regression analysis, the larger size household (odds ratio (OR) 3.03, 95% confidence interval (CI)=1.40-6.54) and an unsatisfactory quality of life related with urinary symptoms (OR 2.98, 95% CI=1.23-7.21) were associated with medical utilization in the group of LUTS. For BPH, the current employment status was related with the medical utilization (OR 2.80, 95% CI=1.10-7.11), in addition to the larger size household (OR 3.24, 95% CI=1.14-9.21). Conclusions : Many men with urinary symptoms do not visit a doctor. This medical underutilization for people with LUTS and BPH may be associated with economic status in Korea.

• Korean Journal of Acupuncture
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• 제26권2호
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• pp.15-25
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• 2009

Objective: This paper aimed to understand influences on EEG conducting acupuncture stimulation, by comparing the changes in the acupoints on the body before and after normal people are treated with acupuncture at PC9 and TE3, which are referred to as Wood points(木穴), and PC5 and TE1, which are referred to as the Metal points(金穴) among the five shu points of Yin pericardium Meridian and Yang Triple Energizer Meridian. Methods: The study was performed on 30 healthy female volunteers in their 20's. EEG was measured for 5 minutes before acupuncture stimulation was conducted on PC9, TE3, PC5 and TE1. During 20 minutes of acupuncture treatment, the same items were continuously measured to find out whether there were any changes in them, and they were measured for 5 minutes after removing the acupuncture needles in order to implement a comparative analysis. Results: Comparision of EEG data before and after the treatment at PC9 shows no significant differences in all wave. Compared with the pre-acupuncture period at TE3, $\delta-\theta$ wave decreased significantly (P<0.05) during the acupuncture stimulation periods. Compared with the pre-acupuncture period at PC5, $\delta-\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Mid $\beta$ wave and high $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods and the post acupuncture periods. Compared with the Pre-acupuncture period at TE1, $\delta-\theta$ wave, $\theta$ wave and high $\alpha$ wave increased significantly (P<0.05) during the acupuncture stimulation periods. And Low $\beta$ wave decreased significantly (P<0.05) during the acupuncture periods. Conclusion: When acupuncture stimulation was performed on PC9 and TE3, referred to as the "Wood points", brain waves were stabled, while when acupuncture was performed on PC5 and TE1, called the "Metal points", a brain was waked. From the findings of this study, we hypothesize that the wood properties, from which growing starts in all things, are related with fast waves of EEG, and the metal properties, which stabilize and converge in all things, are related with slow waves of EEG.

• Journal of Genetic Medicine
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• 제4권1호
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• pp.22-37
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• 2007

The autosomal dominant spinocerebellar ataxias (SCAs) are a group of neurodegenerative diseases, clinically and genetically heterogeneous, characterized by degeneration of spinocerebellar pathways with variable involvement of other neural systems. At present, 27 distinct genetic forms of SCAs are known: SCA1-8, SCA10-21, SCA23, SCA25-28, DRPLA (dentatorubral-pallidoluysian atrophy), and 16q-liked ADCA (autosomal dominant cerebellar ataxia). Epidemiological data about the prevalence of SCAs are restricted to a few studies of isolated geographical regions, and most do not reflect the real occurrence of the disease. In general a prevalence of about 0.3-2 cases per 100,000 people is assumed. As SCA are highly heterogeneous, the prevalence of specific subtypes varies between different ethnic and continental populations. Most recent data suggest that SCA3 is the commonest subtype worldwide; SCA1, SCA2, SCA6, SCA7, and SCA8 have a prevalence of over 2%, and the remaining SCAs are thought to be rare (prevalence <1%). In this review, we highlight and discuss the SCA7. The hallmark of SCA7 is the association of hereditary ataxia and visual loss caused by pigmentary macular degeneration. Visual failure is progressive, bilateral and symmetrical, and leads irreversibly to blindness. This association represents a distinct disease entity classified as autosomal dominant cerebellar ataxia (ADCA) type II by Harding. The disease affectsprimarily the cerebellum and the retina by the moderate to severe neuronal loss and gliosis, but also many other central nervous system structures as the disease progresses. SCA7 is caused by expansion of an unstable trinucleotide CAG repeat in the ATXN7 gene encoding a polyglutamine (polyQ) tract in the corresponding protein, ataxin-7. Normal ATXN7 alleles contain 4-35 CAG repeats, whereas pathological alleles contain from 36->450 CAG repeats. Immunoblott analysis demonstrated that ataxin-7 is widely expressed but that expression levels vary among tissues. Instability of expanded repeats is more pronounced in SCA7 than in other SCA subtypes and can cause substantial lowering of age at onset in successive generations termed ‘anticipation’ so that children may become diseased even before their parents develop symptoms. The strong anticipation in SCA7 and the rarity of contractions should have led to its extinction within a few generations. There is no specific drug therapy for this neurodegenerative disorder. Currently, therapy remains purely symptomatic. Cellular models and SCA7 transgenic mice have been generated which constitute valuable resources for studying the disease mechanism. Understanding the pathogenetic mechanisms of neurodegeneration in SCAs should lead to the identification of potential therapeutic targets and ultimately facilitate drug discovery. Here we summarize the clinical, pathological, and genetic aspects of SCA7, and review the current understanding of the pathogenesis of this disorder. Further, we also review the potential therapeutic strategies that are currently being explored in polyglutamine diseases.

• Allergy, Asthma & Immunology Research
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• 제10권6호
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• pp.698-715
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• 2018

Purpose: Hrd1 has recently emerged as a critical regulator of B-cells in autoimmune diseases. However, its role in the pathogenesis of chronic rhinosinusitis with nasal polyps (CRSwNP) remains largely unexplored. This study aimed to examine Hrd1 expression and B-cell accumulation and their possible roles in CRSwNP. Methods: Quantitative real-time polymerase chain reaction, immunohistochemistry, enzyme-linked immunosorbent assay and Western blotting were used to assess gene and protein expression in nasal tissue extracts. Cells isolated from nasal tissues and peripheral blood mononuclear cells were characterized by flow cytometry. Local antibody production was measured in tissue extracts with a Bio-Plex assay. Additionally, changes in Hrd1 expression in response to specific inflammatory stimuli were measured in cultured dispersed polyp cells. Results: Nasal polyps (NPs) from patients with eosinophilic CRSwNP (ECRS) had increased levels of Hrd1, B-cells and plasma cells compared with NPs from patients with non-eosinophilic CRSwNP (non-ECRS) or other control subjects (P < 0.05). The average Hrd1 levels in B-cells in NPs from ECRS patients were significantly higher than those from non-ECRS patients and control subjects (P < 0.05). NPs also contained significantly increased levels of several antibody isotypes compared with normal controls (P < 0.05). Interestingly, Hrd1 expression in cultured polyp cells from ECRS patients, but not non-ECRS patients, was significantly increased by interleukin-$1{\beta}$, lipopolysaccharide and Poly(I:C) stimulation, and inhibited by dexamethasone treatment (P < 0.05). Conclusions: Differential Hrd1 expression and B-cell accumulation between the ECRS and non-ECRS subsets suggests that they can exhibit distinct pathogenic mechanisms and play important roles in NP.

• 화훼연구
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• 제18권2호
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• pp.136-141
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• 2010

정신적 장애인을 대상으로 체계적인 원예치료 프로그램 마련을 위한 기초자료를 제공하고자 정신적 장애인을 대상으로 실시한 원예치료 프로그램을 분석하였다. 그 결과, 전체 원예치료 프로그램 중 공예활동이 가장 많이 진행되었으며 대상자별로는 지적장애가 가장 많았다. 그리고 시기별로는 전기보다 후기에 많은 프로그램이 진행되었다. 재배활동에서는 일반재배, 대상자별로는 지적장애가 가장 많았고 시기별로도 전기보다는 후기에 프로그램이 증가되었다. 공예활동을 살펴보면 전체적으로 화훼장식품이 가장 많았으며 대상자별로는 지적장애가 많았고 시기별로는 전기보다 후기에 더 많은 프로그램이 진행되었다. 요리활동에서는 차와 관련된 프로그램, 대상자별로는 지적장애가 가장 많았다. 시기별로는 전기보다 후기에 더 많은 프로그램이 진행되었다. 학습활동에서는 오리엔테이션 프로그램이 가장 많았으며, 대상자별로는 정신적장애가 많았고, 시기별로는 전기보다 후기에서 증가했다. 야외활동의 분석결과 전체적으로 소풍이 많았으며, 대상자별로는 지적장애에서 많은 프로그램이 진행되었다. 또한 시기별로는 전기보다 후기에 증가함을 알 수 있었다.

• 한국융합학회논문지
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• 제12권10호
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• pp.97-104
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• 2021

본 연구에서는 연령집단별로 지역사회 노인의 대면이름대기 능력, 생성이름대기 능력, 청력장애 수준, 우울 수준에 차이가 있는지, 그리고 이들 간에 어떠한 상관관계가 있는지, 마지막으로 지역사회 노인의 두 가지 이름대기 능력(대면이름대기와 생성이름대기)을 설명하는 요인은 무엇인지 알아보고자 하였다. 노인 65명을 65~74세 연소 노인, 75~84세 고령 노인, 85세 이상 초고령 노인으로 구분하였고, 이들을 대상으로 대면이름대기 검사로는 K-BNT-15를, 생성이름대기 검사로는 동물 이름대기 검사를, 주관적 청력장애의 측정은 K-HHIE를, 주관적 우울 정도 측정은 GDS를 사용하였다. 첫째, 연령 집단에 따라 대면이름대기 능력과 우울 수준에서 통계적으로 유의한 차이가 있었다. 둘째, 연령과 우울 수준, 청력장애 수준과 우울 수준 간에 정적 상관을, 교육 수준과 우울 수준 간에는 부적 상관을 보였다. 셋째, 대면이름대기 점수는 연령이, 생성이름대기 점수는 우울 수준이 설명하는 것으로 나타났다. 본 연구의 결과는 노년층의 이름대기 능력, 청력장애 정도, 우울 수준을 연령대별로 세분화하여 살펴보고, 이들이 단순히 노화의 결과가 아니라는 것과, 이를 해결하기 위해서는 다양한 분야에서 보다 융합적인 접근이 필요함을 보여주었다.