• Journal of Ginseng Research
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• v.48 no.2
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• pp.202-210
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• 2024

Background: Panax ginseng Meyer polysaccharides exhibit various biological functions, like antagonizing galectin-3-mediated cell adhesion and migration. Galectin-8 (Gal-8), with its linker-joined N- and C-terminal carbohydrate recognition domains (CRDs), is also crucial to these biological processes, and thus plays a role in various pathological disorders. Yet the effect of ginseng-derived polysaccharides in modulating Gal-8 function has remained unclear. Methods: P. ginseng-derived pectin was chromatographically isolated and enzymatically digested to obtain a series of polysaccharides. Biolayer Interferometry (BLI) quantified their binding affinity to Gal-8, and their inhibitory effects on Gal-8 was assessed by hemagglutination, cell migration and T-cell apoptosis. Results: Our ginseng-derived pectin polysaccharides consist mostly of rhamnogalacturonan-I (RG-I) and homogalacturonan (HG). BLI shows that Gal-8 binding rests primarily in RG-I and its β-1,4-galactan side chains, with sub-micromolar K_D values. Both N- and C-terminal Gal-8 CRDs bind RG-I, with binding correlated with Gal-8-mediated function. Conclusion: P. ginseng RG-I pectin β-1,4-galactan side chains are crucial to binding Gal-8 and antagonizing its function. This study enhances our understanding of galectin-sugar interactions, information that may be used in the development of pharmaceutical agents targeting Gal-8.

• Interaction and multiscale mechanics
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• v.5 no.3
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• pp.287-318
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• 2012

We apply a partitioned-solution (iterative-staggered) coupling method based on a fixed Eulerian mesh with the level set function to a large-deformation fluid-structure interaction (FSI) problem where a large-deformable thin structure moves in a high-speed flow field, as an airbag does during deployment. This method combines advanced fluid and structure solvers-specifically, the constrained interpolation profile finite element method (CIP-FEM) for fluid Eulerian mesh and large-deformable structural elements for Lagrangian structural mesh. We express the large-deformable interface as a zero isosurface by the level set function, and introduce virtual nodes with level sets and structural normal velocities to generate the level set function according to the large-deformable interfacial geometry and enforce the kinematic condition at the interface. The virtual nodes are located in the direction normal to the structural mesh. It is confirmed that application of the method to unfolded airbag deployment simulation shows the adequacy of the method.

• International Journal of Quality Innovation
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• v.6 no.2
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• pp.31-45
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• 2005

The target costing technique, mathematically discussed by Sauers, only uses the $C_p$ index along with Taguchi loss function and ${\bar{X}}-R$ control charts to set up goal control limits. The new specification limits derived from Taguchi loss function is linked through the $C_p$ value to ${\bar{X}}-R$ control charts to obtain goal control limits. This study further considers the reflected normal loss function as well as the $C_{pk}$ index along with its lower confidence interval in forming goal control limits. With the use of lower confidence interval to replace the point estimator of the $C_{pk}$ index and reflected normal loss function proposed by Spiring to measure the loss to society, this modified and improved target costing technique would become more robust and applicable in practice. Finally, an example is provided to illustrate how this modified and improved target costing technique works.

• Journal of the Korean Data and Information Science Society
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• v.24 no.6
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• pp.1211-1219
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• 2013

Recently, the usage of skew-normal distribution, instead of classical normal distribution, is rising up in many statistical theories and applications. In this paper, we deal with saddlepoint approximation for the distribution function of sample mean of skew-normal distribution. Comparing to normal approximation, saddlepoint approximation provides very accurate results in small sample sizes as well as for large or moderate sample sizes. Saddlepoint approximations related to the skew-normal distribution, suggested in this paper, can be used as a approximate approach to the classical method of Gupta and Chen (2001) and Chen et al. (2004) which need very complicate calculations. Through simulation study, we verified the accuracy of the suggested approximation and applied the approximation to Robert's (1966) twin data.

• Journal of Physiology & Pathology in Korean Medicine
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• v.23 no.3
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• pp.723-733
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• 2009

The purpose of this study is to evaluate the difference about pathogenesis of normal group and depression group(who' pulmonary function is below expected value). Author used DSOM to investigate oriental pathogenesis. Depression group is consisted of people who's FVC%(forced vital capacity)is below 80% or $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is below 70%, and they don't have history of lung disease(Athma, tuberculosis, COPD, suchlike). Normal group is consisted of people who's FVC%(Forced Vital Capacity) is in 80-120% and $FEV_1$/FVC%(Forced Expiratory Volume in 1sec/FVC) is above 70%. they also don't have history of lung disease. Author carried out each group's PFT(pulmonary function test) by ATS(American Thoracic Society) method. DSOM was used for oriental pathogenesis investigation of two groups. There was significant difference between normal group and depression group in Kidney(p<0.05). In depression group comparison of sex, there was significant difference between male and female in stagnation of qi, cold, heat, spleen, phlegm(p<0.05). In Normal group there was significant difference between male and female in stagnation of qi, blood stasis, cold, heat, spleen(p<0.05). In depression group comparison of smoke, there was no significant difference between smoker and non-smoker(p<0.05). In Normal group comparison of smoke, there was significant difference between smoker and non-smoker in heat(p<0.05). This result showed difference of the pathogenesis between Depression group and Normal group.

• Journal of the Korean Society of Food Science and Nutrition
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• v.29 no.1
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• pp.168-173
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• 2000

The purpose of this study was to investigate the changes of microsomal mixed function oxidase (MFO) and xanthine oxidase activities (XOD) in the liver of rats exposed to microwave. Sprague-Dawley male rats weighing 200$\pm$10g body weight were randomly assigned to a normal and microwave exposed(MW) groups; microwave exposed groups were divided into two groups; microwave (MW) group and green tea(GT) gropu which were fed distilled water and green tea extracts during experimental periods, respectively. Rats were irradiated with microwave at the frequency of 2.45 GHz for 15min and rats wre sacrificed at the 4th day of the microwave irradiaton. The hemoglobin level of GT group was higher than that of the normal gropu and MW group, but the hematocrit value was not significantly different among all experimental gropus. The activity of serum GOT of MW group was significantly increased but that of GT group was similar to normal group. Activities of GPT were not significantly different among all experimental groups. Liver XOD activity was significantly increased in the microwave exposed groups but green tea normalized the XOD activity. The activity of hepatic microsomal cytochrome P450 was significantly increased in MW group compared to normal group and that of GT group was similar to that of the normal group. The activity of hepatic microsomal NADPH-cytochrome P450 reductase was also significantly increased in MW group compared to normal group, but that of GT group was similar to that fo the normal group. In conclusion, the activities of MFO and XOD were elevated by microwave irradiaton, but the activation of MFO system as well as the damage of the liver by microwave were reduced by green tea supplementation.

• Journal of Nutrition and Health
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• v.33 no.6
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• pp.619-624
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• 2000

The purpose of this study was to investigate the effects of vitamin E on microsomal mixed function oxidase system of kidney in streptozotocin(STZ) induced diabetic rats. Sprague-Dawley male rats weighing 140$\pm$10g were randomly assigned to one control and three STZ-diabetic groups which were subdivided into vitamin E free diet(DM-0E group) 40mg vitamin E per kg diet(DM-40E group) and 400mg vitamin E per kg diet(DM-400E group). Vitamin E level of normal group was 40 mg per kg diet. Diabetes was experimentally induced by intravenous administration of 55 mg/kg B.W of STZ in citrate buffer(pH4.3) after 4 weeks feeding of experimental diets. Animals were sacrificed at the 6th day of diabetic state. The contents of cytochrome P450 in kidney were increased by 82, 54, 41% in DM-0E, DM-40E and DM-400E groups respectively when compared with normal group. The contents of cytochrome b5 in kidney were increased by 28% in DM-0E when compared with normal group but those of DM-40E and DM-400E groups were similar to that of normal group. The activities of NADPH-cytochrome P450 reductase in kidney that were increased by 35% in DM-0E group. Levels of TBARS(thiobarbituric acid reactive substance) in kidney were increased by 207, 129% and 72% in DM-0E and DM-400E groups respectively when compared with normal group but those of DM-40E and DM-400E groups were 26,44% lower than that of DM-0E groups. It is know that the activities of MFO system and lipid peroxidation were inhibited in kidney of STZ-induced diabetic rat by administeration of high doses of vitamin E.(Korean J Nutrition 33(6) : 619~624, 2000)

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.16 no.3
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• pp.152-161
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• 2004

Double-peak normal distribution function was suggested as the probability density function of the tidal elevation data in Korean coastal zone. Frequency distribution analysis was carried out using hourly tidal elevation data of the ten tidal gauging stations, i.e., Incheon, Kunsan, Mokpo, Cheju, Yeosu, Masan, Gadeokdo, Pusan, Pohang, and Sokcho which were served through the Internet Homepage by the National Ocean Research Institute. Based on the RMS error and $R^2$ value comparison analysis, it was found that this suggested function as the probability density function of the tidal elevation data was found to be more appropriate than the normal distribution function. The parameters of the double-peak function were estimated optimally using Levenberg-Marquardt method which was modified from the Newton method. The estimated parameters were highly correlated with the non-tidal constants of the tidal gauging stations.

• Speech Sciences
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• v.12 no.4
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• pp.203-213
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• 2005

This study was conducted to investigate the respiratory and aerodynamic function of adductor spasmodic dysphonia (ADSD) patients. Participants were (1) 18 females SD patients with non- Botulinum toxin injection (2) 14 females SD patients who had taken treatment of Botulinum toxin injection. (3) 14 age- and sex- matched normal female controls. Spirometer and phonatory function analyzer were used for respiratory muscle pressure (MIP: Maximum inspiratory pressure), MEP: Maximum expiratory pressure)& MPT(Maximum phonation time) and aerodynamic(F0:Fundamental frequency, intensity, MFR: Mean flow late, Psub: Subglottal pressure) measurement. The results were as follows: (1) Normal group was significantly higher in MIP, MEP, MPT than two SD groups (p < .05); (2) MPT was significantly lower in SD with non-Botulinum toxin injection group than SD with the treatment experience of Botulinum toxin injection (p < .05); (3) All aerodynamic parameters, F0, intensity, MFR, Psub, were not significantly different among three groups(p > .05).The reason of short MPT in ADSD may use lower respiratory pressure than normal group as strategy to decrease their tremulous voice quality. Moreover respiratory muscle pressure was lower than normal group regardless of botulinum toxin injection treatment.

• Communications of the Korean Mathematical Society
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• v.11 no.2
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• pp.335-348
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• 1996

For an open set G in the complex plane C, we prove the existence of an entire function f such that its integer translations forms a finitely normal family exactly on G if and only if G is periodic with period 1 and G has no hole.