• Journal of Veterinary Clinics
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• v.30 no.1
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• pp.41-44
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• 2013

A 4-year-old castrated male Shih-Tzu was presented to the Chonbuk National University Animal Medical Center with a history of melting ulcer in the right eye (OD). Upon ophthalmologic examination, severe keratomalacia of approximately 70% of the entire surface area with a full thickness corneal defect was found in OD. In addition, iris and fibrin clots were observed on the center of the corneal defect. The menace response and dazzle reflex were normal in OS. As the size and damage of corneal perforation was so severe, amniotic membrane (AM) transplantation was considered to repair the cornea instead of direct suture technique, flap methods or corneal transplantation. Equine AM was sutured to the limbus to cover the entire cornea in a single interrupted pattern using 9-0 nylon suture material. On day 79, mild scarring and pigmentation, with almost no vasculature, remained. The menace response and dazzle reflex were normal of OD. Although pigmentation and scarring remained on the cornea, equine AM transplantation can be useful for reconstruction of severe corneal perforation with keratomalacia.

• Journal of Pharmacopuncture
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• v.19 no.2
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• pp.137-144
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• 2016

Objectives: Several studies have revealed that systemic hypertension is strongly associated with cataractogenesis. However, the pathophysiology and treatment is often unclear. In this study, we evaluated the anti-cataractogenic effect of cinnamaldehyde (CA), a natural organic compound, in rats with fructose-induced hypertension. Methods: The rats were divided into six groups. For six weeks, the normal group received a suspension of 0.5% carboxy methyl cellulose (10 mL/kg/day, p.o.) while five other groups received a 10% (w/v) fructose solution in their drinking water to induce hypertension. By the end of the third week hypertension had been induced in all the animals receiving fructose. From the beginning of the fourth week to the end of the sixth week, one of those five groups (control) continued to receive only 10% (w/v) fructose solution, one group (standard) received ramipril (1 mg/kg/day, p.o.) plus 10% (w/v) fructose solution, and three groups (experimental) received CA at doses of 20, 30, and 40 mg/kg/day p.o., plus 10% (w/v) fructose solution. Blood pressure was measured weekly using a non-invasive blood pressure apparatus. After six weeks, the animals were sacrificed, and the anti-cataractogenic effects on the eye lenses were evaluated. Results: Administration of fructose elevated both the systolic and the diastolic blood pressures, which were significantly reduced by CA at all dose levels. In the control group, a significant increase in the malonaldehyde (MDA) level and decreases in the total protein, $Ca^{2+}$adenosine triphosphate (ATP)ase activity, glutathione peroxidase, catalase, superoxide dismutase and glutathione levels, as compared to the normal group, were observed. Administration of CA at all doses significantly restored the enzymatic, non-enzymatic, antioxidants, total protein, and $Ca^{2+}$ATPase levels, but decreased the MDA level, as compared to the control group. Conclusion: The present study revealed that CA modulated the antioxidant parameters of the serum and lens homogenates in hypertension-induced cataractogenic animals.

• Journal of Korean Ophthalmic Optics Society
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• v.17 no.2
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• pp.153-158
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• 2012

Purpose: The purpose of this study was to evaluate the convergence accommodation to convergence (CA/C) ratio and to investigate relationships among age, accommodative amplitude and PD (interpupillary distance) of adults in their early twenties with normal binocular vision. Methods: 44 subjects (mean age, $21.75{\pm}1.16$ years) with healthy eyes were examined. The CA/C ratios were measured by using the difference of Gaussian (DOG) target with retinoscopy. Results: The mean CA/C ratio was $0.052{\pm}0.017$ D/$\Delta$. A moderate negative correction was present between CA/C ratio and age (r = -0.50, p = 0.0005), and a highly positive correction was found between CA/C ratio and accommodative amplitude (r = 0.79, p<0.0001). There was no relation between PD and CA/C ratio. Conclusions: The CA/C ratio presented was mean value for adults in their early twenties with healthy eye between 19 and 25 years of age. There was a high correlation between accommodative amplitude and CA/C ratio. Therefore, the CA/C ratio will be useful basic information for comparison in age, gender and binocular anomalies with similar data from other countries.

• Journal of Korean Ophthalmic Optics Society
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• v.5 no.1
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• pp.173-180
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• 2000

To determine the effect of base curve and diameter of soft contact lenses on the fitting under the various corneal curvature, the model eyes which was made of either stainless steel or ordinary wood, were used as the substitutes for human eyes. The evaluations of fit of the soft contact lenses on both wood model eyes and human eyes were found to be very similar to each other. All the contact lenses except very thin ones became flat after fit on the stainless steel model eyes because the model eye could not preserve enough moisture to hold the edge of contact lenses on the steel ball's surface. The relationships between the base curves of contact lenses and radii of cornea for the optimum (normal) fit were measured as follows : corneal curvature (C.C)<7.6 mm : base curve(B.C) 8.4 mm, C.C 7.6~7.8 mm : B.C 8.4~8.5 mm. C.C 7.8~8.1 mm : B.C 8.6 mm. It is concluded that larger base curve is required for the eyes which have abnormal bulge on its cornea. It is found that very thin soft contact lenses can be easily twisted or folded regardless of moisture content when they were fit on the relatively dry eyes(corneas).

• Journal of rehabilitation welfare engineering & assistive technology
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• v.5 no.1
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• pp.47-52
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• 2011

The functional loot orthoses, when wearing shoes, are in the direct contact with bottom of foots to improve and recover the correctness of abnormal lower limb musculoskeletal imbalance and the primary role of foot and also, it can act to keep the balance and weight of body and support the weakened region, so that it is very helpful to keep body balance for the standing position. In this paper, it was researched that foot orthoses which is accommodable for the function of impact absorption including the gait stability affect on the balanced performances of body in according to the formation and the material of foot part. Taking into account the balanced performances by using the sway velocity, the estimation and comparison of the effects on the balanced performances by each formation and material for foot orthoses was evaluated into significant values(p<0.006) in only the eye-opening posture with Firm state, In this posture, the static process performed by each foot formation reveals in order of normal foot(p<0.010), flat foot(p<0.000) and hollow foot(p<0.003) and then, on the base of each formation of foot part, the result that analyze the effects of the materials of foot orthoses on the balance performance appeared showing that soft materials is more effective on the normal foot and, on the other hand, rigid materials is more effective in balancing on flat foot and hollow foot.

• The Journal of Korean Obstetrics and Gynecology
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• v.24 no.3
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• pp.48-72
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• 2011

Objectives: This study was designed to investigate the effects of Yongdamsagantang on the polycystic ovary(PCO) induced by estradiol valerate(EV) in rats. Methods: After administrating Yongdamsagan-tang to PCO induced rats, we measured the weight of body, ovaries, adrenal glands, and uterus of rats. The observation through naked eye and histopathological observation of ovaries were evaluated. Also, the number of follicle and corpora lutea and content of androstenedione(ADD) and total estrogen were evaluated. The expressions of nerve growth factor(NGF) and corticotropin releasing factor(CRF) were analyzed by immunohistochemistry. The breeding rate and number of implantation with normal male rats were evaluated. Results: - The weight(mg) of ovaries in YST treated group($73.8{\pm}7.6$) was significantly increased(p<0.001) compared with control group($54.3{\pm}4.5$). - The number of mature follicles in YST treated group($7.3{\pm}2.4$) was significantly increased(p<0.01) compared with control group($3.5{\pm}1.2$). - The number of atretic follicles in YST treated group($9.0{\pm}1.5$) was significantly decreased(p<0.01) compared with control group($13.4{\pm}3.8$). - The number of cystic follicles in YST treated group($3.1{\pm}1.1$) was significantly decreased(p<0.01) compared with control group($6.0{\pm}2.0$). - The number of corpora lutea in YST treated group($3.8{\pm}2.1$) was significantly increased(p<0.001) compared with control group($0.3{\pm}0.7$). - The expression of NGF-immunoreactive cells in the ovarian granulosa cells in YST treated group was lesser observed than control group. - The expression of NGF-immunoreactive cells in the adrenal cortex in YST treated group was lesser observed than control group. - The breeding rate in YST treated group(100 %) was significantly increased (p<0.05) compared with control group(50 %). - The number of implantation in YST treated group($6.4{\pm}4.7$) was significantly increased(p<0.05) compared with control group($1.4{\pm}2.6$). Conclusions: We concluded that Yongdamsagan-tang activates the maturation of follicles, normal ovulation, breeding rate and number of implantation. Therefore, this may be effective for the treatment of anovulation, amenorrhea and sterility of PCOS patients.

• Journal of Korean Ophthalmic Optics Society
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• v.12 no.4
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• pp.95-99
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• 2007

This study performed apreliminary test with male high school students in Gwangju metropolitan city in order to determine visual function information of high school students. For the items in this preliminary test, there were inquiry, test for long distance unaided visual acuity, pinhole visual acuity test, colour vision test, cover test and stereo test. Most complaint related to eye was about blurred vision (28.4%) and over 90% of subjects had one or more, and among them, over 50% appealed two or more complaints. 76.1% of all subjects showed less than 0.7 in unaided distance visual acuity. In pinhole visual acuity test, 98% had an improved unaided pinhole visual acuity and most of them experienced an improvement and 2% had no change or dropped. The students with normal stereoscopic vision test were 85.6% and the students under normal range were 14.4%. In colour vision test, 7.9% of them were protanomaly and deuteranomaly and none of them had trichromasy and total color blindness. In cover test, it showed 30.2% of orthophoria, 8.2% of esophoria and 61.5% of exophoria, and none of them had strabismus.

• Korean Journal of Microbiology
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• v.46 no.2
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• pp.152-156
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• 2010

Disposable contact lenses, which are one type of soft contact lenses, provide convenience in use, but also cause various ocular infectious diseases. Microorganisms that cause eye diseases include Acanthamoeba, bacteria, Fungi, and so on. It is impossible to prevent microorganism contamination completely due to the use of hands as wearing contact lenses. The contamination by various microorganisms leads to infectious keratitis, but it is not well known for the exact microorganisms that affect the disease. For this reason, to identify the microorganisms, two groups that are commonly used for disinfection of lenses were divided: normal saline solution and multiple purpose solution. Using these solutions the degree of microorganism contamination was observed according to the days of 1, 3, 5, 10, and 15. Twenty students by two groups from Ophthalmic Optics department at D college in Daegu Metropolitan city participated in the experiment after their ocular health conditions were checked. During they wore one-day disposable lenses for 1, 3, 5, 10, and 15 days, bacteria were cultured in media. The results, which were Gram stained by selecting the cultured colonies, show as followings: Gram positive cocci 33%, Gram-negative cocci 2%, Gram positive bacilli 34%, and the Gram negative bacilli 31%, respectively. As for the identification of potential pathogens, VITEK system and API kit methods were used. Keratitis caused by bacteria known as Staphylococcus aureus, Pseudomonas aeruginosa were detected as a result of wearing contact lenses. This study examined the distribution of bacteria as wearing one-day disposable contact lenses and pathogenic bacteria according to the duration of wearing them. In conclusion, the importance of hygiene when using contact lenses is suggested.

• The Korea Journal of Herbology
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• v.20 no.3
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• pp.1-7
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• 2005

Objectives : In this study, Folium Perillae were examined the possibility to apply as the cosmetics natural materials. Methods : Normal skin softener containing Folium Perillae extracts was manufactured and then its physiological activities function was experimented on. And emollient lotion containing Folium Perillae extracts was manufactured and then it was left under the condition of $-10^{\circ}C,\;0^{\circ}C$, room temperature and $37^{\circ}C$ for a month. Then its stability and safety were tested. Results : The physiological activities function of the normal skin softener was almost same with the electron donating ability, SOD like activity and xanthine oxidase inhibitory effect of Folium Perillae extracts. To find the changes of emollient lotion containing Folium Perillae extracts, the emollient lotion was left under the condition of $-10^{\circ}C,\;0^{\circ}C$, room temperature and $37^{\circ}C$ for a month. Then, when the emollient lotion was observed with the naked eye, pH, viscosity and particle diameter were measured, its changes were not nearly found. Futhermore, as a result of doing patch test to identify the safety of emollient lotion containing Folium Perillae extracts, there was no stimulus on skin. Conclusions : From the above results, it was expected that the physiological activities of Folium Perillae extracts can be maintained when cosmetics containing Folium Perillae extracts are manufactured. And it was proved that Folium Perillae extracts didn't affect the change of cosmetic when they were applied to cosmetic materials. And it was concluded that emollient lotion containing Folium Perillae extracts was safe for skin.

• Korean Journal of Psychosomatic Medicine
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• v.3 no.2
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• pp.166-173
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• 1995

The author compared the anxiety and depression level between glaucoma patents and normal controls by means of STAI(State-Trait Anxiety Inventory) and BDI(Beck Depression Inventory). The subject was the 38 glaucoma patients who visited ophthalmology clinic of Ewha Womans University Mokdong Hospital. The results were as follows : 1) There was no statistically significant difference in BDI and STAI according to age, education, religion, marital status. 2) There was no significant difference in STAI between the glaucoma patient group and the normal control group except that the female patients showed a tendency toward higher anxiety. 3) There was a significant difference in BDI between the female glaucoma patient group and the female control group(P<.01). But in the case of male there was no significant difference in BDI. 4) Eighteen point four percent of the glaucoma patients(10.5% of male patients, 26.4% of female patients) had suspected depressive disorder, and there was a tendency toward depression in 28.9% of glaucoma patients(10.5% of male patients, 47.4% of female patients). 5) There was no significant difference in BDI and STAI according to the use of beta-blocker or the other concommitant physical diseases. 6) The patients of glaucoma were generally concerned about the possibility of blindness, and felt annoyed with the fact that they should use eye drops or oral medication everyday.