• Journal of Surface Science and Engineering
• /
• v.55 no.6
• /
• pp.398-402
• /
• 2022

Vacuum Insulation Panel (VIP) is an high energy efficient insulation system that facilitate slim but high insulation performance, based on based on a porous core material evacuated and encapsulated in a multi-barrier envelope. Although VIP has been on the market for decades now, it wasn't until recently that efforts have been initiated to propose a standard on aging testing. One of the issues regarding VIP is its durability and aging due to pressure and moisture dependent increase of the initial low thermal conductivity with time. It is hard to visually determine at an early stage. Recently, a method of analyzing the damage on the a material surface by applying image processing technology has been widely used. These techniques provide fast and accurate data with a non-destructive way. In this study, the surface VIP images were analyzed using the Harris corner detection algorithm. As a result, 171,333 corner points in the normal packaging were detected, whereas 32,895 of the defective packaging, which were less than the normal packaging. were detected. These results are considered to provide meaningful information for the determination of VIP condition.

• 한국노년학
• /
• v.28 no.4
• /
• pp.925-940
• /
• 2008

As the proportion of old people in contemporary societies steadily increases, the influence on cognitive rehabilitation strategy of the memory deficit associated with normal and pathological aging grows greater as well. This paper reviewed the current memory rehabilitation techniques for older adults. In the first part of this article, human memory systems as a framework for understanding memory aging were considered. In the second part, research findings concerning memory performance in normal aging and Alzheimer's disease were reviewed. Finally, recent evidence for the kinds of memory rehabilitation procedures with proven efficacy were offered. The existent memory rehabilitation technique have focused on prompt of residual explicit memory, use of preserved implicit memory, utilization of memory external memory aids. A suggestion of memory training based on brain plasticity as a novel approach is offered.

• Journal of applied mathematics & informatics
• /
• v.25 no.1_2
• /
• pp.305-314
• /
• 2007

This paper considers single machine scheduling problems where the processing time of a job increases as a function of its position in the sequence. In this model, the later a given job is scheduled in the sequence, the longer its processing time. It is shown that the optimal schedule may be very different from that of the classical version of the problem. We introduce polynomial solutions for the makespan minimization problem, the sum of completion times minimization problem and the sum of earliness penalties minimization problem. For two resource constrained problems, based on the analysis of the problems, the optimal resource allocation methods are presented, respectively.

• BMB Reports
• /
• v.53 no.9
• /
• pp.458-465
• /
• 2020

Metastasis is the main culprit of the great majority of cancerrelated deaths. However, the complicated process of the invasion-metastasis cascade remains the least understood aspect of cancer biology. Telomerase plays a pivotal role in bypassing cellular senescence and sustaining the cancer progression by maintaining telomere homeostasis and genomic integrity. Telomerase reverse transcriptase (TERT) exerts a series of fundamental functions that are independent of its enzymatic cellular activity, including proliferation, inflammation, epithelia-mesenchymal transition (EMT), angiogenesis, DNA repair, and gene expression. Accumulating evidence indicates that TERT may facilitate most steps of the invasion-metastasis cascade. In this review, we summarize important advances that have revealed some of the mechanisms by which TERT facilitates tumor metastasis, providing an update on the non-canonical functions of telomerase beyond telomere maintaining.

• Korean Journal of Pharmacognosy
• /
• v.51 no.1
• /
• pp.49-54
• /
• 2020

The aim of this study was to investigate the epidermal moisturizing effects of artocarpin on normal human epidermal keratinocytes (NHEKs). To investigate the effects of artocarpin on NHEKs, cell viability and the expression of mRNAs related to skin hydration were measured. In addition, hyaluronic acid (HA)-ELISA assay was performed. Here, the effects of artocarpin on AQP3, HAS2, KRT1, and KRT10 mRNA expression, and on HA production, following UVA treatment were reported. The Quantitative real-time PCR results demonstrate that artocarpin increased AQP3, HAS2, KRT1, and KRT10 mRNA levels. The HA-ELISA assay revealed that artocarpin also increased HA production in NHEKs. Through these experiments, the epidermal moisturizing effects of artocarpin have been elucidated, providing evidence that artocarpin may be a potent cosmetic ingredient in skin anti-aging and moisturizing products. Based on these results, I anticipate that further research on the mechanisms of action of artocarpin may allow the development of not only cosmetics, but also medicines and healthcare foods.

• Sleep Medicine and Psychophysiology
• /
• v.8 no.1
• /
• pp.18-21
• /
• 2001

The change of sleep pattern is one of the most often altered normal physiological functions in elderly people. Besides normal change of sleep, insomnia and sleep apnea syndrome (SAS) are (one of) the main complaints. In addition, parasomnia is also frequent in this age group. Several parasomnias frequently found in the elderly are reviewed. Periodic limb movements in sleep (PLMS), restless legs syndrome (RLS), and REM sleep behavior disorder are the most frequent parasomnias in old age. Most parasomnias could be diagnosed by polysomnography, and be treated easily. Therefore, early and precise diagnosis and management for parasomnia in aging people are needed.

• Phonetics and Speech Sciences
• /
• v.6 no.2
• /
• pp.81-88
• /
• 2014

The normal aging process on speech production and these changes are perceived by listeners. This study examined whether age perception changed under various conditions of prosodic manipulations in normal listeners, comparing the prosodic changes according to age and sex in adulthood. The older and younger voices were resynthesized by manipulation of the speaking rate and pitch to shift the perceived age of the groups toward each other. Two-way repeated ANOVA were conducted to determine if the prosodic type of resynthesized cue resulted in a significant shift in perceived age of young and old voices. The manipulation of the speaking rate resulted in a significant shift in perceived age for the older and younger groups. A significant shift in age estimates was not observed for the younger male group when pitch was manipulated. There were significant gender-by-age group interactions for prosodic manipulation type. Age-related changes in the prosodic properties of speech may ultimately influence speech perception.

• Korean Journal of Pharmacognosy
• /
• v.52 no.4
• /
• pp.228-233
• /
• 2021

This research was carried out to investigate the moisturizing effects of Agarum cribrosum extract on normal human epidermal keratinocytes (NHEKs). Moisturizing effects of A. cribrosum extract on NHEKs were measured by quantitative realtime RT-PCR to verify the gene expressions related to skin hydration, hyaluronic acid (HA)-ELISA to detect HA production, and cell viability assays. A. cribrosum extract increased the mRNA levels of the AQP3 and HAS2 genes and HA production in NHEKs. On the other hand, A. cribrosum extract decreased the mRNA level of the KRT1 and KRT10 genes known as differentiated keratinocyte marker in NHEKs. This research showed the moisturizing effects of A. cribrosum extract. The results indicate that A. cribrosum extract can be a potent functional ingredient for skin hydration and anti-aging products. Further study is warranted regarding the use of A. cribrosum extract to develop not only cosmetics but also food and medicine.

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.11 no.1
• /
• pp.165-177
• /
• 2019

This paper considers corrosion wastage of two ship hull structure members as a part of investigated fuel oil tanks of 25 aging bulk carriers. Taking into account that many factors which influence corrosion wastage of ship hull structures are of uncertain nature, the related corrosion rate ($c_1$) is considered here as a real-valued continuous distribution, assuming that the corrosion wastage starts after 5, 6 or 7 years. In all considered cases, by using available data and applying three basic statistical tests, it is established that between two-parameter continuous distributions, normal, Weibull and logistic distributions are best fitted distributions for the mentioned corrosion rate ($c_1$). Note that the presented statistical, numerical and graphical results concerning two mentioned ship hull structure members allow to compare and discuss the corresponding probabilistic estimates for the corrosion rate ($c_1$).

• Proceedings of the Korean Society of Life Science Conference
• /
• 2000.06a
• /
• pp.9-10
• /
• 2000

The aging process is multifactorial and results from the combined effects of inherited(genetic) and acquired factors including life style, food habits, physical activity, and diseases. That give rise to the various approaches in aging. We are trying to study biological changes with aging, In detail we are focused on gene and protein function accompanied by normal or abnormal aging process, especially our efforts are aimed at revealing the functional relationship of proteins in aging as a final product of gene. We expect that proteomic approach to the study of protein function involved in aging should give us variety of integrated data to understand biological changes of long lived lives, We have applied expression proteomics to rat liver bred in dietary restriction or in at libitum to elucidate the effects of food habit on aging. Expression proteomics shows us protein profile in a selected tissue or cells as a whole and gives us the information about protein expression level, posttranslational modification and degenerative modification of expressed proteins. Comparative analysis of young and old rat liver by two dimensional gels shows that gene expression of several proteins was down regulated in old rats and some protein expression level is increased with aging. Dietary restriction slows down these changes of gene expression and in some proteins there's no difference in protein expression level at same ages in comparison with rats bred in at libitum. About forty protein was identified by peptide mass fingerprint with MALDI-TOF and rest of the protein of interest is in the course of identification, Also we are trying to make mitochondrial and cytosolic proteom reference map. These suborganelle proteom map will gives us the information about low abundance proteins and cellular localization of proteins. Proteomics is a growing methodology to study biological system. High throughput qualitative and qualitative aspect of this approach will gives us large amount of integrated information and speed up our understanding about biological system