• 한국콘텐츠학회논문지
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• 제21권6호
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• pp.318-326
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• 2021

본 연구는 고령화 및 저출산에 따라 보건의료분야의 만성질환의 증가 및 전문 인력부족 등의 문제를 해결하고 효율적인 헬스케어를 제공하고자 VR 콘텐츠를 이용한 신체검사의 효과성을 연구하였다. 이에 본 연구는 HTC VIVE Pro VR과 스틱 컨트롤러를 착용하여 원스톱 VR 콘텐츠 신체검사 시스템을 구현하였다. 시스템은 1단계부터 5단계까지이며, 색각테스트, 기억력테스트, 청력테스트, 반응속도테스트, 순간인지능력테스트의 5단계를 순차적으로 거쳐 최종 신체 나이를 판별하는 솔루션으로 구성된다.또한 본 연구가 개발한 원스톱 VR 콘텐츠 신체검사 시스템에 대해 대전 소재 A 상급종합병원 건강검진센터 및 VR/AR 임상시험 센터에 내원한 정상인을 대상으로 사용자 만족도를 검증한 결과, 전체적인 만족도와 재이용의사가 높게 나타났고, 성별에 따라 5단계 순간인지테스트는 유의한 차이가 있었으며, 연령에 따라서 4단계 반응속도테스트, 5단계 순간인지테스트에서 유의한 차이가 나타났다.

• 정보보호학회논문지
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• 제31권6호
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• pp.1105-1114
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• 2021

최근 급상승한 암호 화폐의 인기로 인해 암호 화폐 채굴 악성코드인 크립토재킹 위협이 증가하고 있다. 특히 웹 기반 크립토재킹은 피해자가 웹 사이트에 접속만 하여도 피해자의 PC 자원을 사용해 암호 화폐를 채굴할 수 있으며 간단하게 채굴 스크립트만 추가하면 되기 때문에 공격이 쉽고 성능 열화와 고장의 원인이 된다. 크립토재킹은 피해자가 피해 상황을 인지하기 어렵기 때문에 크립토재킹을 효율적으로 탐지하고 차단할 수 있는 연구가 필요하다. 본 연구에서는 크립토재킹의 대표적인 감염 증상과 스크립트를 지표로 활용하여 효과적으로 크립토재킹을 탐지하는 프레임워크를 제안하고 평가한다. 제안한 크립토재킹 탐지 프레임워크에서 행위 기반 동적 분석 기법으로 컴퓨터 성능 지표를 학습한 K-Nearest Neighbors(KNN) 모델을 활용했고, 스크립트 유사도 기반 정적 분석 기법은 악성 스크립트 단어 빈도수를 학습한 K-means 모델을 크립토재킹 탐지에 활용했다. 실험 결과에 따르면 KNN 모델은 99.6%의 정확도를 보였고, K-means 모델은 정상 군집의 실루엣 계수가 0.61인 것을 확인하였다.

• 대한지역사회영양학회지
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• 제26권6호
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• pp.482-494
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• 2021

Objectives: This study evaluated dietary behavior and nutritional status according to the metabolic syndrome status in Korean menopausal women. Methods: The subjects were 1,392 menopausal women aged 50 to 64 who took part in the Korea National Health and Nutrition Examination Survey of 2016 and 2017. Subjects were classified into normal (NOR) group, pre-metabolic syndrome (Pre-MetS) group, and metabolic syndrome (MetS) groups according to the number of metabolic syndrome risk factors present. Results: The overall prevalence of metabolic syndrome was 33.7%. Using the NOR group as a reference, the odds of belonging to the MetS group in Model 1 adjusted for age were higher at 53% (OR = 1.53, 95% CI:1.011-2.307) for 'not used' subjects compared to 'used' subjects of the nutrition labeling system. Using the NOR group as a reference, every 1g increase in the intake of monounsaturated fatty acids (MUFA) and polyunsaturated fatty acids (PUFA) decreased the odds of belonging to the MetS group in Model 1 adjusted for age by 3% (MUFA, OR = 0.97, 95% CI:0.946-0.991; PUFA, OR = 0.97, 95% CI:0.942-0.993). Conclusions: These results suggest that to reduce the number of risk factors of metabolic syndrome in menopausal women, nutritional education should emphasize the adequate intake of riboflavin, unsaturated fatty acids, protein, and calcium, and also encourage the recognition and use of nutritional labeling. Results of this study are expected to be utilized as basic data for the health management of menopausal women.

• 대한통합의학회지
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• 제10권2호
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• pp.1-11
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• 2022

Purpose : This study was conducted to assess the status of sarcopenia and locomotive syndrome in the Korean elderly population over 65 years of age by applying the recently updated screening tool for diagnostic evaluation of sarcopenia and locomotive syndrome. Methods : Sarcopenia and locomotive syndrome (LS) were diagnosed and evaluated in 210 Korean elderly people over 65 years of age. There were 36 patients in the "sarcopenia group", 164 in the "locomotive syndrome group", and 10 in the "normal group". The collected data were analyzed using the chi-square and Kruskal-Wallis tests. Results : The diagnostic evaluation of sarcopenia and LS showed the presence of sarcopenia in 9.05 % of males and 8.10% females among the Korean elderly population over 65 years of age. Prevalence of stage 1 locomotive syndrome (LS 1) was 95.24 %; stage 2, (LS 2) 36.19 %; and stage 3 (LS 3), 16.19 % among the study population. Both the sarcopenia diagnostic indicator and the LS evaluation indicators showed significant differences between the three groups. All the subjects in the sarcopenia group had LS; further, on comparison of the detailed composition ratio of each patient with LS, the prevalence of LS in the sarcopenia group was found to be: LS 1 41.67 %, LS 2 41.67 %, and LS 3 16.67 %, whereas in the LS group, it was found to be: LS 1 66.46 %, LS 2 16.46 %, and LS 3 17.07 %. The difference between the two groups was statistically significant. Conclusion : It was confirmed that sarcopenia is correlated with LS incidence. This suggests that the evaluation of motor LS can be used as a tool for the early diagnosis and prevention of sarcopenia in cases of functional decline due to aging in the elderly population.

• 한국안전학회지
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• 제37권6호
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• pp.102-107
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• 2022

South Korea will soon be a super-aged society, as more than 20.6% of its population will be 65 years and older by 2025. As of 2022, 17.5% of the total population in South Korea is 65 years and older, which exceeds the set threshold for an aged society, where more than 14% of the population is 65 years and older. The proportion of older subway construction workers has increased. Aging workers and their work stress negatively impact their workability. A previous study demonstrated that the stress index measured using the uBioMacpa measurement device (Macpa stress index) had a significant correlation with work stress in South Korea. The device tests vascular health and measures stress levels via Macpa signal analysis. In this study, the pulse waves of subway construction workers were measured using uBioMacpa to identify their stress levels. The stress levels were analyzed by age, years of service, job position, employment type, and work type. Herein, these statistics could not be easily represented by a normal distribution; therefore, the Kruskal-Wallis test, a nonparametric statistical method, was used for the analysis of data. The results showed that age, job position, employment type, and working type affected the Macpa stress index and the stress levels of workers increased with age. In terms of job position, technical engineers were more stressed than other workers because of their poor working environment. In terms of employment type, daily-wage workers were more stressed than other workers. In terms of working type, tunneling, waterproofing, and construction scored the highest Macpa stress indexes without any significant difference, whereas earthworks scored the lowest. Based on the analysis of Macpa stress index, safety and health management plans were proposed to reduce the stress levels of workers. Moreover, a manual for efficient stress management must be developed for subway construction workers.

• 대한의용생체공학회:의공학회지
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• 제44권1호
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• pp.53-63
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• 2023

There have been many studies from the genetic system to physical activity and emotional expression such that there are gender differences. The purpose of this study was to determine how the structural characteristics of cortical thickness differ between males and females. This study used data from the Human Connectome Project (HCP). To analyze age-specific sexual dimorphisms of cortical thickness, selected 8-80 year old subjects were divided into five detailed age range groups according to each criterion. A total of 1,700 individual brain MRI T1 data were registered in stereotaxic space for analysis and classified into white matter (WM), gray matter (GM), and cerebro-spinal fluid (CSF). For surface-based analysis, the WM/GM surface was reconstructed from a spherical polygon model with 40962 vertices per hemisphere, and each vertex was extended to the GM/CSF boundary. Cortical thickness was then measured between each vertex using the t-link method. In the statistical analysis, intracranial volume was used as a covariate to exclude the effect of the difference in brain size of each individual, and the result of using age as a covariate was added to confirm the age effect within each group. Gender differences in cortical thickness had significant results by group. This may be an index to explain diseases with sexual dimorphism in prevalence or become a basis for explaining the characteristics of each sex that appear in behavior, personality, and aging. Therefore, the results of our study could be a criterion for age classification in future studies and for understanding 'normal' sexual dimorphism.

• 대한본초학회지
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• 제29권1호
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• pp.7-12
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• 2014

Objectives : Polygoni Multiflori Radix (PMR), the roots of Polygonum multiflorum Thunberg, is used to nourish the blood and yin and used for preventing premature greying of the hair. There are some articles on its preventing effects on the melanogenesis. However, there is no report about its effects on the collagen and elastin. The present study was designed to investigate its effects on collagen metabolism and elastase activity. Methods : The effects of PMR on type I procollagen production and collagenase activity in human normal fibroblasts Hs68 after UVB (312 nm) irradiation were measured by ELISA method. Cells were pretreated with the PMR for 24 hours prior to UVB irradiation. After UVB irradiation, cells were retreated with the sample and incubated for additional 24 hours. The amount of collagen type I was measured with a procollagen type I C-peptide assay kit. The activity of collagenase was measured with a MMP-1 human biotrak ELISA system. The elastase activities after treatment of PMR were measured as well. Results : In the present study, the collagen production was not increased. However, the increased collagenase activity after UVB damage was significantly recovered to $50.2{\pm}14.5%$, $8.2{\pm}3.1%$, and $10.0{\pm}3.3%$ (10, 30, and $100{\mu}g/ml$). The elastase activities (10, 100, and $1000{\mu}g/ml$) significantly reduced to $75.2{\pm}5.2%$, $40.3{\pm}1.2%$, and $27.0{\pm}1.9%$, respectively. Conclusion : PMR showed the inhibitory effects on collagenase and elastase activity. These results suggest that PMR may have potential as an anti-aging ingredient in cosmetic herbal treatment.

• 대한본초학회지
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• 제28권3호
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• pp.1-5
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• 2013

Objectives : This study was designed to investigate the collagen metabolism and tyrosinase activity of Polygonati Rhizoma extracts (PR). It's effects are to tonify spleen qi and augment the spleen yin. It enrichs the yin and moisten the lung. Methods : The effect of PR on type I procollagen production and collagenase (matrix metalloproteinase-1, henceforth referred as MMP-1) activity in human normal fibroblasts Hs68 after ultraviolet B (UVB, 312 nm) irradiation was measured by ELISA method. The tyrosinase activity after treatment of PR was measured. Results : There were no cytotoxicity at concentrations of 10, 30, $100{\mu}g/ml$. The reduced type I procollagen production was recovered by PR in UVB damaged Hs68 cells at a concentration of $100{\mu}g/ml$ ($16.2{\pm}0.0$ ng/ml) from control group ($13.9{\pm}0.5$ ng/ml). However there was no statistical significance. PR reduced The increased MMP-1 activity after UVB damage at concentrations of $10{\mu}g/ml$, $30{\mu}g/ml$, and $100{\mu}g/ml$ in a dose dependent manner ($42.2{\pm}20.5%$, $44.8{\pm}8.5%$, and $22.0{\pm}5.8%$). PR $100{\mu}g/ml$ treatment showed the statistical significace (p < 0.05). PR significantly reduced the tyrosinase activity at a concentration of 10 mg/ml ($32.0{\pm}12.8%$, p < 0.05). However, the L-DOPA oxidation was not changed. Conclusion : PR showed the anti-wrinkle effects and whitening effects in vitro. Although more researches are needed to validate the efficacy, these results suggest that PR may have potential as an anti-aging ingredient in cosmetic herb markets.

• 한국융합학회논문지
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• 제13권5호
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• pp.357-363
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• 2022

한국은 저출생 현상과 급속한 고령화로 인하여 노인돌봄 위기에 처해 있다. 2008년 노인장기요양보험이 본격적으로 실시되면서 노인돌봄의 사회화가 이루어지게 되었으나 다양하지 못한 서비스 선택권, 맞춤형 돌봄의 부족, 커뮤니티 케어의 불안정함 등으로 돌봄의 공백은 아직 사회문제로 남아있다. 또한 고령화의 진전에 따라 치매유병율의 증가는 새로운 사회위기이다. 이러한 상황에서 복지기술은 부족한 자원과 증가하는 수요의 공백을 메꾸어줄 미래의 중요한 대안이다. 본 논문에서는 지역에서 다양하게 제공되고 있는 치매서비스를 경험한 바 있는 경증치매노인 집단그룹면접, 치매고위험군 집단그룹면접을 통해 복지기술에 대한 친밀성, 접근성, 치매예방방안 등을 파악하였다. 치매 정도에 따른 차이는 있으나 두 그룹 모두 복지기술을 활용한 치매서비스에 관심이 높았다. 특히, 일상생활에서 자립적 훈련은 친밀한 도구인 TV나 전화를 활용하는 방안이 제시되었고 경증치매노인군의 경우 데이케어센터에서 기술활용을 위한 도움서비스와 가정 내 연계방안의 필요성이 제시되었다.

• Archives of Plastic Surgery
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• 제49권2호
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• pp.275-284
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• 2022

Background Population aging has led to an increased incidence of pressure ulcers, resulting in a social burden and economic costs. We developed a three-dimensional knitted fabric (3-DKF) with a pressure-reducing function that can be applied topically in the early stages of pressure ulcers to prevent progression. Methods We evaluated the effects of the 3-DKF in a streptozotocin-induced diabetes mellitus pressure ulcer mouse model, and the fabric was preliminarily applied to patients. Twelve-week-old male C57BL/6 mice were used for the animal experiments. In the pressure ulcer mouse model, an ischemia-reperfusion injury was created using a magnet on the dorsa of the mice. Pressure was measured with BodiTrak before and after applying the 3-DKF to 14 patients at risk of sacral pressure ulcers. Results In the 3-DKF-applied mice group, the ulcers were shallower and smaller than those in the control group. Compared with the mice in the control group, the 3-DKF group had lower platelet-derived growth factor-α and neutrophil elastase expression, as parameters related to inflammation, and increased levels of transforming growth factor (TGF)-β1, TGF-β3, proliferating cell nuclear antigen, and α-smooth muscle actin, which are related to growth factors and proliferation. Additionally, typical normal tissue staining patterns were observed in the 3-DKF group. In the preliminary clinical analysis, the average skin pressure was 26.2 mm Hg before applying the 3-DKF, but it decreased to an average of 23.4 mm Hg after 3-DKF application. Conclusion This study demonstrated that the newly developed 3-DKF was effective in preventing pressure ulcers through testing in a pressure ulcer animal model and preliminary clinical application.