대한의용생체공학회:의공학회지 (Journal of Biomedical Engineering Research)

  • 제44권1호
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  • Pages.53-63
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  • 2023
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  • 1229-0807(pISSN)
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  • 2288-9396(eISSN)
대한의용생체공학회 (The Korean Society of Medical and Biological Engineering)
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연령별 대뇌 피질 두께의 성별 차이에 대한 형태학적 분석

Morphological Analysis of Age-related Gender Differences in Cortical Thickness

  • 서해석 (대구가톨릭대학교 의공학과) ;
  • 김수현 (대구가톨릭대학교 의공학과) ;
  • 윤의철 (대구가톨릭대학교 의공학과)
  • Haeseok, Seo (Department of Biomedical Engineering. Daegu Catholic University) ;
  • Suhyun, Kim (Department of Biomedical Engineering. Daegu Catholic University) ;
  • Uicheul, Yoon (Department of Biomedical Engineering. Daegu Catholic University)
  • 투고 : 2023.01.26
  • 심사 : 2023.02.14
  • 발행 : 2023.02.28
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초록

There have been many studies from the genetic system to physical activity and emotional expression such that there are gender differences. The purpose of this study was to determine how the structural characteristics of cortical thickness differ between males and females. This study used data from the Human Connectome Project (HCP). To analyze age-specific sexual dimorphisms of cortical thickness, selected 8-80 year old subjects were divided into five detailed age range groups according to each criterion. A total of 1,700 individual brain MRI T1 data were registered in stereotaxic space for analysis and classified into white matter (WM), gray matter (GM), and cerebro-spinal fluid (CSF). For surface-based analysis, the WM/GM surface was reconstructed from a spherical polygon model with 40962 vertices per hemisphere, and each vertex was extended to the GM/CSF boundary. Cortical thickness was then measured between each vertex using the t-link method. In the statistical analysis, intracranial volume was used as a covariate to exclude the effect of the difference in brain size of each individual, and the result of using age as a covariate was added to confirm the age effect within each group. Gender differences in cortical thickness had significant results by group. This may be an index to explain diseases with sexual dimorphism in prevalence or become a basis for explaining the characteristics of each sex that appear in behavior, personality, and aging. Therefore, the results of our study could be a criterion for age classification in future studies and for understanding 'normal' sexual dimorphism.

키워드

과제정보

이 결과물은 2020년도 대구가톨릭대학교 학술 연구비 지원에 의한 것임.

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