• 생물정신의학
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• 제21권1호
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• pp.1-13
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• 2014

Normal aging causes changes in the brain volume, connection, function and cognition. The brain changes with increases in age and difference of gender varies at all levels. Studies about normal brain aging using various brain magnetic resonance imaging (MRI) variables such as gray and white matter structural imaging, proton spectroscopy, apparent diffusion coefficient, diffusion tensor imaging and functional MRI are reviewed. Total volume of brain increases after birth but decreases after 9 years old. During adulthood, total volume of brain is relatively stable. After 35 years old, brain shrinks gradually. The changes of gray and white matters by aging show different features. N-acetylaspartate decreases or remains unchanged but choline, creatine and myo-inositol increase with aging. Apparent diffusion coefficient decreases till 20 years old and then becomes stable during adulthood and increase after 60 years old. Diffusion tensor properties in white matter tissue are variable during aging. Resting-state functional connectivity decreases after middle age. Structural and functional brain changes with normal aging are important for studying various psychiatric diseases such as dementia, schizophrenia and bipolar disorder. Our review may be helpful for studying longitudinal changes of these diseases and successful aging.

• The Journal of Korean Physical Therapy
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• 제16권1호
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• pp.49-59
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• 2004

Chronic and acute musculoskeletal disorders associated with aging are a challenges to the physical therapy. An understanding of the pathophysiology of normal and pathological aging is imperative for making effective clinical decisions. The foundation for understanding the aging musculoskeletal system is understanding the sequence of normal musculoskeletal development, which begins prenatally

• BMB Reports
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• 제47권1호
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• pp.8-14
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• 2014

Telomerase plays a pivotal role in the pathology of aging and cancer by maintaining genome integrity, controlling cell proliferation, and regulating tissue homeostasis. Telomerase is essentially composed of an RNA component, Telomerase RNA or TERC, which serves as a template for telomeric DNA synthesis, and a catalytic subunit, telomerase reverse transcriptase (TERT). The canonical function of TERT is the synthesis of telomeric DNA repeats, and the maintenance of telomere length. However, accumulating evidence indicates that TERT may also have some fundamental functions that are independent of its enzymatic activity. Among these telomere-independent activities of hTERT, the role of hTERT in gene transcription has been investigated in detail. Transcriptional regulation is a fundamental process in biological systems. Several studies have shown a direct involvement of hTERT in gene transcription. This mini-review will focus on the role of hTERT in gene transcription regulation, and discuss its possible mechanisms.

• 말소리와 음성과학
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• 제4권2호
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• pp.135-143
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• 2012

Discourse is regarded as an important component of communication assessment, but studies about the discourse characteristics of the elderly are scant. The purpose of this study was to confirm the effects of aging, gender, and educational level on discourse in elderly people with normal cognitive function. Forty normal elderly and forty young people participated in this study. A picture description task (Boston Cookie-Theft picture) was used to examine discourse function. The description task was analyzed for both productivity (total number of sentences, total number of syllables, and syllables per sentence) and semantics (CIU ratio). The results were as follows: 1) Only CIU ratio differed significantly according to age. 2) In the total number of syllables and syllables per sentence, females demonstrate a higher number than males. 3) The CIU ratio differed significantly according to educational level. These results suggest that impairment of communicative function is an aspect of cognitive impairment that can be related to aging. Also, discourse performance in the elderly is associated with their gender and educational level.

• 한국축산식품학회지
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• 제43권5호
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• pp.901-913
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• 2023

This study aimed to investigate changes in the quality of meat aged using Jeju scoria earthenware. Water-holding properties, pH, color, tenderization, fatty acid composition, and free amino acid characteristics of aged pork loin were evaluated to determine the effects of wet and dry (normal and Jeju Scoria) aging methods and aging time (0, 10, 20, 30, and 40 days) on meat quality. The aging methods altered pH and CIE L^* after 10 days of aging. However, the aging method did not alter the pH and CIE L^* of the aged pork loin after 10 days of aging. The shear force was significantly lower in the Scoria aging method than in the wet aging method after 10 and 20 days of aging. Both the normal and Scoria aging methods increased aging loss compared to the wet aging method, which could be attributed to longer air exposure times of the two non-packaged aging methods than in the packaged aging method. The scoria aging method had significantly higher contents and ratios of saturated (SFA) to mono-unsaturated fatty acids but lower ratios of poly-unsaturated fatty acids to SFA than the wet aging method. The content of most free amino acids significantly increased with aging time, especially those related to the sweet, and umami categories. In summary, this study suggests that the Scoria aging method provides positive aspects of eating quality, such as improvement of meat tenderness and taste, including umami, with minimum changes in the overall meat quality.

• 대한지역사회작업치료학회지
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• 제9권2호
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• pp.13-22
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• 2019

목적 : 본 연구는 정상노화 과정에 따른 일화기억 저하 양상을 일화기억의 하위요소인 사물, 공간위치, 시간순서 기억을 중심으로 파악하고자 하였다. 연구방법 : 20대부터 80대 이상까지의 건강한 젊은 성인과 노인 77명이 본 연구에 참여하였으며, 일화기억을 평가하기 위한 컴퓨터 인지과제를 수행하였다. 인지과제는 사물, 공간위치, 시간순서 기억을 각각 평가하기 위한 세 가지 항목으로 구성되어 있었으며, 주변에서 흔하게 볼 수 있는 사진 10장을 이용하여 검사를 진행하였다. 사진 10장을 본 이후에 사진 속의 사물의 종류, 사물의 위치, 사진이 제시된 순서를 물어보는 과정을 통해 평가를 진행하였으며, 각 하위검사의 정답률을 연령대별로 분석하였다. 결과 : 연구 결과, 사물과 공간위치 기억은 정상노화에 큰 영향을 받지 않는 반면, 시간순서 기억은 정상노화 과정 속에서 큰 폭으로 저하되는 것을 알 수 있었다. 세부적으로 살펴보면 시간순서 기억은 40대 이상부터 20~30대에 비해 유의한 저하가 발생하는 것을 관찰할 수 있었고 80대 이후에는 사물 기억이 가장 높은 것으로 확인되었다. 즉 정상 노화 과정에 따라 시간순서 기억이 가장 먼저 감소되고 사물 기억이 가장 마지막에 저하되는 것을 확인하였다. 결론 : 본 연구는 정상노화 과정에 따른 일화기억의 하위요소별 저하 양상을 제시하였다. 사물 기억에 초점을 맞춘 기존의 신경심리학적 검사들을 통해 제한적으로 확인하였던 공간위치와 시간순서 기억의 저하 양상을 세부적으로 확인할 수 있었다. 본 연구 결과는 정상노화에 따른 일화기억의 저하에서 벗어난 일화기억의 손상을 선별하는데 도움이 될 것이며, 정상노인에게 시행되는 예방적인 인지 중재에 공간위치와 시간순서 기억의 훈련이 포함되어야 할 근거를 제시한다.

• Molecules and Cells
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• 제42권3호
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• pp.210-217
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• 2019

The maintenance of mitochondrial function is closely linked to the control of senescence. In our previous study, we uncovered a novel mechanism in which senescence amelioration in normal aging cells is mediated by the recovered mitochondrial function upon Ataxia telangiectasia mutated (ATM) inhibition. However, it remains elusive whether this mechanism is also applicable to senescence amelioration in accelerated aging cells. In this study, we examined the role of ATM inhibition on mitochondrial function in Hutchinson-Gilford progeria syndrome (HGPS) and Werner syndrome (WS) cells. We found that ATM inhibition induced mitochondrial functional recovery accompanied by metabolic reprogramming, which has been known to be a prerequisite for senescence alleviation in normal aging cells. Indeed, the induced mitochondrial metabolic reprogramming was coupled with senescence amelioration in accelerated aging cells. Furthermore, the therapeutic effect via ATM inhibition was observed in HGPS as evidenced by reduced progerin accumulation with concomitant decrease of abnormal nuclear morphology. Taken together, our data indicate that the mitochondrial functional recovery by ATM inhibition might represent a promising strategy to ameliorate the accelerated aging phenotypes and to treat age-related disease.

• 통합자연과학논문집
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• 제16권3호
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• pp.75-80
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• 2023

Bipolar disorder is a mental illness characterized by extreme mood and behavioral swings, such as highs of euphoria and lows of depression. It is a socially significant disorder in which people with the disorder experience intense mood swings and, for those with severe bipolar disorder, it is even difficult leading a normal life. High stress levels in people with mental illness can lead to neuroendocrine disruption, and it is strongly linked to aging. When the neuroendocrine system becomes vulnerable to these mental illnesses and stress, it is likely to accelerate aging. And it's the epigenetic clock that can measure the extent of this accelerated aging. The Epi clock, a pan tissue clock, measures aging through DNA methylation, and the degree of methylation is modified and changed by environmental conditions in the body. Therefore we wanted to check the changes in the epigenetic age of the patients with bipolar disorder. While we found no significant differences in epigenetic age, we did confirm the possibility that people with bipolar disorder have different methylation than normal people. We also found that the EPIC array data fit better on the Epi clock than on the Horvath clock with age-accelerated data from normal people.

• 한국콘텐츠학회논문지
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• 제12권5호
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• pp.280-292
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• 2012

인간의 인지-화용언어 능력은 일반적으로 연령이 증가함에 따라 저하된다. 노년층의 인지-화용언어 능력을 평가하는 것은 인지 기능이나 치매 등 관련 질병들에 대한 예측에 도움이 된다. 본 연구에서는 노년층의 인지-화용언어 능력을 평가하기 위한 기존의 도구들을 분석하고, 현재 저자들이 연구 개발 중인 평가영역 및 문항들에 대한 내용타당도(content validity)를 검증하고자 하였다. 이를 위해 17명의 언어치료사 및 임상심리사들이 판단한 척도점수에 근거하여 내용타당도 지수(Content Validity Index, CVI)를 산정하였다. 연구 결과, 주의력, 기억력, 조직화 능력, 추론력, 문제해결력, 집행기능, 화용언어 등 7개 영역 모두 CVI가 .75를 초과하였다. 이에 따라, 현 문항들이 노년층의 인지-화용언어 능력을 평가하기 위한 목적과 적절히 부합하는 내용적 타당성을 지니는 것으로 입증되었다.

• 혜화의학회지
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• 제8권1호
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• pp.593-623
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• 1999

This experimental study was designed to verify the anti-aging efficacy of Eukmigihwangtang (EMGHT) and Rehmannia Radix, and determine the specific role and actions of Rehmannia Radix. Normal rat (2 months old), aging rat (8 months old), and pathologically induced rat (2 months old, injected 30mg/kg of streptozotocin) are observed to study the aging eliciting factors such as peroxide contents and enzyme activities. The following results were obtained in this study: 1. For the body weight changes, normal group given Rehmannia Radix showed decrease in the body weight compared to the control group, aging group given EMGHT and Rehmannia Radix showed significant decrease in the body weight, and STZ injected group showed suppression to the body weight loss when given EMGHT and Rehmannia Radix. 2. For the content changes in serum lipid peroxide, normal group showed increasing level as the rat gets older. Aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the lipid peroxide level compared to the control group. Decrease was more prominant in the group given EMGHT. 3. For the changes in serum hydroxyl radical, normal group did not show significant changes, but aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the hydroxyl radical level compared to the control group. Decrease was more prominant in the group given EMGHT. 4. For the changes in serum superoxide dismutase (SOD) activity, normal group did not show significant changes, but aging group given EMGHT and Rehmannia Radix showed significant increase in the SOD activity compared to the control group. STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the SOD activity compared to the control group. 5. For the content changes in hepatic lipid peroxide, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease in the lipid peroxide level compared to the control group. 6. For the changes in hepatic cytochrome P-450 activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. Cytochrome b5 activity was significantly decreased only in the STZ injected group given EMGHT and Rehmannia Radix. 7. For the changes in hepatic aminopyrine demethylase and aniline hydroxylase activity, aging group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. STZ injected group given EMGHT and Rehmannia Radix showed significant increase in the aminopyrine demethylase activity, and showed significant decrease in the aniline hydroxylase activity compared to the control group. 8. For the content changes in hepatic protein bound-SH and nonprotein bound-SH, againg group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group. 9. For the content changes in hepatic glutathione level, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group. 10. For the changes in hepatic glutathione S-transferase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase and decrease, respectively, compared to the control group. 11. For the changes in hepatic glutathione reductase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant increase compared to the control group, while $\gamma$-Glutamylcystein synthetase activity did not show significant changes. 12. For the changes in hepatic superoxide dismutase activity, aging group and STZ injected group given EMGHT and Rehmannia Radix showed significant decrease compared to the control group. From the above results, the antioxidant effects of EMGHT and Rehmannia Radix were proved, as well as the role of Rehmannia Radix, a chief of EMGHT, was examined. In addition, since no change was reconized as the quantity of Rehmannia Radix and the order herbs increased, the reasonableness on EMGHT was proven with respect to its composition and quantity. Thus, the significance of EMGHT could be objectively exmined in terms of its composition and quantity. Considering animals used in the experiment, there were obvious changes in aging rats and pathologically induced rats than in normal rats. Consequently, it was noticeable that EMGHT and Rehmannia Radix were working selectively on the subjects.