• Clinical Psychopharmacology and Neuroscience
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• v.16 no.4
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• pp.449-460
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• 2018

Objective: Prior functional magnetic resonance imaging (fMRI) work has revealed that children/adolescents with disruptive behavior disorders (DBDs) show dysfunctional reward/non-reward processing of non-social reinforcements in the context of instrumental learning tasks. Neural responsiveness to social reinforcements during instrumental learning, despite the importance of this for socialization, has not yet been previously investigated. Methods: Twenty-nine healthy children/adolescents and 19 children/adolescents with DBDs performed the fMRI social/non-social reinforcement learning task. Participants responded to random fractal image stimuli and received social and non-social rewards/non-rewards according to their accuracy. Results: Children/adolescents with DBDs showed significantly reduced responses within the caudate and posterior cingulate cortex (PCC) to non-social (financial) rewards and social non-rewards (the distress of others). Connectivity analyses revealed that children/adolescents with DBDs have decreased positive functional connectivity between the ventral striatum (VST) and the ventromedial prefrontal cortex (vmPFC) seeds and the lateral frontal cortex in response to reward relative to non-reward, irrespective of its sociality. In addition, they showed decreased positive connectivity between the vmPFC seed and the amygdala in response to non-reward relative to reward. Conclusion: These data indicate compromised reinforcement processing of both non-social rewards and social non-rewards in children/adolescents with DBDs within core regions for instrumental learning and reinforcement-based decision-making (caudate and PCC). In addition, children/adolescents with DBDs show dysfunctional interactions between the VST, vmPFC, and lateral frontal cortex in response to rewarded instrumental actions potentially reflecting disruptions in attention to rewarded stimuli.

• Asian Pacific Journal of Cancer Prevention
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• v.13 no.4
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• pp.1281-1284
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• 2012

Background: Platinum-hased chemotherapy for advanced non-small cell lung cancer (NSCLC) is still considered the first choice, presenting a modest survival advantage. However, the patients eventually experience disease progression and require second-line therapy. While there are reliable predictors to identify patients receiving first-line chemotherapy, very little knowledge is available about the prognostic factors in patients who receive second-line treatments. The present study was therefore performed. Methods: We retrospectively reviewed 107 patients receiving second-line treatments from August 2002 to March 2012 in the Dicle University, School of Medicine, Department of Medical Oncology. Fourteen potential prognostic variables were chosen for analysis in this study. Univariate and multivariate analyses were conducted to identify prognostic factors associated with survival. Result: The results of univariate analysis for overall survival (OS) were identified to have prognostic significance: performance status (PS), stage, response to first-line chemotherapy response to second-line chemotherapy and number of metastasis. PS, diabetes mellitus (DM), response to first-line chemotherapy and response to second-line chemotherapy were identified to have prognostic significance for progression-free survival (PFS). Multivariate analysis showed that PS, response to first-line chemotherapy and response to second-line chemotherapy were considered independent prognostic factors for OS. Furthermore, PS and response to second-line chemotherapy were considered independent prognostic factors for PFS. Conclusion: In conclusion, PS, response to first and second-line chemotherapy were identified as important prognostic factors for OS in advanced NSCLC patients who were undergoing second-line palliative treatment. Furthermore, PS and response to second-line chemotherapy were considered independent prognostic factors for PFS. It may be concluded that these findings may facilitate pretreatment prediction of survival and can be used for selecting patients for the correct choice of treatment.

• Structural Engineering and Mechanics
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• v.49 no.4
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• pp.479-489
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• 2014

In the present study a parametric analysis is conducted to study the effect of pile dimension and soil properties on the nonlinear dynamic response of pile subjected to lateral sinusoidal load at the pile head. The study is conducted on soil-pile model of different pile diameter, pile length and soil modulus, and results are compared to get the effect. The soil-pile system is modelled using Finite element method. The programming is done in MATLAB. Time history analysis of model is done for varying non-dimensional frequency of load and the results are compared to get the non-dimensional frequency at which pile head displacement is maximum in each case. Maximum possible bending moment and soil-pile interacting forces for the dynamic excitation of the pile is also compared. When results are compared with the linear response, it is observed that non-dimensional frequency is reduced in nonlinear response on account of reduction in the soil stiffness due to yielding. Nonlinear response curve shows high amplitude as compared to linear response curve.

• Asian Pacific Journal of Cancer Prevention
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• v.17 no.11
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• pp.4917-4920
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• 2016

For advanced non-small-cell lung cancer (NSCLC) cases, a platinum-based regimen is the first-line chemotherapy treatment. The excision repair cross-complementing group 1 (ERCC1) plays an important role in DNA repair and has been related to resistance to platinum chemotherapy. This study aimed to investigate the effects of the ERCC1 (C118T) polymorphism on treatment response in 26 Thai advanced NSCLC patients receiving first line platinum-based chemotherapy during January to July 2015 at King Chulalongkorn Memorial Hospital (KCMH). DNA was extracted from peripheral blood lymphocytes and the single nucleotide polymorphism of ERCC1 was genotyped using a real-time PCR method with the TaqMan assay. The distribution of C/C, C/T and T/T genotypes was 57.7 %, 34.6 % and 7.7 %, respectively. The response rate to platinum-based chemotherapy in the wild type (C/C) of ERCC1 (C118T) was better than with the variant types (C/T and T/T) but the difference was not statistically significant (29.7% vs 9.1%, P=0.274). The results showed that a genetic polymorphism in ERCC1 might influence patient response to platinum-based chemotherapy. Further multicenter studies are now required to confirm the results of our study.

• Structural Engineering and Mechanics
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• v.64 no.4
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• pp.473-485
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• 2017

An isolated building, composed of superstructure and isolation system which have very different damping properties, is typically non-classical damping system. This results in inapplicability of traditional response spectrum method for isolated buildings. A multidimensional response spectrum method based on complex mode superposition is herein introduced, which properly takes into account the non-classical damping feature in the structure and a new method is developed to estimate velocity spectra from the commonly used displacement or pseudo-acceleration spectra based on random vibration theory. The error of forced decoupling method, an approximated approach, is discussed in the viewpoint of energy transfer. From the base-isolated benchmark model, as a numerical example, application of the procedure is illustrated companying with comparison study of time-history method, forced decoupling method and the proposed method. The results show that the proposed method is valid, while forced decoupling approach can't reflect the characteristics of isolated buildings and may lead to insecurity of structures.

• Structural Engineering and Mechanics
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• v.85 no.5
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• pp.655-664
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• 2023

Reinforced concrete (RC) shear wall structures are one of the most widely used structural systems to resist seismic loading all around the world. Although there have been several efforts to provide conceptually simple procedures to reasonably assess the seismic demands of structures over recent decades, it seems that lesser effort has been put on a number of structural forms such as RC shear wall structures. Therefore, this study aims to represent a simple linear response spectrum-based method which can acceptably predict the nonlinear displacements of a non-ductile RC shear wall structure subjected to an individual ground motion record. An effective period and an equivalent damping ratio are introduced as the dynamic characteristics of an equivalent linear SDOF system relevant to the main structure. By applying the fundamental mode participation factor of the original MDOF structure to the linear spectral response of the equivalent SDOF system, an acceptable estimation of the nonlinear displacement response is obtained. Subsequently, the accuracy of the proposed method is evaluated by comparison with another approximate method which is based on linear response spectrum. Results show that the proposed method has better estimations for maximum nonlinear responses and is more utilizable and applicable than the other one.

• Journal of the korean academy of Pediatric Dentistry
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• v.24 no.1
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• pp.301-312
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• 1997

The purpose of this study was to evaluate the analgesic effect on pulp induced by pulsed Nd : YAG laser according to the power density, irradiated time and the method of application (Non-contact vs contact) in vivo. Experiments were carried out on 90 volunteers who have sound 4 canines. Each canine was grouped by the intensity and the time of irradiation of pulsed Nd : YAG laser was measured. Mean EPT response(units) was measured at 5 min, 30 min, and 60 min after irradiation with various intensity(1.5-3W, 15-30Hz), irradiated time (1.5min, 3min), and application method (Non-contact and contact). The results were as follows: 1. 5 minutes after irradiation, the mean EPT response(units) was increased by 32 % in the non-contact method and by 35% in the contact method of application. Which showed significant difference in mean EPT response(units) compared to not-lased canine in each groups(P<0.05). 2. The mean EPT response(units) with irradiating condition according to the various laser intensity, and the irradiation time stastically did not show significant difference in each groups as time elapsed. 3. There was no significant difference between the non-contact and contact method in the mean EPT response(units). 4. The mean EPT response(units) returned to the baseline value within 30 miuntes. In regard to the above results, the analgesic effect on pulp induced by pulsed Nd : YAG laser resulted a slight increase of pulpal pain threshold, but it was not as high as to replace the role of drug analgesia as whole. This technique can be used for inducing pulpal analgesia as adjunct to other pain control methods and is needed to develop better analgesic effects.

• Structural Engineering and Mechanics
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• v.35 no.3
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• pp.349-364
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• 2010

The impact behaviour and the impact-induced damage in laminated composite cylindrical shell subjected to transverse impact by a foreign object are studied using three-dimensional non-linear transient dynamic finite element formulation. A layered version of 20 noded hexahedral element incorporating geometrical non-linearity is developed based on total Langragian approach. Non-linear system of equations resulting from non-linear strain displacement relation and non-linear contact loading are solved using Newton-Raphson incremental-iterative method. Some example problems of graphite/epoxy cylindrical shell panels are considered with variation of impactor and laminate parameters and influence of geometrical non-linear effect on the impact response and the resulting damage is investigated.

• Structural Engineering and Mechanics
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• v.85 no.4
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• pp.545-562
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• 2023

In this work, superharmonic and subharmonic resonance of rotating stiffened FGM truncated conical shells exposed to harmonic excitation in a thermal environment is investigated. Utilizing classical shell theory considering Coriolis acceleration and the centrifugal force, the governing equations are extracted. Non-linear model is formulated employing the von Kármán non-linear relations. In this study, to model the stiffener effects the smeared stiffened technique is utilized. The non-linear partial differential equations are discretized into non-linear ordinary differential equations by applying Galerkin's method. The method of multiple scales is utilized to examine the non-linear superharmonic and subharmonic resonances behavior of the conical shells. In this regard, the effects of the rotating speed of the shell on the frequency response plot are investigated. Also, the effects of different semi-vertex angles, force amplitude, volume-fraction index, and temperature variations on the frequency-response graph are examined for different rotating speeds of the stiffened FGM truncated conical shells.

• Proceedings of the KIEE Conference
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• 2003.11b
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• pp.127-130
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• 2003

In this paper, a hypothesis in order that the impulse response of a stable linear system does not change sign is suggested. For fixed zeros of the systems, the problem of synthesizing such a system is reduced to the problem of finding a proper denominator polynomial so that the step response of the overall system will not overshoot. The hypothesis is associated with the generalized time constant by Kim[5]. Under the hypothesis, we propose several methods that allow to compose a continuous time LTI systems achieving non-negative impulse response.