• Asian Pacific Journal of Cancer Prevention
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• v.13 no.12
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• pp.6391-6395
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• 2012

Background: Ovarian cancer is ranked as the fifth most common cause of cancer death in women. In Malaysia, it is the fourth most common cancer in females. CA125 has been the tumor marker of choice in ovarian cancer but its diagnostic specificity in early stages is only 50%. Hence, there is a critical need to identify an alternative tumor marker that is capable of detecting detect ovarian cancer at an early stage. HE4 is a new tumor marker proposed for the early diagnosis of ovarian cancer and disease recurrence. Currently, none of the normal ranges of HE4 quoted in the literature are based on data for a multiethnic Asian population. Therefore, the aim of this study was to determine reference intervals for HE4 in an Asian population presenting in University Malaya Medical Centre, a tertiary reference hospital. Materials and Methods: 300 healthy women were recruited comprising 150 premenopausal and 150 postmenopausal women, aged from 20-76 years. All women were subjected to a pelvic ultrasonograph and were confirmed to be free from ovarian pathology on recruitment. Serum HE4 levels were determined by chemiluminescent microparticle immunoassay (CMIA, Abbott Architect). The reference intervals were determined following CLSI guidelines (C28-A2) using a non-parametric method. Results: The upper limits of the $95^{th}$ percentile reference interval (90%CI) for all the women collectively were 64.6 pmol/L, and 58.4 pmol/L for premenopausal) and 69.0 pmol/L for postmenopausal. The concentration of HE4 was noted to increase with age especially in women who were more than 50 years old. We also noted that our proposed reference limit was lower compared to the level given by manufacturer Abbott Architect HE4 kit insert (58.4 vs 70 pmol/L for premenopausal group and 69.0 vs 140 pmol/L in the postmenopausal group). The study also showed a significant difference in HE4 concentrations between ethnic groups (Malays and Indians). The levels of HE4 in Indians appeared higher than in Malays (p<0.05), while no significant differences were noted between the Malays and Chinese ethnic groups. Conclusions: More data are needed to establish a reference interval that will better represent the multiethnic Malaysian population. Probably a larger sampling size of equal representation of the Malay, Chinese, Indians as well as the other native ethnic communities will give us a greater confidence on whether genetics plays a role in reference interval determination.

• Journal of the HCI Society of Korea
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• v.1 no.1
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• pp.37-44
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• 2006

Specular reflections provide the visual feedback that describes the material type of an object, its local shape, and lighting environment. In photorealistic rendering, there have been a number of research available to render specular reflections effectively based on a local reflection model. In traditional cel animations and cartoons, specular reflections plays important role in representing artistic intentions for an object and its related environment reflections, so the shapes of highlights are quite stylistic. In this paper, we present a method to render and control stylized specular reflections using projective textures based on principal curvature analysis. Specifying a texture as a pattern of a highlight and projecting the texture on the specular region of a given 3D model, we can obtain a stylized representation of specular reflections. For a given polygonal model, a view point, and a light source, we first find the maximum specular intensity point, and then locate the texture projector along the line parallel to the normal vector and passing through the point. The orientation of the projector is determined by the principal directions at the point. Finally, the size of the projection frustum is determined by the principal curvatures corresponding to the principal directions. The proposed method can control the position, orientation, and size of the specular reflection efficiently by translating the projector along the principal directions, rotating the projector about the normal vector, and scaling the principal curvatures, respectively. The method is be applicable to real-time applications such as cartoon style 3D games. We implement the method by Microsoft DirectX 9.0c SDK and programmable vertex/pixel shaders on Nvidia GeForce FX 7800 graphics subsystems. According to our experimental results, we can render and control the stylized specular reflections for a 3D model of several ten thousands of triangles in real-time.

• Journal of Korea Spatial Information System Society
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• v.12 no.1
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• pp.66-75
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• 2010

The authors argues that the current road updating system based on traditional aerial photograph or multi-spectral satellite image appears to be non-user friendly due to lack of the frequent cartographic representation for the new construction sites. Google Earth are currently being emerged as one of important places to extract road features since the RGB satellite image with high multi-temporal resolution can be accessed freely over large areas. This paper is primarily intended to evaluate optimal threshold of RGB pixel values to extract road features from Google Earth. An empirical study for five experimental sites was conducted to confirm how a RGB picture provided Google Earth can be used to extact the road feature. The results indicate that optimal threshold of RGB pixel values to extract road features was identified as 126, 125, 127 for manual operation which corresponds to 25%, 30%, 19%. Also, it was found that display scale difference of Google Earth was not very influential in tracking required RGB pixel value. As a result the 61cm resolution of Quickbird RGB data has shown the potential to realistically identified the major type of road feature by large scale spatial precision while the typical algorithm revealed successfully the area-wide optimal threshold of RGB pixel for road appeared in the study area.

• Journal of Korean Ophthalmic Optics Society
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• v.19 no.4
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• pp.435-443
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• 2014

Purpose: The purpose of this study was to analyze the design identity visual elements of optical shop brand$\underline{s}$ in order to provide objective data necessary for optical shop brands' design development. Methods: This study examined the design identity concept of the optical shop brands and analyzed visual elements of brand design identity with a focus on the symbols of domestic franchise optical shops, type of a symbol mark, representation style of logo type, color usage, use or non-use of character, etc. Results: Many symbols were directly associated with the eyeglasses, such as eyeglasses and eyes, face and iris. Along with that, letters or figures were also observed. For the type of symbol, most types were found to have the designs that took spherical and word mark shapes. Particularly, the word mark type had English words more often than Korean words. For logo types, the gothic format was dominant. In relation to the thickness of letter, thick boldface type was commonly used. The combination of 2 degrees was the color frequency used most often in the optical shop brand design. For the frequency of color usage, black and red colors were used most often. Particularly, the orange color, as well as the black color, was also often used for the main color of symbols or logo types. Meanwhile, the characters were used only in some optical shop. Most characters were animals and expressed in the cartoon and graphical forms. Conclusions: Typifier, symbol mark, logo type, color, and character are the elements forming the basic development system for brand design identity. Systematic design is needed which clearly ensures the function and role along with the mutual consistency as a important visual component of the optical shop brand.

• Journal of Sasang Constitutional Medicine
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• v.11 no.2
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• pp.185-194
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• 1999

Recently some report has been published on the classification of Sasang constitution by analysis of genetic polymorphism. In this study, to present the ideas in the study on the classification of Sasang constitution based on the genetic variation of individuals, we reviewed the previous studies dealing with relationship between genetic polymorphism and Sasang constitution and suggested new molecular biological methodologies applicable to the classification of Sasang constitution. The results were as follow; 1. In the studies on the classification of constitution by analysis of genetic polymorphism, the special genes were desirable as subjects rather than the non-functional part of genome such as inter-gene and intron. Since microsatellite is usually located in inter-gene or intron, representation of constitutions may not associated with the polymorphism of certain microsatellite. 2. It may possible that polymorphism patterns of the genes related to the expression of individuality is associated with the types of Sasang constitutions. Therefore, angiotensin converting enzyme (ACE) which known have some role in the determination the human performance is one of the candidate genes can use for the classification of Sasang constitutions. 3. It is well known that HLA types are very variable in human and closely associated with the determination of susceptibility for certain disease. The studies on the polymorphism of HLA types may applicable to the classification of Sasang constitutions. 4. DNA chip technique which developed recently for the analysis of the expression of human genes may powerful tools in the study of Sasang medicine.

• Spatial Information Research
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• v.19 no.6
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• pp.101-109
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• 2011

Climate change affects all components of the global environment system and, in turn, all components mutually interact and affect climate change through non-linear feedback processes. It is thus necessary to study the interaction between the climate and the environment, in order to comprehensively understand and predict climate and environment change. However, current relevant systems are limited to particular areas and do not sufficiently support the mutual linking of research studies. Therefore, this study develops prototype a GIS based integrated DB management system for supporting the climate and environment data storage, management and distribution. The integrated DB management system was developed using VB.NET languages and ArcObjects component. First, considering the demands of climate environment experts, the study areas are selected and the methods of data management and utilization were defined. In addition, a location-based GIS DB was created in order to aid in understanding climate change through visual representation. Finally, the integrated DB management system provides an efficient data management and distribution data and it creates synergistic effect on climate and environment study. It also contributes significantly to the comprehensive diagnosis and prediction of climate change and environment systems.

• Journal of Korea Water Resources Association
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• v.35 no.2
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• pp.161-171
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• 2002

It has been known that the accurate estimates of 2-dimensional water quality model parameters are difficult for non-experts due to the complexity of theoretical background and input requirement and complicated inter-relationship between model Parameters. The main goal of this study is to Provide expert system for the optimal estimation of water quality model parameters, which is based on the development of chaining mechanism according to the sensitivity analysis of model parameter interactions and GUI interface system on ArcView Avenue. The selected study area is the 35.3- km main Han river starting from Paldang Dam site to the Point of Indo bridge and the tributary inflows including pollutant data are used for the system application and validation. The estimated main model parameters are 0.367 for transverse dispersion coefficient, 0.074 for and 0.162 for. It also shows that the simulated water quality constituents such as DO and BOD based on the estimated model parameters are well agreed with the observed ones. It can be concluded that the developed GIS-based expert system for water quality model parameter estimation and graphical representation of water quality analysis is useful for the scientific water quality management.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.22 no.4
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• pp.637-637
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• 1997

In this paper, format conversion filters are proposed, which have advantages in hardware implementation compared to the ones proposed in MPEG-4 Video Verification Model. since each coefficients of the proposed filters is constrained to have less than two non-zero digits in minimal signed digit representation, multiplication of input and the coefficient can be implemented by a single adder. As a result, the proposed filters have advantages in hardware complexity and speed, compared to the filters which are usually implemented by integer multiplier or carry save adders. Six kinds of filters are proposed in MPEG-4 Video Verification Model for size conversion of 2:1, 4:1, 5:3 and 5:6. We design 5 filters for the same purpose and compare the performance. The remaining one is very simple to implement. For comparing the filtering performance, we first compare the results of sine wave frequency conversion as an indirect but meaningful comparison. Second. We compute the PSNR of the images obtained from the proposed filters and the ones proposed by MPEG, with reference to the images obtained by using double precision arithmetic and high order filter. The results show that the performance of the proposed filters is almost the same as that of the filters proposed by MPEG. In conclusion, the peroformance of the proposed filters is comparable to that of the ones in MPEG-4, while requiring lower hardware complexity and providing high operating speed.

• Tunnel and Underground Space
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• v.20 no.2
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• pp.97-104
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• 2010

The materials failure relation $\ddot{\Omega}=A{(\dot{\Omega})}^\alpha$ where $\Omega$ is a measurable quantity such as displacement and the dot superscript is the time derivative, may be used to analyze the accelerating creep of materials. Coefficients, A and $\alpha$, are determined by fitting given data sets. In this study, it is tried to predict the failure time of tunnel using the materials failure relation. Four fitting techniques of applying the materials failure relation are attempted to forecast a failure time. Log velocity versus log acceleration technique, log time versus log velocity technique, inverse velocity technique are based on the linear least squares fits and non-linear least squares technique utilizes the Levenberg-Marquardt algorithm. Since the log velocity versus log acceleration technique utilizes a logarithmic representation of the materials failure relation, it indicates the suitability of the materials failure relation applied to predict a failure time of tunnel. A linear correlation between log velocity and log acceleration appears satisfactory(R=0.84) and this represents that the materials failure relation is a suitable model for predicting a failure time of tunnel. Through comparing the real failure time of tunnel with the predicted failure times from four curve fittings, it is shown that the log time versus log velocity technique results in the best prediction.

• Journal of Korean Philosophical Society
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• v.139
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• pp.265-313
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• 2016

This research aims to reconstruct the philosophical content and essence of Schopenhauer's metaphysics of music in his book, Die Welt als Wille und Vorstellung, particularly in paragraph 52, and to pay close attention to its theoretical account of music in the context of traditional musical aesthetics. The question whether Schopenhauer's theory of music is about aesthetics of feeling or about absolute music is dealt with at the end of this paper. It can be answered only within the whole system of his philosophy, because Schopenhauer's theory of music is the result of his philosophical reflections, and plays an important part in his metaphysics of the will. Schopenhauer's music theory, or rather his metaphysics of music, thus cannot be treated separately from Schopenhauer's metaphysics of the will, and is connected organically with it. As the metaphysics of the will lies in suspense between the traditional metaphysical philosophy and the non-metaphysical philosophy after Nietzsche, between the idealism and the philosophy of the body, the music aesthetics of Schopenhauer oscillates between the (romantic) aesthetics of feeling and the modern idea of absolute music.