• 한국시뮬레이션학회논문지
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• 제20권1호
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• pp.97-105
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• 2011

하천에서, 생물막은 녹갈색의 얇은 막의 형태로 돌, 식물, 그리고 기타 구조물의 표면에 부착되어 있다. 생물막은 주로 영양물의 순환, 수질정화, 바닥 침전물 제거, 그리고 먹이사슬내의 에너지 흐름에 매우 중요한 역할을 한다. 본 연구에서, 우리는 유체 흐름 안에서, 독소-생산 종과 독소-민감 종의 복합적 생물막을 전산 모사하는 모델을 개발하였다. 유체 흐름으로는 균일한 흐름과 불 균일한 흐름 두 가지를 고려하였다. 균일한 흐름은 확률 프로세스로 구현되었으며, 불 균일한 흐름은 나비어-스톡스 방정식으로 구현되었다. 모델에서, 독소-생산종과 독소-민감종 간의 상호작용을 고려하기 위해, 종 개체의 번식률과 사망률이 고려되어졌다. 우리는 서로 다른 두 유체 흐름 내에서 전산 모사 되어진 생물막의 구조적 형상에 대해서 간략히 논의 하였다.

• Structural Engineering and Mechanics
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• 제52권3호
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• pp.613-632
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• 2014

In the early design stage of ships, the two most important structural analyses are performed to identify the structural capacity and safety. The first step is called global strength analysis (longitudinal strength analysis or hull girder strength analysis) and the second step is local buckling analysis (stiffened panel strength analysis). This paper deals with the ultimate strength performance of Arctic Sea Route-going commercial ships considering the effect of low temperature. In this study, two types of structural analyses are performed in Arctic sea conditions. Three types of ship namely oil tanker, bulk carrier and container ship with four different sizes (in total 12 vessels) are tested in four low temperatures (-20, -40, -60 and $-800^{\circ}C$), which are based on the Arctic environment and room temperature ($20^{\circ}C$). The ultimate strength performance is analysed with ALPS/HULL progressive hull collapse analysis code for ship hulls, then ALPS/ULSAP supersize finite element method for stiffened panels. The obtained results are summarised in terms of temperature, vessel type, vessel size, loading type and other effects. The important insights and outcomes are documented.

• Molecules and Cells
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• 제40권7호
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• pp.450-456
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• 2017

Mammalian physiology and behavior are regulated by an internal time-keeping system, referred to as circadian rhythm. The circadian timing system has a hierarchical organization composed of the master clock in the suprachiasmatic nucleus (SCN) and local clocks in extra-SCN brain regions and peripheral organs. The circadian clock molecular mechanism involves a network of transcription-translation feedback loops. In addition to the clinical association between circadian rhythm disruption and mood disorders, recent studies have suggested a molecular link between mood regulation and circadian rhythm. Specifically, genetic deletion of the circadian nuclear receptor Rev-$erb{\alpha}$ induces mania-like behavior caused by increased midbrain dopaminergic (DAergic) tone at dusk. The association between circadian rhythm and emotion-related behaviors can be applied to pathological conditions, including neurodegenerative diseases. In Parkinson's disease (PD), DAergic neurons in the substantia nigra pars compacta progressively degenerate leading to motor dysfunction. Patients with PD also exhibit non-motor symptoms, including sleep disorder and neuropsychiatric disorders. Thus, it is important to understand the mechanisms that link the molecular circadian clock and brain machinery in the regulation of emotional behaviors and related midbrain DAergic neuronal circuits in healthy and pathological states. This review summarizes the current literature regarding the association between circadian rhythm and mood regulation from a chronobiological perspective, and may provide insight into therapeutic approaches to target psychiatric symptoms in neurodegenerative diseases involving circadian rhythm dysfunction.

• 대한약침학회지
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• 제18권2호
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• pp.76-85
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• 2015

Objectives: Radix Ginseng has been traditionally used as an adaptogen that acts on the adrenal cortex and stimulates or relaxes the nervous system to restore emotional and physical balance and to improve well-being in cases of degenerative disease and/or old age. Radix Ginseng has been used for a long time, but the safety of ginseng pharmacopuncture needs testing. This study was done to analyze the single-dose toxicity of water- soluble ginseng pharmacopuncture (GP) intramuscular injections in rats. Methods: All experiments were performed at Biotoxtech, an institution authorized to perform non clinical studies under the regulations of Good Laboratory Practice (GLP). Each group contained 10 Sprague-Dawley rats, 5 males and 5 females. GP was prepared in a sterile room at the Korean Pharmacopuncture Institute under regulations of Good Manufacturing Practice (GMP). GP dosages were 0.1, 0.5 and 1.0 mL for the experimental groups; normal saline was administered to the control group. The animals general condition was examined daily for 14 days, and the rats were weighed on the starting day and at 3, 7 and 14 days after administration of the pharmacopuncture. Hematological and biochemistry tests and autopsies were done to test the toxicological effect of GP after 14 days. This study was performed with approval from the Institutional Animal Ethics Committee of Biotextech. Results: No deaths were found in this single-dose toxicity test of intramuscular injections of GP, and no significant changes in the general conditions, body weights, hematological and biochemistry tests, and autopsies were observed. The local injection site showed no changes. Based on these results, the lethal dose was assumed to be over 1.0 mL/animal in both sexes. Conclusion: These results suggest that GP is relatively safe. Further studies, including a repeated toxicity test, are needed to provide more concrete evidence for the safety of GP.

• International Journal of Computer Science & Network Security
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• 제21권12호
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• pp.316-322
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• 2021

The problem of corruption and the spread of corruption crime today is not only one of the main social problems, but also an obstacle to the implementation of reforms in Ukraine. Given the complexity, scale and diversity of the impact of corruption, it is an undisputed threat to national security. At the state level, corruption threatens, firstly, state security as a result of its spread in public authorities and the combination of political and business spheres; secondly, in the domestic political sphere as a result of non-compliance and violation by officials of public authorities and local governments of the laws of Ukraine; thirdly, in the economic sphere as a result of the dominance of personal interests of civil servants over national ones; fourthly, in other spheres, namely, military, social, ecological, informational, foreign policy, etc. The origins of corruption are diverse and are formed not only in the country but also abroad. The current corruption threat is the result of the country's ineffective domestic and foreign anticorruption policies. Acceleration of the spread and manifestation of external corruption threats is associated with a number of unresolved foreign policy issues against the background of the development of globalization and integration processes, in particular: economic and financial dependence of the country on international financial institutions and organizations; as well as from foreign countries that pose a potential threat due to their ambitious plans to expand our country; unresolved issues regarding the international legal consolidation of borders, etc. It is noted that the current conditions for the development of state security, due to new challenges and threats, need to improve and implement new measures to prevent corruption as a negative impact of the main threats to national economic security. As a result of the study, the main measures to counter the main threats to the economic security of the state were identified.

• 농촌계획
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• 제29권3호
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• pp.53-67
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• 2023

In this study, the problem of the idleness of public buildings in rural areas is seriously emerging, but there are no clear standards for assessing the utilization of these buildings. Therefore, this study endeavors to investigate the actual state of idleness of buildings created by rural area development projects based on the criteria for each type. As part of this study, rural facilities were selected in two locations in Sangju City and Miryang City among the target areas of the Rural Agreement. Utilization evaluation criteria were developed to identify the conditions of underutilization. In order to determine the utilization pattern for each facility type, an in-depth interview with the operator and an inspection of the facility were conducted. Based on the analysis, the degree of utilization (e.g., low use, non-use, etc.) was different for each facility type, and among the four facility types (rural tourism, culture and welfare, exercise and recreation, income-based), rural tourism was rated as the least efficient. It has been found that the operating entity's capacity has a significant influence on the utilization of facilities. Socioeconomic factors, such as a decrease in utilization rates, are greatly influenced by the operating entity's capacity. Therefore, support from local governments as well as the national level is required to recycle idle facilities. Lastly, this study suggests the need for different standards for utilization, depending on the type of facility. This moves beyond checking the degree of idleness by the same standard that was previously implemented.

• 한국해안·해양공학회논문집
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• 제35권4호
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• pp.84-94
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• 2023

재현기간에 따른 설계주기 추정에는 일반적으로 파고-주기 관계곡선을 이용한다. 본 연구에서는 설계주기 추정을 위한 파고-주기 관계곡선의 매개변수를 선형, 로버스트 선형, 비선형 함수를 이용하여 추정하고 그 계수를 비교-평가하였다. 매개변수 추정에 사용한 자료는 해양수산부(2019) 설계파고 추정에 사용한 연 최대 파고-주기 자료이며, 태풍, 비태풍 조건으로 구분하여 매개변수 추정에 이용하였다. 추정 매개변수는 해역의 지점에 따라 뚜렷한 차이를 보였으며, 추정기법의 경우에는 태풍 조건의 자료의 경우 비선형과 선형 기법이 큰 차이를 보이고 있는 것으로 파악되었다. 또한 SPM 공식과 GODA 공식을 평균하여 추정하는 Suh et al.(2008, 2010) 제안 방법은 절편 매개변수는 과소추정, 경사 매개변수는 과대 추정하는 것으로 파악되었으며, 해역의 국지적인 특성 반영에는 한계가 있는 것으로 판단된다.

• 대한토목학회논문집
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• 제28권3C호
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• pp.159-166
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• 2008

흙은 변형률에 따라 강성이 감소하는 비선형적 변형 특성을 가지지만, 매우 작은 변형률 영역($<10^{-3}%$)에서는 선형탄성적 특성을 갖는다고 알려져 있다. 본 연구에서는 응력 경로 시험 중 실시한 다축 벤더엘리먼트 시험을 통해 다양한 응력 상태에서 사질토의 이방적 전단탄성계수를 측정하고, 그 변화를 분석하고자 하였다. 응력 경로 시험에서는 내부 변형률 측정 장치 및 3 방향의 벤더 엘리먼트가 부착된 삼축 시험기를 이용하였다. 전단 중 응력비가 -0.5~1.5의 범위를 벗어나게 되면 축 방향 전단탄성계수는 응력과의 경험적 상관관계와 차이가 발생하였고, 이로부터 시료의 항복이 전단파 전달 구조를 변화시킴을 알 수 있었다. 수평방향 전단탄성계수의 변화는 전단 중 체적 상태의 변화와 밀접한 관계가 있음을 알 수 있었다.

• 아태비즈니스연구
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• 제15권1호
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• pp.289-304
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• 2024

Purpose - Focusing on the FGI research method, the current status and issues of barrier-free tourism in Gangwon State were identified, and specific activation plans were derived Design/methodology/approach - This study conducted in-depth interviews with 20 experts related to the tourism industry. The issues, current status, and activation plan of barrier-free tourism in Gangwon State recognized by experts in tourism policy, tourism administration, tourism management, and tourism service industry were derived. Findings - First, the tendency of businesses to be promoted based on the non-disabled by not recognizing the weak as the main tourism demand group, second, confusion caused by the unification of terms related to barrier-free tourism, third, lack of finding tourism constraints subdivided according to the type and degree of disability, fourth, tourism information and evaluation indicators provided by prioritizing the convenience of suppliers rather than consumers, and fifth, the nature of the project focused on improving access to physical infrastructure. Subsequently, the results of the analysis of the plan to revitalize the barrier-free tourism industry in Gangwon State were as follows. First, education and programs to improve disability awareness appropriate to local conditions were activated, second, related information was unified and project sustainability was improved by creating a control tower for the barrier-free tourism industry at the provincial level, third, to overcome the employment crisis based on finding locally tailored jobs related to tourism care professionals, and fourth, to continuously secure quantitative and qualitative data and establish utilization plans. Research implications or Originality - First, it presents theoretical implications for related fields by providing issues and activation measures related to barrier-free tourism from the perspective of experts who are still lacking in research in academia. The practical implications are that based on the opinions of experts working in the tourism field, more specific issues of the barrier-free tourism industry in the province were presented, and policy and practical solutions were presented accordingly, suggesting realistic alternatives that can be carried out in the actual field.

• 지구물리와물리탐사
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• 제13권3호
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• pp.203-218
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• 2010

지진 지반운동의 증폭 유발 요인인 부지 효과는 지역적 및 국부적 부지 조건에 직접적인 영향을 받게 됨에도 불구하고, 현행 국내 내진 설계 기준의 부지 분류와 그에 따른 부지 증폭계수는 미국 서부 지역의 기준을 준용한다. 이러한 내진 기준의 경우, 단주기와 중장주기에 관한 두 종류의 부지 증폭계수들을 30 m 심도까지의 평균 전단파속도라는 기준에 따라 A 부터 E까지의 다섯 종류로 분류한다. 본 연구에서는 국내 부지 조건을 반영한 부지 분류 체계를 제시할 목적으로, 경주, 홍성, 해미, 사천의 네 지역에 대해 체계적인 부지 특성 평가를 수행하였으며, 현장에서는 지표면부터 기반암까지의 전단파속도 깊이분포를 결정하고 실내에서는 지반의 비선형적 물성을 획득하였다. 국내 토사층은 미국 서부에 비해 상대적으로 얕고 강성이 크게 파악되었고, 그로 인해 국내의 부지 주기는 상대적으로 작고 좁은 범위에 분포하였다. 현장과 실내에서 구한 지반 특성을 이용하여 등가선형 및 비선형 기법을 적용한 다양한 부지고유 지진응답 해석을 총 75부지를 대상으로 실시하였다. 해석 결과로부터 현행 국내 기준에 정의된 부지 증폭계수는 지반운동을 단주기에서는 과소 평가하고 중장주기에서는 과대평가함을 알 수 있었다. 이러한 차이는 국내와 미국 서부간의 기반암 심도를 포함한 국부적 지반 특성들의 차이로 인한 것이다. 본 연구의 해석 결과와 한반도 대상의 선행 연구 결과들을 토대로 대표 기준인 부지 주기와 추가 기준으로서의 30 m 보다 얕은 심도까지의 평균 전단파속도를 도입함으로써, 국내 지역적 부지 특성을 고려한 지반운동과 설계 스펙트럼을 신뢰성 높게 결정할 수 있는 새로운 부지 분류 체계를 개발하였다.