• Korean Journal of Clinical Laboratory Science
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• v.54 no.4
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• pp.298-306
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• 2022

This study sought to evaluate the mechanism of cellular injury caused by ferrous sulfate (FeSO₄) and the protective effects of Parnassia palustris L. (PP) extract against FeSO₄-induced cytotoxicity of cultured C6 glioma cells. FeSO₄ is known to cause neurotoxicity and induce Parkinson's disease. The antioxidative effects of PP, such as superoxide dismutase (SOD)-like and superoxide anion-radical (SAR)-scavenging activities, as well as effects on cell viability, were studied. FeSO₄ significantly decreased cell viability in a dose-dependent manner and the XTT₅₀ value, the concentration of FeSO₄ which reduced the cell viability by half, was measured at 63.3 μM in these cultures. FeSO₄ was estimated to be highly cytotoxic by the Borenfreund and Puerner toxicity criteria. Quercetin, an antioxidant, significantly improved cell viability, damaged by FeSO₄-induced cytotoxicity. While evaluating the protective effects of the PP extract on FeSO₄-induced cytotoxicity, it was observed that the extract significantly increased cell viability compared to the FeSO₄-treated group. Also, the PP extract showed superoxide dismutase (SOD)-like and superoxide anion radical (SAR)-scavenging activities. Based on these findings, it can be concluded that FeSO₄ induced oxidative stress-related cytotoxicity, and the PP extract effectively protected against this cytotoxicity via its antioxidative effects. In conclusion, natural antioxidant sources such as PP may be agents useful for preventing oxidative stress-related cytotoxicity induced by heavy metal compounds such as the FeSO₄, a known Parkinsonism inducer.

• Journal of Korea Entertainment Industry Association
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• v.13 no.6
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• pp.277-286
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• 2019

The aim of this study was to investigate the effects of computer-based cognitive rehabilitation and traditional cognitive training on the working memory and executive function of patients with mild traumatic brain injury. The sample consisted of 20 patients with mild traumatic brain injury who had received rehabilitation treatment in a rehabilitation unit. The subjects were assigned to either the experimental (n = 10) or control group (n = 10). The experimental group received computer-based cognitive rehabilitation and traditional cognitive training for 60 minutes, whereas the control group received only traditional cognitive training for 60 minutes. Both the groups received their respective interventions for 60 minutes a day and 5 times per week across a period of 4 weeks. Working memory and executive function were assessed using the digit span test (forward and backward), visual memory 1 and 2 of the Motor-free Visual Perception Test-3, trail making test, and Stroop test (A and B) both before and after the intervention. The experimental group showed a significantly greater improvement in visual memory and performance on the Stroop test A than the control group. These findings suggest that computer-based cognitive rehabilitation and traditional cognitive training are more effective in promoting positive changes in the working memory and executive function of individuals with mild traumatic brain injury than traditional cognitive training.

• Journal of the Korea Society of Computer and Information
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• v.28 no.7
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• pp.113-120
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• 2023

The purpose of this study was the accuracy of cardiac compression, fatigue, and physiological changes of the rescuer for different mask type in cardiopulmonary resuscitation(CPR). Data collection was from 9 to 12 May 2022, the participants were a total of 24 paramedic students with a BLS provider at D University. The students participated in an experiment in which 12 students each wore a surgical mask (Dental mask) and a fine particle 94% blocking mask (KF94 mask) and performed CPR for 2 minutes over a total of 7 times. As a result of the study, in the analysis of the quality of the rescuer's chest compression according to the type of mask, there was a significant difference in the compression speed (F=24.91, p<.001) and bad compression hand position (F=14.54, p=.024) in the group wearing the KF94, Fatigue showed significant differences in both the Dental mask group (F=51.16, p<.001) and the KF94 mask group (F=63.49, p<.001). Among the physiological changes, heart rate showed a significant difference between the Dental mask group (F=34.79, p<.001) and the KF94 mask group (F=35.55, p<.001), and the respiratory rate showed a significant difference between the Dental mask group (F=25.02, p=.001) and the KF94 mask group(F=23.02, p=.002). Therefore, in order to improve the quality of efficient chest compression and reduce the fatigue and physiological changes of rescuers, it will be necessary for rescuers to wear suitable personal protective equipment.